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Regulatory T cells percentage in peripheral blood before and after eradication of <i>Helicobacter pylori</i>

Health 2014年第4期6卷 236-242页

作者： Yuka Satoh Hatsue Ogawara Osamu Kawamura Yasuyuki Shimoyama Motoyasu Kusano akihiko yokohama Takayuki Saitoh Hiroshi Handa Norifumi Tsukamoto Hirokazu Murakami Department of Blood Transfusion Service Gunma University Hospital Maebashi Japan Department of Endoscopy and Endoscopic Surgery Gunma University Hospital Maebashi Japan Department of Laboratory Sciences Course of Health Sciences Gunma Graduate School of Health Sciences Maebashi Japan Department of Medicine and Clinical Science Gunma Graduate School of Medicine Maebashi Japan Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Maebashi Japan Faculty of Health Sciences Gunma Paz College Takasaki Japan Oncology Center Gunma University Hospital Maebashi Japan

Helicobacter pylori (H. pylori) induces gastroduodenal diseases and vigorous humural and cellular immune abnormalities. In order to clarify the immunological changes before and after eradication of H. pylori, the percentages and ratios of the following cells in the peripheral blood of 32 H. pylori-infected patients and 25 control subjects were analyzed: CD4+ T cells, CD8+ T cells, T helper 1 cells (Th1), T helper 2 cells (Th2), CD4+CD25+ T cells, Foxp3+ regulatory T cells (Treg), CD4/CD8 ratio, and Th1/Th2 ratio. CD4/CD8 ratio was significantly higher in H. pylori-infected patients before (mean ± SD, 2.9 ± 1.9) and after (mean ± SD, 2.8 ± 1.6) eradication of H. pylori than in control subjects (mean ± SD, 2.1 ± 0.9). The percentage of Th2 cells was significantly higher in H. pylori-infected patients (mean ± SD, 2.6 ± 1.1) than in control subjects (mean ± SD, 1.9 ± 1.1;p < 0.02). The percentage of Th2 cells after eradication of H. pylori (mean ± SD, 2.3 ± 1.4) was lower than that before eradication. There was no significant difference between control subjects (mean ± SD, 4.1% ± 1.5%) and patients before H. pylori eradication (mean ± SD, 4.5% ± 2.4%) in the percentage of Tregs, but the percentage was significantly higher in patients after H. pylori eradication (mean ± SD, 5.2% ±2.6%) than in control subjects. The function of peripheral induced Tregs was reported to suppress the excessive immune reaction in chronic inflammation. These data suggest that Tregs may proliferate and be activated to suppress the activation of humoral immunity in H. pylori-infected patients, and these changes continue after 3 months or later of successful eradication of H. pylori.

关键词： Helicobacter pylori Regulatory T Cell Th1 Cell Th2 Cell

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Numerical Simulation of Solidification Process on Single Crystal Ni-Based Superalloy Investment Castings

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Journal of Materials Science & Technology 2007年第1期23卷 47-54页

作者： Jing YU Qingyan XU Kai CUI Baicheng LIU akihiko KIMATSUKA Key Laboratory for Advanced Materials Processing Technology Ministry of Education Department of Mechanical Engineering Tsinghua University Beijing 100084 China Ishikawajima-Harima Heavy Industries Co. Ltd. Isogo-Ku Yokohama 235-8501 Japan

Bridgman directional solidification of investment castings is a key technology for the production of reliable and highly efficient gas turbine blades. In this paper, a mathematical model for three-dimensional （3D） simulation of solidification process of single crystal investment castings was developed based on basic heat transfer equations. Complex heat radiation among the multiple blade castings and the furnace wall was considered in the model. Temperature distribution and temperature gradient in superalloy investment castings of single blade and multiple ones were investigated, respectively. The calculated cooling curves were compared with the experimental results and agreed well with the latter. It is indicated that the unsymmetrical temperature distribution and curved liquid-solid interface caused by the circle distribution of multiple turbine blades are probably main reasons why the stray grain and other casting defects occur in the turbine blade.

