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A chemotaxis model to explain WHIM neutrophil accumulation in the bone marrow of WHIM mouse model

Blood Science 2019年第1期1卷 102-112页

作者： Ai Kia Yip akhila balachander Leonard DLTan Ka Hang Liong Rui Zhen Tan Karl Balabanian Francoise Bachelerie Lai Guan Ng Keng-Hwee Chiam Bioinformatics Institute(BII) A∗STAR(Agency for ScienceTechnology and Research)Biopolis138671 Singapore Singapore Immunology Network(SIgN) A∗STAR(Agency for ScienceTechnology and Research)Biopolis138648 Singapore Singapore Institute of Technology Dover Drive138683 Singapore INSERM UMR-S996 Laboratory of Excellence in Research on Medication and Innovative TherapeuticsUniversitéParis-Sud92140 ClamartFrance State Key Laboratory of Experimental Hematology Institute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences288 Nanjing RoadTianjin 300020China

Neutrophils are essential immune cells that defend the host against pathogenic microbial *** are produced in the bone marrow and are retained there through CXCR4–CXCL12 ***,patients with the Warts,Hypogammaglobulinemia,Infections,and Myelokathexis(WHIM)syndrome are prone to infections due to increased accumulation of neutrophils in the bone marrow leading to low numbers of circulating *** neutrophils accumulate in the bone marrow in this condition is poorly *** better understand factors involved in neutrophil accumulation in the bone marrow,neutrophils from wildtype and WHIM mouse models were characterized in their response to CXCL12 *** neutrophils were found to exert stronger traction forces,formed significantly more lamellipodia-type protrusions and migrated with increased speed and displacement upon CXCL12 stimulation as compared to wildtype *** speed of WHIM neutrophils showed a larger initial increase upon CXCL12 stimulation,which decayed over a longer time period as compared to wildtype *** proposed a computational model based on the chemotactic behavior of neutrophils that indicated increased CXCL12 sensitivity and prolonged CXCR4 internalization adaptation time in WHIM neutrophils as being responsible for increased accumulation in the bone *** findings provide a mechanistic understanding of bone marrow neutrophil accumulation in WHIM condition and novel insights into restoring neutrophil regulation in WHIM patients.

关键词： Cell migration Cell traction force CXCL12 sensitivity CXCR4 internalization WHIM syndrome

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A chemotaxis model to explain WHIM neutrophil accumulation in the bone marrow

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Blood Science 2021年第3期3卷 99-99页

作者： Yip, Ai Kia balachander, akhila Tan, Leonard D. L. Liong, Ka Hang Tan, Rui Zhen Balabanian, Karl Bachelerie, Francoise Ng, Lai Guan Chiam, Keng-Hwee

In the article titled“A chemotaxis model to explain WHIM neutrophil accumulation in the bone marrow”,published on pages 102–112,Issue 1,Volume 1 of Blood Science,^(1) the Ethical Consideration statement“All animals were kept in certificated *** procedures for care and use of animals were approved by the Ethics Committee of Singapore Immunology Network(SIgN),A∗STAR(Agency for Science,Technology and Research),with approval number 161120,date April-7,*** applicable institutional and governmental regulations concerning the ethical use of animals were followed.”was *** Journal and the authors wish to apologize for this error.

关键词： approval statement Blood

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