检索结果-南通市图书馆

Identification of microbial metabolites that accelerate the ubiquitindependent degradation of c-Myc

Oncology Research 2023年第5期31卷 655-666页

作者： ZIYU LIU akiko OKANO EMIKO SANADA YUSHI FUTAMURA TOSHIHIKO NOGAWA KOSUKE ISHIKAWA KENTARO SEMBA JIANG LI XIAOMENG LI HIROYUKI OSADA NOBUMOTO WATANABE Bioprobe Application Research Unit RIKEN CSRSSaitama351-0198Japan Graduate School of Medical and Dental Sciences Tokyo Medical and Dental UniversityTokyo113-8510Japan Chemical Biology Research Group RIKEN CSRSSaitama351-0198Japan Chemical Resource Development Research Unit RIKEN CSRSSaitama351-0198Japan Molecular Structure Characterization Unit RIKEN CSRSSaitama351-0198Japan Japan Biological Informatics Consortium(JBIC) Tokyo135-8073Japan Department of Life Science and Medical Bioscience School of Advanced Science and EngineeringWaseda UniversityTokyo162-8480Japan Medical-Industrial Translational Research Center Fukushima Medical UniversityFukushima960-1295Japan Guangdong Engineering Research Center of Oral Restoration and Reconstruction Affiliated Stomatology Hospital of Guangzhou Medical UniversityGuangzhouChina KingMed School of Laboratory Medicine Guangzhou Medical UniversityGuangzhouChina Department of Pharmaceutical Sciences University of ShizuokaShizuoka422-8526Japan

Myc belongs to a family of proto-oncogenes that encode transcription *** overexpression of c-Myc causes many types of ***,we established a system for screening c-Myc inhibitors and identified antimycin A by screening the RIKEN NPDepo chemical *** specific mechanism of promoting tumor cell metastasis by high c-Myc expression remains to be *** this study,we screened approximately 5,600 microbial extracts using this system and identified a broth prepared from Streptomyces ***19-A0402 strongly inhibits c-Myc transcriptional *** purification of the hit broth,we identified compounds closely related to the aglycone of cytovaricin and had a structure similar to that of oligomycin *** to oligomycin A,the hit compounds inhibited mitochondrial complex *** mitochondria dysfunction caused by the compounds induced the production of reactive oxygen species(ROS),and the ROS activated GSK3α/βthat phosphorylated c-Myc for *** study provides a successful screening strategy for identifying natural products as potential c-Myc inhibitors as potential anticancer agents.

关键词： High-throughput screening Phosphorylation Reactive oxygen species

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer/testis antigen, Kita-Kyushu lung cancer antigen-1 and ABCD stratification for diagnosing gastric cancers

引用

World Journal of Gastroenterology 2020年第4期26卷 424-432页

作者： akiko Shida Takashi Fukuyama Nobue Futawatari Haruki Ohmiya Yoshinobu Ichiki Tetsuro Yamashita Yatsushi Nishi Noritada Kobayashi Hitoshi Yamazaki Masahiko Watanabe Yoshihito Takahashi Division of Pathology Kitasato UniversitySagamiharaKanagawa 252-0374Japan Division of Biomedical Research Kitasato University Medical CenterKitamotoSaitama 364-8501Japan Division of Surgery Toho UniversityOhashi Medical CenterMegurokuTokyo 153-8515Japan Department of Biological Chemistry and Food Sciences Faculty of AgricultureIwate UniversityMoriokaIwate 020-8505Japan Division of Surgery Kitasato University Medical CenterKitamotoSaitama 364-8501Japan Division of Pathology Kitasato University Medical CenterKitamotoSaitama 364-8501Japan Division of Surgery Kitasato UniversitySagamiharaKanagawa 252-0374Japan