关键词： Directional solidification Single crystal Investment casting Numerical simulation

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Modeling three-dimensional forest structures to drive canopy radiative transfer simulations of bidirectional reflectance factor

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International Journal of Digital Earth 2018年第10期11卷 981-1000页

作者： Wei Yang Hideki Kobayashi Xuehong Chen Kenlo Nishida Nasahara Rikie Suzuki akihiko Kondoh Center for Environmental Remote Sensing Chiba UniversityChibaJapan Department of Environmental Geochemical Cycle Research Japan Agency for Marine-Earth Science and TechnologyYokohamaJapan State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijingPeople’s Republic of China Faculty of Life and Environmental Sciences University of TsukubaTsukubaJapan

Three-dimensional(3-D)Monte Carlo-based radiative transfer(MCRT)models are usually used for benchmarking in intercomparisons of the canopy radiative transfer(RT)***,the 3-D MCRT models are rarely applied to develop remote sensing algorithms to estimate essential climate variables of forests,due mainly to the difficulties in obtaining realistic stand structures for different forest biomes over regional to global ***,some of important tree structure parameters such as canopy height and tree density distribution have been available *** enables to run the intermediate complexities of the 3-D MCRT *** consequently developed a statistical approach to generate forest structures with intermediate complexities depending on the inputs of canopy height and tree *** aims at facilitating applications of the 3-D MCRT models to develop remote sensing retrieval *** proposed approach was evaluated using field measurements of two boreal forest stands at Estonia and USA,*** demonstrated that the simulations of bidirectional reflectance factor(BRF)based on the measured forest structures agreed well with the BRF based on the generated structures from the proposed approach with the root mean square error(RMSE)and relative RMSE(rRMSE)ranging from 0.002 to 0.006 and from 0.7%to 19.8%,*** of the computed BRF with corresponding MODIS reflectance data yielded RMSE and rRMSE lower than 0.03 and 20%,*** the results from the current study are limited in two boreal forest stands,our approach has the potential to generate stand structures for different forest biomes.

关键词： Bidirectional reflectance factor remote sensing forest structure radiative transfer model

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Alanine Aminotransferase as the First Test Parameter for Wilson's Disease

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Journal of Clinical and Translational Hepatology 2019年第4期7卷 293-296页

作者： Hisao Hayashi Kazumasa Watanabe Ayano Inui Ayako Kato Yasuaki Tatsumi akihiko Okumura Tomoo Fujisawa Koichi Kato Department of Medicine Aichi Gakuin University School of PharmacyChikusa-kuNagoyaJapan Department of Gastroenterology Kainan HospitalYatomiJapan Department of Pediatric Gastroenterology and Hepatology Saiseikai Yokohama Toub HospitalYokohamaKanagawaJapan

Background and Aims: The liver is the first organ affected by toxic copper in the classical and severe hepatic forms of Wilson's disease(WD).Because their associated chronic liver damage is mostly asymptomatic,an intervention using a special test including serum alanine aminotransferase(ALT)activity is needed for detecting ***: Using the modified international criteria for the diagnosis of WD,45 patients were selected from the collective databases of our institutions,and 7 infants were reviewed from the *** patients had the severe hepatic form,with nor-moceruloplasminemia and no mutations in *** rapid ALT change during hemolytic anemia was adjusted for a *** diagnostic potential of the ALT test was assessed from the age-dependent natural course of the liver damage of ***: The natural course had three *** were still low in some infants younger than 4 *** were high in all children between the ages of 4 and 8 years-old;then,they reduced to low levels in some patients over 9 years of *** high ALT stage represents chronic active hepatitis,and the sub-sequent low ALT stage is due to silent *** hepatic cop-per content is a reliable but invasive test,while urinary copper secretion is an alternative,non-invasive test for copper toxicosis of *** serum ceruloplasmin and ATP7B analyses are sub-type tests of *** response to anti-copper regimens is the final test ***: ALTcould be the first parameter to test to detect WD in children between the ages of 4 and 8 years.

