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Crystal Structure Study on Non-Coplanarly Organized Accumulating Aromatic Rings Molecules: Spatial Organization of C,C,N-Triaryl Substituted Imines

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Crystal Structure Theory and Applications 2013年第4期2卷 139-147页

作者： akiko okamoto Atsushi Nagasawa Siqingaowa Noriyuki Yonezawa Department of Organic and Polymer Materials Chemistry Tokyo University of Agriculture and Technology Tokyo Japan

The X-ray crystal structures of C,C,N-triaryl-substituted imine compounds, which have methoxy or hydroxy group adjacent to the imino moiety, are reported and discussed in comparison with those of the precursor ketone compounds, 1-(4-chlorobenzoyl)-2,7-dimethoxynaphthalene and 1-(4-chlorobenzoyl)-2-hydroxy-7-methoxynaphthalene. In crystals, three aromatic rings in a molecule of the methyl ether-retained imine compound are positioned almost perpendicularly to each other by giving non-coplanar spatial organization of the single molecular structure [dihedral angles: 85.32(18)° for C-linked phenyl ring and naphthalene ring;79.27(17)° for N-linked phenyl ring and naphthalene ring;84.78(17)° for C-linked phenyl ring and N-linked phenyl ring]. Spatial organization of the analogous methyl ether-cleaved imine compound has essentially same topology [dihedral angles 80.39(6)° for the C-linked phenyl ring and naphthalene ring;82.35(6)° for the N-linked phenyl ring and naphthalene ring;87.09(7)° for C- and N-linked phenyl rings]. These structural features of triarylimines apparently differ from those of the precursor ketones. Two aromatic rings in the methyl ether-cleaved ketone compound make smaller dihedral angle [58.10(6)°] by intramolecular hydrogen bond between ketonic carbonyl group and hydroxy group [2.5573(16) A] than that of the methyl ether-retained ketone [72.06(7)°]. In molecular packing, the methyl ether-retained imine forms tubular molecular alignments composed of R—S dimeric molecular pairs, whereas the methyl ether-retained ketone affords consecutively stacks of one configurated molecules.

关键词： Non-Coplanarly Accumulated Aromatic Rings Spatial Organization Triarylimine

Crystal Structure and Solution Structural Dynamic Feature of 1,8-Dibenzoyl-2,7-Dimethoxynaphthalene

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Crystal Structure Theory and Applications 2012年第3期1卷 121-127页

作者： akiko okamoto Shoji Watanabe Kosuke Nakaema Noriyuki Yonezawa Department of Organic and Polymer Materials Chemistry Tokyo University of Agriculture and Technology Tokyo Japan

The crystal structure and the dynamic feature of molecular structure in solution for 1,8-dibenzoyl-2,7-dimethoxynaph-thalene are revealed by X-ray crystallographic analysis and VT-NMR measurements. In crystal, the molecule of the title compound is located on a twofold rotation axis. The two benzoyl groups are situated in an opposite direction. The dihedral angle between the mean planes of the phenyl ring and the naphthalene ring system is 80.25(6). The benzene ring and carbonyl moiety in each benzoyl group are almost coplanar. The molecular packing is stabilized by weak C–H…O hydrogen bonds and aπ-πstacking interaction between the benzene rings [centroid-centroid and interplanar distances of 3.6383(10) and 3.294 , respectively]. In solution, the temperature-dependent rotation behavior of the C–C bond between the benzene ring and the ketonic carbonyl group has been observed by1H VT-NMR measurements. Furthermore, comparison of the C–C bond rotation behavior between the benzene ring and the carbonyl group with 1-ben-zoyl-2,7-dimethoxynaphthalene has clarified that the C–C bond between the ketonic carbonyl group and the naphthalene ring rotates slower than the 1,8-dibenzoylated homologue.

关键词： Non-Coplanarly Accumulated Aromatic Rings Molecules Crystal Structural Features Bond Rotation Behavior in Solution X-Ray Crystallography VT-NMR Spectroscopy

Chemospecific and Regioselective Ethereal Methyl-Oxygen Bond Cleavage Behavior of Aroylated Dimethoxynaphthalenes by Combined Action of AlCl3and Aroyl Group

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International Journal of Organic Chemistry 2012年第3期2卷 194-201页

作者： akiko okamoto Ryosuke Mitsui Shoji Watanabe Takahiro Tsubouchi Noriyuki Yonezawa Department of Organic and Polymer Materials Chemistry Tokyo University of Agriculture and Technology Naka-machi Koganei Tokyo Japan Departmentof Organic and Polymer Materials Chemistry Tokyo University of Agriculture and Technology Naka-machi Koganei Tokyo Japan

AlCl3-mediated cleavage of ethereal methyl–oxygen bond in aroylated 2,7-dimethoxynaphthalene compounds proceeds chemospecifically and regioselectively. The ethereal bond at the β(2)-position of 1-monoaroylated 2,7-dimethoxynaphthalene is cleaved readily and predominantly against the β(7)-position, whereas scission of β-ethereal bonds of 1,8-diaroylated 2,7-dimethoxynaphthalene hardly undergoes like the non-aroylated mother frame compound of 2,7-dimethoxynaphthalene.

