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World Journal of Psychiatry 2024年第5期14卷 726-734页

作者： akihiro Shiina Tomihisa Niitsu Masaomi Iyo Chiyo Fujii Division of Medical Treatment and Rehabilitation Chiba University Center for Forensic Mental HealthChiba-shi 2608670Japan Department of Psychiatry Chiba University Graduate School of MedicineChiba-shi 2608670Japan Department of Community Mental Health&Law National Center of Neurology and PsychiatryKodaira-shi 1878553Japan

BACKGROUND The management of offenders with mental disorders has been a significant concern in forensic *** Japan,the introduction of the Medical Treatment and Supervision Act in 2005 addressed the ***,numerous psychiatric patients at risk of violence still find themselves subject to the administrative involuntary hospitalization(AIH)scheme,which lacks clarity and updated *** To explore current as well as optimized learning strategies for risk assessment in AIH decision *** We conducted a questionnaire survey among designated psychiatrists to explore their experiences and expectations regarding training methods for psychiatric assessments of offenders with mental *** The findings of this study’s survey suggest a prevalent reliance on traditional learning approaches such as oral education and on-the-job *** This underscores the pressing need for structured training protocols in AIH ***,feedback derived from inpatient treatment experiences is identified as a crucial element for enhancing risk assessment skills.

关键词： Forensic psychiatry Administrative involuntary hospitalization Psychiatric assessment Risk assessment Mental disorders Training protocols Clinical practice Structured learning Feedback mechanisms Program development

No-touch isolation technique in emergency pancreaticoduodenectomy for neoplastic hemorrhage: Two case reports and review of literature

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1910-1917页

作者： akihiro Cho Satoshi Katagiri Masao Ota Shunsuke Onizawa Ryota Higuchi Toshiya Sugishita Yukiko Niwa Takeshi Ishita Toshihiko Mouri Akita Kato Moe Iwata Division of Gastroenterological Surgery Tokyo Women’s Medical UniversityYachiyo Medical CenterChiba 276-8524Japan

BACKGROUND Emergency pancreaticoduodenectomy(EPD)is a rare event for complex periam-pullary *** intraoperative blood loss is correlated with poor post-operative *** SUMMARY Two patients underwent EPD using a no-touch isolation technique,in which all arteries supplying the pancreatic head region were ligated and divided before manipulation of the pancreatic head and *** operative times were 220 and 239 min,and the blood loss was 70 and 270 g,*** patients were discharged on the 14^(th) and 10^(th) postoperative day,***-two patients underwent EPD for the treatment of neoplastic *** mean operative time was 361.6 min,and the mean blood loss was 747.3 *** comp-lication rate was 37.5%.The in-hospital mortality rate was 9.38%.CONCLUSION The no-touch isolation technique is feasible,safe,and effective for reducing intraoperative blood loss in EPD.

关键词： No-touch isolation technique Pancreaticoduodenectomy Emergency pancre-aticoduodenectomy Neoplastic bleeding Superior mesenteric artery first approach Case report

A Comparative Study of Two Tree-Based Models for Predicting Flyrock Velocity at Open Pit Bench Mining

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Open Journal of Applied Sciences 2024年第2期14卷 267-287页

作者： Ezatullah Rawnaq Bassir Esmatyar akihiro Hamanaka Takashi Sasaoka Hideki Shimada Department of Earth Resources Engineering Kyushu University Fukuoka Japan Department of Mining and Mineral Engineering Suleyman Demirel University Isparta Türkiye

Blasting is a cost-effective technique to break hard rock volumes by using explosives in the mining and civil engineering realms. Moreover, although blasting is a designed process and plays an indispensable role in these industries, it can also have multiple adverse environmental impacts. One such effect is flyrock, which poses risks to nearby machinery, and residential structures, and can even lead to injuries or fatalities. To optimize blasting efficiency as well as restrict side effects, prediction of the blast aftereffects is vital. Therefore, the present work focuses on using two machine learning methods to predict the velocity of flyrock in the open pit mine. To address this issue, a comprehensive dataset was gathered from the open pit mine. Then, Decision Tree and Random Forest algorithms were employed to predict flyrock velocity. The Random Forest model demonstrated superior performance compared to the Decision Tree model. Nonetheless, the performance of the Decision Tree model was deemed satisfactory, as evidenced by its coefficient of determination value of 0.83, mean squared error (MSE) of 4.2, and mean absolute percentage error (MAPE) of 5.6%. Considering these metrics, it is reasonable to conclude that tree-based algorithms can be effective in predicting flyrock velocity.

