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World Journal of Pediatrics 2022年第11期18卷 781-785页

作者： Takashi Furuta Hiroki Yasudo Seigo Okada Yuji Ohnishi akiko Kawakami-miyake Yasuo Suzuki Shouichi Ohga Shunji Hasegawa Department of Pediatrics Yamaguchi University Graduate School of Medicine1-1-1 MinamikogushiUbeYamaguchi755-8505Japan Department of Pediatrics Graduate School of Medical SciencesKyushu University3-1-1 MaidashiHigashi-kuFukuoka812-8582Japan

Kawasaki disease(KD)is an acute febrile ilness characterized by systemic vasculitis affecting the small-and mediumsized arteries in children [1,2].One of the most critical complications of KD is the development of coronary artery lesions(CALs)approximately after 12 days of ilness,which may lead to myocardial infarction[3].High-dose intravenous immunoglobulin(IVIG)and oral administration of aspirin have been established as the first-line therapy for KD[4,5].

关键词： intravenous acute immunoglobulin

Systematic Relationship between Sr Content and the Lattice Constants in Sr Substituted Hydroxyapatite Thin Films

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Journal of Crystallization Process and Technology 2017年第1期7卷 1-10页

作者： Hiroaki Nishikawa Ayaka Saito akiko miyake Yuichiro Tashiro Yoshiya Hashimoto Faculty of Biology-Oriented Science and Technology Kindai University Kinokawa Japan Graduate School of Biology-Oriented Science and Technology Kindai University Kinokawa Japan Department of Removable Prosthodontics and Occlusion Osaka Dental University Hirakata Japan Department of Biomaterials Osaka Dental University Hirakata Japan

To increase the biocompatibility of hydroxyapatite (HA), Ca10(PO4)6(OH)2, the Sr substitution of Ca into the HA structure was effected to yield Ca10-xSrx(PO4)6(OH)2(Sr-HA). For medical and dental applications, it is important that Sr-HA is prepared as a thin film so that the Sr fully substitutes the Ca sites in the HA structure and does not form segregated impurities consisting of Sr compounds. If the segregated Sr forms different amounts of different impurities, the dissolution of the Sr into the living body will not be reproducible across different samples. To confirm the Sr substitution into the Ca site in the HA structure, the systematic variation in the lattice constants of the Sr-HA with Sr content was evaluated as the first step. The a- and c-axis lengths were found to exhibit a linear relationship with the Sr content for six samples with different Sr contents, indicating that the prepared Sr-HA thin films likely possessed partial Sr substitution into the Ca sites of the HA structure. This result is an important first step in the accurate evaluation of the biological effects of Sr-HA thin films.

关键词： Sr Substituted Hydroxyapatite X-Ray Diffraction Lattice Constant Pulsed Laser Deposition Technique

Circulating immunocompetent cell profiles during oral cyclosporin therapy for immunoglobulin-resistant Kawasaki disease

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World Journal of Pediatrics 2021年第6期17卷 671-673页

作者： Seigo Okada Yuji OhnishiTakashi Furuta Yasuo Suzuki akiko Kawakami-miyake Chie Matsuguma Takako Waniishi Hiroki Yasudo Shunji Hasegawa Department of Pediatrics Yamaguchi University Graduate School of Medicine1-1-1 MinamikogushiUbeYamaguchi 755-8505Japan

Although the standard treatment for Kawasaki disease(KD)is intravenous immunoglobulin(IVIG)combined with oral aspirin,18%of 1st IVIG is refractory[1].Recently,the efficacy of immunomodulatory drugs for IVIG-resistant KD,such as prednisolone,infliximab(IFX),and cyclosporine(CsA),has been reported[2-5].However,optimal immunomodulatory therapy for IVIG-resistant KD has not yet been established.

关键词： immuno drugs immunoglobulin

Effectiveness of antibiotic prophylaxis for acute esophageal variceal bleeding in patients with band ligation: A large observational study

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World Journal of Gastroenterology 2024年第3期30卷 238-251页

作者： Chikamasa Ichita Sayuri Shimizu Tadahiro Goto Uojima Haruki Naoya Itoh Masao Iwagami akiko Sasaki Gastroenterology Medicine Center Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Department of Health Data Science Yokohama City UniversityYokohama 236-0027KanagawaJapan TXP Research TXP Medical Co.Ltd.Chiyoda-ku 101-0042TokyoJapan Department of Clinical Epidemiology and Health Economics School of Public HealthThe University of TokyoBunkyo-ku 113-0033TokyoJapan Department of Genome Medical Sciences Project Research InstituteNational Center for Global Health and MedicineIchikawa 272-8516ChibaJapan Division of Infectious Diseases Aichi Cancer CenterNagoya 464-8681AichiJapan Department of Health Services Research Institute of MedicineUniversity of TsukubaTsukuba 305-8575IbarakiJapan

