检索结果-南通市图书馆

Effects of drug-polymer dispersions on solubility and in vitro diffusion of artemisinin across a polydimethylsiloxane membrane

引用

Chinese Science Bulletin 2012年第14期57卷 1685-1692页

作者： SHAHZAD Yasser SHAH Syed Nisar hussain ANSARI Muhammad Tayyab RIAZ Romana SAFDAR Aasma hussain Talib malik Madeeha Faculty of Pharmacy Bahauddin Zakariya University Division of Pharmacy and Pharmaceutical Sciences School of Applied SciencesUniversity of Huddersfield Hamdard Institute of Pharmaceutical Sciences Hamdard University

Artemisinin(ART) is a sesquiterpene lactone with an endo-peroxide bridge that is thought to be responsible for its antimalarial *** has low oral bioavailability because of aqueous insolubility,which leads to local toxicity at the site of *** present work focused on increasing its solubility and evaluating its permeation across a model membrane to mimic transdermal delivery that bypasses the hepatic *** this purpose,physical mixtures(PM),solid dispersions(SD) and lyophilized dispersions(LD) with different drug-polymer ratios(1:0.5,1:1,1:2,1:4 and 1:9) were prepared using the hydrophilic polymer polyvinylpyrrolidone(PVP).Drug-polymer dispersions were characterized using X-ray diffraction(XRD) and Fourier transform infrared spectroscopy(FTIR).Solubility was measured in three solvents:de-ionized water,phosphate buffered saline(PBS) and *** toluene-water partition coefficient was evaluated and compared with the literature and calculated logP *** vitro diffusion of ART was studied across a polydimethylsiloxane membrane from a saturated solution of drug-polymer *** patterns showed a gradual decrease in crystallinity of ART with increasing polymer concentration,while FTIR confirmed no interactions between ART and *** was increased up to 4-,5-and 8-fold for LD in water,PBS and methanol,*** logP for toluene-water was 2.65 ± 0.3,which is in good agreement with literature and calculated logP *** was enhanced,which is attributed to the decrease in crystallinity and increase in wettability of the *** ART flux was significantly higher than that of pure ART(0.12 ± 0.01) with increasing PVP concentration for SD and LD *** conclusion,drug-polymer dispersions with PVP improve the pharmaceutical properties of ART in the order LD>SD>PM.

关键词：聚合物分散体溶解度测定聚硅氧烷外扩散青蒿素药物傅里叶变换红外光谱水性高分子

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Predictors of survival in autoimmune liver disease overlap syndromes

引用

World Journal of Hepatology 2024年第9期16卷 1269-1277页

作者： Dujinthan Jayabalan Yi Huang Luis Calzadilla-Bertot malik Janjua Bastiaan de Boer John Joseph Wendy Cheng Simon Hazeldine Briohny W Smith Gerry C MacQuillan Michael C Wallace George Garas Leon A Adams Gary P Jeffrey Medical School University of Western AustraliaNed-lands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Anatomical Pathology PathWest Laboratory MedicineNedlands 6009Western AustraliaAustralia Department of Gastroenterology and Hepatology Royal Perth HospitalPerth 6000Western AustraliaAustralia Department of Gastroenterology and Hepatology Fiona Stanley HospitalMurdoch 6150Western AustraliaAustralia Medical School University of Western AustraliaNedl-ands 6009Western AustraliaAustralia

BACKGROUND Survival in patients with autoimmune liver disease overlap syndromes(AILDOS)compared to those with single autoimmune liver disease is *** To investigate the survival of patients with AILDOS and assess the accuracy of non-invasive serum models for predicting liver-related *** Patients with AILDOS were defined as either autoimmune hepatitis and primary biliary cholangitis overlap(AIH-PBC)or autoimmune hepatitis and primary sclerosing cholangitis overlap(AIH-PSC)and were identified from three tertiary centres for this cohort ***-related death or transplantation(liver-related mortality)was determined using a population-based data linkage *** scores for liver-related death were compared for accuracy[including liver outcome score(LOS),Hepascore,Mayo Score,model for end-stage liver disease(MELD)score and MELD incorporated with serum sodium(MELD-Na)score].RESULTS Twenty-two AILDOS patients were followed for a median of 3.1 years(range,0.35-7.7).Fourteen were female,the median age was 46.7 years(range,17.8 to 82.1)and median Hepascore was 1(range,0.07-1).At five years post enrolment,57%of patients remained free from liver-related mortality(74%AIH-PBC,27%AIH-PSC).There was no significant difference in survival between AIH-PBC and *** was a significant predictor of liver-related mortality(P<0.05)in patients with AIH-PBC(n=14)but not AIH-PSC(n=8).A LOS cut-point of 6 discriminated liver-related mortality in AIH-PBC patients(P=0.012,log-rank test,100%sensitivity,77.8%specificity)(Harrell's C-statistic 0.867).The MELD score,MELD-Na score and Mayo Score were not predictive of liver-related mortality in any *** Survival in the rare,AILDOS is *** current study supports the LOS as a predictor of liver-related mortality in AIH-PBC *** trials investigating predictors of survival in AILDOS are required.

