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Binding of Cry δ-endotoxins to brush border membrane vesicles of Helicoverpa armigera and Helicoverpa punctigera （Lepidoptera： Noctuidae）

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Insect Science 2005年第4期12卷 231-240页

作者： CHUNYAN LIAO LIZ BROOKS STEPHEN C. TROWELL raymond J. akhurst CSIRO Entomology Australian National University ACT Australia Division of Biochemistry and Molecular Biology Australian National University ACT Australia

The relatively low susceptibility ofHelicoverpa armigera to CrylAc, its history of resistance to chemical insecticides and the seasonal decline in expression of CrylAc in transgenic cotton necessitated the development of cotton expressing two insecticidal proteins to provide sustainable control of this multinational pest. To manage the resistance issue, it was essential that the second insecticidal protein have a significantly different mode of action to CrylAc. A common feature of resistance to CrylA proteins in several species as well as H. armigera has been a change in the binding site. A study of binding sites for some Cry proteins in the brush border membrane vesicles （BBMV） ofH. armigera and Helicoverpa punctigera was undertaken. The binding affinity for CrylAc was higher than for CrylAb, matching their relative toxicities, and CrylAc and CrylAb were found to share at least one binding site in both I-1. armigera and I-1. punctigera. However Cry2Aa did not compete with CrylAc for binding and so could be used in transgenic cotton in combination with CrylAc to control H. armigera and manage resistance. Variation in the susceptibilities of three different H. armigera strains to CrylAc correlated with the parameter Bmax/Kcom.

关键词： Helicoverpa armigera Helicoverpa punctigera Bacillus thuringiensis δ-endotoxin brush border membrane vesicles ligand binding

Prospective evaluation of ^(18)F-FDG positron emission tomography in the preoperative staging of patients with hepatic colorectal metastases

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 539-554页

作者： Tim akhurst Mithat Gönen raymond E.Baser Lawrence H.Schwartz Scott Tuorto Lynn A.Brody Anne Covey Karen T.Brown Steven M.Larson Yuman Fong Department of Radiology Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA Peter MacCallum Cancer Centre VictoriaAustralia Department of Epidemiology and Biostatistics Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA Department of Surgery Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA

Background:Despite considerable advances in preoperative imaging,up to one-third of patients operatively explored for hepatic colorectal metastases are unexpectedly found to harbor unresectable intrahepatic or extrahepatic ***:The current study is a prospective,blinded study comparing utility of[18F]2-fluoro-2-deoxyglucose positron emission tomography(18F-FDG-PET)to computed tomography(CT)and CT arterial portography(CTAP)as preoperative ***:The 125 planned subjects were *** seen on FDG-PET alone changed therapy for 23 of 125 patients(18%).FDG-PET confirmed other radiologic findings in 16 cases(13%),for an overall influence on therapy in 39 cases(31%).FDG-PET was the most sensitive diagnostic imaging test for extrahepatic cancer;it was 80-90%sensitive for extrahepatic cancer and 70-90%*** the 28 cases of unresectable disease due to extrahepatic disease,FDG-PET findings solely changed therapies in 16 cases(57%)and influenced therapy in seven other cases(25%).Of the 21 unresectable cases due to extent of intrahepatic disease,FDG-PET did not solely change therapy in ***,FDG-PET had the lowest sensitivity for hepatic sites compared with CT or *** particular,small(<1 cm)liver tumors were particularly poorly detected by *** area under the receiver operating characteristic(ROC)curve for small tumors was 0.58 and for patients on chemotherapy it was 0.66,a modest improvement over no ***:FDG-PET is an important test for preoperative staging of patients with hepatic colorectal metastases,affecting treatment decisions in nearly one-third of *** high yield is due mainly to detection of extrahepatic *** is therefore recommended in patients with extrahepatic lesions suspected to be disseminated cancer or those with high risk for extrahepatic *** is not a good test for identification of small tumors in the liver.

