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Case series of three patients with hereditary diffuse gastric cancer in a single family:Three case reports and review of literature

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World Journal of Gastroenterology 2020年第42期26卷 6689-6697页

作者： Masahiro Hirakawa Kohichi Takada Masanori Sato Chisa Fujita Naotaka Hayasaka Takayuki Nobuoka Shintaro Sugita aki ishikawa Miyako Mizukami Hiroyuki Ohnuma Kazuyuki Murase Koji Miyanishi Masayoshi Kobune Ichiro Takemasa Tadashi Hasegawa akihiro Sakurai Junji Kato Department of Medical Oncology Sapporo Medical University School of MedicineSapporo 060-8556HokkaidoJapan Department of Gastroenterology National Hospital Organization Hokkaido Cancer CenterSapporo 003-0804HokkaidoJapan Department of Surgery Surgical Oncology and ScienceSapporo Medical University School of MedicineSapporo 060-8556HokkaidoJapan Department of Surgical Pathology Sapporo Medical University School of MedicineSapporo 060-8556HokkaidoJapan Department of Medical Genetics Sapporo Medical University School of MedicineSapporo 060-8556HokkaidoJapan Department of Hematology Sapporo Medical University School of MedicineSapporo 060-8556HokkaidoJapan

BACKGROUND Hereditary diffuse gastric cancer(HDGC)is a familial cancer syndrome often associated with germline mutations in the CDH1 ***,the frequency of CDH1 mutations is low in patients with HDGC in East Asian ***,we report three cases of HDGC harboring a missense CDH1 variant,c.1679C>G,from a single Japanese *** SUMMARY A 26-year-old female(Case 1)and a 51-year-old male(father of Case 1),who had a strong family history of gastric cancer,were diagnosed with advanced diffuse gastric *** genetic counselling,a 25-year-old younger brother of Case 1 underwent surveillance esophagogastroduodenoscopy that detected small signet ring cell carcinoma foci as multiple pale lesions in the gastric *** analysis revealed a CDH1 c.1679C>G variant in all three *** It is important for individuals suspected of having HDGC to be actively offered genetics *** report will contribute to an increased awareness of HDGC.

关键词： Hereditary diffuse gastric cancer Signet ring cell carcinoma CDH1 Ecadherin Endoscopic findings Case report

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半夏厚朴汤治疗抑郁症研究进展

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贵州中医药大学学报 2024年第4期46卷 73-78页

作者： [马来西亚]林逸舒 [日本]石川明全丽芳王耀瑭 [马来西亚]尹宝乐王丽莉上海中医药大学国际教育学院上海201203 上海中医药大学附属曙光医院传统医学科上海201203 上海中医药大学附属岳阳医院上海201203 内蒙古医科大学内蒙古呼和浩特手010110

《金匮要略》中记载半夏厚朴汤由半夏,厚朴,紫苏,生姜,茯苓所组成,其病机多与气滞血瘀有关,常用于治疗多种消化系统疾病,其中包括抑郁症,失眠,呼吸系统疾病,反流性食管炎等。还可用于呼吸系统疾病如冠心病,慢性支气管炎和肺心病的治疗,... 详细信息

《金匮要略》中记载半夏厚朴汤由半夏,厚朴,紫苏,生姜,茯苓所组成,其病机多与气滞血瘀有关,常用于治疗多种消化系统疾病,其中包括抑郁症,失眠,呼吸系统疾病,反流性食管炎等。还可用于呼吸系统疾病如冠心病,慢性支气管炎和肺心病的治疗,效果明显。近年来,随着社会生活节奏的日益加快和人们生活压力以及各种精神紧张因素的增加,使抑郁症的发病率逐年上升。目前的研究发现抑郁情绪和个体的心理状态有着密切的关系,精神心理因素是抑郁情绪的一个重要组成部分。表现为情绪低落,思维迟缓,意志消沉等抑郁症状。近年来有更多研究认为职业倦怠是抑郁产生的重要因素。随着社会进步与教育水平提升,职业紧张性抑郁症患病率呈显著增长态势。半夏厚朴汤有疏肝理气,健脾燥湿,化痰祛瘀的作用。目前关于半夏厚朴汤治疗抑郁症及作用机制的研究较少,且缺乏系统性总结。本研究旨在探讨半夏厚朴汤在抑郁症流行病学及中医认知方面的应用,深入剖析近年来药理作用研究进展,为临床治疗抑郁症提供更多新思路。

关键词：半夏厚朴汤抑郁症经方中医治疗研究进展

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One-, Two-, and Three-Dimensional Supramolecular Assemblies Based on Tubular and Regular Polygonal Structures of Pillar[n]arenes

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CCS Chemistry 2019年第1期1卷 50-63页

作者： Shixin Fa Takahiro Kakuta Tada-aki Yamagishi Tomoki Ogoshi WPI Nano Life Science Institute(WPI-NanoLSI) Kanazawa UniversityKakuma-machiKanazawaIshikawa 920-1192Japan Graduate School of Natural Science&Technology Kanazawa UniversityKakuma-machiKanazawaIshikawa 920-1192Japan

