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Serum manganese superoxide dismutase and thioredoxin are potential prognostic markers for hepatitis C virus-related hepatocellular carcinoma

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World Journal of Gastroenterology 2011年第44期17卷 4890-4898页

作者： Tsutomu Tamai Hirofumi Uto Yoichiro Takami Kouhei Oda Akiko Saishoji Masashi Hashiguchi Kotaro Kumagai Takeshi Kure Seiichi Mawatari akihiro moriuchi Makoto Oketani Akio Ido Hirohito Tsubouchi Department of Digestive and Lifestyle Related Diseases Human and Environmental SciencesHealth ResearchKagoshima University Graduate School of Medical and Dental Sciences

AIM:To evaluate the clinical significance of oxidative stress markers in patients with hepatitis C virus(HCV)related hepatocellular carcinoma(HCC).METHODS:Sixty-four consecutive patients who were admitted to Kagoshima University Medical and Dental Hospital were enrolled in this retrospective *** patients had chronic liver disease(CLD) due to infection with *** patients with HCV-related HCC,34 with HCV-related CLD without HCC(non-HCC),and 20 healthy volunteers(HVs) were *** associations between serum manganese superoxide dismutase(MnSOD) and thioredoxin(TRX) levels and clinical parameters or patient prognosis were analyzed over a mean follow-up period of 31.7 ***:The serum MnSOD levels were significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.03) or HVs(P < 0.001).Similarly,serum TRX levels were also significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.04) or HVs(P < 0.01).However,serum levels of MnSOD and TRX were not correlated in patients with *** patients with HCC,the overall survival rate(OSR) was lower in patients with MnSOD levels ≥ 110 ng/mL than in patients with levels < 110 ng/mL(P = 0.01),and the OSR tended to be lower in patients with TRX levels < 80 ng/mL(P = 0.05).In addition,patient prognosis with HCC was poorest with serum MnSOD levels ≥ 110 ng/mL and serum TRX levels < 80 ng/***,a multivariate analysis using a Cox proportional hazard model and serum levels of five factors(MnSOD,prothrombin time,serum albumin,serum α-fetoprotein(AFP),and serum des-γ-carboxy prothrombin) revealed that MnSOD levels ≥ 110 ng/mL(risk ratio:4.12,95% confidential interval:1.22-13.88,P = 0.02) and AFP levels ≥ 40 ng/mL(risk ratio:6.75;95% confidential interval:1.70-26.85,P < 0.01) were independent risk factors associated with a poor patient ***:Serum MnSOD and TRX levels are potential clinical biomarkers that predict patient prognosis in

关键词： Oxidative stress Manganese superoxide dismutase Thioredoxin Hepatitis C virus Hepatocellular carcinoma

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Hybrid Polyaniline Systems under Chiral and Redox Control

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复旦学报（自然科学版） 2005年第5期44卷 707-708页

作者： Toshikazu Hirao Toshiyuki moriuchi Kenji Morita Department of Applied Chemistry Graduate School of Engineering Osaka University Yamada-oka Suita Osaka 565-0871 JapanDepartment of Applied Chemistry Graduate School of Engineering Osaka University Yamada-oka Suita Osaka 565-0871 JapanDepartment of Applied Chemistry Graduate School of Engineering Osaka University Yamada-oka Suita Osaka 565-0871 Japan

Polyanilines are one of the promising electrically conducting π-conjugated polymers with chemical stability. In recent year, there has been increased interest in chiral induction of polyanilines because of their potential use in diverse areas. Chiral polyaniline has been reported to be formed only by the chiral acid dopant[1]. In our previous papers, complexation of polyanilines or their oligomers with transition metals modulates the redox properties of the quinonediimine unit, which is related to the catalytic function in the oxidation reaction[2].The controlled complexation with palladium(Ⅱ) compounds has been achieved to afford the cross-linked network conjugated complexes, in which the quinonediimine moieties serve as bridging coordination sites[3].Another hybrid system consisting of π-conjugated polymer and transition metal is also described.