关键词： Flyrock Machine Learning Bench Blasting Coefficient of Determination

Positive Effect of Transcranial Direct Current Stimulation on Visual Verbal Working Memory in Patients with Attention-Deficit/Hyperactivity Disorder

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Open Journal of Psychiatry 2024年第4期14卷 334-346页

作者： Tomoko Uchida Daisuke Matsuzawa Tadashi Shiohama Katsunori Fujii akihiro Shiina Masamitsu Naka Katsuo Sugita Eiji Shimizu Naoki Shimojo Hiromichi Hamada Department of Pediatrics Graduate School of Medicine Chiba University Chiba Japan Research Center for Child Mental Development Chiba University Chiba Japan Division of Medical Care and Treatment Center for Forensic Mental Health Chiba University Chiba Japan Department of Cognitive Behavioral Physiology Graduate School of Medicine Chiba University Chiba Japan

Background: Working memory is an executive function that plays an important role in many aspects of daily life, and its impairment in patients with attention-deficit/hyperactivity disorder (ADHD) affects quality of life. The dorsolateral prefrontal cortex (DLPFC) has been a good target site for transcranial direct current stimulation (tDCS) due to its intense involvement in working memory. In our 2018 study, tDCS improved visual-verbal working memory in healthy subjects. Objective: This study examines the effects of tDCS on ADHD patients, particularly on verbal working memory. Methods: We conducted an experiment involving verbal working memory of two modalities, visual and auditory, and a sustained attention task that could affect working memory in 9 ADHD patients. Active or sham tDCS was applied to the left DLPFC in a single-blind crossover design. Results: tDCS significantly improved the accuracy of visual-verbal working memory. In contrast, tDCS did not affect auditory-verbal working memory and sustained attention. Conclusion: tDCS to the left DLPFC improved visual-verbal working memory in ADHD patients, with important implications for potential ADHD treatments.

关键词： Working Memory Attention-Deficit/Hyperactivity Disorder Dorsolateral Prefrontal Cortex Transcranial Direct Current Stimulation

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人工智能及其在生命科学中的应用与展望

山东师范大学学报（自然科学版） 2024年第2期39卷 117-142页

作者：潘杰中山皓博山东师范大学生命科学学院济南250014 北京大学医学部北京100191

人工智能(Artificial Intelligence, AI)技术已成为全球众多行业乃至社会变革的重要推动力。智能机器已经进入自我编程、自主学习与自我修复的阶段,人类社会开始走进全面AI时代,包括教育在内的几乎所有领域中AI技术的应用越来越普遍,必... 详细信息

人工智能(Artificial Intelligence, AI)技术已成为全球众多行业乃至社会变革的重要推动力。智能机器已经进入自我编程、自主学习与自我修复的阶段,人类社会开始走进全面AI时代,包括教育在内的几乎所有领域中AI技术的应用越来越普遍,必将对人类生活产生前所未有的积极影响。在大生命科学领域中所获得的天量复杂数据,需要借助现代智能化、数字化以及多模态大模型等技术手段的应用,才能更迅速、更精准、更智能、更实用化地予以解析。本文简述了AI技术及其在生命科学相关领域中的应用现状,并展望了其在教育和科研活动中的发展趋势,以期为对“AI+生命科学”感兴趣的读者提供参考资料。

关键词：人工智能生命科学智能化数字化人机融合智能

Magnetic and magnetocaloric properties in GdZn_(2) synthesized by ball milling

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Journal of Rare Earths 2022年第3期40卷 462-466,I0004页

作者： Keisuke T.Matsumoto akihiro Hosokawa Koichi Hiraoka Graduate School of Science and Engineering Ehime University3Bunkyo-choMatsuyamaEhime790-8577Japan