Pillar[n]arenes,which were first reported by our groupin2008,arepromisingmacrocycliccompounds in supramolecular *** simple,tubular,and highly symmetrical shape of pillar[n]arenes has allowed various supramolecular ass... 详细信息

关键词： macrocyclic compounds supramolecular assembly host-guest interaction

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Machine-learning-assisted discovery of polymers with high thermal conductivity using a molecular design algorithm

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npj Computational Materials 2019年第1期5卷 569-579页

作者： Stephen Wu Yukiko Kondo Masa-aki Kakimoto Bin Yang Hironao Yamada Isao Kuwajima Guillaume Lambard Kenta Hongo Yibin Xu Junichiro Shiomi Christoph Schick Junko Morikawa Ryo Yoshida The Institute of Statistical Mathematics Research Organization of Information and SystemsTachikawaTokyo 190-8562Japan The Graduate University for Advanced Studies TachikawaTokyo 190-8562Japan Center for Materials research by Information Integration(CMI2) Research and Services Division of Materials Data and Integrated System(MaDIS)National Institute for Materials Science(NIMS)TsukubaIbaraki 305-0047Japan Institute of Physics and Competence Centre CALOR University of Rostock18059 RostockGermany Japan Advanced Institute of Science and Technology NomiIshikawa 923-1292Japan PRESTO JSTKawaguchiSaitama 332-0012Japan The University of Tokyo Bunkyo-kuTokyo 113-8656Japan Tokyo Tech World Research Hub Initiative(WRHI) Tokyo Institute of TechnologyTokyo 226-8503Japan Tokyo Institute of Technology Meguro-kuTokyo 152-8550Japan

The use of machine learning in computational molecular design has great potential to accelerate the discovery of innovative ***,its practical benefits still remain unproven in real-world applications,particularly in polymer *** demonstrate the successful discovery of new polymers with high thermal conductivity,inspired by machine-learning-assisted polymer *** discovery was made by the interplay between machine intelligence trained on a substantially limited amount of polymeric properties data,expertise from laboratory synthesis and advanced technologies for thermophysical property *** a molecular design algorithm trained to recognize quantitative structure—property relationships with respect to thermal conductivity and other targeted polymeric properties,we identified thousands of promising hypothetical *** these candidates,three were selected for monomer synthesis and polymerization because of their synthetic accessibility and their potential for ease of processing in further *** synthesized polymers reached thermal conductivities of 0.18–0.41 W/mK,which are comparable to those of state-of-the-art polymers in non-composite thermo-plastics.

关键词： conductivity thermal property

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Sex- and Age-Specific Associations of Social Status and Health-Related Behaviors with Health Check Attendance: Findings from the Cross-Sectional Kanazawa Study

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Health 2017年第9期9卷 1285-1300页

作者： Hiromasa Tsujiguchi Daisuke Hori Yasuhiro Kambayashi Toshio Hamagishi Hiroki Asakura Junko Mitoma Masami Kitaoka Anyenda Enoch Olando Nguyen Thi Thu Thao Yohei Yamada Koichiro Hayashi Tadashi Konoshita Takiko Sagara aki Shibata Hiroyuki Nakamura Department of Environmental and Preventive Medicine Graduate School of Medical Sciences Kanazawa University Kanazawa Japan Third Department of Internal Medicine Fukui University School of Medicine Eiheiji Japan

Health checks are key features of primary and secondary disease prevention. The aim of this study was to examine the sex- and age-specific association of social status and health-related behaviors with health check attendance in eligible persons. Data were derived from the Kanazawa Study 2011 (n = 12,781), a cross-sectional study which investigated all the residents in model areas of Kanazawa City, ishikawa Prefecture, Japan. We selected participants aged 23 years or older with National Health Insurance (n = 4920). Attendance at health checks was the outcome. We used social status and health-related behaviors as predictor variables. We analyzed them by sex and applied stratified analyses by age groups for each sex. The bivariate analyses were conducted by means of cross-tabs. We calculated health check attendance rates by each variable. We used Pearson’s χ2-test to examine statistically significant differences. We fitted logistic regression models to estimate adjusted odds ratios (ORs) of attendance in the past one year. We computed ORs in a logistic regression model containing all variables described above. Workingmen and women aged 23 to 39 years and aged 40 to 64 years had significantly increased ORs for health check attendance compared with non-working persons. Men, men aged 23 to 39 years and men aged 65 years or older with more physical activity had significantly increased ORs for health check attendance. Male ex-smokers, female ex- and non-smokers, male ex-smokers aged 65 years or older, and female non-smokers aged 40 to 64 years had significantly increased ORs. The findings suggest that population groups with lower social status or increased risks of adverse health effects are less likely to attend health checks than those with higher social status or decreased risks in particular sex and age groups. It indicates that diverse approaches are required to realize the full benefit of health checks.

