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Observation of Atherosclerotic Plaque Phantoms through Saline or Blood Layers by Near-Infrared Hyperspectral Imaging

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Optics and Photonics Journal 2014年第10期4卷 271-279页

作者： Katsunori Ishii akiko Kitayabu Ryo Nagao Kunio Awazu Medical Beam Physics Laboratory Graduate School of Engineering Osaka University Osaka Japan Graduate School of Frontier Biosciences Osaka University Osaka Japan The Center for Advanced Medical Engineering and Informatics Osaka University Osaka Japan

We observed atherosclerotic plaque phantoms using a novel near-infrared (NIR) hyperspectral imaging (HSI) technique. Data were obtained through saline or blood layers to simulate an angioscopic environment for the phantom. For the study, we developed a NIR-HSI system with an NIR supercontinuum light source and mercury-cadmium-telluride camera. Apparent spectral absorbance was obtained at wavelengths of 1150 - 2400 nm. Hyperspectral images of lipid were constructed using a spectral angle mapper algorithm. Bovine fat covered with saline or blood was observed using hyperspectral images at a wavelength around 1200 nm. Our results show that NIR-HSI is a promising angioscopic technique with the potential to identify lipid-rich plaques without clamping and saline injection.

关键词： Hyperspectral Imaging Near-Infrared Range Atherosclerotic Plaque Angioscopy

Risk factors for bleeding after endoscopic submucosal dissection of colorectal neoplasms

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World Journal of Gastroenterology 2014年第7期20卷 1839-1845页

作者： Sho Suzuki akiko Chino Teruhito Kishihara Naoyuki Uragami Yoshiro Tamegai Takanori Suganuma Junko Fujisaki Masaaki Matsuura Takao Itoi Takuji Gotoda Masahiro Igarashi Fuminori Moriyasu Department of Gastroenterology Cancer Institute HospitalJapanese Foundation for Cancer ResearchTokyo 135-8550Japan Fuminori Moriyasu Department of Gastroenterology and HepatologyTokyo Medical UniversityTokyo 160-0023Japan Bioinformatics Group Genome Centerand Division of Cancer GenomicsCancer InstituteJapanese Foundation for Cancer ResearchTokyo 135-8550Japan

AIM: To investigate the risk factors for delayed bleeding following endoscopic submucosal dissection (ESD) treatment for colorectal neoplasms.

关键词： Adverse event Bleeding Colorectal neoplasms Endoscopic submucosal dissection Hemorrhage

Selective changes in the <i>α</i>-adrenoceptor-mediated contraction in the senescent rat urinary bladder

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Health 2012年第9期4卷 743-749页

作者： Tomomi Aita Akira Ishihata akiko Yamada Yumi Katano Division of Theoretical Nursing and Pathophysiology Yamagata University School of Medicine Yamagata Japan

The urinary bladder is innervated and functionally regulated by the autonomic nervous system. In order to elucidate the mechanism of functional changes in aged rat urinary bladder, we studied the influence of senescence on, 1) the α-adrenergic contractile response to phenylephrine in the urinary bladder body and trigone, 2) the muscarinic contractile response to carbachol in the body and trigone. The binding characteristics of [3H]quinuclidinyl benzilate (QNB) to muscarinic cholinoceptors were compared in young and aged bladder. Bladders from young (2 - 3 month-old) and aged (27 month-old) male Fischer 344 rats were isolated, cut into strips and mounted in the organ bath, then the developed tension was recorded. Histologically, the aged bladder did not show pathologic changes such as inflammation and hypertrophy. Carbachol-induced contraction in aged rat bladder was identical to that obtained in young rat. In the receptor binding assay, [3H]QNB maximal binding capacity and Kd value were not significantly changed in aged bladder. In contrast, a selective α-adrenergic agonist phenylephrine, elicited greater contractions both in the aged body and trigone than those in young rats. The augmentation of α-adrenoceptor-mediated contractions in aged bladder may induce urinary dysfunction such as voiding difficulty.

关键词： Bladder Smooth Muscle Aging α-Adrenoceptor Muscarinic Receptor

Crystal Structure and Solution Structural Dynamic Feature of 1,8-Dibenzoyl-2,7-Dimethoxynaphthalene

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Crystal Structure Theory and Applications 2012年第3期1卷 121-127页

作者： akiko Okamoto Shoji Watanabe Kosuke Nakaema Noriyuki Yonezawa Department of Organic and Polymer Materials Chemistry Tokyo University of Agriculture and Technology Tokyo Japan

The crystal structure and the dynamic feature of molecular structure in solution for 1,8-dibenzoyl-2,7-dimethoxynaph-thalene are revealed by X-ray crystallographic analysis and VT-NMR measurements. In crystal, the molecule of the title compound is located on a twofold rotation axis. The two benzoyl groups are situated in an opposite direction. The dihedral angle between the mean planes of the phenyl ring and the naphthalene ring system is 80.25(6). The benzene ring and carbonyl moiety in each benzoyl group are almost coplanar. The molecular packing is stabilized by weak C–H…O hydrogen bonds and aπ-πstacking interaction between the benzene rings [centroid-centroid and interplanar distances of 3.6383(10) and 3.294 , respectively]. In solution, the temperature-dependent rotation behavior of the C–C bond between the benzene ring and the ketonic carbonyl group has been observed by1H VT-NMR measurements. Furthermore, comparison of the C–C bond rotation behavior between the benzene ring and the carbonyl group with 1-ben-zoyl-2,7-dimethoxynaphthalene has clarified that the C–C bond between the ketonic carbonyl group and the naphthalene ring rotates slower than the 1,8-dibenzoylated homologue.