In this study,we prepared GdZn_(2)by mechanical alloying method and measured its magnetization to reveal the magnetic and magnetocaloric *** a milling time(MT)≥10 and 20 h,the GdZn_(2)phase was confirmed by X-ray diffraction *** MT=40 and 60 h,amorphous like patterns are *** MT=10 and 20 h,magnetization(M)as a function of temperature below 80 K shows ferromagnetic-like *** observed values of M are 4.5μ_(B) at 5 K for MT=10 and 20 h,which is smaller than that of the theoretical expected value of 7μ_(B).For MT=40 and 60 h,the long-range ferromagnetic order collapses because there is no spontaneous *** value ofΔT,whereΔT is the full width at half maximum of the magnetic entropy change(ΔS_(m)(T)),increases significantly for MT≤20 h because of the gradual release of magnetic entropy by the milling *** M decreases with increasing MT,the maximum values of|ΔS_(m)|,the relative cooling power,and the refrigerant capacity also decreases.

关键词： Mechanical alloying Magnetocaloric effect GdZn_(2) Rare earths

Amelioration of acidic soil using fy Ash for Mine Revegetation in PostMining Land

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International Journal of Coal Science & Technology 2022年第3期9卷 201-206页

作者： akihiro Hamanaka Takashi Sasaoka Hideki Shimada Shinji Matsumoto Department of Earth Resources Engineering Faculty of EngineeringKyushu University819-0395 FukuokaJapan Geological Survey of Japan National Institute of Advanced Industrial Science and Technology(AIST)305-8567 TsukubaJapan

This paper described the use of fy ash for soil amelioration of acidic soils to promote plant *** mining sites,acid sulfate soils/rocks,which contain sulfde minerals(*** FeS_(2)),have appeared as a result of overburden *** excessively acidic condition inhibits plant growth due to the dissolution of harmful elements,such as Al,Fe,and *** ash,an alkaline byproduct of coal combustion generated in thermal power plants is expected to be adopted to ameliorate acidic ***,the mixing ratio of fy ash must be considered because excessive addition of fy ash can have a negative impact on plant growth due to its physical/chemical *** pot trials using Acacia mangium demonstrate the evolution of plant growth with a 5%–10%addition of fy ash into acidic *** the acidic soil has a high potential for metal dissolution,the metal ions leached from the acidic soil are large,making it difcult to improve plant growth due to osmotic and ionic *** work suggests that the efects of fy ash on metal ions leached from the soil have to be considered for the amelioration of acidic soil.

关键词： Acid Soil Coal Ash Metal Accumulation Plant Growth

The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis

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Cellular & Molecular Immunology 2023年第7期20卷 714-738页

作者： Teizo Yoshimura Chunning Li Yuze Wang akihiro Matsukawa Department of Pathology and Experimental Medicine Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama University2-5-1 ShikataKita-kuOkayama 700-8558Japan.

Breast cancer is the most prevalent cancer worldwide,and metastasis is the leading cause of death in cancer *** monocyte chemoattractant protein-1(MCP-1/CCL2)was isolated from the culture supernatants of not only mitogen-activated peripheral blood mononuclear leukocytes but also malignant glioma cells based on its in vitro chemotactic activity toward human ***-1 was subsequently found to be identical to a previously described tumor cell-derived chemotactic factor thought to be responsible for the accumulation of tumor-associated macrophages(TAMs),and it became a candidate target of clinical intervention;however,the role of TAMs in cancer development was still controversial at the time of the discovery of *** in vivo role of MCP-1 in cancer progression was first evaluated by examining human cancer tissues,including breast *** correlations between the level of MCP-1 production in tumors and the degree of TAM infiltration and cancer progression were *** contribution of MCP-1 to the growth of primary tumors and metastasis to the lung,bone,and brain was examined in mouse breast cancer *** results of these studies strongly suggested that MCP-1 is a promoter of breast cancer metastasis to the lung and brain but not *** mechanisms of MCP-1 production in the breast cancer microenvironment have also been *** the present manuscript,we review studies in which the role of MCP-1 in breast cancer development and progression and the mechanisms of its production were examined and attempt to draw a consensus and discuss the potential use of MCP-1 as a biomarker for diagnosis.