关键词： Alanine aminotransferase ATP7B Ceruloplasmin Chronic active hepatitis Wilson's disease

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Laparoscopic repair of diaphragmatic hernia associating with radiofrequency ablation for hepatocellular carcinoma:A case report

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World Journal of Clinical Cases 2022年第20期10卷 7020-7028页

作者： Junya Tsunoda Tomohiko Nishi Takafumi Ito Gaku Inaguma Tomohiko Matsuzaki Hiroaki Seki Nobutaka Yasui Michio Sakata akihiko Shimada Hidetoshi Matsumoto Department of Surgery Keiyu HospitalYokohama 220-8521Japan Department of Internal Medicine Keiyu HospitalYokohama 220-8521Japan

BACKGROUND Radiofrequency ablation(RFA)is an effective treatment for early-stage hepatocellular carcinoma(HCC).Although RFA is a relatively safe technique compared with surgery,several complications have been reported to be following/accompanying this *** diaphragmatic hernia caused by RFA is rare;however,the best surgical approach for its treatment is *** present a case of laparoscopic repair of diaphragmatic hernia due to *** SUMMARY An 80-year-old woman with segment VIII HCC was treated twice in 5 years with RFA;28 mo after the second RFA,the patient complained of right hypochondriac *** tomography revealed that the small intestine was incarcerated in the right *** patient was diagnosed with diaphragmatic hernia and underwent laparoscopic repair by non-absorbable running *** patient’s postoperative course was favorable,and the patient was discharged on postoperative day *** diaphragmatic hernia has not recurred 24 mo after *** Laparoscopic treatment of iatrogenic diaphragmatic hernia is effective and minimally invasive.

关键词： Diaphragmatic hernia Radiofrequency ablation Hepatocellular carcinoma Complication Laparoscopic surgery Case report

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Effect of Walking Speed Intervention for Stroke Hemiplegia Using Neurorehabilitation-Robot

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Health 2019年第11期11卷 1487-1492页

作者： Hirofumi Tanabe Toshimasa Mikawa akihiko Kondo Hiroshi Tanabe Department of Medical Treatment for Health Shonan University of Medical Sciences Yokohama Kanagawa Japan Department of Occupational Therapy Yokohama Rehabilitation Center Yokohama Kanagawa Japan

Sufficient hip joint extension range of motion is important in improving the walking speed of patients with spastic hemiplegia. In this study, we developed a piston device for the hip (PDH) that simulates the action of the piston technique for hip joints (PTH), which is a method for improving hip joint extension range of motion. We then evaluated the efficacy of PDH on 10 spastic hemiplegia patients suffering from a limited range of hip joint extension. Results confirmed rapid improvement of hip joint range of motion and increase in walking speed.

关键词： Device Gait Step Length Hemiplegia

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One-Stage Bilateral Total Hip Arthroplasty for Hemophilic Spontaneous Ankylotic Hip: A Case Report

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Case Reports in Clinical Medicine 2020年第9期9卷 269-274页

作者： Mariko Asahi Atsushi Kusaba akihiko Maeda Saiji Kondo Takahide Tsuchiya Institute of Joint Replacement and Rheumatology Ebina General Hospital Kawaraguchi Ebina Kanagawa Japan Department of Orthopaedic Surgery Showa University Fujigaoka Hospital Fujigaoka Aoba-ku Yokohama Japan Department of Hematology Ebina General Hospital Kawaraguchi Ebina Kanagawa Japan

Total hip arthroplastys (THAs) for hemophilic spontaneous ankylotic hips are rare. We performed one-stage bilateral THA for hemophilic patient and I would like to report the results of the case. A 61-year-old male had been diagnosed with mild hemophilia A as a neonate. He had severe pain in both hips and moderate pain in both knees. His hips were ankylotic and had no mobility. Uncemented simultaneous bilateral THAs were performed under general anesthesia. This case suggests that one-stage THA can be a good option for hemophilic hips, provided that sufficient substitution therapy is used.

关键词： Hemophilic Arthropathy One-Stage Bilateral THA Complication

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Is There Any Relationship between Total Hip Arthroplasty and Urinary Incontinent?