关键词： Autoimmune liver disease overlap syndromes Liver outcome score Liver-related death Hepascore Autoimmune hepatitis Primary biliary cholangitis Primary sclerosing cholangitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Roman Urdu News Headline Classification Empowered with Machine Learning

引用

Computers, Materials & Continua 2020年第11期65卷 1221-1236页

作者： Rizwan Ali Naqvi Muhammad Adnan Khan Nauman malik Shazia Saqib Tahir Alyas Dildar hussain Department of Unmanned Vehicle Engineering Sejong UniversitySeoul05006Korea Department of Computer Science Lahore Garrison UniversityLahore54000Pakistan School of Computational Sciences Korea Institute for Advanced StudySeoul02455Korea

Roman Urdu has been used for text messaging over the Internet for years especially in Indo-Pak *** from the subcontinent may speak the same Urdu language but they might be using different scripts for *** communication using the Roman characters,which are used in the script of Urdu language on social media,is now considered the most typical standard of communication in an Indian landmass that makes it an expensive information *** Text classification is a solved problem but there have been only a few efforts to examine the rich information supply of Roman Urdu in the *** is due to the numerous complexities involved in the processing of Roman Urdu *** complexities associated with Roman Urdu include the non-availability of the tagged corpus,lack of a set of rules,and lack of standardized spellings.A large amount of Roman Urdu news data is available on mainstream news websites and social media websites like Facebook,Twitter but meaningful information can only be extracted if data is in a structured *** have developed a Roman Urdu news headline classifier,which will help to classify news into relevant categories on which further analysis and modeling can be *** author of this research aims to develop the Roman Urdu news classifier,which will classify the news into five categories(health,business,technology,sports,international).First,we will develop the news dataset using scraping tools and then after preprocessing,we will compare the results of different machine learning algorithms like Logistic Regression(LR),Multinomial Naïve Bayes(MNB),Long short term memory(LSTM),and Convolutional Neural Network(CNN).After this,we will use a phonetic algorithm to control lexical variation and test news from different *** preliminary results suggest that a more accurate classification can be accomplished by monitoring noise inside data and by classifying the *** applying above mentioned different machine learnin

关键词： Roman urdu news headline classification long short term memory recurrent neural network logistic regression multinomial naïve Bayes random forest k neighbor gradient boosting classifier

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An Efficient Mechanism for Product Data Extraction from E-Commerce Websites

引用

Computers, Materials & Continua 2020年第12期65卷 2639-2663页

作者： malik Javed akhtar Zahur Ahmad Rashid Amin Sultan H.Almotiri Mohammed A.Al Ghamdi Hamza Aldabbas University of Engineering and Technology TaxilaPakistan Computer Science Department Umm Al-Qura UniversityMakkah CitySaudi Arabia Al-Balqa Applied University Al-SaltJordan

A large amount of data is present on the web which can be used for useful purposes like a product recommendation,price comparison and demand forecasting for a particular *** are designed for human understanding and not for ***,to make data machine-readable,it requires techniques to grab data from web *** have addressed the problem using two approaches,i.e.,knowledge engineering and machine *** of the art knowledge engineering approaches use the structure of documents,visual cues,clustering of attributes of data records and text processing techniques to identify data records on a web *** learning approaches use annotated pages to learn *** rules are used to extract data from unseen web *** structure of web documents is continuously ***,new techniques are needed to handle the emerging requirements of web data *** this paper,we have presented a novel,simple and efficient technique to extract data from web pages using visual styles and structure of *** proposed technique detects Rich Data Region(RDR)using query and correlative words of the *** is then divided into data records using style *** elements are removed using a Common Tag Sequence(CTS)and formatting *** system is implemented using JAVA and runs on the dataset of real-world working *** effectiveness of results is evaluated using precision,recall,and F-measure and compared with five existing systems.A comparison of the proposed technique to existing systems has shown encouraging results.

