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Morphomics via next-generation electron microscopy

Journal of Molecular Cell Biology 2023年第12期15卷 12-27页

作者： Raku Son Kenji Yamazawa akiko Oguchi Mitsuo Suga Masaru Tamura Motoko Yanagita Yasuhiro Murakawa Satoshi Kume RIKEN-IFOM Joint Laboratory for Cancer Genomics RIKEN Center for Integrative Medical SciencesYokohama 230-0045Japan Department of Nephrology Graduate School of MedicineKyoto UniversityKyoto 606-8507Japan Advanced Manufacturing Support Team RIKEN Center for Advanced PhotonicsWako 351-0198Japan Multimodal Microstructure Analysis Unit RIKEN–JEOL Collaboration CenterKobe 650-0047Japan Technology and Development Team for Mouse Phenotype Analysis RIKEN BioResource Research CenterTsukuba 305-0074Japan Institute for the Advanced Study of Human Biology(ASHBi) Kyoto UniversityKyoto 606-8501Japan IFOM—The FIRC Institute of Molecular Oncology Milan 20139Italy Laboratory for Pathophysiological and Health Science RIKEN Center for Biosystems Dynamics ResearchKobe 650-0047Japan Center for Health Science Innovation Osaka City UniversityOsaka 530-0011Japan Osaka Electro-Communication University Neyagawa 572-8530Japan

The living body is composed of innumerable fine and complex *** these structures have been studied in the past,a vast amount of information pertaining to them still remains *** attempting to observe these ultra-structures,the use of electron microscopy(EM)has become ***,conventional EM settings are limited to a narrow tissue area,which can bias ***,new trends in EM research have emerged,enabling coverage of far broader,nano-scale fields of view for two-dimensional wide areas and three-dimensional large ***,cutting-edge bioimage informatics conducted via deep learning has accelerated the quantification of complex morphological *** together,these technological and analytical advances have led to the comprehensive acquisition and quantification of cellular morphology,which now arises as a new omics science termed‘morphomics’.

关键词： comprehensive morphological analysis next-generation electron microscopy 3D bioimaging imaging database deep learning

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The Process of How Elderly Patients with Lung Cancer Who Are Receiving Molecularly Targeted Therapy with Oral Agents Establish Self-Management

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Health 2017年第13期9卷 1801-1816页

作者： akiko Fukawa Faculty of Nursing Osaka Medical College Osaka Japan

Purpose: In Japan, many elderly cancer patients are receiving chemotherapy using oral molecularly targeted drugs. They receive treatment in outpatient setting and have a need to self-manage at home. The purpose of this study was to clarify how elderly patients with lung cancer who are undergoing treatment with molecularly targeted drugs in outpatient setting establish self-management. Methods: The study used Kinoshita’s Modified Grounded Theory. Semi-structured interviews were conducted with 17 patients (eight males and nine females). Results: This study identified six categories: Accepting life with cancer, Maintaining activities of daily living without feeling shackled by cancer, Reconsidering how to continue being themselves in daily life until life comes to an end, Using trial and error to integrate treatment and daily living, Formulating their criteria for continuing treatment, and Obtaining help from caregivers. Conclusion: The self-management process in elderly patients consisted of maintaining treatment and integrating treatment with daily living. And they are exploring the effects of treatment and side effects in order to live their own life. Implications for Nursing: In many elderly patients with lung cancer the purpose of treatment is curative extension of survival and improved quality of life. Our findings suggest that is important we help patients to identify how patients want to live, identify ways to improve their quality of life, and share the goals of treatment between the patient and the caregiver.

关键词： Elderly Patients Lung Cancer Self-Management Molecularly Targeted Drugs

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Mice-lacking LMP2, immuno-proteasome subunit, as an animal model of spontaneous uterine leiomyosarcoma

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Protein & Cell 2010年第8期1卷 711-717页

作者： Takuma Hayashi akiko Horiuchi Kenji Sano Nobuyoshi Hiraoka Yae Kanai Tanri Shiozawa Susumu Tonegawa Ikuo Konishi Department of Immunology and Infectious Disease Shinshu University Graduate School of MedicineMatsumotoNagano 390-8621Japan Department of Obstetrics and Gynecology Shinshu University School of MedicineMatsumotoNagano 390-8621Japan Department of Laboratory Medicine Shinshu University HospitalMatsumotoNagano 390-8621Japan Pathology Division National Cancer Center Research InstituteTokyo 104-0045Japan Picower Institution and Department of Biology Massachusetts Institute of TechnologyCambridgeMassachusetts 02139USA Department of Obstetrics and Gynecology Kyoto University Graduate School of MedicineSakyo-kuKyoto 606-8501Japan Promoting Business using Advanced Technology Japan Science and Technology Agency(JST)Kawaguchi-shiSaitama 332-0012Japan

