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Understanding normal and abnormal development of the Wolffian/epididymal duct by using transgenic mice

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Asian Journal of Andrology 2015年第5期17卷 749-755,I0007页

作者： aki Murashima Bingfang Xu Barry T Hinton Department of Developmental Genetics Institute of Advanced Medicine Wakayama Medical University 811-1 Kimiidera Wakayama 641-8509 Wakayama Japan Department of Cell Biology University of Virginia School of Medicine Charlottesville VA 22908 USA

The development of the Wolffian/epididymal duct is crucial for proper function and, therefore, male fertility. The development of the epididymis is complex; the initial stages form as a transient embryonic kidney; then the mesonephros is formed, which in turn undergoes extensive morphogenesis under the influence of androgens and growth factors. Thus, understanding of its full development requires a wide and multidisciplinary view. This review focuses on mouse models that display abnormalities of the Wolffian duct and mesonephric development, the importance of these mouse models toward understanding male reproductive tract development, and how these models contribute to our understanding of clinical abnormalities in humans such as congenital anomalies of the kidney and urinary tract （CAKUT）.

关键词： epididymis mesonephros transgenic mice Wolffian duct

Variation of stress intensity factors for several interface crack problems under arbitrary material combinations

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Science China(Physics,Mechanics & Astronomy) 2012年第11期55卷 2128-2134页

作者： ZHANG Yu NODA Nao-aki LAN Xin TAKAISHI Ken-Taro Department of Mechanical Engineering Kyushu Institute of Technology1-1 Sensui-choTobata-kuKitakyushu-shiFukuoka804-8550Japan

In this paper the variation of interface stress intensity factors is considered under arbitrary material combinations for several problems such as central internal interface cracks, periodic interface cracks, and edge interface cracks. The stress intensity factors for all these problems have been determined in terms of Dundurs＇ parameters a, b by the application of FEM in the authors＇ previous papers. In this paper, the variations of the stress intensity factors for all these problems are discussed under arbitrary a, b, then the maximum and minimum values of dimensionless stress intensity factors FI,max, FII,max, FI,min, FII,max are indicated on the map of a, b. As an example, it is found that FI,max always appears when （a, b）= （0.2,0.3）, and FI,min always appears when （a, b）= （1,0）, for the central internal interface cracks independent of crack length.

关键词： Interface crack Stress intensity factor Fracture mechanics

A trichobezoar in a child with undiagnosed celiac disease: A case report

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World Journal of Gastroenterology 2014年第5期20卷 1357-1360页

作者： Iaki Irastorza Carlos Tutau Juan Carlos Vitoria Pediatric Gastroenterology and Nutrition Unit University Hospital Cruces and School of Medicine University of the Basque Country Pediatric Gastroenterology and Nutrition Unit University Hospital Cruces

Celiac disease is a chronic, immune-mediated enteropathy caused by a permanent sensitivity to ingested gluten cereals that develops in genetically susceptible individuals. The classic presentation of celiac disease includes symptoms of malabsorption but has long been associated with cognitive, emotional, and behavioral disorders. We describe an 8-year-old patient with nonscarring alopecia and diagnosed with trichotillomania. Furthermore, she presented with a 3-year history of poor appetite and two or three annual episodes of mushy, fatty stools. Laboratory investigations showed a normal hemoglobin concentration and a low ferritin level. Serologic studies showed an elevated tissue immunoglobulin G anti-tissue transglutaminase level. A duodenal biopsy showed subtotal villous atrophy and crypt hyperplasia, and a large gastric trichobezoar was found in the stomach. Immediately after beginning a gluten-free diet, complete relief of trichotillomania and trichophagia was achieved. In this report, we describe a behavioral disorder as a primary phenomenon of celiac disease, irrespective of nutritional status.

关键词： Celiac disease Trichobezoar Trichotillomania Behavioral disorder Malabsorption syndrome

Immune regulation by protein ubiquitination: roles of the E3 ligases VHL and Itch

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Protein & Cell 2019年第6期10卷 395-404页

作者： Daisuke aki Qian Li Hui Li Yun-Cai Liu Jee Ho Lee Institute for Immunology Tsinghua-Peking Center for Life Sciences School of Medicine Tsinghua University Beijing 100084 China La Jolla Institute for Allergy and Immunology La Jolla CA 92037 USA