关键词： Document object model rich data region common tag sequence web data extraction deep web mining

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The charge state distribution of B, C, Si, Ni, Cu and Au ions on 5 MV pelletron accelerator

引用

Nuclear Science and Techniques 2017年第5期28卷 43-47页

作者： Ali Awais Javaid hussain Muhammad Usman Waheed Akram Kashif Shahzad Turab Ali Ishaq Ahmad malik Maaza Experimental Physics Laboratories National Centre for Physics Islamabad 44000 Pakistan UNESCO-UNISA Africa Chair in Nanosciences/ Nanotechnology College of Graduate Studies University of South Africa Muckleneuk Ridge PO Box 392 PretoriaSouth Africa Nanosciences African Network (NANOAFNET) iThemba LABS-National Research Foundation 1 Old Faure RoadPO Box 722 Somerset West Western Cape Province 7129South Africa

Stripper gas and terminal potential play a key role for the charge state distribution in a tandem pelletron accelerator. The knowledge of this distribution is important for experiments performed on tandem accelerators. The charge state distribution of B, C, Si, Ni, Cu and Au beams is measured by using Ar as stripper gas, and terminal potential is varied from 0.3 to 3.0 MV on 5UDH-2 tandem pelletron accelerator installed at the National Centre for Physics, Islamabad. The individual charge state is measured after the switching magnet at 15° in high-energy portion. It is observed that the higher charge states are stable in the range of lower and middle atomic masses of periodic table, whereas higher atomic mass(Au) shows beam current instability in higher charge states. For carbon,the charge distribution at 1.7 MV terminal potential by varying stripper gas pressure is also studied, which resulted in decreased overall transmission with good current value for higher charge states.

关键词： Pelletron accelerator Charge state distribution Stripper gas Terminal potential

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Risk stratification of renal transplant recipients using routine parameters: Implication of learning from SARS-CoV-2 into transplant follow-up program

引用

World Journal of Transplantation 2023年第6期13卷 344-356页

作者： Abbas Ghazanfar Madiha Abbas Md Walid hussain malik Kayal Renal and Transplant Unit St Georges University Hospitals NHS Foundation TrustLondon SW170QTUnited Kingdom Department of Anesthesia and Intensive Care Medicine Epsom and St Helier University Hospitals NHS TrustLondon KT87EGUnited Kingdom Department of Renal and Transplant Surgery St Georges University Hospitals NHS Foundation TrustLondon SW170QTUnited Kingdom

BACKGROUND Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection is a global pandemic that is associated with a high risk of morbidity and mortality among recipients of solid organ *** the course of acute SARS-CoV-2 infection,various laboratory markers have been identified as predictors for high risk of *** To risk stratify renal transplant recipients(RTxR)using general demographic parameters,comorbidities and routine laboratory markers for the severity of the disease and its *** believe that learning about these routinely monitored parameters can help us plan better strategies for the RTxR follow-up *** This present study includes RTxR who acquired SARS-CoV-2 infection from March 2020 to February *** recorded the basic demographics,comorbidities and routine laboratory *** investigated the impact of SARS-CoV-2 infection on RTxRs and risk-stratified the progression of disease severity and outcomes in terms of recovery or *** From 505 RTxRs in our renal transplant follow-up program,29(7.75%)RTxRs had PCR-positive SARS-CoV-2 *** recorded 8 deaths from SARS-CoV-2 infection giving an overall mortality rate of 1.6%but a significant 27.6%mortality in SARS-CoV-2 positive *** more than 68 years,non-Caucasian ethnicity and male gender were associated with a significant drop in survival probability;P≤0.001.<0.001 and<0.0001 respectively.87.5%of the deceased were diabetic;P≤*** glomerular filtration rate of less than 26 mL/min/1.73 m2,serum albumin less than 20 g/L,Hemoglobin less than 9.6 g/L and serum calcium less than 1.70 mmol/L were all associated with significantly increased risk of mortality;P=0.0128,<0.001,<0.0001 and 0.0061 *** This study has identified some routinely used modifiable parameters in predicting a higher risk of mortality and *** knowledge can be used in RTxR follow-up programs by addressing these parameters

关键词： SARS-CoV-2 mortality Renal transplant recipients Glomerular filtration rate Anemia Albumin Calcium Reducing morbidity and mortality Renal transplant follow-up program

