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Quantitative Assessment of Protective Effects of Antioxidant Agents against Drug-Induced Nephrotoxicity Using Dynamic Contrast-Enhanced Computed Tomography

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Open Journal of Medical Imaging 2016年第3期6卷 53-71页

作者： Kenya Murase akihiro kitamura Atsushi Tachibana Yoshinori Kusakabe Risa Matsuura Shohei Miyazaki Department of Medical Physics and Engineering Division of Medical Technology and Science Faculty of Health Science Graduate School of Medicine Osaka University Osaka Japan

Purpose: The purpose of this study was to develop a method for quantifying the extent of renal dysfunction due to drug-induced nephrotoxicity using dynamic contrast-enhanced computed tomography (DCE-CT) and to investigate the protective effects of various antioxidant agents against cis-dichlorodiammineplatinum (cisplatin)-induced nephrotoxicity in rats using this method. Materials and Methods: The DCE-CT studies were performed in 8-week-old male Sprague-Dawley rats. The CT scanning started 4 s before a bolus intravenous injection of iodinated contrast agent (CA) (150 mgI/kg) from the tail vein using an automatic injector and lasted 90 s at 1-s intervals. The contrast clearance per unit renal volume (K1) was estimated from the DCE-CT data using the Patlak model. The renal volume (V) was calculated by manually delineating the kidney on the CT image. The contrast clearance of the entire kid-ney (K) was obtained by . First, to investigate the effect of CA itself, the DCE-CT studies were performed without injecting cisplatin 2, 4, and 7 days after the first DCE-CT study on day 0. Second, to investigate the effect of injected dose of cisplatin, the DCE-CT study was performed after the intraperitoneal (i.p.) injection of cisplatin (1.8 mg/kg) and was repeated every other day for one week. Finally, to investigate the protective effects of antioxidant agents [L-arginine (300 mg/kg), N-acetylcysteine (500 or 1000 mg/kg), methimazole (40 mg/kg), captopril (60 mg/kg), and taurine (750 mg/kg)], the DCE-CT studies were performed on days 0, 2, 4, and 7 after the i.p. injection of cisplatin (3.6 mg/kg). For comparison, the DCE-CT data were also acquired without injecting the antioxidant agents (CDDP group). Results: When cisplatin was not injected, there were no significant changes in the K value as compared to that on day 0 within the studied period. The K valuesignificantly (p < 0.05) decreased with increasing dose of cisplatin. Although some differences were observed in the exte

关键词： Dynamic Contrast-Enhanced Computed Tomography Drug-Induced Nephrotoxicity Cisplatin Glomerular Filtration Rate Creatinine Clearance Animal Experiments

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家蚕信息素生物合成活化神经肽-Ⅱ(PBAN-Ⅱ)的氨基酸序列

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国外农学（蚕业） 1992年第1期 49-50页

作者： akihiro kitamura 张雨青

昆虫性信息素是由雄性信息素腺散发出来的,作为引诱剂以吸引交尾。许多种蛾子信息素腺中性信息素的产生是由一种名为信息素生物合成活化神经肽(PBAN)刺激的,这种神经肽是由咽下神经节和脑或脑合成的。在棉铃虫Heliothiszea中首次对PBAN... 详细信息

昆虫性信息素是由雄性信息素腺散发出来的,作为引诱剂以吸引交尾。许多种蛾子信息素腺中性信息素的产生是由一种名为信息素生物合成活化神经肽(PBAN)刺激的,这种神经肽是由咽下神经节和脑或脑合成的。在棉铃虫Heliothiszea中首次对PBAN作了描述,它是一种由33个氨基酸残基组成的单链肽,在羧基端被酰胺化。

关键词：家蚕信息素生物合成氨基酸

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Construction of Design Guidelines for Optimal Automotive Frame Shape Based on Statistical Approach and Mechanical Analysis

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Computer Modeling in Engineering & Sciences 2021年第8期128卷 731-742页

作者： Masanori Honda Chikara Kawamura Isamu Kizaki Yoichi Miyajima akihiro Takezawa Mitsuru kitamura Mazda Motor Corporation 3-1 ShinchiFuchu-choAki-gunHiroshima730-8670Japan Department of Applied Mechanics and Aerospace Engineering School of Fundamental Science and EngineeringWaseda University3-4-1 OkuboShinjuku-kuTokyo169-8555Japan Division of Advanced Science and Engineering Graduate School of Advanced Science and EngineeringHiroshima University1-4-1 KagamiyamaHigashihiroshimaHiroshima739-8527Japan

A body frame composed of thin sheet metal is a crucial structure that determines the safety performance of a *** a correct weight and high-performance automotive body is an emerging engineering *** improve the performance of the automotive frame,we attempt to reconstruct its design criteria based on statistical and mechanical *** first,a fundamental study on the frame strength is conducted and a cross-sectional shape optimization problem is developed for designing the cross-sectional shape of an automobile frame having a very high mass efficiency for *** optimization is carried out using the nonlinear finite element method and a meta-modeling-based genetic *** analysis of the obtained set of optimal results is performed to identify the dominant design variables by employing the smoothing spline analysis of variance,the principal component analysis,and the self-organizing map *** relationship between the cross-sectional shape and the objective function is also analyzed by hierarchical clustering.A design guideline is obtained from these statistical approach results.A comparison between the statistically obtained design guideline and the conventional one based on the designers’experience is performed based on mechanical interpretation of the optimal cross-sectional ***,a mechanically reasonable new general-purpose design guideline is proposed for the cross-sectional shape of the automotive frame.