Protein ubiquitination is an important means of posttranslational modification which plays an essential role in the regulation of various aspects of leukocyte development and function. The specificity of ubiquitin tagging to a protein substrate is determined by E3 ubiquitin ligases via defined E3-substrate interactions. In this review, we will focus on two E3 ligases, VHL and Itch, to discuss the latest progress in understanding their roles in the differentiation and function of CD4+ T helper cell subsets, the stability of regulatory T cells, effector function of CD8+ T cells, as well as the development and maturation of innate lymphoid cells. The biological implications of these E3 ubiquitin ligases will be highlighted in the context of normal and dysregulated immune responses including the control of homeostasis, inflammation, auto-immune responses and anti-tumor immunity. Further elucidation of the ubiquitin system in immune cells will help in the design of new therapeutic interventions for human immunological diseases and cancer.

关键词： ubiquitin E3ligase VHL HIF Itch WWP2 Cbl-b inflammation autoimmunity

Importance of abdominal X-ray to confirm the position of levonorgestrel-releasing intrauterine system:A case report

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World Journal of Clinical Cases 2022年第15期10卷 4904-4910页

作者： aki Maebayashi Kanoko Kato Nobuki Hayashi Masaji Nagaishi Kei Kawana Obstetrics and Gynecology Nihon University HospitalTokyo 1018309Japan Obstetrics and Gynecology Nihon University School of MedicineTokyo 1738610Japan

BACKGROUND Levonorgestrel-releasing intrauterine systems(LNG-IUSs)gradually release levonorgestrel into the uterus and is effective against hypermenorrhoea and *** associated with the insertion include expulsion,displacement,and uterine *** identification of copper intrauterine devices(IUDs)is possible due to echogenicity from the copper ***,the barium sulfate coatings of LNG-IUSs do not always provide hyperechoic *** barium sulfate and copper are radiopaque and clearly identifiable on ***,X-ray imaging is required to locate *** SUMMARY A 46-year-old woman with hypermenorrhoea due to submucosal myomas was treated with LNG-IUS at another *** LNG-IUS insertions had apparently been followed by spontaneous expulsion,although objective confirmation using imaging was not *** patient was referred to our institution for *** the first visit,there appeared to be no device in the uterus,and none was observed on transvaginal ***,two LNGIUSs were observed in the pelvis on abdominal plain X-rays prior to *** myomectomy was performed,and the two LNG-IUSs were found to have perforated the *** devices were safely removed during surgery,and the submucosal myomas were also *** perforated section of the myometrium was minimal+ADs-therefore,a repair operation was not *** Plain abdominal X-rays facilitate the determination of whether an LNG-IUS is in the uterine ***,it is important to confirm a device’s location,regardless of whether spontaneous expulsion is suspected,prior to inserting another device.

关键词： Hysteroscope Intrauterine devices Levonorgestrel-releasing intrauterine system Submucosal myoma Uterine perforation Case report

Overlapping public health crises during the coronavirus disease pandemic

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World Journal of Emergency Medicine 2021年第2期12卷 151-153页

作者： Nilanga aki Bandara Ricky Jhauj Jayson Fernando Vahid Mehrnoush Namal Wijesinghe University of British Columbia School of Kinesiology Vancouver Vancouver V6T 1Z1Canada Department of Physiotherapy University of MelbourneParkville VIC 3010Australia Hackensack University Medical Center Hackensack 07601USA Faculty of Medicine University of British ColumbiaVancouver V6T 1Z3Canada General Sir John Kotelawala Defence University Ratmalana 10390Sri Lanka

To date, the worldwide death toll from the coronavirus disease (COVID-19) pandemic has rapidly *** are in the midst of a global pandemic that poses enormous challenges to our healthcare systems *** department (ED) physicians have played a significant role in saving lives of patients infected with severe acute respiratory syndrome coronavirus 2 (SARSCo V-2).Efficient,timely,andaccuratediagnosisand application of the most appropriate treatment modality to save lives are important tasks for ED physicians.