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International Journal of Clinical Medicine 2023年第4期14卷 197-205页

作者： Mariko Asahi Saiji Kondo Atsushi Kusaba akihiko Maeda Koji Kanzaki Institute of Joint Replacement and Rheumatology Zama General Hospital Zama Japan Department of Orthopedic Surgery Showa University Fujigaoka Hospital Yokohama Japan

Introduction: In my daily practice as a hip surgeon, I have observed some circumstances where urinary incontinence (UI) improves after total hip arthroplasty (THA). We investigated UI symptoms before and after THA at our facility and considered the factors that influence UI. Patients and Method: The subjects were 113 female patients who underwent primary THA in our facility. An anterior lateral approach was used in all cases. Using the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF), we conducted an investigation into the presence of UI before and 2 weeks after THA. An improvement in UI was defined as a decrease of 1 point or more, a worsening is defined as an increase of 1 point or more. Results: The responses from the 113 subjects were analyzed. Of the 113 patients, prior to THA, UI was prevalent among 59 patients and was absent among 54 patients. In the group where UI was prevalent, it improved after THA in 50 patients (85%), remained unchanged in 5 (8%) and worsened in 4 (7%). In the group where UI was absent, 49 patients (91%) remained unchanged and UI appeared in 5 (9%). Compared with the non-prevalence group (62 patients), the prevalence group (50 patients) had a noticeable improvement rate of internal rotation of the surgical hip side (P Conclusion: UI greatly reduces the quality of life (QOL). In this study, there is a possibility that THA improves UI.

关键词： Total Hip Arthroplasty Urinary Incontinence Obturator Internus

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Synthesis and Molecular Structures of Two Novel π-Conjugation Extended Dithia[3.3]metacyclophanes

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Crystal Structure Theory and Applications 2017年第1期6卷 1-10页

作者： Tetsuji Moriguchi Daisuke Yakeya Venkataprasad Jalli akihiko Tsuge Kenji Yoza Department of Applied Chemistry Faculty of Engineering Kyushu Institute of Technology Kitakyushu Japan Bruker AXS Yokohama Japan

Two novel dithia[3.3]metacyclophanes substituted with ethynyl groups were synthesized as small-sized metacyclophanes from the corresponding brominated dithia-metacyclophanes via C-C bond formation reaction. These compounds were characterized by using 1H NMR, mass spectrometry and elemental analyses. The exact structures were determined by using X-ray diffraction analyses. X-ray diffraction analysis results revealed that these compounds have anti conformations because of existence of intermolecular π-π interaction and some short contacts in the crystal. The long wavelength fluorescence was observed for one of the compound having a pyrene moiety in solid state because of the existence of the intermolecular π-π interaction between two pyrene units.

关键词： Cyclophane X-Ray Analysis Suzuki Coupling π-Conjugation

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Quantitative Evaluation of Bitterlich Sampling for Estimating Basal Area in Sparse Boreal Forests and Dense Tropical Forests

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Open Journal of Forestry 2017年第2期7卷 143-156页

作者： Wei Yang Hideki Kobayashi Kenlo Nishida Nasahara Rikie Suzuki akihiko Kondoh Center for Environmental Remote Sensing Chiba University Chiba Japan Department of Environmental Geochemical Cycle Research Japan Agency for Marine-Earth Science and Technology Yokohama Japan Faculty of Life and Environmental Sciences University of Tsukuba Tsukuba Japan

Bitterlich sampling is an extensively used technique in worldwide forest inventories. Although it has been proved that estimates of basal area from Bitterlich sampling are mathematically unbiased, its precision for individual forest stands may be fairly poor. An extension of validation efforts to different forest biomes could therefore provide more comprehensive assessment and understanding of the Bitterlich sampling technique. In this study, this technique was quantitatively evaluated by using simulated sparse boreal forests and dense tropical forests from an empirical forest structure model (EFSM). Theoretical estimation of basal areas and practical estimation influenced by the hidden-tree effect were both compared with true basal areas of the simulated forests. The evaluation results indicated that: 1) Bitterlich sampling can yield acceptable accuracy and precision when the count number (CN) of trees was set to 10 for the studied boreal and tropical forests with distinct characteristics, 2) the theoretical estimation of basal area can be improved by increasing the CN values for both forests, and 3) when the hidden-tree effect is encountered, the accuracy for tropical forests will be decreased by increasing the CN values, whereas the accuracy for boreal forests can still be improved. Accordingly, a relatively high CN, at a reasonable cost, is recommended for sparse boreal forests to improve the accuracy of basal area estimation. In contrast, for dense tropical forests, a CN of ten is appropriate to mitigate the hidden-tree effect.

关键词： Angle-Count Sampling Basal Area Forest Structure Modeling Boreal Forests Tropical Forests

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