BACKGROUND The ABCD stratification[combination of serum pepsinogen(PG)levels and titers of antibody(immunoglobulin G,IgG)against Helicobacter pylori(***)]is effective for the classification of individuals at risk of developing gastric cancer(GC).The Kita–Kyushu lung cancer antigen-1(KK-LC-1)is a Cancer/Testis antigen frequently expressed in *** To evaluate the effectiveness of KK-LC-1 and ABCD stratification in the diagnosis of *** We analyzed the gene expression of KK-LC-1 in surgical specimens obtained from GC *** levels of serum PG I/PG II and IgG against *** were *** to their serological status,the patients were classified into the four groups of the ABCD *** Of the 77 examined patients,63(81.8%)expressed *** IgG titers of *** and PG II were significantly higher in patients expressing KK-LC-1 than those measured in patients not expressing KK-LC-1(P=0.0289 and P=0.0041,respectively).The expression of KK-LC-1 in group C[PG method(+)/*** infection(+)]was as high as 93.9%***-LC-1 was also detected in group A[-/-].CONCLUSION The KK-LC-1 expression in GC was associated with *** infection and atrophic status,so that,KK-LC-1 may be a useful marker for the diagnosis of GC.

关键词： Gastric cancer Tumor antigen Cancer/testis antigen Kita–Kyushu lung cancer antigen-1 Helicobacter pylori Early detection of cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Achieving the best bowel preparation for colonoscopy

引用

World Journal of Gastroenterology 2014年第47期20卷 17709-17726页

作者： Adolfo Parra-Blanco Alex Ruiz Manuel Alvarez-Lobos Ana Amorós Juan Cristóbal Gana Patricio Ibáez akiko Ono Takahiro Fujii Department of Gastroenterology Escuela de MedicinaPontificia Universidad Católica de ChileSantiago 833-0024Chile Department of Gastroenterology Hospital Universitario de la Candelaria38916 Santa Cruz de TenerifeSpain Gastroenterology and Nutrition Unit Division of PediatricsEscuela de MedicinaPontificia Universidad Católica de ChileSantiago 833-0024Chile Department of Gastroenterology Hospital Universitario Virgen de la Arrixaca30001 MurciaSpain TF Clinic Tokyo 197-0804Japan

Bowel preparation is a core issue in colonoscopy,as it is closely related to the quality of the *** often find that bowel preparation is the most unpleasant part of the *** is widely accepted that the quality of cleansing must be excellent to facilitate detecting neoplastic *** spite of its importance and potential implications,until recently,bowel preparation has not been the subject of much *** most commonly used agents are high-volume polyethylene glycol(PEG)electrolyte solution and sodium *** has been some confusion,even in published meta-analyses,regarding which of the two agents provides better *** is clear now that both PEG and sodium phosphate are effectivewhen administered with proper ***,the timing of administration is recognized as one of the central factors to the quality of *** bowel preparation agent should be administered,at least in part,a few hours in advance of the *** low volume agents are available,and either new or modified schedules with PEG that usually improve *** adjuvants can also be used to reduce the volume of PEG,or to improve the efficacy of other *** factors apart from the choice of agent can improve the quality of bowel *** instance,the effect of diet before colonoscopy has not been completely clarified,but an exclusively liquid diet is probably not required,and a low-fiber diet may be preferable because it improves patient satisfaction and the quality of the *** patients,such as diabetics and persons with heart or kidney disease,require modified procedures and certain *** preparation for pediatric patients is also reviewed *** such cases,PEG remains the most commonly used *** detecting neoplasia is not the main objective with these patients,less intensive preparation may *** considerations must be made for patients with inflammatory bowel disease,including

关键词： Colonoscopy Optimal preparation Polyethylene glycol Sodium phosphate Special patients Timing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Crystal Structure Study on Non-Coplanarly Organized Accumulating Aromatic Rings Molecules: Spatial Organization of C,C,N-Triaryl Substituted Imines

引用

Crystal Structure Theory and Applications 2013年第4期2卷 139-147页

作者： akiko Okamoto Atsushi Nagasawa Siqingaowa Noriyuki Yonezawa Department of Organic and Polymer Materials Chemistry Tokyo University of Agriculture and Technology Tokyo Japan

