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Loss-of-Function of a Ubiquitin-Related Modifier Promotes the Mobilization of the Active MITE mPing

Molecular Plant 2013年第3期6卷 790-801页

作者： Takuji Tsukiyama Shota Teramoto KanakoYasuda Akira Horibata Nanako Mori Yutaka Okumoto Masayoshi Teraishi Hiroki Saito Akiko Onishi Kanako Tamura Takatoshi Tanisaka Division of Agronomy and Horticulture Science Graduate School of Agriculture Kyoto University Kitashirakawa Sakyo Kyoto 606-8502 Japan Faculty of Biology-Oriented Science and Technology Kinki University Kinokawa Wakayama 649-6433 Japan

Miniature inverted-repeat transposable elements （MITEs） are widespread in both prokaryotic and eukaryotic genomes, where their copy numbers can attain several thousands. Little is known, however, about the genetic factor（s） affecting their transpositions. Here, we show that disruption of a gene encoding ubiquitin-like protein markedly enhances the transposition activity of a MITE roPing in intact rice plants without any exogenous stresses. We found that the transposition activity of roPing is far higher in the lines harboring a non-functional allele at the Rurml （Rice ubiquitin-related modifier-I） locus than in the wild-type line. Although the alteration of cytosine methylation pattern triggers the activation of transposable elements under exogenous stress conditions, the methylation degrees in the whole genome, the roPing-body region, and the roPing-flanking regions of the non-functional Rurml line were unchanged. This study provides experimental evidence for one of the models of genome shock theory that genetic accidents within cells enhance the transposition activities of transposable elements.

关键词： Oryza sativa MITE mPing ubiquitin-related modifier methylation genome shock theory.

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Adverse effect on proliferation of human salivary gland tumor cells by estrogen and progesterone after introduction of their receptor

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中国口腔颌面外科杂志 2008年第B5期6卷 142-142页

作者： Tomoki Sumida Tomohide Yoshimura Akiko Onishi Koh-ichi Nakashiro Hiroyuki Hamakawa Department of Oral and Maxillofacial Surgery Ehime UniversitySchool of Medicine Ehime Japan

Purpose: Morphologic mimicry and similarity in the expression of steroid hormone receptors between salivary gland tumors (SGTs) and breast tumors are well-known phenomena and are occasionally debated in the field of surgical pathology。Estrogen (ES) and Progesterone (PG), the female sex steroid hormone, are intimately involved in breast cancer progression。However, little is known regarding its role in SGTs。Therefore, purpose of this study is to clarify the effect of sex steroid hormone on proliferation in SGT cells。Methods: In this study, we used ACCM, a human adenoid cystic carcinoma cell line established from the salivary gland, in order to clarify the role of their receptor on cell proliferation。Results: No effect of ES and PG on cell proliferation was observed in the estrogen receptor (ER) and progesterone receptor (PR)-deficient aggressive ACCM cells。However, after introducing ER and PR into the ACCM cells, ES accelerated, and PG markedly inhibited the proliferative activity of the cells。This adverse effect on cell proliferation was accompanied by the change of the expression levels of p21, Idl and c-myc。Conclusion: Our results provide significant insights into the mechanism of the proliferative property of the cells via the function of sex steroid hormone receptor。It is also suggested that the antagonist or blocker of ER, and PR reintroduction therapy might be a viable method of inhibiting human SGT progression。

关键词：唾液腺肿瘤细胞临床分析治疗方法

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