BACKGROUND Esophageal variceal bleeding is a severe complication associated with liver cirrhosis and typically necessitates endoscopic hemostasis.The current standard treatment is endoscopic variceal ligation(EVL),and Western guidelines recom-mend antibiotic prophylaxis following hemostasis.However,given the impro-vements in prognosis for variceal bleeding due to advancements in the management of bleeding and treatments of liver cirrhosis and the global concerns regarding the emergence of multidrug-resistant bacteria,there is a need to reassess the use of routine antibiotic prophylaxis after hemostasis.AIM To evaluate the effectiveness of antibiotic prophylaxis in patients treated for EVL.METHODS We conducted a 13-year observational study using the Tokushukai medical database across 46 hospitals.Patients were divided into the prophylaxis group(received antibiotics on admission or the next day)and the non-prophylaxis group(did not receive antibiotics within one day of admission).The primary outcome was composed of 6-wk mortality,4-wk rebleeding,and 4-wk spontaneous bacterial peritonitis(SBP).The secondary outcomes were each individual result and in-hospital mortality.A logistic regression with inverse probability of treatment weighting was used.A subgroup analysis was conducted based on the Child-Pugh classification to determine its influence on the primary outcome measures,while sensitivity analyses for antibiotic type and duration were also performed.RESULTS Among 980 patients,790 were included(prophylaxis:232,non-prophylaxis:558).Most patients were males under the age of 65 years with a median Child-Pugh score of 8.The composite primary outcomes occurred in 11.2%of patients in the prophylaxis group and 9.5%in the non-prophylaxis group.No significant differences in outcomes were observed between the groups(adjusted odds ratio,1.11;95%confidence interval,0.61-1.99;P=0.74).Individual outcomes such as 6-wk mortality,4-wk rebleeding,4-wk onset of SBP,and in-hospital mortality were not significantly different between

关键词： Esophageal varices Endoscopic hemostasis Antibiotic prophylaxis Liver cirrhosis Inverse probability of treatment weighting

Giant Brunner's gland hyperplasia of the duodenum successfully resected en bloc by endoscopic mucosal resection: A case report

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 368-375页

作者： Makomo Makazu akiko Sasaki Chikamasa Ichita Chihiro Sumida Takashi Nishino Miki Nagayama Shinichi Teshima Gastroenterology Medicine Center Shonan Kamakura General HospitalKamakura 247-8533Japan Department of Gastroenterology Shonan Kamakura General HospitalKanagawa 247-8533Japan Department of Pathology Shonan Kamakura General HospitalKamakura 247-8533Japan

BACKGROUND Duodenal Brunner's gland hyperplasia(BGH)is a therapeutic target when complications such as bleeding or gastrointestinal obstruction occur or when malignancy cannot be ruled out.Herein,we present a case of large BGH treated with endoscopic mucosal resection(EMR).CASE SUMMARY An 83-year-old woman presented at our hospital with dizziness.Blood tests revealed severe anemia,esophagogastroduodenoscopy showed a 6.5 cm lesion protruding from the anterior wall of the duodenal bulb,and biopsy revealed the presence of glandular epithelium.Endoscopic ultrasonography(EUS)demonstr-ated relatively high echogenicity with a cystic component.The muscularis propria was slightly elevated at the base of the lesion.EMR was performed without complications.The formalin-fixed lesion size was 6 cm×3.5 cm×3 cm,showing nodular proliferation of non-dysplastic Brunner's glands compartmentalized by fibrous septa,confirming the diagnosis of BGH.Reports of EMR or hot snare polypectomy are rare for duodenal BGH>6 cm.In this case,the choice of EMR was made by obtaining information on the base of the lesion as well as on the internal characteristics through EUS.CONCLUSION Large duodenal lesions with good endoscopic maneuverability and no evident muscular layer involvement on EUS may be resectable via EMR.

