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Advances in Aging Research 2017年第4期6卷 55-60页

作者： Hiroshi Yonezu Hiroshi Mikami Koichi Oba Katsutoshi Miyatake Michihiro Takai akihiro nitta Department of Orthopedics Yoshinogawa Medical Center Yoshinogawa Japan

The prevalence of osteoporosis and decline in renal function increases with age. Therefore, the coexistence rate of both these conditions rises in the elderly population. Abnormalities in mineral bone metabolism are major complications in chronic kidney disease (CKD). However, in elderly osteoporotic patients without a history of CKD, there are few reports on the relationship between calcium (Ca), phosphorus (P), and parathyroid hormone (PTH), and renal function. The purpose of this study was to investigate the relationship between Ca, P, and PTH, and renal function in elderly osteoporosis patients with no history of CKD. We evaluated 169 patients who had been treated for osteoporosis. The eGFR decreased with age resulting in a negative correlation (r = -0.514, p p p p p < 0.01, respectively). Even if Ca and P are in the normal range, in case of a poor effect of an osteoporotic therapeutic drug, it is necessary to consider the measurement of intact PTH in elderly osteoporosis patients with no history of CKD.

关键词： Calcium Phosphorus Parathyroid Hormone Renal Function Elderly Osteoporotic Patients

Successful Treatment with a Weekly Injection of Teriparatide for the Nonunion of a Distal Humerus Fracture

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Open Journal of Orthopedics 2017年第7期7卷 173-179页

作者： Hiroshi Yonezu Hiroshi Mikami Koichi Oba Katsutoshi Miyatake Michihiro Takai akihiro nitta Department of Orthopedics Yoshinogawa Medical Center Yoshinogawa Tokushima Japan

A distal humerus fracture nonunion is one of the complications with which we should be vigilant. It requires an open reduction and rigid internal fixation. However, treatment with an operative procedure is difficult because the small bones involved in distal humerus fracture nonunion or if osteoporosis is present. And an improvement in the function of the elbow joint is not satisfied because of a postoperative elbow joint contracture. Furthermore, the risk of anesthesia to elderly patients restricts the use of an operation for treatment. A weekly injection of teriparatide has the ability to stimulate bone formation. We present a case of an 87-year-old woman treated with a weekly injection of teriparatide for the nonunion of a distal humerus fracture.

关键词： Distal Humerus Fracture Nonunion Teriparatide

The Correlation between Femoral Anteversion and Femoral Condyle Rotation in Patients with Osteoarthritis of the Hip Joint: Investigation about the Asian Female Patients

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Open Journal of Orthopedics 2017年第11期7卷 369-374页

作者： Hiroshi Yonezu Hiroshi Mikami Koichi Oba Katsutoshi Miyatake Michihiro Takai akihiro nitta Department of Orthopedics Yoshinogawa Medical Center Tokushima Japan

An abnormality of femoral anteversion (FA) is often recognized in patients with osteoarthritis of the hip joint (hip OA). And it is considered that rotation abnormality in the knee and the lower leg occurs as compensation, in cases of FA abnormality. The purpose of this study was to assess the magnitude and variability of FA and femoral condyle rotation (FCR) in order to identify the association between FA and FCR in female patients with hip OA who require total hip arthroplasty. A total of 174 hips from 174 hip OA patients undergoing THA were included in this study. All patients were Asian women (average age: 71.1 years). An equilateral correlation was accepted in FA and FCR. It was thought that FA abnormality might be accompanied by morphological rotation abnormalities of the knee joint. Caution is needed in considering femoral anteversion using the posterior condylar line. We must consider FA in patients undergoing THA after having considered the whole leg rotation.

关键词： Femoral Anteversion Femoral Condyle Rotation Osteoarthritis of the Hip Posterior Condylar Line Epicondylar Line Total Hip Arthroplasty (THA)

EXPERIMENTAL ANIMAL TUMOR IMMUNOTHERAPY WITH BACTERIAL POLYSACCHARIDE

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中华医学杂志(英文版) 1981年第6期94卷 375-378页

作者：赵家琪 Kazuo nitta 新田和男 On leave from Immunology Section Dongzhimen HospitalBeijing. Chemotherapy Division National Cancer Center Research InstituteTokyo

A carboxymethyl-polysaccharide of bacterialorigin,CM-TAK,exhibits very strong antitumoractivity in a subcutaneous sarcoma 180(S180)sclid tumor,when intraperitoneally injected at20 mg/kg/day every other day,starting on day1 and totalling up to 5 times or by 1 shotcf 100 mg/kg either on day 1,day 7 or day *** ratios of tumor growth are nearly100% by any mode of injection *** manymice,tumors completely disappear after treat-ment with CM-TAK.