关键词：氨苯聚乙烯混合物氧化还原控制共轭聚合体手性合成

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Remission of primary low-grade gastric lymphomas of the mucosa-associated lymphoid tissue type in immunocompromised pediatric patients

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World Journal of Gastroenterology 2006年第16期12卷 2625-2628页

作者： Yasuharu Ohno Taichirou Kosaka Izumi Muraoka Takashi Kanematsu Akira Tsuru Eiichi Kinoshita Hiroyuki moriuchi Division of Pediatric Surgery Department of SurgeryNagasaki University Graduate School of Biomedical SciencesNagasakiJapan Department of Pediatrics Nagasaki University Graduate School of Biomedical SciencesNagasakiJapan

We report the remission of primary gastric lymphoma of the mucosa-associated lymphoid tissue （MALT） type in two immunocompromised pediatric patients. Patient 1, a 14-year-old boy in an immunocompromised state of unknown cause, complained of repeated abdominal pain. Examinations revealed gastric MALT with local invasion and lymph node involvement. Serum anti-Helicobacter pylori （H pylon） antibody was positive. H pylori eradication was abandoned due to its adverse effects. The MALT lesion spontaneously regressed over the next 24 months without any treatment for lymphoma. Patient 2, a 6-year-old boy, underwent cord blood transplantation for the treatment of adrenoleukodystrophy. He was administered immunosuppressants for graft-versus-host disease after transplantation. Nausea and hematochezia appeared and further examinations revealed gastric MALT with H pylori gastritis. Treatment consisting of medication for the Hpylori infection alone eradicated the Hpylori and completely resolved the patient＇s MALT lesion, as well. Patients i and 2 were followed up over periods of 10 years and 3 years, respectively, without any signs of relapse. In conclusion, gastric lymphoma of the MALT type can be cured by conservative treatment even in immunocompromised pediatric patients.

关键词： Pediatric gastric lymphoma IVlucosa-associated lymphoid tissue Immunocompromised states

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Comparison of cerebral activation between motor execution and motor imagery of self-feeding activity

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Neural Regeneration Research 2021年第4期16卷 770-774页

作者： Moemi Matsuo Naoki Iso Kengo Fujiwara Takefumi moriuchi Daiki Matsuda Wataru Mitsunaga Akira Nakashima Toshio Higashi Unit of Medical Science Nagasaki University Graduate School of Biomedical SciencesNagasakiJapan Center for Child Mental Health Care and Education Nagasaki UniversityNagasakiJapan Department of Rehabilitation Faculty of Health SciencesTokyo Kasei UniversitySaitamaJapan Zeshinkai General Incorporated Association Nagasaki Rehabilitation HospitalNagasakiJapan The Japanese Red Cross Nagasaki Genbaku HospitalNagasakiJapan Unit of Rehabilitation Nagasaki University HospitalNagasakiJapan

Motor imagery is defined as an act wherein an individual contemplates a mental action of motor execution without apparent *** practice executed by repetitive motor imagery can improve motor performance without simultaneous sensory input or overt *** aimed to investigate cerebral hemodynamics during motor imagery and motor execution of a self-feeding activity using *** study included 21 healthy right-handed *** self-feeding activity task comprised either motor imagery or motor execution of eating sliced cucumber pickles with chopsticks to examine eight regions of interest:pre-supplementary motor area,supplementary motor area,bilateral prefrontal cortex,premotor area,and sensorimotor *** mean oxyhemoglobin levels were detected using near-infrared spectroscopy to reflect cerebral *** mean oxyhemoglobin levels during motor execution were significantly higher in the left sensorimotor cortex than in the supplementary motor area and the left premotor ***,significantly higher oxyhemoglobin levels were detected in the supplementary motor area and the left premotor area during motor imagery,compared to motor *** motor area and premotor area had important roles in the motor imagery of self-feeding ***,the activation levels of the supplementary motor area and the premotor area during motor execution and motor imagery are likely affected by intentional cognitive *** of cerebral activation differed in some areas during motor execution and motor imagery of a self-feeding *** study was approved by the Ethical Review Committee of Nagasaki University(approval No.18110801)on December 10,2018.

关键词： Activities of Daily Living brain function hemodynamics imagery(psychotherapy) mental practice motor cortex near-infrared neuroimaging neuroscience rehabilitation spectroscopy

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Lamivudine treatment enabling right hepatectomy for hepatocellular carcinoma in decompensated cirrhosis

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World Journal of Gastroenterology 2012年第20期18卷 2586-2590页

作者： Koichi Honda Masataka Seike Shin-ichiro Maehara Koichiro Tahara Hideaki Anai Akira moriuchi Toyokichi Muro First Department of Internal Medicine Oita UniversityOita 879-5593Japan Department of Surgery National Hospital Organization Oita Medical CenterOita 870-0263Japan Department of Pathology National Hospital Organization Oita Medical CenterOita 870-0263Japan Department of Gastroenterology and Hepatology National Hospital Organization Oita Medical CenterOita 870-0263Japan