关键词： Aroylated 2 7-Dialkoxynaphthalene Chemospecific and Regioselective Scission of Ethereal Alkyl–Oxygen Bond Combined Action of AlCl3 and Aroyl Group Neighboring Group Effect

Activation of neurogenesis in the hippocampus is a novel therapeutic target for Alzheimer's disease

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Neuroprotection 2023年第2期1卷 139-142页

作者： Akihiko Taguchi Yuka Okinaka akiko Takeda Takayuki okamoto Johannes Boltze Carsten Claussen Sheraz Gul Department of Regenerative Medicine Research Foundation for Biomedical Research and Innovation at KobeHyogoJapan Department of Pharmacology Faculty of MedicineShimane UniversityIzumoShimaneJapan School of Life Sciences University of WarwickCoventryUK Fraunhofer Institute for Translational Medicine and Pharmacology ITMP HamburgGermany Fraunhofer Cluster of Excellence for Immune-Mediated Diseases CIMD HamburgGermany

The pathologies associated with age-related brain dysfunction,including Alzheimer's disease(AD),Parkinson's disease,Lewy body dementia,and vascular dementia,often share similarities across multiple diseases.1 While various factors,such as amyloidβ,Tau protein,α-synuclein,chronic inflammation,and impaired cerebral microcirculation have been suggested as potential therapeutic targets,addressing a single factor is unlikely to be sufficient in preventing or treating age-related brain *** from these observations.

关键词： therapeutic Alzheimer impaired

Ocular Surface and Tear Functions

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Ocular Surface and Tear Functions

Condyloma acuminatum of the anal canal,treated with endoscopic submucosal dissection

中华医学会第十二届全国眼科学术大会

作者： Ogawa Yoko Dogru Murat Tatematsu Yukako Uchino Miki okamoto Shinichiro Okada Naoko Igarashi Ayako Kujira akiko Tsubota Kazuo Department of Ophthalmology Eye and ENT Hospital of Fudan University School of MedicineShanghaiChina.

To investigate the effect of 0.05% topical cyclosporin on the ocular surface and tear functions in patients with chronic Graft —Versus—Host Disease(cGVHD)related dry ***- ods:26 eyes of 13 patients(6 males and 7 fem...

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World Journal of Gastroenterology 2016年第8期22卷 2636-2641页

作者： akiko Sasaki Takeshi Nakajima Hideto Egashira Kotaro Takeda Shinnosuke Tokoro Chikamasa Ichita Sakue Masuda Haruki Uojima Kazuya Koizumi Takeshi Kinbara Taku Sakamoto Yutaka Saito Makoto Kako Gastroenterology Medicine Center Shonan Kamakura General Hospital 1370-1 Okamoto Kamakura Endoscopy Division National Cancer Center Hospital5-1-1 Tsukiji Chuoku Diagnostic Pathology Shonan Kamakura General Hospital 1370-1 Okamoto Kamakura

Condyloma acuminatum(CA) is a common sexually transmitted disease caused by human papilloma virus infection. Not all individuals develop persistent, progressive disease, but careful follow up is required with moderate-to-severe dysplasia to prevent progression to malignancy. Standard therapies include surgical treatments(trans-anal resection and transanal endoscopic microsurgery) and immunotherapeutic and topical methods(topical imiquimod); however, local recurrence remains a considerable problem. Here, we report a case with superficial CA of the anal canal, treated with endoscopic submucosal dissection(ESD). A 28-year-old man presented with a chief complaint of hematochezia. Digital exam did not detect a tumor. Screening colonoscopy revealed 10-mm long, whitish condyles extending from the anal canal to the lower rectum. The lesion covered almost the whole circumference, and only a small amount of normal mucosa remained. Magnifying endoscopy with narrow band imaging showed brownish hairpin-shaped, coiled capillaries. Although histopathological diagnosis by biopsy revealed CA, accurate histological differentiation between CA, papilloma, and squamous cell carcinoma can be difficult with a small specimen. Therefore, weperformed diagnostic ESD, which provides a complete specimen for precise histopathological evaluation. The pathological diagnosis was CA, with moderate dysplasia(anal intraepithelial neoplasia 2). There was no recurrence at 16 mo after the initial ESD. Compared to surgical treatment, endoscopic diagnosis and resection could be performed simultaneously and the tumor margin observed clearly with a magnifying chromocolonoscopy, resulting in less recurrence. These findings suggest that endoscopic resection may be an alternative method for CA that prevents recurrence.

关键词： Condylomata acuminate Recurrence Endoscopy Dissection Carcinoma in situ