Uterine tumors are the most common type of gynecologic *** leiomyosarcoma(LMS)is rare,accounting for 2%to 5%of tumors of the uterine *** LMS develops more often in the muscle tissue layer of the uterine body than in the uterine *** development of gynecologic tumors is often correlated with female hormone secretion;however,the development of uterine LMS is not substantially correlated with hormonal conditions,and the risk factors are not yet *** evaluation combined with PET/CT can be useless in the diagnosis and surveillance of uterine ***,a diagnostic biomarker,which distinguishes malignant LMS and benign tumor leiomyoma(LMA)is yet to be ***,it is necessary to analyze risk factors associated with uterine LMS in order to establish a method of ***2-deficient mice spontaneously develop uterine LMS,with a disease prevalence of~40%by 14 months of *** is therefore of interest whether human uterine LMS shows a loss of LMP2 *** found LMP2 expression is absent in human LMS,but present in human ***,defective LMP2 expression may be one of the risk factors for ***2 is potentially a diagnostic biomarker for uterine LMS,and gene therapy with LMP2-encording DNA may be a new therapeutic approach.

关键词： LMP2 uterine leiomyosarcoma uterine leiomyoma diagnostic biomarker

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Pancreatic schwannoma:Case report and an updated 30-year review of the literature yielding 47 cases

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World Journal of Gastroenterology 2012年第13期18卷 1538-1544页

作者： Toshiyuki Moriya Wataru Kimura Ichiro Hirai akiko Takeshita Koji Tezuka Toshihiro Watanabe Masaomi Mizutani Akira Fuse First Department of Surgery Yamagata University Faculty of Medicine2-2-2 Iida-NishiYamagata 990-9585Japan

Pancreatic schwannomas are rare neoplasms. Authors briefly describe a 64-year-old female patient with cystic pancreatic schwannoma mimicking other cystic tumors and review the literature. Databases for PubMed were searched for English-language articles from 1980 to 2010 using a list of keywords, as well as references from review articles. Only 41 articles, including 47 cases, have been reported in the English literature. The mean age was 55.7 years （range 20-87 years）, with 45% of patients being male. Mean tumor size was 6.2 cm （range 1-20 cm）. Tumor location was the head （40%）, head and body （6%）, body （21%）, body and tail （15%）, tail （4%）, and uncinate process （13%）. Thirty-four percent of patients exhibited solid tumors and 60% of patients exhibited cystic tumors. Treatment included pancreati- coduodenectomy （32%）, distal pancreatectomy （21%）, enucleation （15%）, unresectable （4%）, refused opera- tion （2%） and the detail of resection was not specified in 26% of patients. No patients died of disease with a mean follow-up of 15.7 mo （range 3-65 too）, although 5 （11%） patients had a malignancy. The tumor size was significantly related to malignant tumor （13.8 ＋ 6.2 cm for malignancy vs 5.5 ＋ 4.4 cm for benign, P = 0.001） and cystic formation （7.9 ~ 5.9 cm for cystic tumor vs 3.9 ＋ 2.4 cm for solid tumor, P = 0.005）. The preoperative diagnosis of pancreatic schwannoma remains difficult. Cystic pancreatic schwannomas should be considered in the differential diagnosis of cystic neoplasms and pseudocysts. In our caset intraoperative frozen sec- tion confirmed the diagnosis of a schwannoma. Simple enudeation may be adequate, if this is possible.

关键词： Pancreatic schwannoma Pancreas Schwanno-ma Neurinoma Resection Imaging Enucleation Progno-sis Cystic

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Semantic Distribution of Polysemous Verbs in Junior High School English Textbooks in Japan

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Language and Semiotic Studies 2016年第2期2卷 113-127页

作者： akiko Matsukubo J.F.Oberlin University Japan

This paper reports how the polysemous word TAKE is treated in the junior high school textbooks in Japan and its semantic distributions. Also, it looks into the ways in which Japanese junior high school students actually use TAKE in their compositions and analyses its semantic distributions in their writings. This paper uses the BBC 500 Word essay compositions(BBC 500 words) to compare these compositions with the ones written by English native speakers. Comparing the different semantic distributions of the word TAKE in Japanese junior high school textbooks, Japanese students' compositions and BBC 500 words, it is clear that compositions in BBC 500 words have a better balance. This result suggests that the English native speaking children use TAKE to convey various meanings. Also the core meaning of TAKE is the highest among the three contexts under investigation. This paper suggests the textbooks should include many more various objects to enable students to learn to use them in various situations and the core meaning of TAKE should be presented in the textbooks more often. Furthermore, the semantic features of the polysemous words and their semiotic value in English should be introduced in the textbooks and taught in intentional ways.