A 69-year-old man was admitted to our hospital in October 2003,for further examination of two liver *** was diagnosed with hepatocellular carcinoma(HCC) arising from decompensated hepatitis B virus(HBV)-related ***-term lamivudine administration improved liver function dramatically despite repeated treatment for *** Child-Pugh score was 9 points at start of lamivudine treatment,improving to 5 points after 1 *** indocyanine green at 15 min after injection test score was 48%before lamivudine treat-ment,improving to 22%after 2 years and to 5%after 4 *** ablation controlled the HCC foci and maintained his liver *** April 2009,abdominal computed tomography revealed a tumor thrombus in the right portal *** his indocyanine green test results had improved to less than 10%,we performed a right hepatectomy,which was *** our knowledge,there have been no documented reports of patients undergoing successful right hepatectomy for HCC arising from decompensated *** findings observed in our patient indicate the importance of nucleoside analogs for treating HBV-related HCC.

关键词： Hepatitis B virus Lamivudine Hepatocellular carcinoma Decompensated cirrhosis Hepatectomy

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A method for using video presentation to increase the vividness and activity of cortical regions during motor imagery tasks

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Neural Regeneration Research 2021年第12期16卷 2431-2437页

作者： Kengo Fujiwara Masatomo Shibata Yoshinaga Awano Koji Shibayama Naoki Iso Moemi Matsuo Akira Nakashima Takefumi moriuchi Wataru Mitsunaga Toshio Higashi Department of Clinical Services Nagasaki Rehabilitation HospitalNagasakiJapan Graduate School of Biomedical Sciences Nagasaki UniversityNagasakiJapan Department of Rehabilitation Faculty of Health SciencesTokyo Kasei UniversityTokyoJapan

In recent years,mental practice(MP)using laterally inverted video of a subject’s non-paralyzed upper limb to improve the vividness of presented motor imagery(MI)has been shown to be effective for improving the function of a paralyzed upper ***,no studies have yet assessed the activity of cortical regions engaged during MI task performance using inverse video presentations and neurophysiological *** study sought to investigate changes in MI vividness and hemodynamic changes in the cerebral cortex during MI performance under the following three conditions in near-infrared spectroscopy:MI-only without inverse video presentation(MI-only),MI with action observation(AO)of an inverse video presentation of another person’s hand(AO+MI(other hand)),and MI with AO of an inverse video presentation of a participant’s own hand(AO+MI(own hand)).Participants included 66 healthy right-handed adults(41 men and 25 women;mean age:26.3±4.3 years).There were 23 patients in the MI-only group(mean age:26.4±4.1 years),20 in the AO+MI(other hand)group(mean age:25.9±5.0 years),and 23 in the AO+MI(own hand)group(mean age:26.9±4.1 years).The MI task involved transferring 1 cm×1 cm blocks from one plate to another,once per second,using chopsticks held in the non-dominant *** on a visual analog scale(VAS),MI vividness was significantly higher in the AO+MI(own hand)group than in the MI-only group and the AO+MI(other hand)group.A main effect of condition was revealed in terms of MI vividness,as well as regions of interest(ROIs)in certain brain areas associated with motor *** data suggest that inverse video presentation of a person’s own hand enhances the MI vividness and increases the activity of motor-related cortical areas during *** study was approved by the Institutional Ethics Committee of Nagasaki University Graduate School of Biomedical and Health Sciences(approval No.18121303)on January 18,2019.

关键词： action observation cortical activity inverse video presentation mental practice motor imagery motor palsy paralysis recovery rehabilitation stroke

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Corticospinal excitability during motor imagery is diminished by continuous repetition-induced fatigue

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Neural Regeneration Research 2021年第6期16卷 1031-1036页

作者： Akira Nakashima Takefumi moriuchi Daiki Matsuda Takashi Hasegawa Jirou Nakamura Kimika Anan Katsuya Satoh Tomotaka Suzuki Toshio Higashi Kenichi Sugawara Department of Rehabilitation Juzenkai HospitalNagasakiJapan Graduate School of Biomedical Sciences Nagasaki UniversityNagasakiJapan School of Rehabilitation Kanagawa University of Human ServicesYokosukaJapan