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identification of Hydrocarbon Potential of Talhar Shale: Member of Lower Goru Formation Using Well Logs Derived Parameters, Southern Lower Indus Basin, Pakistan

引用

Journal of Earth Science 2018年第3期29卷 587-593页

作者： Muhsan Ehsan Hanming Gu malik Muhammad akhtar Saiq Shakeel Abbasi Zaheen Ullah Institute of Geophysics and Geomatics China University of Geosciences Department of Earth and Environmental Sciences Bahria University Islamabad School of Environmental Studies China University of Geosciences Faculty of Earth Resources China University of Geosciences

Using well logs data only, the evaluation of shale gas hydrocarbon potential of Talhar Shale Member of Lower Goru Formation has been a challenge in Southern Lower Indus Basin in Pakistan. Well logs data analysis is helpful to evaluate the gas potential of source shale rocks. We introduced and applied empirical and graphical method to fulfil this task and derived geochemical parameters from well logs data. The method mentioned is cheap and fast. Talhar Shale has kerogen type Ⅲ and type Ⅱ which are montmorillonite clay and have potential to produce oil and gas. Talhar Shale has better sorption property. Empirical formulas are used to derive parameters, using well logs of porosity, density and uranium. Porosity and volume of kerogen, calculated from density log, give average values of 11.8% and 11.4%. Average value of level of maturity index （LMI） derived from log is 0.54, which indicates that it is at the early stage of maturity. Vitrinite reflectance is between 0.5%-0.55% as calculated by graphical method and empirical formula. Talhar Shale is at onset of oil generation, with main products of oil and gas. It is a good potential source in the study area.

关键词： Talhar Shale kerogen type sorption property thermal maturity vitrinite reflectance(Ro) Southern Lower Indus Basin.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

凉山州地质灾害发育特征与时空分布规律

引用

沉积与特提斯地质 2024年第3期44卷 478-492页

作者：徐伟铁永波郑玄殷万清付小麟欧文白永健 Ireneusz malik Małgorzata Wistuba 中国地质调查局成都地质调查中心(西南地质科技创新中心) 四川成都610218 自然资源部地质灾害风险防控工程技术创新中心四川成都611734 自然资源部成都地质灾害野外科学观测研究站四川成都610000 凉山州地质环境监测站四川西昌615000 四川省国土空间生态修复与地质灾害防治研究院四川成都610081 卡托维兹西里西亚大学地球科学研究所波兰卡托维兹41-200

凉山州地处横断山系东北缘、川滇构造带南段,受活动构造、地形地貌、河流切割等作用影响,发育有地质灾害总数4016处,以中、小型土质滑坡和中、小型沟谷泥石流为主,是四川省地质灾害高风险地区。本文采用资料收集、数理统计、ArcGIS软件... 详细信息

凉山州地处横断山系东北缘、川滇构造带南段,受活动构造、地形地貌、河流切割等作用影响,发育有地质灾害总数4016处,以中、小型土质滑坡和中、小型沟谷泥石流为主,是四川省地质灾害高风险地区。本文采用资料收集、数理统计、ArcGIS软件分析等方法分析发现,按行政区分析,德昌县是地质灾害发育数量最多的县市,为387处;宁南县是灾害发育密度最高的县市,为17.7处/100 km^(2);按流域分析,安宁河流域的地质灾害数量最多,达779处;美姑河流域的灾害发育密度最高,达11.18处/100 km^(2)。以灾害发育密度为指标对不同灾害类型地质灾害的空间分布进行分析,滑坡方面,划分为4个极高密度区和15个高密度区,滑坡发育受活动构造、易滑地层(红层、昔格达组等)控制作用影响较大;崩塌方面,划分为2个极高密度区和5个高密度区,崩塌沿河谷及支沟、活动构造呈带状分布,受水电站库区开发建设、公路建设等工程活动切坡影响较大;泥石流方面,划分为2个极高密度区和10个高密度区,泥石流发育受构造断裂、地形地貌和人类工程活动影响较大。研究成果可为凉山州的防灾减灾工作提供数据支撑和科学参考。

关键词：地质灾害发育特征时空分布规律

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Entropy generation applications in flow of viscoelastic nanofluid past a lubricated disk in presence of nonlinear thermal radiation and Joule heating