关键词： Automotive structure shape optimization data mining statistical approach crash-performance

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Selective excitation of two-wave structure depending on crystal orientation under shock compression

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Science China(Physics,Mechanics & Astronomy) 2020年第11期63卷 59-71页

作者： QiLin Xiong Takahiro Shimada Takayuki kitamura ZhenHuan Li Department of Mechanics Huazhong University of Science&TechnologyWuhan 430074China Hubei Key Laboratory of Engineering Structural Analysis and Safety Assessment Wuhan 430074China Department of Mechanical Engineering and Science Kyoto UniversityKyoto 615-8540Japan

Single crystals subjected to shock compression exhibit responses with distinct two-wave structures for certain crystal ***,little is known to date regarding how the shock response depends on crystal orientation,and especially why the two-wave structure depends on the crystal *** this work,molecular dynamics simulations of shock compressions in copper single crystals are performed to investigate the orientation dependence of shock responses and the corresponding deformation *** copper single crystals with[001],[011],[012],and[123]crystal orientations along the depth direction are ***[011],[012],and[123]crystal orientations of copper single crystals show distinct two-wave structures in their shock responses,while such a two-wave structure in the shock response is not seen for those orientations having a[001]crystal *** potential causes are analyzed by considering the propagation velocities of both elastic and plastic *** develop a technique for identifying twin structures in face-centered cubic crystals and this technique can effectively identify the twin *** morphology of shock-induced defects(e.g.,dislocations and twins)shows the significant dependence of crystal orientation and the mechanisms behind these are discussed in ***,the Johnson-Cook constitutive model describing dynamic deformations at high temperatures and high strain rates is used to analyze the relationships between the shock responses and microscopic *** predictions of the Johnson-Cook constitutive model are consistent with the results of the molecular dynamics simulations.

关键词： orientation-dependent two-wave structure shock compression copper molecular dynamics

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Toner Display Based on Movement of Tribo-electrically Charged Particles

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仪器仪表学报 2004年第S3期25卷 36-38+55页

作者： Takashi kitamura Information and Image Sciences Department Japan Chiba University 263-8522 Faculty of Engineering

The mechanism of toner display based on an electrical movement of black and white charged particles has been investigated. Two kinds of particles of black and white charged in the different electric polarity are enclosed in two ITO transparent electrodes using an insulating spacer. The particle movement is controlled by the external electric field applied between two transparent electrodes. The black toner is adhered on the electrode by an electrostatic force across the CTL to display a black image. The toners can be put back to the counter electrode by applying a reverse electric field, and a white image is formed. The black and white solid images are displayed by the switch of polarity of applied voltage in toner display cell. The polarity of charge and the value of charge to mass ratio of two particles were measured by observation of the particle separation on the surface-type electrodes and using q/m meter, respectively.

关键词： Toner display Electronic paper Particle

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A Nano-Cantilever Method for Crack Initiation at the Free Edge of the Cu/Si Interface in Nanoscale Components

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Acta Mechanica Solida Sinica 2016年第4期29卷 416-428页

作者： Xiaoyuan Wang Yabin Yan Qiang Wan Takashi Sumigawa Takayuki kitamura Institute of Systems Engineering China Academy of Engineering Physics Department of Mechanical Engineering and Science Kyoto University

Straight and Bent nano-cantilever specimens are respectively proposed to investigate the single-mode and mixed-mode crack initiation at the Cu/Si interface edge in nanoscale components. With a minute loading apparatus, all nanoscale samples are in situ loaded and observed. Numerical analysis is employed to acquire the critical interfacial stress distributions during crack initiation. The stress concentration regions near the edge of Cu/Si interface in all specimens are within the scale of 100 nm, and the critical normal and shear stresses have a circular relation in nanoscale components, which represents the fracture criterion of the interface in nanoscale components.

关键词： nanoscale cantilever interface crack initiation mixed mode thin film

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Mesenchymal stem cells-derived extracellular vesicles as‘natural’drug delivery system for tissue regeneration

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BIOCELL 2022年第4期46卷 899-902页

作者： KENJI TSUJI SHINJI kitamura JUN WADA Department of Nephrology RheumatologyEndocrinology and MetabolismOkayama University Academic Field of MedicineDentistry and Pharmaceutical SciencesOkayama700-8558Japan

Mesenchymal stem cells(MSCs)have abilities to mediate tissue protection through mechanisms of antiapoptosis,anti-oxidative stress and anti-fibrosis as well as tissue regeneration through mechanisms of cell proliferation,differentiation and *** effects by MSCs are mediated by a variety of factors,including growth factors,cytokines and extracellular vesicles(EVs).Among these factors,EVs,containing proteins,mRNA and microRNAs(miRNA),may carry their contents into distant tissues with high ***,the treatment with MSC-derived EVs may be promising as‘natural’drug delivery systems(DDS).Especially,the treatment of MSCderived EVs with the manipulation of specific miRNAs expression has been reported to be beneficial under a variety of diseases and tissue *** overexpression of specific miRNAs in the EVs might be through pre-loading method using the gene editing system by plasmid vector or post-loading method to load miRNA mimics into EVs by electroporation or calcium chloride-mediated *** current several challenges for clinical use,it should open the next era of regenerative medicine for a variety of *** this article,we highlight the therapeutic potential of MSC-derived EVs as‘natural’DDS and current challenges.