关键词： Breast cancer chemokines chemokine receptors metastasis macrophages

Torque control strategy with V2X information for HEVs to minimize fuel consumption

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Control Theory and Technology 2022年第2期20卷 197-209页

作者： Yasutaka Okada Shunki Nishii akihiro Takeshita Kazuki Harada Yudai Yamasaki Department of Mechanical Engineering The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan

Today,much information from traffic infrastructures and sensors of ego vehicle is *** such information has a potential for internal combustion engine vehicle to reduce fuel consumption in real *** this paper,a powertrain controller for a hybrid electric vehicle aiming to reduce fuel consumption is introduced,which uses information from traffic signals,the global positioning system and sensors,and the preceding *** study was carried out as a benchmark problem of engine and powertrain control simulation and modeling 2021(E-COSM 2021).The developed controller firstly decides reference acceleration of the ego vehicle using the traffic signal and the position information and the preceding vehicle *** acceleration and deceleration leading to increase in unnecessary fuel consumption is ***,the reference engine,generator,and motor torques are decided to achieve the reference acceleration and minimize fuel *** addition,the reference engine,generator and motor torques were decided by the given fuel consumption map for the engine,and by the virtual fuel consumption maps for the generator and the *** virtual fuel consumption is derived from the efficiency maps of the generator and the motor using a given equivalent factor,which converts electricity consumption to fuel for the generator and the *** this study,a controller was designed through the benchmark problem of E-COSM 2021 for minimizing total fuel consumption of the engine,the generator,and the *** developed controller was evaluated in driving *** result shows that operating the powertrain in efficient area is a key factor in reducing total fuel consumption.

关键词： Powertrain optimization Fuel consumption minimization Hybrid electric vehicle Speed following system

Associations of body mass index and hospital-acquired disability with post-discharge mortality in older patients with acute heart failure

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Journal of Geriatric Cardiology 2022年第3期19卷 209-217页

作者： akihiro sakuyam. Masakazu Saitoh Kentaro Hori Yuichi Adachi Keigo Iwai Masatoshi Nagayama Department of Physical Therapy Faculty of Health ScienceJuntendo UniversityTokyoJapan Department of Rehabilitation Sakakibara Heart InstituteTokyoJapan Department of Cardiology Sakakibara Heart InstituteTokyoJapan

OBJECTIVES To investigate the effect of hospital-acquired disability(HAD)on all-cause mortality after discharge according to the body mass index(BMI)in older patients with acute decompensated heart *** We included 408 patients aged≥65 years who were hospitalized for acute decompensated heart failure and had undergone an acute phase of cardiac rehabilitation at the Sakakibara Heart Institute between April 2013 and September 2015(me-dian age:82 years,interquartile range(IQR):76-86;52%male).Patients were divided into three groups based on BMI at hospital admission:underweight(<18.5 kg/m^(2)),normal weight(18.5 to 25 kg/m^(2)),and overweight(≥25 kg/m^(2)).HAD was defined as a decrease of at least five points at discharge compared to before hospitalization according to the Barthel *** The median follow-up period was 475(IQR:292-730)days,and all-cause mortality during the follow-up period was 84 deaths(21%).According to multivariate Cox regression analysis,being underweight(HR:1.941,95%CI:1.134−3.321,P=0.016)or overweight(HR:0.371,95%CI:0.171−0.803,P=0.012),with normal BMI as the reference,and HAD(HR:1.857,95%CI:1.062−3.250,P=0.030)were independently associated with all-cause *** with HAD exhibited a significantly lower cumulative survival rate in the underweight group(P=0.001)and tended to have a lower cumulative survival rate in the normal weight group(P=0.072).HAD was not significantly associated with cumulative survival in the overweight group(P=0.392).CONCLUSIONS BMI and HAD independently predicted all-cause mortality after discharge in older patients with acute de-compensated heart ***,HAD was significantly associated with higher all-cause mortality after discharge,espe-cially in the underweight group.

关键词： patients acute index