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Nutritional supplement drink reduces inflammation and postoperative depression in patients after off-pump coronary artery bypass surgery

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World Journal of Cardiology 2021年第8期13卷 348-360页

作者： Satoshi Matsushita akie shimada Taira Yamamoto Kazuo Minematsu Hirotaka Inaba Kenji Kuwaki Atsushi Amano Department of Cardiovascular Surgery Juntendo University Faculty of MedicineTokyo 113-8421Japan Department of School Health Graduate School of EducationNagasaki UniversityNagasaki 852-8521Japan Department of Cardiovascular Surgery Juntendo University Urayasu HospitalChiba 279-0021Japan Department of Cardiovascular Surgery Tokai University Hachioji HospitalTokyo 192-0032Japan

BACKGROUND Coronary artery bypass grafting is a surgical treatment for ischemic heart *** development in surgical technique and improvement of perioperative management reduced the postoperative complications,some patients still delayed in progress of postoperative *** this study,we aimed to investigate the effect of daily intake of an herbal medicine-containing drink for rehabilitation after surgery in patients with ischemic heart *** To investigate the effect of taking an herbal medicine-containing,commercially available drink for postoperative rehabilitation in those *** Patients who underwent isolated off-pump coronary artery bypass(OPCAB)surgery were divided into two groups depend on the timing of the admission to the hospital:the Yunker(YKR)group,that consumed one bottle of a caffeine-free nutritional supplement drink on a daily basis and the control group(CTL)that underwent regular *** A total of 229 patients(CTL=130,YKR=99)were *** significant differences were observed in the baseline characteristics between the two *** YKR group had a significantly increased number of daily steps postoperatively(P<0.05)and had significantly lower postoperative serum tumor necrosis factor-alpha levels(P<0.01),while no significant differences were observed in the levels of other inflammatory or stress-related cytokines(interleukin-6,adiponectin,superoxide dismutase,and urine 8-hydroxy-2′-deoxyguanosine)between the two ***,the YKR group showed a significant improvement in the Hospital Anxiety and Depression Score(P<0.05).Moreover,there were no differences in postoperative complications and the duration of postoperative hospital stay between the two *** Our results demonstrated that the daily intake of an herbal medicine-containing drink after OPCAB surgery may have beneficial effects on cardiac rehabilitation by reducing inflammation markers and depression.

关键词： Herbal medicine Inflammation Cardiac rehabilitation Moderate-to-vigorous intensity physical activity Off-pump coronary artery bypass

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