关键词： polysemous word semantic distribution junior high school textbook

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Genetic analysis of group composition and relatedness in white-headed langurs

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Integrative Zoology 2013年第4期8卷 410-416页

作者： Zhijin LIU Chengming HUANG Qihai ZHOU Youbang Li Yuefeng WANG Ming LI Osamu TAKENAKA akiko TAKENAKA Key Laboratory of Animal Ecology and Biological Conservation Institute of ZoologyChinese Academy of SciencesBeijingChina Provincial Key Laboratory of Ecology Guangxi Normal UniversityGuangxiChina Primate Research Institute Kyoto UniversityInuyamaJapan Nagoya Bunri University Nagoya Japan

We collected fecal samples of white-headed langurs from 3 of the 4 remaining habitat fragments(Fa,Fb and CZ)located in southwestern Guangxi,China in Nov 2005,and used 5 microsatellite loci and the SRY gene to assess the relatedness between 46 langurs within and between *** observed 2 forms of group structure:one-male/multi-female groups(OMGs)and all-male groups(AMGs).One AMG in Fa was composed of 2 generations,included a father,2 sons and 1 unrelated male,and all OMGs in all 3 habitats included 1 resident male,several adult females and *** the 21 identified father-offspring cases,the resident male fathered 20(95%)and the non-resident male sired 1(5%),suggesting that adult males had overwhelming priority of access to females as the resident male in an OMG,while the non-resident male may also have the opportunity to adopt surreptitious mating strategies.

关键词： langur microsatellites paternity reproductive strategy Trachypithecus poliocephalus leucocephalus

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Effectiveness of antibiotic prophylaxis for acute esophageal variceal bleeding in patients with band ligation: A large observational study

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World Journal of Gastroenterology 2024年第3期30卷 238-251页

作者： Chikamasa Ichita Sayuri Shimizu Tadahiro Goto Uojima Haruki Naoya Itoh Masao Iwagami akiko Sasaki Gastroenterology Medicine Center Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Department of Health Data Science Yokohama City UniversityYokohama 236-0027KanagawaJapan TXP Research TXP Medical Co.Ltd.Chiyoda-ku 101-0042TokyoJapan Department of Clinical Epidemiology and Health Economics School of Public HealthThe University of TokyoBunkyo-ku 113-0033TokyoJapan Department of Genome Medical Sciences Project Research InstituteNational Center for Global Health and MedicineIchikawa 272-8516ChibaJapan Division of Infectious Diseases Aichi Cancer CenterNagoya 464-8681AichiJapan Department of Health Services Research Institute of MedicineUniversity of TsukubaTsukuba 305-8575IbarakiJapan

BACKGROUND Esophageal variceal bleeding is a severe complication associated with liver cirrhosis and typically necessitates endoscopic *** current standard treatment is endoscopic variceal ligation(EVL),and Western guidelines recom-mend antibiotic prophylaxis following ***,given the impro-vements in prognosis for variceal bleeding due to advancements in the management of bleeding and treatments of liver cirrhosis and the global concerns regarding the emergence of multidrug-resistant bacteria,there is a need to reassess the use of routine antibiotic prophylaxis after *** To evaluate the effectiveness of antibiotic prophylaxis in patients treated for *** We conducted a 13-year observational study using the Tokushukai medical database across 46 *** were divided into the prophylaxis group(received antibiotics on admission or the next day)and the non-prophylaxis group(did not receive antibiotics within one day of admission).The primary outcome was composed of 6-wk mortality,4-wk rebleeding,and 4-wk spontaneous bacterial peritonitis(SBP).The secondary outcomes were each individual result and in-hospital mortality.A logistic regression with inverse probability of treatment weighting was used.A subgroup analysis was conducted based on the Child-Pugh classification to determine its influence on the primary outcome measures,while sensitivity analyses for antibiotic type and duration were also *** Among 980 patients,790 were included(prophylaxis:232,non-prophylaxis:558).Most patients were males under the age of 65 years with a median Child-Pugh score of *** composite primary outcomes occurred in 11.2%of patients in the prophylaxis group and 9.5%in the non-prophylaxis *** significant differences in outcomes were observed between the groups(adjusted odds ratio,1.11;95%confidence interval,0.61-1.99;P=0.74).Individual outcomes such as 6-wk mortality,4-wk rebleeding,4-wk onset of SBP,and in-hospital mo

关键词： Esophageal varices Endoscopic hemostasis Antibiotic prophylaxis Liver cirrhosis Inverse probability of treatment weighting

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Third-line therapies in patients with Kawasaki disease refractory to first-and second-line intravenous immunoglobulin therapy

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World Journal of Pediatrics 2022年第11期18卷 781-785页