关键词： Mesenchymal stem cells Extracellular vesicles Drug delivery system microRNA Regeneration

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A review on the application of modified continuum models in modeling and simulation of nanostructures

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Acta Mechanica Sinica 2016年第1期32卷 83-100页

作者： K.F.Wang B.L.Wang T.kitamura Graduate School at Shenzhen Harbin Institute of Technology Department of Mechanical Engineering Kyoto University

Analysis of the mechanical behavior of nanos- tructures has been very challenging. Surface energy and non- local elasticity of materials have been incorporated into the traditional continuum analysis to create modified continuum mechanics models. This paper reviews recent advancements in the applications of such modified continuum models in nanostructures such as nanotubes, nanowires, nanobeams, graphenes, and nanoplates. A variety of models for these nanostructures under static and dynamic loadings are men- tioned and reviewed. Applications of surface energy and nonlocal elasticity in analysis of piezoelectric nanomateri- als are also mentioned. This paper provides a comprehensive introduction of the development of this area and inspires fur- ther applications of modified continuum models in modeling nanomaterials and nanostructures.

关键词： Surface elasticity Nonlocal continuum Nanotubes Nanobeams Nanoplates Modeling andsimulations

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An effective method for laboratory acoustic emission detection and location using template matching

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第5期14卷 1642-1651页

作者： Xinglin Lei Tomohiro Ohuchi Manami kitamura Xiaying Li Qi Li National Institute of Advanced Industrial Science and Technology(AIST) Tsukuba305-8567Japan Geodynamics Research Center Ehime UniversityMatsuyama790-8577Japan State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China

In this paper, a template matching and location method, which has been rapidly adopted in microseismic research in recent years, is applied to laboratory acoustic emission(AE) monitoring. First, we used traditional methods to detect P-wave first motions and locate AE hypocenters in three dimensions. In addition, we selected events located with sufficient accuracy(normally corresponding AE events of relatively larger energy, showing clear P-wave first motion and a higher signal-to-noise ratio in most channels) as template events. Then, the template events were used to scan and match other poorly located events in triggered event records or weak events in continuous records. Through crosscorrelation of the multi-channel waveforms between the template and the event to be detected, the weak signal was detected and located using a grid-searching algorithm(with the grid centered at the template hypocenter). In order to examine the performance of the approach, we calibrated the proposed method using experimental data of different rocks and different types of experiments. The results show that the proposed method can significantly improve the detection capability and location accuracy, and can be applied to various laboratory and in situ experiments, which use multi-channel AE monitoring with waveforms recorded in either triggering or continuous mode.

关键词： Acoustic emission Template matching and location Waveform cross-correlation Grid search

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Topology Optimization and Fatigue Analysis of Temporomandibular Joint Prosthesis

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World Journal of Mechanics 2017年第12期7卷 323-339页

作者： Musaddiq A. Al-Ali Muazez A. Al-Ali akihiro Takezawa Mitsuru kitamura Department of Transportation and Environmental Engineering Graduate School of Engineering Hiroshima University Hiroshima Japan Department of Oral and Maxillofacial Pathology College of Dentistry University of Baghdad Baghdad Iraq

Treatment of bone tumors in the mandible often involves extensive excavation of affected bone, followed by mandibular reconstruction. Prosthetic implants may be needed to restore jaw functionality. The challenges of making prosthetic bone implants include stress shielding and extending the mechanical life of the implant. We have developed a design algorithm to improve the efficiency of prosthesis design. A finite element model of the patient case is constructed from a computer tomography scan, and the computer implements topology optimization techniques to design the prosthesis with limited stress shielding affected by highly biomechanical compatibility. Topology optimization facilitates the design of low weight structures by automatically introducing holes into the structure. This is governed by engineering predetermined constraints to meet certain job specifications. Such a design will be tested for fatigue life before it is ready to be manufactured and used. Topology optimization can be performed as a design process to achieve a final design that takes stress shielding into consideration. The problem of stress shielding is solved by matching the stiffness of the orthopedic implant to the original bone that is being replaced. The material we used was titanium alloy (Ti-6Al-7Nb). Volume fraction of the orthodox implant was used (0.2872 for the studied case) as volume constraints. Compliance of the bulk bone was set as a further constraint to match the stiffness of the bone with the designed structure. Our results show a good life expectancy for the designed parts, with 12% higher life expectancy for stress-based topology optimization than for compliance-based topology optimization.

关键词： Topology Optimization Temporomandibular Joint Fatigue Stress Shielding

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