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Time to take another Iook at perceived disadvantages of robotic hepatectomy

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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 208-210页

作者： Yasushi Hasegawa Hiroyuki nitta Takeshi Takahara Akira Sasaki Department of Surgery Iwate Medical University School of MedicineMorioka CityIwateJapan

Robotic hepatectomy remains controversial to date,despite continuous advances in the technology and more surgeons gaining experience with the *** et al.(1)recently published an interesting article in Hepatobiliary Surgery and Nutrition,titled"Selecting incision-dominant cases for robotic liver resection:towards outpatient hepatectomy with rapid recovery."The authors evaluated 97 cases of robotically-assisted liver resection(RLR)arguing that it is difficult to reach the superior-posterior liver segments with the straight instruments used in conventional laparoscopic liver resection(LLR).The articulated instruments of the surgical robot are better suited for hepatectomies in these difficult-to-reach areas of the *** concluded that cases where the incision of an open approach would be large and affect recovery results in the highest likelihood of patients benefitting from a robotic *** think that the authors present an interesting perspective by focusing on the strong points of RLR compared to LLR.

关键词： hepatectomy Surgery straight

A case of diffuse alveolar hemorrhage following synthetic cathinone inhalation

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World Journal of Emergency Medicine 2020年第3期11卷 182-184页

作者： Masakazu nitta Taro Tamakawa Natsuo Kamimura Tadayuki Honda Hiroshi Endoh Advanced Emergency and Critical Care Center Niigata University Medical and Dental HospitalChuo-kuNiigataJapan

Dear editor,Diffuse alveolar hemorrhage(DAH)sometimes causes a life-threatening condition;thus,prompt diagnosis and treatment for DAH is ***,a variety of diseases(e.g.,systemic autoimmune diseases,infectious diseases,drugs)are associated with the development of DAH,which occasionally causes diffi culty with identifying the specifi c etiology.

关键词： alveolar diseases diagnosis

Phenolic rigid organic filler/isotactic polypropylene ***

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Frontiers of Chemical Science and Engineering 2008年第3期2卷 236-241页

作者： Dongming QI Lei YANG Minghua WU Heming LIN Kohhei nitta Key Laboratory of Advanced Textile Materials and Manufacturing Technology Ministry of EducationZhejiang Sci-Tech UniversityHangzhou 310018China Graduate School of Natural Science&Technology Kanazawa UniversityKanazawaIshikawa920-1192Japan

A novel phenolic rigid organic filler(KT)was melt-mixed with an isotactic polypropylene(iPP)to prepare a series of PP/KT composites,with or without maleic anhydride grafted polypropylene(MAPP)as *** evolution of filler morphology during melt-mixing and melt-pressure processes was monitored by scanning electron microscope(SEM)and polarized optical microscope(POM).The influences of shear force,pressure time,filler content and MAPP concentration on the final filler dispersion were *** found that this rigid organic filler readily melted and dispersed homogenously into the iPP matrix through a fission-fusion process during the melt-mixing *** a balanced dispersion,which was closely related to shear force and MAPP concentration,can be *** the meltpressure process,parts of the filler particles combined gradually through a coalescence ***,the incorporation of MAPP can effectively inhibit the tendency to coalesce and refine the filler particles sizes into ***,a series of PP/KT composites with controllable filler particles size and narrow size distribution can be obtained just by adjusting process conditions and MAPP *** addition,due to the in-situ formation mechanism,the filler phase possessed a typical solid true-spherical shape.

关键词： rigid organic filler polypropylene dispersion in-situ formation

Adaptive-sampling near-Doppler-limited terahertz dual-comb spectroscopy with a free-running single-cavity fiber laser

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Advanced Photonics 2020年第3期2卷 50-60页

作者： Jie Chen Kazuki nitta Xin Zhao Takahiko Mizuno TakeoMinamikawa Francis Hindle Zheng Zheng Takeshi Yasui Beihang University School of Electronic and Information EngineeringBeijingChina Tokushima University Graduate School of Advanced Technology and ScienceTokushimaJapan JST ERATO MINOSHIMA Intelligent Optical SynthesizerTokushimaJapan Tokushima University Institute of Post-LED PhotonicsTokushimaJapan Tokushima University Graduate School of TechnologyIndustrial and Social SciencesTokushimaJapan Tokushima University Research Cluster on“Multi-scale VibrationalMicroscopy forComprehensive Diagnosis and Treatment of Cancer”TokushimaJapan Universitédu Littoral Côte d’Opale Laboratoire de Physico-Chimie de l’AtmosphèreDunkerqueFrance Beihang University Beijing Advanced Innovation Center for Big Data-based Precision MedicineBeijingChina

Dual-comb spectroscopy(DCS)is an emerging spectroscopic tool with the potential to simultaneously achieve a broad spectral coverage and ultrahigh spectral resolution with rapid data ***,the need for two independently stabilized ultrafast lasers significantly hampers the potential application of *** demonstrate mode-resolved DCS in the THz region based on a free-running singlecavity dual-comb fiber laser with the adaptive sampling *** the use of a free-running single-cavity dual-comb fiber laser eliminates the need for two mode-locked lasers and their frequency control,the adaptive sampling method strongly prevents the degradation of spectroscopic performance caused by the residual timing jitter in the free-running dual-comb ***-limit-approaching absorption features with linewidths down to 25 MHz are investigated for low-pressure acetonitrile/air mixed gas by comb-mode-resolved THz *** successful demonstration clearly indicates its great potential for the realization of lowcomplexity,Doppler-limited THz spectroscopy instrumentation.