关键词： Positron emission tomography(PET) computed tomography(CT) colorectal hepatic metastases surgery

昆虫病原线虫Neoaplectana和Heterorhabditis共生细菌Xenorhabdus spp.两种型的形态学和功能

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环境昆虫学报 1981年第4期 52-58页

作者： R.J.akhurst 田伟金

前言三个属的昆虫病原线虫已知与细菌有特殊的共生关系:线虫Neoaplectana spp.和Heterorhabditis spp.与细菌Xenorhabdus spp.共生(Thomas和Poinar,1979),线虫Steinernema kraussei与细菌Flavobacterium sp.共生(Mracek,1977)。每一种... 详细信息

关键词：共生细菌感染期 Heterorhabditis Neoaplectana Xenorhabdus spp 昆虫病原线虫种型

IS RESISTANCE TO CRY1AC WIDESPREAD IN AUSTRALIAN POPULATIONS OF H. ARMIGERA?

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IS RESISTANCE TO CRY1AC WIDESPREAD IN AUSTRALIAN POPULATIONS...

The ⅩⅤth International Plant Protection Congress

作者： R.J.MAHON R.A.akhurst L.BIRD K.M.OLSEN CSIRO Entomology GPO Box 1700 Canberra ACT 2601 AUSTRALIA CSIRO Entomology GPO Box 1700 Canberra ACT 2601 AUSTRALIA CSIRO Entomology GPO Box 1700 Canberra ACT 2601 AUSTRALIA CSIRO Entomology GPO Box 1700 Canberra ACT 2601 AUSTRALIA

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小菜蛾对苏云金芽胞杆菌的抗药性研究

华中农业大学学报 1998年第3期17卷 214-217页

作者：李建洪伍建宏喻子牛 Ray akhurst 华中农业大学植保系华中农业大学生命科技学院澳大利亚CSIRO昆虫研究所

采用人工饲料感染法监测了我国不同地区小菜蛾田间种群对中国标准品Ｃｓ３ａｂ－１９９１的敏感性。结果表明：广东省深圳、东莞、广州的田间小菜蛾对苏云金芽胞杆菌产生了明显的抗性，最高抗性倍数分别为８．９，６．５，２．１。深圳... 详细信息

采用人工饲料感染法监测了我国不同地区小菜蛾田间种群对中国标准品Ｃｓ３ａｂ－１９９１的敏感性。结果表明：广东省深圳、东莞、广州的田间小菜蛾对苏云金芽胞杆菌产生了明显的抗性，最高抗性倍数分别为８．９，６．５，２．１。深圳的抗性小菜蛾种群在无毒条件下饲养，抗性会自然减退，经５代之后抗性消失。

关键词：苏云金芽胞杆菌小菜蛾抗性

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离体结肠FDGPET的可行性

国际医学放射学杂志 2009年第5期32卷 490-490页

作者： M.J.Gollub T.J.akhurst M.J.Williamson J.Shia J.L.Humm W.D.Wong 唐光健 Department of Radiology Memorial Sloan-Kettering Cancer Center

为促进将来“FDG摄取阳性的结肠病变与免疫组化分析表现直接相关研究，研究者检验了人类切除的离体结肠FDGPET显像的可行性。此项研究由学术委员会批准，符合健康医疗保险要求。在获取病人的知情同意书后，5例肿瘤病人于术中注射了FDG，... 详细信息

为促进将来“FDG摄取阳性的结肠病变与免疫组化分析表现直接相关研究，研究者检验了人类切除的离体结肠FDGPET显像的可行性。此项研究由学术委员会批准，符合健康医疗保险要求。在获取病人的知情同意书后，5例肿瘤病人于术中注射了FDG，约3h后对他们术后的离体结肠进行显像。在此相当有限的时间间隔内结肠可以显像，并可确定息肉与癌肿。

关键词： GPET显像结肠病变 FDG 离体免疫组化分析学术委员会知情同意书医疗保险

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