The X-ray crystal structures of C,C,N-triaryl-substituted imine compounds, which have methoxy or hydroxy group adjacent to the imino moiety, are reported and discussed in comparison with those of the precursor ketone compounds, 1-(4-chlorobenzoyl)-2,7-dimethoxynaphthalene and 1-(4-chlorobenzoyl)-2-hydroxy-7-methoxynaphthalene. In crystals, three aromatic rings in a molecule of the methyl ether-retained imine compound are positioned almost perpendicularly to each other by giving non-coplanar spatial organization of the single molecular structure [dihedral angles: 85.32(18)° for C-linked phenyl ring and naphthalene ring;79.27(17)° for N-linked phenyl ring and naphthalene ring;84.78(17)° for C-linked phenyl ring and N-linked phenyl ring]. Spatial organization of the analogous methyl ether-cleaved imine compound has essentially same topology [dihedral angles 80.39(6)° for the C-linked phenyl ring and naphthalene ring;82.35(6)° for the N-linked phenyl ring and naphthalene ring;87.09(7)° for C- and N-linked phenyl rings]. These structural features of triarylimines apparently differ from those of the precursor ketones. Two aromatic rings in the methyl ether-cleaved ketone compound make smaller dihedral angle [58.10(6)°] by intramolecular hydrogen bond between ketonic carbonyl group and hydroxy group [2.5573(16) A] than that of the methyl ether-retained ketone [72.06(7)°]. In molecular packing, the methyl ether-retained imine forms tubular molecular alignments composed of R—S dimeric molecular pairs, whereas the methyl ether-retained ketone affords consecutively stacks of one configurated molecules.

关键词： Non-Coplanarly Accumulated Aromatic Rings Spatial Organization Triarylimine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Allergic Contact Dermatitis Syndrome Due to Tocopherol Acetate, in Addition to Glycyrrhetinic Acid

引用

Journal of Cosmetics, Dermatological Sciences and Applications 2012年第1期2卷 38-40页

作者： Kentaro Ohko akiko Ito Masaaki Ito Division of Dermatology Graduate School of Medical and Dental Sciences Niigata University Niigata Japan

Natural vitamin E is suggested to have an antioxidant function. However, the synthetic form of vitamin E, DL-tocopherol, which has been widely used in topical ointments, may cause allergic contact dermatitis. Here, we report a case of allergic contact dermatitis with erythema multiforme-like eruption caused by a topical ointment. Patch testing indicated a positive allergic reaction to an anti-inflammatory ointment the patient had been using and its ingredient, DL-alpha-tocopheryl acetate (vitamin E). In addition, a positive reaction to glycyrrhetinic acid was observed. Both vitamin E and glycyrrhetinic acid are useful ingredients of topical applications. However, the possibility that both can cause contact dermatitis, albeit rarely, should be considered.

关键词： Allergic Contact Dermatitis Tocopheryl Acetate Vitamin E Enoxolone 18-Glycyrrhetinic Acid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Characterization of a recombinant Akabane mutant virus with knockout of a nonstructural protein NSs in a pregnant goat model

引用

Virologica Sinica 2016年第3期31卷 274-277页

作者： akiko Takenaka-Uema Norasuthi Bangphoomi Chieko Shioda Kazuyuki Uchida Fumihiro Gen Kentaro Kato Takeshi Haga Shin Murakami Hiroomi Akashi Taisuke Hoimoto Department of Veterinary Microbiology Graduate School of Agricultural and Life SciencesThe University of Tokyo Department of Infection Control and Disease Prevention Graduate School of Agricultural and Life SciencesThe University of Tokyo Department of Preclinical and Applied Animal Science Faculty of Veterinary ScienceMahidol University Department of Veterinary Pathology Graduate School of Agricultural and Life SciencesThe University of Tokyo National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary Medicine

Dear Editor,Akabane virus(AKAV),an orthobunyavirus,is transmitted primarily by biting midges and is widely distributed throughout the world except the *** was first isolated from mosquitoes in Japan(Oya et al.,1961).Although pregnant cows,ewes,and goats infected with AKAV exhibit no clinical signs of disease,in utero infections result in abortion,premature birth,stillbirth。

关键词： pregnant mutant abortion premature birth primarily vaccine throughout removed inoculated

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Serum manganese superoxide dismutase and thioredoxin are potential prognostic markers for hepatitis C virus-related hepatocellular carcinoma