关键词： Duodenum Brunner’s gland hyperplasia Brunner’s gland hamartoma Brunner’s gland adenoma Endoscopic mucosal resection Case report

Education Programs for Invasive Procedures Involving Nurses: A Scoping Review

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Open Journal of Nursing 2024年第5期14卷 200-224页

作者： Hiromi Shibuya akiko Saito Masumi Mugiyama Noyuri Yamaji Chisato Eto Satoshi Shibuya Department of Nursing Faculty of Health Science Technology Bunkyo Gakuin University Tokyo Japan Department of Health Care Policy and Health Economics Institute of Medicine University of Tsukuba Ibaraki Japan Institute of Clinical Epidemiology Showa University Tokyo Japan Department of Family Nursing Division of Health Science and Nursing Graduate School of Medicine The University of Tokyo Tokyo Japan Department of Global Health Nursing Graduate School of Nursing St. Luke&#8217s International University Tokyo Japan School of Nursing Tokyo Women&#8217s Medical University Tokyo Japan Department of Integrative Physiology School of Medicine Kyorin University Tokyo Japan

Background: Implementing invasive procedures is an important part of patient management by clinical nurses;however, there are gaps between nurses’ actual knowledge and skills and expected professional care capacity. Purpose: This scoping review aimed to map the existing literature related to recent institution-provided educational programs for invasive procedures involving clinical nurses. This study seeks to understand the contents of educational programs and the methods for assessing educational effects. Methods: This scoping review was completed using the following four databases: PubMed (MEDLINE), Embase, Cochrane Library, and Emcare for the period 2000-2022. We included studies that used all forms of educational approaches (e.g., didactic lectures, hands-on training, or on-the-job training). This scoping review considered peer-reviewed publications published in English using quantitative, qualitative, or mixed approaches. A total of 83 studies underwent in the final analysis. Results and Conclusion: A combination of didactic lectures and hands-on training was provided as an educational program in most studies. Contrary to our prediction, educational interventions with advanced technologies such as VR are extremely rare, suggesting that the effectiveness of advanced technologies in learning invasive procedures should be examined to facilitate and retain educational effects more efficiently in future studies. Regarding the assessment of educational effects, nurses’ cognitive (i.e., theoretical knowledge about procedures), psychomotor (i.e., implementing procedures), and psychological aspects (e.g., confidence and self-efficacy in procedures) were evaluated using questionnaires and observational methods. While most studies used a one-group pretest-posttest design, the ratio of randomized controlled trials (RCT) was relatively low. Thus, an RCT design should be introduced in future studies to test the validity of the developed educational program more accurately.

关键词： Training Education Invasive Procedure Nurses Assessment

Side-Chain Type Ferrocene Macrocycles

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Precision Chemistry

Precision Chemistry 2024年第4期2卷 143-150页

作者： Bin Lan Jindong Xu Lingyun Zhu Xinyu Chen Hideya Kono Peihan Wang Xin Zuo Jianfeng Yan akiko Yagi Yongshen Zheng Songhua Chen Yaofeng Yuan Kenichiro Itami Yuanming Li Key Laboratory of Molecule Synthesis and Function Discovery(Fujian Province University) College of ChemistryFuzhou UniversityFuzhou 350108China Institute of Transformative Bio-Molecules(WPI-ITbM) Nagoya UniversityNagoya 464-8602Japan School of Materials Science and Engineering National Institute for Advanced MaterialsNankai UniversityTianjin 300350China Institute of Transformative Bio-Molecules(WPIITbM) Nagoya UniversityNagoya 464-8602Japan College of Chemistry and Material Science Longyan UniversityLongyan 364012China

A class of side-chain type ferrocene macrocycles with a radially conjugated system is introduced in this study.The stereo configurations of these ferrocene rings were determined through single-crystal X-ray diffraction analysis.Notably,in the solid state,the ferrocene rings exhibit a distinctive herringbone stacking pattern imposed by a ferrocene-to-ring host−guest interaction.Through UV−vis absorption spectroscopy,electrochemical measurements,and theoretical calculations,valuable insights into the electronic properties of these rings were obtained.In addition,the single crystal of macrocycle A_(2)B demonstrates a second-order nonlinear optical response.As a class of organometallic nanorings,this work holds great potential for further exploration in the fields of organometallic chemistry,molecular electronics,and host−guest chemistry.

关键词： Ferrocene Conjugated Macrocycles Organometallic Macrocycles Second-Order Nonlinear Optical Nanoring

Influences of Horticultural Therapy and Functional Recovery Training at a Day-Care Center for the Elderly and Text Mining of Care Records by AI

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Open Journal of Therapy and Rehabilitation 2024年第2期12卷 117-131页

作者： Seigo Koura Shinya Matsutani Kazuho Nagao Yu Fukushima akiko Ikeda Takeshi Oshikawa Tomohiro Inagaki Kentaro Higashi Faculty of Graduate School Postdoctoral Course in Health Care Medicine Nishikyusyu University Kanzaki Japan Social Welfare Corporation Kanjikai Miyakonojyo Japan Sophia Phyto-Therapy College Tokyo Japan

