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The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis

Cellular & Molecular Immunology 2023年第7期20卷 714-738页

作者： Teizo Yoshimura Chunning Li Yuze Wang akihiro matsukawa Department of Pathology and Experimental Medicine Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama University2-5-1 ShikataKita-kuOkayama 700-8558Japan.

Breast cancer is the most prevalent cancer worldwide,and metastasis is the leading cause of death in cancer *** monocyte chemoattractant protein-1(MCP-1/CCL2)was isolated from the culture supernatants of not only mitogen-activated peripheral blood mononuclear leukocytes but also malignant glioma cells based on its in vitro chemotactic activity toward human ***-1 was subsequently found to be identical to a previously described tumor cell-derived chemotactic factor thought to be responsible for the accumulation of tumor-associated macrophages(TAMs),and it became a candidate target of clinical intervention;however,the role of TAMs in cancer development was still controversial at the time of the discovery of *** in vivo role of MCP-1 in cancer progression was first evaluated by examining human cancer tissues,including breast *** correlations between the level of MCP-1 production in tumors and the degree of TAM infiltration and cancer progression were *** contribution of MCP-1 to the growth of primary tumors and metastasis to the lung,bone,and brain was examined in mouse breast cancer *** results of these studies strongly suggested that MCP-1 is a promoter of breast cancer metastasis to the lung and brain but not *** mechanisms of MCP-1 production in the breast cancer microenvironment have also been *** the present manuscript,we review studies in which the role of MCP-1 in breast cancer development and progression and the mechanisms of its production were examined and attempt to draw a consensus and discuss the potential use of MCP-1 as a biomarker for diagnosis.

关键词： Breast cancer chemokines chemokine receptors metastasis macrophages

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In-Tube Rocket Propulsion Using Repetitive Laser Pulses

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Journal of Thermal Science 2011年第3期20卷 201-204页

作者： akihiro Sasoh Department of Aerospace Engineering Nagoya UniversityFuro-choChikusa-kuNagoya 464-8603Japan

In 'in-tube propulsion,' that is the combination of conventional rocket propulsion and ballistic range operation,propulsion performance can be enhanced with increases in thrust due to spatial confinement and in payload capa-bility because propellant can be placed off board a *** paper describes proofed concepts of in-tube propulsion by using repetitive laser pulses.

关键词： Propulsion Laser Thrust Blast wave Ablation

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Flow Structure Around the Intake of a Vertical Pump

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Journal of Thermal Science 2006年第2期15卷 121-125页

作者： akihiro WADA Research and Development Dept. Torishima Pump MFG. Co. Ltd. 1-1-8 Miyata-cho Takatsuki Osaka 569-8660 Japan

The flow structure around the intake of a vertical pump is investigated experimentally and numerically in order to obtain a guideline in designing the optimum shape of the intake of vertical pumps, in which their installation area is demanded to be minimum without losing the high performance. We concentrate our attention on the expansion ratio of the intake as a representative characteristic of the shape of the pumps and investigate the effect of the expansion ratio on pump performance. It is concluded that the optimum expansion ratio ranges in 1.1-1.2 if we take into consideration that the area needed for the installation of the pump should be minimum.

关键词： vertical pump shape of intake flow structure around the intake

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Screening of functionalized self-assembling peptide nanofiber scaffolds with angiogenic activity for endothelial cell growth

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Progress in Natural Science:Materials International 2011年第2期21卷 111-116页

作者： akihiro HORII Olympus America Inc. 3500 Corporate ParkwayCenter ValleyPA 18034USA

Promotion of angiogenesis in tissue engineering is of vital significance to the survival of transplants,which leads the way of tissue *** this study,we screened six short peptides with potentially angiogenic activities to functionalize self-assembling peptide nanofiber scaffolds RADA16-I(Ac-(RADA)4-CONH2).Fluorescence microscopy images of endothelial cells morphology on peptide scaffolds exhibited good cell attachments and Survivals on these six functionalized peptide scaffolds, especially on peptide scaffolds RAD/KLT and RAD/*** proliferation examination also confirmed the excellent cell growth on these two functionalized peptide *** peptide motifs KLT(KLTWQELYQLKYKGI) and PRG(PRGDSGYRGDS) had positive effects on endothelial cell survival and growth,which implied that these two peptides might have great promise for promoting angiogenesis in vitro and in vivo.

关键词： self-assembling peptide angiogenesis tissue engineering endothelial cell

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New microscopic wave function of α-condensation

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Frontiers of physics 2011年第3期6卷 320-336页

作者： akihiro TOHSAKI Research Center for Nuclear Physics Osaka University Ibaraki-shi Osaka 567-0047 Japan

We explain how to treat a microscopic wave function of α-condensation taking a 3α-nucleus as a typical example. The wave function has been originally proposed ten years before by Horiuehi, Ropke, Schuck and the present author （Phys. Rev. Lett., 2001, 87： 192501）. The microscopic model, which fully takes into account the Pauli principle between all the constituent nucleons, effective inter- nucleon forces and the Coulomb force, can play an important role in reproducing an α-gas nature thanks to α-condensation as an excited state of α-like nuclei. An essential point of the wave function is to describe their ground state simultaneously. We study its typical features by giving an analytical formula of the norm kernel and the kernel concerning the one-body operator for 3α-condensation.

关键词： α-cluster model analytical formula α-condensation

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Does flexible small-diameter colonoscope reduce insertion pain during colonoscopy?