关键词： Health Check Social Status Health-Related Behaviors Secondary Prevention Health Care

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Prevalence of Chronic Pain, Especially Headache, and Relationship with Health-Related Quality of Life in Middle-Aged Japanese Residents

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Health 2016年第1期8卷 116-124页

作者： Junko Mitoma Masami Kitaoka Hiroki Asakura Enoch Olando Anyenda Daisuke Hori Nguyen Thi Thu Tao Toshio Hamagishi Koichiro Hayashi Fumihiko Suzuki Yukari Shimizu Hiromasa Tsujiguchi Yasuhiro Kambayashi Yuri Hibino Tadashi Konoshita Takiko Sagara aki Shibata Hiroyuki Nakamura Department of Environmental and Preventive Medicine Graduate School of Medical Science Kanazawa University Ishikawa Japan Third Department of Internal Medicine Fukui University School of Medicine Fukui Japan

The aim of this study was to evaluate the prevalence of chronic pain (CP) and the relationship between CP, especially headache adjusted for CP at other sites, and health-related quality of life (HRQoL) in middle-aged Japanese residents. We examined the prevalence of CP (defined as pain persisting for 3 months or more) and HRQoL (SF-36) in 1117 middle-aged residents of Japan. We assessed the eight dimensions of health status and the 3 component SF-36 summary score to evaluate HRQoL. The prevalence of CP was 15.3% among men and 15.1% among women. Multiple linear regression analysis demonstrated that lumbar pain (p β = -0.132), knee pain (p β = -0.115), foot pain (p = 0.042, β = -0.065), and age (p β = -0.154) were independently correlated with a lower physical component score (PCS). Older age (ppβ = -0.096), knee pain (p β = -0.109), upper limb pain (p β = -0.098), and lumbar pain (p = 0.022, β = -0.077) all showed a significant negative correlation with MCS. The presence of chronic headache (p = 0.011, β = -0.082) was the only factor significantly correlated with a lower role component score (RCS). We identified a negative correlation between chronic headache and RCS, unlike the relation between musculoskeletal pain and PCS or MCS, suggesting that RCS was an independently influenced by CP differently from PCS or MCS in Japanese residents.

关键词： Quality of Life Chronic Pain Headache SF-36 Pain

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The Association between Activity of Daily Living and the Combination of Alzheimer’s Disease and Cataract in Elderly Requiring Nursing Care

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Health 2016年第10期8卷 994-1003页

作者： Toshio Hamagishi Toshimitsu Inagawa Yasuhiro Kambayashi Hiromasa Tsujiguchi Masami Kitaoka Junko Mitoma Hiroki Asakura Fumihiko Suzuki Daisuke Hori Enoch Olando Anyenda Nguyen Thi Thu Thao Yuri Hibino Koichi Hayashi aki Shibata Takiko Sagara Jiro Okochi Kiyoshi Takamoku Kotaro Hatta Tadashi Konoshita Hiroyuki Nakamura Department of Environmental and Preventive Medicine Graduate School of Medical Science Kanazawa University Ishikawa Japan Department of Food Sciences and Nutrition School of Human Environmental Sciences Mukogawa Women’s University Hyogo Japan Department of Lifestyle Studies Kobe Shoin Women’s University Hyogo Japan Department of Nutritional Sciences for Well-Being Kansai University of Welfare Sciences Osaka Japan Japan Association of Geriatric Health Service Facilities Tokyo Japan Department of Psychiatry Juntendo University Nerima Hospital Tokyo Japan Third Department of Internal Medicine Fukui University School of Medicine Fukui Japan

Some clinical and epidemiological studies have suggested that Alzheimer’s Disease (AD) and cataract, may share common pathogenetic mechanisms, subsequently a positive association between the prevalence of AD and cataract, although other studies found no significant relationship between dementia and visual impairment including cataract in the elderly. Little is known about the association between Activity of Daily Living (ADL) and the combination of AD and cataract. To examine the association between ADL and the combination of AD and cataract, we performed a national survey in nursing care institutions in Japan, examining the decreased ADL in elderly with and without AD and cataract for 453 elderly aged 85.0 ± 8.13 years. The proportion, 43.5% of AD in subjects without cataract was significantly higher than that, 23.5% with cataract. Almost all ADL in AD with cataract was significantly lower than that without cataract, although all ADL in cataract patients receiving surgery in AD was significantly (all p < 0.002) higher than that in cataract patients without surgery in AD, as was confirmed by the multiple regression analysis incorporating into the relevant factors as independent variables. These results showed that ADL scores including cognitive functions decreased by cataract were increased by the surgery in the patients with AD. A significantly negative association between AD and cataract seen in our data, which was inconsistent with the previous result, might lead to the necessities of the clinical diagnosis for slight severity of cataract for patients with AD.

关键词： Alzheimer’s Disease Cataract Elderly Activity of Daily Living Cognitive Function

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