Application of continuous repetition of motor imagery can improve the performance of exercise ***,there is a lack of more detailed neurophysiological evidence to support the formulation of clear standards for interventions using motor ***,identification of motor imagery intervention time is necessary because it exhibits possible central ***,the purpose of this study was to elucidate the development of fatigue during continuous repetition of motor imagery through objective and subjective *** study involved two *** experiment 1,14 healthy young volunteers were required to imagine grasping and lifting a 1.5-L plastic bottle using the whole *** participant performed the motor imagery task 100 times under each condition with 48 hours interval between two conditions:500 mL or 1500 mL of water in the bottle during the demonstration *** fatigue and a decrease in pinch power appeared under the 1500-mL *** were changes in concentration ability or corticospinal excitability,as assessed by motor evoked potentials,between each set with continuous repetition of motor imagery also under the 1500-mL ***,in experiment 2,12 healthy volunteers were required to perform the motor imagery task 200 times under the 1500-mL *** concentration ability and corticospinal excitability *** is the first study to show that continuous repetition of motor imagery can decrease corticospinal excitability in addition to producing mental *** study was approved by the Institutional Ethics Committee at the Nagasaki University Graduate School of Biomedical and Health Sciences(approval No.18121302)on January 30,2019.

关键词： central nervous system concentration continuous repetition of motor imagery corticospinal excitability mental fatigue motor evoked potential motor imagery muscle fatigue neurophysiology transcranial magnetic stimulation

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Development of Non-Halogen Flame Retardant Optical Fiber and Optical Fiber Cord

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光学学报 2003年第S1期23卷 5-6页

作者： Kazunori Tanaka Kaoru Okuno Tomoyuki Hattori Kiyoaki moriuchi Hiroshi Hayami Wataru Katsurashima Yoshikyo Tamekuni Yokohama R&D Laboratories Sumitomo Electric Industries Ltd. 1 Taya-cho Sakae-ku Yokohama 244-8588 JapanYokohama R&D Laboratories Sumitomo Electric Industries Ltd. 1 Taya-cho Sakae-ku Yokohama 244-8588 JapanYokohama R&D Laboratories Sumitomo Electric Industries Ltd. 1 Taya-cho Sakae-ku Yokohama 244-8588 JapanYokohama R&D Laboratories Sumitomo Electric Industries Ltd. 1 Taya-cho Sakae-ku Yokohama 244-8588 JapanYokohama R&D Laboratories Sumitomo Electric Industries Ltd. 1 Taya-cho Sakae-ku Yokohama 244-8588 JapanYokohama R&D Laboratories Sumitomo Electric Industries Ltd. 1 Taya-cho Sakae-ku Yokohama 244-8588 JapanYokohama R&D Laboratories Sumitomo Electric Industries Ltd. 1 Taya-cho Sakae-ku Yokohama 244-8588 Japan

A non-halogen highly flame-retardant 0.9mm optical fiber and 2.0mm simplex optical cord, which are harmonized with the ecosystem, have been developed. The characteristics of them are presented in this paper.

关键词： of test Development of Non-Halogen Flame Retardant Optical Fiber and Optical Fiber Cord been have

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癌细胞与脂肪组织的相互作用:与乳腺钼靶检查毛刺征的相关性研究

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国际医学放射学杂志 2016年第3期 309-310页

作者： H.moriuchi J.Yamaguchi H.Hayashi H.Ohtani I.Shimokawa H.Abiru 孔祥 Department of Surgery National Hospital OrganizationSaga Hospital

摘要目的探讨乳腺钼靶检查出现毛刺征肿块与组织学检查肿瘤边缘脂肪组织浸润之间的相关性。方法本项回顾性研究得到了伦理审查委员会批准,并免除知情同意书的要求。本研究共纳入了1999—2009年间478例接受手术的浸润性乳腺癌病人。采用l... 详细信息

摘要目的探讨乳腺钼靶检查出现毛刺征肿块与组织学检查肿瘤边缘脂肪组织浸润之间的相关性。方法本项回顾性研究得到了伦理审查委员会批准,并免除知情同意书的要求。本研究共纳入了1999—2009年间478例接受手术的浸润性乳腺癌病人。采用logistic回归模型、Cox比例风险回归模型和Kaplan-Meier法比较乳腺钼靶检查发现毛刺征肿

关键词：乳腺钼靶检查相关性肿块病人脂肪组织浸润毛刺征癌细胞

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