引用

Communications in Theoretical Physics 2021年第9期73卷 37-50页

作者： Aamar Abbasi Waseh Farooq M Ijaz Khan Sami Ullah Khan Yu-Ming Chu Zahid hussain M Y malik Department of Mathematics University of Azad Jammu and Kashmir Muzaffarabad13100 Pakistan Department of Mathematics and Statistics Riphah International University I-14Islamabad 44000Pakistan Department of Mathematics COMSATS University IslamabadSahiwal 57000Pakistan Department of Mathematics Huzhou UniversityHuzhou 313000China Department of Mathematics College of SciencesKing Khalid UniversityAbha 61413Saudi Arabia

Entropy generation is the loss of energy in thermodynamical systems due to resistive forces,diffusion processes,radiation effects and chemical *** main aim of this research is to address entropy generation due to magnetic field,nonlinear thermal radiation,viscous dissipation,thermal diffusion and nonlinear chemical reaction in the transport of viscoelastic fluid in the vicinity of a stagnation point over a lubricated *** conservation laws of mass and momentum along with the first law of thermodynamics and Fick’s law are used to discuss the flow,heat and mass transfer,while the second law of thermodynamics is used to analyze the entropy and *** numbers of independent variables in the modeled set of nonlinear partial differential equations are reduced using similarity variables and the resulting system is numerically approximated using the Keller box *** effects of thermophoresis,Brownian motion and the magnetic parameter on temperature are presented for lubricated and rough *** local Nusselt and Sherwood numbers are documented for both linear and nonlinear thermal radiation and lubricated and rough *** representations of the entropy generation number and Bejan number for various parameters are also shown for lubricated and rough *** concentration of nanoparticles at the lubricated surface reduces with the magnetic parameter and Brownian *** entropy generation declines for thermophoresis diffusion and Brownian motion when lubrication effects are *** is concluded that both entropy generation and the magnitude of the Bejan number increase in the presence of *** current results present many applications in the lubrication phenomenon,heating processes,cooling of devices,thermal engineering,energy production,extrusion processes etc.

关键词： entropy generation viscoelastic fluid lubricated surface nonlinear thermal radiation Joule heating Keller box method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interaction of cetyltrimethylammonium bromide with drug in aqueous/electrolyte solution:A combined conductometric and molecular dynamics method study

引用

Chinese Journal of Chemical Engineering 2018年第1期26卷 159-167页

作者： Md.Anamul Hoque Md.Masud Alam Mohammad Robel Molla Shahed Rana malik Abdul Rub Mohammad A.Halim Mohammed Abdullah Khan Farida akhtar Department of Chemistry Jahangirnagar UniversitySavarDhaka 1342Bangladesh Chemistry Department Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Center of Excellence for Advanced Materials Research King Abdulaziz UniversityJeddah 21589Saudi Arabia Division of Quantum Chemistry BICCBThe Red-Green Computing Centre218 Elephant RoadDhaka 1205Bangladesh Institut Lumière Matière Université Lyon 1-CNRSUniversitéde Lyon69622 Villeurbanne CedexFrance

Interaction between beta-lactum antibiotic drug ciprofloxacin hydrochloride(CFH)and cationic surfactant cetyltrimethylammonium bromide(CTAB)was performed conductometrically in aqueous as well as in the occurrence of different salts(NaCl,KCl as well as NH_4Cl)over the temperature range of 298.15–323.15 K at the regular interval of 5 *** drug has been suggested for the treatment of bacterial infections such as urinary tract infections and acute sinusitis.A clear critical micelle concentration(CMC)was obtained for pure CTAB as well as(CFH+CTAB)mixed *** decrease in CMC values of CTAB caused by the addition of CFH reveals the existence of the interaction between the components and therefore it is the indication of micelle formation at lower concentration of CTAB and their CMC values further decrease in attendance of salts.A nonlinear behavior in the CMC versus T plot was observed in all the *** ΔG_m^0 values are found to be negative in present study systems demonstrated the stability of the *** values of ΔH_m^0 and ΔS_m^0 reveal the existence of hydrophobic and electrostatic interactions between CFH and *** thermodynamic properties of transfer for the micellization were also evaluated and discussed in *** dynamic simulation disclosed that environment of water and salts have impact on the hydrophobic interaction between CFH and *** water and salts,CTAB adopts spherical micelle in which charged hydrophilic groups are interacted with waters whereas hydrophobic tails form the core of the *** hydrophobic core region is highly conserved and *** addition,micelle formation is more favorable in aqueous Na Cl solution than other solutions.

关键词： Ciprofloxacin hydrochloride Cetyltrimethylammonium bromide Molecular dynamics Flydrophobic interaction Salt effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：