关键词： diagnosis acute respiratory

Electro-tribological properties of diamond like carbon coatings

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Friction 2020年第2期8卷 451-461页

作者： Iñigo BRACERAS Iñigo IBÁNEZ Santiago DOMINGUEZ-MEISTER Xabier VELASCO Marta BRIZUELA Iñaki GARMENDIA Tecnalia Research&Innovation Mikeletegi Pasealekua 2Donostia-San Sebastian 20009Spain Mechanical Engineering Department University of the Basque Country UPV/EHUPlaza de Europa1Donostia-San Sebastian 20018Spain

Diamond like carbon(DLC)coatings typically present good self-lubricating tribological properties that could be of interest in sliding dielectric contacts in multiple electrical *** this work electro-tribological studies have been performed on several DLC coatings against aluminum in different humidity conditions,in which the coefficients of friction(CoFs)and electrical contact resistance(ECR)were continuously *** show that CoF and ECR data can be linked to the properties of the coatings(thickness,finishing,microstructure,residual stresses,and wettability)and the degradation modes of their tribological and electrical ***,electro-tribological data can provide valuable information about the performance of dielectric coatings,the reasons behind it,and assist in the development of the *** also shows potential for on-line monitoring of coated parts in operation.

关键词： DLC electro-tribology ECR-electrical contact resistance coefficient of friction

基于临界应力强度因子的胶接对接接头抗拉强度简便预测方法

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工程力学 2017年第11期34卷 218-224页

作者：李戎梁斌 NODA Nao-aki 河南科技大学土木工程学院河南洛阳471023 九州工业大学机械系日本北九州市804-8550

为了能够对胶接对接接头进行抗拉强度预测,该文以有限元分析方法为基础,通过利用参考问题的无量纲应力强度因子、接头模型与参考问题模型之间应力值的比值以及接头抗拉强度的试验数值,得到了胶接对接接头的临界应力强度因子数值,从而提... 详细信息

为了能够对胶接对接接头进行抗拉强度预测,该文以有限元分析方法为基础,通过利用参考问题的无量纲应力强度因子、接头模型与参考问题模型之间应力值的比值以及接头抗拉强度的试验数值,得到了胶接对接接头的临界应力强度因子数值,从而提出了一个基于临界应力强度因子的胶接对接接头抗拉强度的简便预测新方法。该方法能够在保证精确度的基础上快速计算出胶接对接接头的应力强度因子,通过使用任意某一胶层厚度时的抗拉强度试验数值预测出其他胶层厚度时对接接头的抗拉强度数值。通过三种胶接对接接头的算例对比分析,证明了该方法的预测结果与实际结果非常接近,预测精度良好,便于工程应用。

关键词：胶接对接接头粘结抗拉强度预测有限元分析方法临界应力强度因子胶层厚度

Screening for 26 per-and polyfluoroalkyl substances(PFAS)in German drinking waters with support of residents

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Eco-Environment & Health 2023年第4期2卷 235-242页

作者： Vanessa Ingold Alexander Kämpfe aki Sebastian Ruhl German Environment Agency Section II 3.3Schichauweg 5812307BerlinGermany German Environment Agency Section II 3.2Heinrich-Heine-Straße 1208645Bad ElsterGermany Technische Universität Berlin Chair of Water TreatmentKF4Straße des 17.Juni 13510623BerlinGermany

The occurrence of per-and polyfluoroalkyl substances(PFAS)in water cycles poses a challenge to drinking water quality and *** order to counteract the large knowledge gap regarding PFAS in German drinking water,89 drinking water samples from all over Germany were collected with the help of residents and were analyzed for 26 PFAS by high-performance liquid chromatography with tandem mass spectrometry(HPLC-MS/MS).The 20 PFAS recently regulated by sum concentration(PFAS_(∑20)),as well as six other PFAS,were quantified by targeted *** all drinking water samples,PFAS_(∑20 )was below the limit of 0.1μg/L,but the sum concentrations ranged widely from below the limit of quantification up to 80.2 ng/*** sum concentrations(PFASP4)of perfluorohexanesulfonate(PFHxS),perfluorooctanesulfonate(PFOS),perfluorooctanoate(PFOA),and perfluorononanoate of 20 ng/L were exceeded in two *** most frequently detected individual substances were PFOS(in 52%of the samples),perfluorobutanesulfonate(52%),perfluorohexanoate(PFHxA)(44%),perfluoropentanoate(43%)and PFHxS(35%).The highest single concentrations were 23.5 ng/L for PFHxS,15.3 ng/L for PFOS,and 10.1 ng/L for *** regionally elevated concentrations were identified,but some highly urbanized areas showed elevated *** of substitution PFAS,including 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate and 2,2,3-trifluor-3-[1,1,2,2,3,3-hexafluor-3-(trifluormethoxy)propoxy]-propanoate(anion of ADONA),were very low compared to regulated *** most frequently detected PFAS were examined for co-occurrences,but no definite correlations could be found.

关键词： Persistent chemicals Organic micro-pollutants EU drinking water directive Indicator PFAS Drinking water