引用

World Journal of Gastroenterology 2011年第44期17卷 4890-4898页

作者： Tsutomu Tamai Hirofumi Uto Yoichiro Takami Kouhei Oda akiko Saishoji Masashi Hashiguchi Kotaro Kumagai Takeshi Kure Seiichi Mawatari Akihiro Moriuchi Makoto Oketani Akio Ido Hirohito Tsubouchi Department of Digestive and Lifestyle Related Diseases Human and Environmental SciencesHealth ResearchKagoshima University Graduate School of Medical and Dental Sciences

AIM:To evaluate the clinical significance of oxidative stress markers in patients with hepatitis C virus(HCV)related hepatocellular carcinoma(HCC).METHODS:Sixty-four consecutive patients who were admitted to Kagoshima University Medical and Dental Hospital were enrolled in this retrospective *** patients had chronic liver disease(CLD) due to infection with *** patients with HCV-related HCC,34 with HCV-related CLD without HCC(non-HCC),and 20 healthy volunteers(HVs) were *** associations between serum manganese superoxide dismutase(MnSOD) and thioredoxin(TRX) levels and clinical parameters or patient prognosis were analyzed over a mean follow-up period of 31.7 ***:The serum MnSOD levels were significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.03) or HVs(P < 0.001).Similarly,serum TRX levels were also significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.04) or HVs(P < 0.01).However,serum levels of MnSOD and TRX were not correlated in patients with *** patients with HCC,the overall survival rate(OSR) was lower in patients with MnSOD levels ≥ 110 ng/mL than in patients with levels < 110 ng/mL(P = 0.01),and the OSR tended to be lower in patients with TRX levels < 80 ng/mL(P = 0.05).In addition,patient prognosis with HCC was poorest with serum MnSOD levels ≥ 110 ng/mL and serum TRX levels < 80 ng/***,a multivariate analysis using a Cox proportional hazard model and serum levels of five factors(MnSOD,prothrombin time,serum albumin,serum α-fetoprotein(AFP),and serum des-γ-carboxy prothrombin) revealed that MnSOD levels ≥ 110 ng/mL(risk ratio:4.12,95% confidential interval:1.22-13.88,P = 0.02) and AFP levels ≥ 40 ng/mL(risk ratio:6.75;95% confidential interval:1.70-26.85,P < 0.01) were independent risk factors associated with a poor patient ***:Serum MnSOD and TRX levels are potential clinical biomarkers that predict patient prognosis in

关键词： Oxidative stress Manganese superoxide dismutase Thioredoxin Hepatitis C virus Hepatocellular carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Usefulness of Magnetic Particle Imaging for Monitoring the Effect of Magnetic Targeting

引用

Open Journal of Medical Imaging 2016年第2期6卷 33-41页

作者： Tomomi Kuboyabu akiko Ohki Natsuo Banura Kenya Murase Department of Medical Physics and Engineering Division of Medical Technology and Science Faculty of Health Science Graduate School of Medicine Osaka University Osaka Japan

Purpose: Magnetic targeting refers to the attachment of therapeutic agents to magnetizable particles such as magnetic nanoparticles (MNPs) and then applying magnetic fields to concentrate them to the targeted region such as solid tumors. The purpose of this study was to investigate the usefulness of magnetic particle imaging (MPI) for monitoring the effect of magnetic targeting using tumor-bearing mice. Materials and Methods: Colon-26 cells (1 × 106 cells) were implanted into the backs of eight-week-old male BALB/c mice. When the tumor volume reached approximately 100 mm3, the mice were divided into treated (n = 8) and untreated groups (n = 8). The tumors in the treated group were directly injected with MNPs (Resovist?, 250 mM) and a neodymium magnet was attached to the tumor surface, whereas the magnet was not attached to the tumor in the untreated group. The mice were imaged using our MPI scanner and the average and maximum MPI values were obtained by drawing a region of interest (ROI) on the tumor, with the threshold value for extracting the contour of the tumor being taken as 40% of the maximum MPI value in the ROI. The relative tumor volume growth (RTVG) was calculated from (V ? V0)/V0, where V0 and V represented the tumor volume immediately before and after the injection of MNPs, respectively. Results: The average and maximum MPI values in the treated group were significantly higher than those in the untreated group 3 days after the injection of MNPs, suggesting the effectiveness of magnetic targeting. There were no significant differences in RTVG between the two groups. Conclusion: Our preliminary results suggest that MPI is useful for monitoring the effect of magnetic targeting.