关键词： Non-Coplanarly Accumulated Aromatic Rings Molecules Crystal Structural Features Bond Rotation Behavior in Solution X-Ray Crystallography VT-NMR Spectroscopy

Clinical outcomes of enteroscopy using the double-balloon method for strictures of the small intestine

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World Journal of Gastroenterology 2005年第7期11卷 1087-1089页

作者： Keijiro Sunada Hironori Yamamoto Hiroto Kita Tomonori Yano Hiroyuki Sato Yoshikazu Hayashi Tomohiko Miyata Yutaka Sekine akiko Kuno Michiko Iwamoto Hirohide Ohnishi Kenichi Ido Kentaro Sugano Department of Internal Medicine

AIM:To evaluate the clinical outcome of enteroscopy, using the double-balloon method, focusing on the involvement of neoplasms in strictures of the small intestine. METHODS: Enteroscopy, using the double-balloon method, was performed between December 1999 and December 2002 at Jichi Medical School Hospital, 3apan and strictures of the small intestine were found in 17 out of 62 patients. These 17 consecutive patients were subjected to analysis. RESULTS: The double-balloon enteroscopy contributed to the diagnosis of small intestinal neoplasms found in 3 out of 17 patients by direct observation of the strictures as well as biopsy sampling. Surgical procedures were chosen for these three patients, while balloon dilation was chosen for the strictures in four patients diagnosed with inflammation without involvement of neoplasm. CONCLUSION: Double-balloon enteroscopy is a useful method for the diagnosis and treatment of strictures in the small bowel.

关键词： Double-balloon enteroscopy Strictures Small intestine

Involvement of the TAGE-RAGE system in non-alcoholic steatohepatitis: Novel treatment strategies

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World Journal of Hepatology 2014年第12期6卷 880-893页

作者： Masayoshi Takeuchi Jun-ichi Takino akiko Sakasai-Sakai Takanobu Takata Tadashi Ueda Mikihiro Tsutsumi Hideyuki Hyogo Sho-ichi Yamagishi Department of Advanced Medicine Medical Research Institute Kanazawa Medical University Uchinadamachi Ishikawa 920-0293 Japan Laboratory of Biochemistry Faculty of Pharmaceutical Sciences Hiroshima International University Kure Hiroshima 737-0112 Japan Department of Hepatology Kanazawa Medical University Uchinada-machi Ishikawa 920-0293 Japan Department of Gastroenterology and Metabolism Hiroshima University Hospital Hiroshima 734-8551 Japan Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications Kurume University School of Medicine Kurume Fukuoka 830-0011 Japan

Non-alcoholic fatty liver disease(NAFLD)is a major cause of liver disease around the *** includes a spectrum of conditions from simple steatosis to non-alcoholic steatohepatitis(NASH)and can lead to fibrosis,cirrhosis,liver failure,and/or hepatocellular *** is also associated with other medical conditions such as obesity,diabetes mellitus(DM),metabolic syn-drome,hypertension,insulin resistance,hyperlipidemia,and cardiovascular disease(CVD).In diabetes,chronic hyperglycemia contributes to the development of both macro-and microvascular conditions through a variety of metabolic ***,it can cause a variety of metabolic and hemodynamic conditions,including upregulated advanced glycation end-products(AGEs)*** our previous study,the most abundant type of toxic AGEs(TAGE);i.e.,glyceraldehyde-derived AGEs,were found to make a significant contribution to the pathogenesis of DM-induced ***,accumulating evidence suggests that the binding of TAGE with their receptor(RAGE)induces oxidative damage,promotes inflammation,and causes changes in intracellular signaling and the expression levels of certain genes in various cell populations including hepatocytes and hepatic stellate *** of these effects could facilitate the pathogenesis of hypertension,cancer,diabetic vascular complications,CVD,dementia,and ***,inhibiting TAGE synthesis,preventing TAGE from binding to RAGE,and downregulating RAGE expression and/or the expression of associated effector molecules all have potential as therapeutic strategies against ***,we examine the contributions of RAGE and TAGE to various conditions and novel treatments that target them in order to prevent the development and/or progression of NASH.