Background: In Japan, due to the COVID-19 pandemic, various behavioral restrictions were implemented from March 2020, resulting in an increased number of elderly people with reduced participation in care and rehabilitation. As a result, the decline in motor and cognitive functions became more pronounced. Purpose: The study examined how activities combining passive horticultural therapy, which is always introduced, with active functional recovery training, which is used in the functional recovery training of patients with hemiplegia, influence the behavior of elder people using the facility. Methods: 36 elder people with care need 1 or 2 who regularly used the day-care facilities after the pandemic ended and who agreed to participate in the study was included. The assessment data were every three months from December 2021 to December 2023 after the COVID-19 pandemic, the MMSE and Moca-J, TMIG-Index, and GDS15. AI-based text mining was used to compare changes in visit reports before and after the introduction of the Posture Chart and Red Code, and the relationship between the language used. Results: The results of MMSE and Moca-J were both significantly higher in Group B and C than in Group A. TIMG assessment, was significantly higher in Group B and C than in Group A, and Group C was significantly higher than Group B. The GDS, an assessment of depression in old age, tended to be significantly higher in Group A than in Groups B and C. In the “Co-Occurrence Network Analysis” shown after the introduction of the latest functional recovery training equipment such as the Red Cord, its results showed a high association between the words Bathing and CARE and words such as POSTURE, Red-Code, and AI, App, which are used in functional training and rehabilitation, and their analysis. Conclusion: At day-care facilities specializing in functional recovery training and rehabilitation, a combination of horticultural therapy and the latest functional training equipment found to help maintain the physical and mental health of elderl

关键词： Horticultural Therapy Hand Care Treatment Senior Day-Care Center Functional Recovery Training KH-Corder

Cellular response against cytosolic leakage of mitochondrial DNA: insights into the pathology of Parkinson’s disease

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Neural Regeneration Research 2022年第12期17卷 2682-2684页

作者： akiko Sakai Hideaki Matsui Department of Neuroscience of Disease Brain Research InstituteNiigata UniversityNiigataJapan

Mitochondria are important organelles for cellular metabolism and homeostasis,and their abnormalities are implicated in various diseases.Since mitochondria originate from protobacterium,their components are easily recognized by pathogen sensors called pattern-recognition receptors as foreign substances in the cytoplasm.This is prominent for mitochondrial DNA(mtDNA)which has different properties from nuclear DNA,such as low,if any,methylation status,vulnerability to oxidation due to the proximity to the oxidative phosphorylation machinery,and its circular structure.Recent studies indicate that perturbations in mitochondrial function and homeostasis cause mtDNA to leak into the cytoplasm,where it triggers the innate immune response(West and Shadel,2017).Although inflammatory response is a cellular strategy to resist viral infections,it can also lead to undesirable outcomes by damaging own cells and tissues.

关键词： homeostasis metabolism insight

Clinical features of acute esophageal mucosal lesions and reflux esophagitis Los Angeles classification grade D: A retrospective study

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World Journal of Gastrointestinal Surgery 2023年第3期15卷 408-419页

作者： Chikamasa Ichita akiko Sasaki Sayuri Shimizu Department of Gastroenterology Medicine Center Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Department of Health Data Science Yokohama City UniversityYokohama 236–0027KanagawaJapan

BACKGROUND Acute esophageal mucosal lesions(AEMLs)are an underrecognized and largely unexplored disease.Endoscopic findings are similar,and a higher percentage of AEML could be misdiagnosed as reflux esophagitis Los Angeles classification grade D(RE-D).These diseases could have different pathologies and require different treatments.AIM To compare AEML and RE-D to confirm that the two diseases are different from each other and to clarify the clinical features of AEML.METHODS We selected emergency endoscopic cases of upper gastrointestinal bleeding with circumferential esophageal mucosal injury and classified them into AEML and RE-D groups according to the mucosal injury’s shape on the oral side.We examined patient background,blood sampling data,comorbidities at onset,endoscopic characteristics,and outcomes in each group.RESULTS Among the emergency cases,the AEML and RE-D groups had 105(3.1%)and 48(1.4%)cases,respectively.Multiple variables exhibited significantly different results,indicating that these two diseases are distinct.The clinical features of AEML consisted of more comorbidities[risk ratio(RR):3.10;95%confidence interval(CI):1.68–5.71;P<0.001]and less endoscopic hemostasis compared with RE-D(RR:0.25;95%CI:0.10–0.63;P<0.001).Mortality during hospitalization was higher in the AEML group(RR:3.43;95%CI:0.82–14.40;P=0.094),and stenosis developed only in the AEML group.CONCLUSION AEML and RE-D were clearly distinct diseases with different clinical features.AEML may be more common than assumed,and the potential for its presence should be taken into account in cases of upper gastrointestinal bleeding with comorbidities.

关键词： Acute esophageal mucosal lesion Comorbidities Esophageal reflux Black esophagus Acute necrotizing esophagitis