作者： Takashi Furuta Hiroki Yasudo Seigo Okada Yuji Ohnishi akiko Kawakami-Miyake Yasuo Suzuki Shouichi Ohga Shunji Hasegawa Department of Pediatrics Yamaguchi University Graduate School of Medicine1-1-1 MinamikogushiUbeYamaguchi755-8505Japan Department of Pediatrics Graduate School of Medical SciencesKyushu University3-1-1 MaidashiHigashi-kuFukuoka812-8582Japan

Kawasaki disease(KD)is an acute febrile ilness characterized by systemic vasculitis affecting the small-and mediumsized arteries in children [1,2].One of the most critical complications of KD is the development of coronary artery lesions(CALs)approximately after 12 days of ilness,which may lead to myocardial infarction[3].High-dose intravenous immunoglobulin(IVIG)and oral administration of aspirin have been established as the first-line therapy for KD[4,5].

关键词： intravenous acute immunoglobulin

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Intestinal anisakiasis treated successfully with conservative therapy:Importance of clinical diagnosis

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World Journal of Gastroenterology 2014年第2期20卷 598-602页

作者： Santosh Shrestha akiko Kisino Makoto Watanabe Hirosi Itsukaichi Kazumitsu Hamasuna Giichiro Ohno Atsushi Tsugu Department of Gastro-Intestinal Surgery Tokatsu Hospital Chiba 270-0174 Japan

Intestinal anisakiasis is not only a rare parasitic disease,but is also difficult to *** symptoms are not specific and are often very severe and abrupt,and the findings of clinical imaging are very ***,intestinal anisakiasis is often misdiagnosed as acute abdomen or intestinal obstruction and is treated ***,if intestinal anisakiasis could be diagnosed correctly,it is well treated *** experienced three cases of intestinal anisakiasis,which were diagnosed correctly and treated successfully with conservative therapy.A correct clinical history and imaging interpretation helped us diagnose intestinal anisakiasis correctly and thus treat the patients successfully with conservative therapy.

关键词： Acute abdomen Computed tomography findings Clinical diagnosis Intestinal anisakiasis Conservative therapy

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Does Helicobacter pylori eradication therapy for peptic ulcer prevent gastric cancer?

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World Journal of Gastroenterology 2009年第34期15卷 4290-4297页

作者： Katsuhiro Mabe Mikako Takahashi Haruhumi Oizumi Hideaki Tsukuma akiko Shibata Kazutoshi Fukase Toru Matsuda Hiroaki Takeda Sumio Kawata Division of Gastroenterology KKR Sapporo Medical Center Internal Medicine Tsuruoka Kyoritsu Hospital Internal Medicine Oizumi Medical Clinic Department of Cancer Control and Statistics Osaka Medical Center for Cancer and Cardiovascular Diseases Yamagata Prefectural Medical Center for Cancer and Lifestyle-Related Disease Internal Medicine Yamagata Prefectural Central Hospital Yamagata Prefectural Shonai Public Health Center Department of Gastroenterology Faculty of MedicineYamagata University

AIM:To investigate the effects of Helicobacter pylori (H pylori)eradication therapy for treatment of peptic ulcer on the incidence of gastric cancer. METHODS:A multicenter prospective cohort study was conducted between November 2000 and December 2007 in Yamagata Prefecture,*** study included patients with H pylori-positive peptic ulcer who decided themselves whether to receive H pylori eradication(eradication group)or conventional antacid therapy(non-eradication group).Incidence of gastric cancer in the two groups was determined based on the results of annual endoscopy and questionnaire surveys,as well as Yamagata Prefectural Cancer Registry data,and was compared between the two groups and by results of H pylori ***:A total of 4133 patients aged between 13 and 91 years(mean 52.9 years)were registered,and 56 cases of gastric cancer were identified over a mean follow-up of 5.6 *** sex-and age-adjusted incidence ratio of gastric cancer in the eradication group, as compared with the non-eradication group,was 0.58 (95%CI:0.28-1.19)and ratios by follow-up period(3 years)were 1.16(0.27-5.00),0.50 (0.17-1.49),and 0.34(0.09-1.28),*** follow-up tended to be associated with better prevention of gastric cancer,although not to a significant *** significant difference in incidence of gastric cancer was observed between patients with successful eradication therapy(32/2451 patients,1.31%)and those with treatment failure(11/639 patients,1.72%).Among patients with duodenal ulcer,which is known to be more prevalent in younger individuals,the incidence of gastric cancer was significantly less in those with successful eradication therapy(2/845 patients,0.24%)than in those with treatment failure(3/216 patients,1.39%). CONCLUSION:H pylori eradication therapy for peptic ulcer patients with a mean age of 52.9 years at registration did not significantly decrease the incidence of gastric cancer.

关键词： Helicobacter pylori Peptic ulcer Gastric cancer Eradication therapy Cancer prevention

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