关键词： optical comb terahertz dual-comb spectroscopy molecular spectroscopy

Laser Treatment of Cutaneous Lesions with Image-Guided Fine Spot-Scanning Irradiation

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Laser Treatment of Cutaneous Lesions with Image-Guided Fine ...

Establishment and characterization of an opisthorchiasis-associated cholangiocarcinoma cell line (KKU-100)

2007亚洲光电子会议保健与生物医学光学分会场

作者： Isami nitta akihiro Kanno Yasushi Kan Takezawa Yoshimasa Tomohiro Maruyama Yoshitaka Maeda Faculty of Engineering Niigata University 8050 Ikarashi 2 Niigata 950-2181 Japan Niigata Ken Area Industry Promotion Center 1-17 Sugoro Sanjyo 955-0092 Japan ACTIVE Co. Ltd.2-2-9 Shinsan Nagaoka 940-2127 Japan Saiseikai Niigata Daini Hospital 280-7 Teraji Niigata 950-1104 Japan Brain Research Institute Niigata University1-757 Asahi-machi-dori Niigata 951-8585 Japan

We propose a new laser irradiation method for the treatment of cutaneous lesions in plastic surgery. In general, lasers with a spot size of 1 to 10 mm are used in irradiation on diseased skin. Although the target absorbs more light energy according to the theory of selective photothermolysis, the surrounding tissue, however, is still somewhat damaged. In proposed method, an f-theta lens, which is assembled by a shrink fitter, focuses the irradiation laser beam to a very fine spot with the size of 125 μm. Guided by the captured object-image, such laser beam is conducted by a pair of galvanometer-driven mirrors to irradiate only the desired tissue target without thermal damage to surrounding tissue. Moreover, an optical coherence tomography, whose probe is capable of wide field of view, can be used to provide the guidance information for the best treatment. The usefulness of the developed laser therapy apparatus was demonstrated by performing an experiment on the removal of tattoo pigment.

关键词： laser surgery laser therapy laser scanning f-theta lens shrink fitter optical coherence tomography finite element method optical design

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World Journal of Gastroenterology 2005年第22期11卷 3392-3397页

作者： Banchob Sripa Saman Leungwattanawanit Takayuki nitta Chaisiri Wongkham Vajarabhongsa Bhudhisawasdi Anucha Puapairoj Chongrak Sripa Masanao Miwa Department of Pathology Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand Liver Fluke and Cholangiocarcinoma Research Center Khon Kaen University Khon Kaen 40002 Thailand Department of Pathology Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand Institute of Basic Medical Science University of Tsukuba Ibaraki 305-8575 Tsukuba Japan Department of Biochemistry Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand Liver Fluke and Cholangiocarcinoma Research Center Khon Kaen University Khon Kaen 40002 Thailand Department of Surgery Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand Liver Fluke and Cholangiocarcinoma Research Center Khon Kaen University Khon Kaen 40002 Thailand Department of Pathology Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand Puapairoj Liver Fluke and Cholangiocarcinoma Research Center Khon Kaen University Khon Kaen 40002 Thailand

AM: To establish and characterize a new cholangiocarcinoma cell line from a patient living in the Opisthorchis viverrini (O. viverrini) endemic area of Northeast Thailand. METHODS: Fresh liver biopsy and bile specimens were obtained from a 65-year-old Thai woman with cholangiocarcinoma of the ports hepatis. After digestion, the cells were cultured in Ham's F12 media. The established cell line was then characterized for growth kinetics, cell morphology, imm-unocytochemistry and cytogenetics. Tumorigenicity of the cell line was determined by heterotransplanting in nude mice. RESULTS: The primary tumor was a poorly differentiated tubular adenocarcinoma. Examination of the bile revealed malignant cells with O. viverrin eggs. The cholangiocarcinoma cell line KKU-100 was established 4 mo after the primary culture-population doubling time was 72 h. KKU-100 possesses compact and polygonal-shaped epithelial cells. Immunocytochemically, this cell line exhibited cytokeratin, EMA, CEA, and CA125, but not a-fetoprotein (AFP), CA19-9, desmin, c-met, or p53. Such protein expressions parallel those of the primary tumor. Cytogenetic analysis identified aneuploidy karyotypes with a modal chromosome number of 78 and marked chromosomal structural changes. Inoculation of KKU-100 cells into nude mice produced a transplantable, poorly differentiated aden-ocarcinoma, similar to the original tumor. CONCLUSION: KKU-100 is the first egg-proven, Opisthorchis- associated cholangiocarcinoma cell line, which should prove useful for further investigations of the tumor biology of this cancer.

关键词： Cholangiocarcinoma Cell line Establishment Characterization Opisthorchiasis