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Advanced glycation end-products Toxic advanced glycation end-products Receptor for advanced glycation end-products Toxic advanced glycation end-products-receptor for advanced glycation end-products system Diabetes mellitus Cardiovascular disease Dietary fructose Dietary advanced glycation end-products

Effects of adacolumn selective leukocytapheresis on plasma cytokines during active disease in patients with active ulcerative colitis

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World Journal of Gastroenterology 2006年第21期12卷 3393-3399页

作者： Hiroyuki Hanai Takayuki Iida Masami Yamada Yoshihiko Sato Ken Takeuchi Tatsuo Tanaka Kenji Kondo Masataka Kikuyama Yasuhiko Maruyama Yasushi Iwaoka akiko Nakamura Kazuhisa Hirayama Abby R Saniabadi Fumitoshi Watanabe Hamamatsu South Hospital Center for Gastroenterology and IBD Research Department Endoscopic and Photodynamic Medicine Hamamatsu UniversityHamamatsuJapan Hamamatsu Medical Centre Hamamatsu Japan Seirei General Hospital Hamamatsu Japan Department Endoscopic and Photodynamic Medicine Hamamatsu University HamamatsuJapan Hamamatsu Rosai Hospital Hamamatsu Japan Fujueda General Hospital Fujieda Japan Hamamatsu Insurance Hospital Hamamatsu Japan Immunoresearch Laboratories Takasaki Japan Yasuhiko Maruyama Fujueda General Hospital FujiedaJapan

AIM： To investigate the relationship between ulcerative colitis （UC） clinical activity index （CAI） and circulating levels of IL-1ra, IL-10, IL-6 and IL-18. METHODS： Blood levels of IL-1ra, IL-10, IL-6 and IL-18 were measured in 31 patients with active UC, the mean CAI was 11.1, ranging from 5-25; and 12 healthy individuals as controls. Patients were given granulocyte and monocyte adsorptive apheresis （GMA） with Adacolumn. Leucocytes which bear the FcyR and complement receptors were adsorbed to the column leucocytapheresis carriers. Each patient could receive up to 11 GMA sessions over 8 wk. RESULTS： We found strong correlations between CAI and IL-10 （r = 0.827, P 〈 0.001）, IL-6 （r = 0.785, P 〈 0.001） and IL-18 （r = 0.791, P 〈 0.001）. IL-1ra was not correlated with CAI. Following GMA therapy, 24 of the 31 patients achieved remission and the levels of all 4 cytokines fell to the levels in healthy controls. Further, blood levels of IL-1ra and IL-10 increased at the column outflow and inflow at 60 min suggesting release from leucocytes that adhered to the carriers. CONCLUSION： Elevated blood levels of IL-6 and IL-18 together with peripheral blood granulocytes and monocytes/macrophages in patients with active UC show activative behaviour and increased survival time can be proinflammatory and the targets of GMA therapy.

关键词： Interleukin-1 receptor antagonist Interleukin-6 Interleukin-10 Interleukin-18 Ulcerative colitis

Significance of three step prescription checking by pharmacists

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 213-214页

作者： Mikako Shimone Daisuke Nagano Asami Matsushita Junko Tsukamoto Yu Yanai akiko Kaneta Kyoko Obayashi Takuya Araki Koujirou Yamamoto Department of Pharmacy Gunma University Hospital3-39-15 Showa-machiMaebashi 371-8511Japan Department of Clinical Pharmacology Gunma University Graduate School of Medicine3-39-22 Showa-machiMaebashi 371-8511Japan

In many hospitals,prescription checks are conducted by 2 or 3 individual pharmacists at each step of prescription checking,dispensing,and final checking to maintain the safety and efficacy of pharmaceutical therapies in Japan[1,2].In Gunma University Hospital,we also check all prescriptions by 3 pharmacists at each step of dispensing(3 step prescription check system)with the exception of night *** this study,to assess the significance of our 3 step prescription check system for managing safety of pharmaceutical therapies,we investigated prescriptions that needed the confirmation of questionable points and prescription corrections.

关键词： Prescription checking Safe management Data analysis Questionable points to physicians

Reduction and Block Staining of Human Hair Shafts and Insect Cuticles by Ammonium Thioglycolate to Enhance Transmission Electron Microscopic Observations

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Journal of Cosmetics, Dermatological Sciences and Applications 2013年第2期3卷 157-161页

作者： Shigeru Sato Yoshihiro Sasaki akiko Adachi Tokuya Omi Department of Dermatology Nippon Medical School Tokyo Japan Division of Morphological and Biomolecular Research Graduate School of Medicine Nippon Medical School Tokyo Japan

We have developed a method where, after glutaraldehyde fixation, human hair shafts and insect cuticles are treated with ammonium thioglycolate (ATG) to improve ultrastructural staining. Conventional transmission electron microscopic (TEM) preparations do not distinguish the A-layer and the exocuticles of hair shafts. However, after ATG treatment, the A-layer appears in higher contrast. ATG treatment has also been used to observe the fibrillar structure in the cortex. In the cuticle of beetles, the epicuticle is stained by ATG. Although the human hair shaft (keratin) and insect cuticle (chitin) are composed of different materials, both can be reduced by the ATG solution. The ammonium in the ATG solution reacts with hair shafts and insect cuticles, causing a reduction of swelled cuticles. Therefore, ATG not only stains, but also reduces human hair shafts and the cuticles of beetles.

关键词： Reduction and Block Staining Ammonium Thioglycolate Human Hair Insect Cuticle Electron Microscopy