关键词： Magnetic Particle Imaging Magnetic Targeting Magnetic Nanoparticles Tumor-Bearing Mice

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficacy of combination therapy with natriuretic and aquaretic drugs in cirrhotic ascites patients: A randomized study

引用

World Journal of Gastroenterology 2017年第45期23卷 8062-8072页

作者： Haruki Uojima Hisashi Hidaka Tsuyoshi Nakayama Ji Hyun Sung Chikamasa Ichita Shinnosuke Tokoro Sakue Masuda akiko Sasaki Kazuya Koizumi Hideto Egashira Makoto Kako Department of Gastroenterology Shonan Kamakura General Hospital Department of Gastroenterology Internal MedicineKitasato University School of Medicine Department of Gastroenterology Shonan Atsugi Hospital

AIM To assess the effects of a combination therapy with natriuretic and aquaretic drugs in cirrhotic ascites *** A two-center,randomized,open-label,prospective study was conducted. Japanese patients who met the criteria were randomized to trial group and the combination diuretic group(received 7.5 mg of tolvaptan) or the conventional diuretic group(received 40 mg of furosemide) for 7 d in addition to the natriuretic drug which was used prior to enrolment in this study. The primary endpoint was the change in body weight from the baseline. Vital signs,fluid intake,and laboratory and urinary data were assessed to determine the pharmacological effects after administration of aquaretic and natriuretic *** A total of 56 patients were randomized to receive either tolvaptan(n = 28) or furosemide(n = 28). In the combination and conventional diuretic groups,the average decrease in body weight from the baseline was 3.21 ± 3.17 kg(P < 0.0001) and 1.75 ± 2.36 kg(P = 0.0006),respectively,when measured on the final dosing day. Following 1 wk of treatment,a significantly greater reduction in body weight was observed in the combination diuretic group compared to that in the conventional diuretic group(P = 0.0412).CONCLUSION Compared to a conventional diuretic therapy with only a natriuretic drug,a combination diuretic therapy with natriuretic and aquaretic drugs is more effective for patients with cirrhotic ascites.

关键词： Tolvaptan Liver cirrhosis Diuretic effect Ascites Hepatic edema

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Certified Infertility Nurses’ Perceptions and Practice on Male Infertility Nursing and Related Factors

引用

Open Journal of Nursing 2018年第1期8卷 1-13页

作者： akiko Mori Kyoko Asazawa Ruriko Hoshi Yasushi Yumura Department of Midwifery and Women’s Health Graduate School of Nursing Science St. Luke’s International University Tokyo Japan Department of Nursing Tokyo Healthcare University Tokyo Japan Nursing Department Yokohama City University Medical Center Yokohama Japan Reproduction Center Yokohama City University Medical Center Yokohama Japan

Purpose: The aims of this study were to clarify the complaints and concerns expressed by couples that included a partner with male infertility, certified infertility nurses’ nursing practice and perceptions of nursing for these couples, and factors related to these perceptions and practices. Methods: A quantitative cross-sectional study was conducted. Prospective participants were sent an anonymous self-administered questionnaire containing items pertaining to the complaints and concerns expressed by couples that included a partner with male infertility, and nursing practice and perceptions of nursing for these couples. Results: In total, 133 questionnaires were distributed, 74 responses were received, and 69 of these responses were valid. Couples’ complaints and concerns consisted of a three-factor structure comprising psychological burden, lack of knowledge and information, and problems with partners. Nurses reported that the complaints and concerns of couples that included a partner with male infertility differed between male and female partners. Factors related to nursing practice and nurses’ perceptions of nursing were identified. Conclusions: Participants felt that psychological burden and problems were more serious for female partners than they were for male partners, and concern regarding the physical health of the partner receiving treatment was greater in male partners than it was in female partners.

关键词： Professional Practice Fertility Nurse Male Infertility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：