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World Journal of Gastroenterology 2000年第5期6卷 659-663页

作者： Yoshiharu Uno akihiro Munakata First Department of Medicine School of MedicineHirosaki University036- 8216Japan

AIM It is well known that colonoscopy can bedifficult due to abdominal pain induced duringcolonoscope insertion,if sedative agents are ***,an extra-flexible,small-diameter colonoscope(CF-SV,Olympus Inc.,Japan)was developed in order to improve safetyand *** aim of this study was toaccess the usefulness of the *** One hundred patients undergoingsigmoidoscopy were recruited and colonoscopywas performed by one ***,a routine-type colonoscope(CF-2301)was inserted into the colon *** the patient complained ofabdominal pain(even if mild),the scope wasnot advanced further and was withdrawn afterthe anatomic location of its tip was ***,the CF-SV was inserteduntil it reached the cecun or the site whereabdominal pain *** abdominalsurgery and abdominal disease were consideredas unfavorable factors(UF)and the relationshipbetween abdominal pain and UF,age and genderwere ***,the colonicinsertion pressures in 36 patients with abdominalpain were measured with a force *** Thirty-four cases(34%)felt no painwith the CF-2301 and successful pancolon-0scopies to the cecum were ***-six cases(66%)complained of abdominal *** procedure was painless for 47% of men and24% of women,*** CF-2301 scopefailed to reach the sigmoid-descending colon junctions in 59(89.4%)of the 66 patientscomplaining of abdominal ***,CF-SVreached proximal area in 94.9% of those whofailed with *** median pressure forpain-inducing was 700 g/cm^*** Unsedated patients with UFwere prone to complain of pain when thestandard-type CF-2301 scope was *** developed extra-flexible CF-SV is usefulfor the aged and for those with UF or being proneto suffer from abdominal *** agentsmay be unnecessary if this new type ofcolonoscope is used.

关键词： colonoscopy abdominal pain flexible colonoscope insertion pressure unfavorable factors sigmoidoscopy

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Krein Parameters of Fiber-Commutative Coherent Configurations

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Algebra Colloquium 2020年第1期27卷 1-10页

作者： Keiji Ito akihiro Munemasa Research Center for Pure and Applied Mathematics Graduate School of Information SciencesTohoku UniversitySendaiJapan

For fiber-commutative coherent configurations,we show that Krein parameters can be defined essentially *** a consequence,the general Krein condition reduces to positive semidefiniteness of finitely many matrices determined by the parameters of a coherent *** mention its implications in the coherent configuration defined by a generalized *** also simplify the absolute bound using the matrices of Krein parameters.

关键词： coherent configuration association scheme Krein parameter Krein condition generalized quadrangle absolute bound

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Effect of a Curved Duct Upstream on Performance of Small Centrifugal Compressors for Automobile Turbochargers

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Journal of Thermal Science 2013年第1期22卷 92-96页

作者： Shigeta Kikuchi Nobuhiko Yamasaki akihiro Yamagata Department of Aeronautics and Astronautics Kyushu University Products Development Center IHI Corporation

Since the automobile turbochargers are installed in an engine compartment with limited space, the ducts upstream of the turbocharger compressor may be curved in a complex manner. In the present paper, the effect of a curved duct upstream on performance of small centrifugal compressors for automobile turbochargers is discussed. The computational fluid dynamics (CFD) analysis of a turbocharger compressor validated for the compressor model with the straight pipe applied to the compressor with the curved pipe are executed, and the deterioration of the performance for the curved pipe is confirmed. It is also found that the deterioration of compressor performance is caused by the interaction of the secondary flow and the impeller.

关键词： Cartesian grid cylindrical grid validation calculation

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Magnetic and magnetocaloric properties in GdZn_(2) synthesized by ball milling

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Journal of Rare Earths 2022年第3期40卷 462-466,I0004页

作者： Keisuke T.Matsumoto akihiro Hosokawa Koichi Hiraoka Graduate School of Science and Engineering Ehime University3Bunkyo-choMatsuyamaEhime790-8577Japan

In this study,we prepared GdZn_(2)by mechanical alloying method and measured its magnetization to reveal the magnetic and magnetocaloric *** a milling time(MT)≥10 and 20 h,the GdZn_(2)phase was confirmed by X-ray diffraction *** MT=40 and 60 h,amorphous like patterns are *** MT=10 and 20 h,magnetization(M)as a function of temperature below 80 K shows ferromagnetic-like *** observed values of M are 4.5μ_(B) at 5 K for MT=10 and 20 h,which is smaller than that of the theoretical expected value of 7μ_(B).For MT=40 and 60 h,the long-range ferromagnetic order collapses because there is no spontaneous *** value ofΔT,whereΔT is the full width at half maximum of the magnetic entropy change(ΔS_(m)(T)),increases significantly for MT≤20 h because of the gradual release of magnetic entropy by the milling *** M decreases with increasing MT,the maximum values of|ΔS_(m)|,the relative cooling power,and the refrigerant capacity also decreases.

关键词： Mechanical alloying Magnetocaloric effect GdZn_(2) Rare earths

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Study on Rotational Frequency Noise in a Centrifugal Compressor for Automobile Turbochargers

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Journal of Thermal Science 2014年第1期23卷 53-59页

作者： Daichi Wakaki Yuta Sakuka Nobuhiko Yamasaki akihiro Yamagata Department of Aeronautics and Astronautics Kyushu University Products Development Center IHI Corporation

The rotational frequency noise(also known as the pulsation noise) due to the mistuning of impeller blade rows introduced at the manufacturing stage of the impellers is observed in the small-sized centrifugal compressor for automobile turbochargers. The present paper addresses the elucidation of the generating mechanism and parameter dependency such as the kind and degree of mistuning. In order to analyze numerically the rotational frequency noise due to mistuning, the unsteady computational fluid dynamics(CFD) of the whole compressor including volute is executed, and the resultant time history of the pressure is fed into the spectral analysis.

关键词： Centrifugal compressor Impeller Diffuser Volute Pulsation noise Mistuning

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