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Cannabis use disorder and severe sepsis outcomes in cancer patients:Insights from a national inpatient sample

World Journal of Critical Care Medicine 2025年第2期14卷 92-104页

作者： Avinaash R Sager Rupak Desai Maneeth Mylavarapu Dipsa Shastri Nikitha Devaprasad Shiva N Thiagarajan Deepak Chandramohan Anshuman Agrawal Urmi Gada akhil jain Internal Medicine St.Elizabeth’s Medical CenterBostonMA 02135United States Outcomes Research Independent ResearcherAtlantaGA 30033United States Public Health Adelphi UniversityGarden CityNY 11530United States Internal Medicine East Tennessee State UniversityJohnsonTN 37614United States Internal Medicine SRM Medical College Hospital and Research CenterPotheri 603211India Department of Nephrology University of Alabama at BirminghamBirminghamAL 35001United States Internal Medicine Kasturba HospitalManipal 576104India Infectious Diseases Deenanath HospitalErandwane 411004India Department of Hematology and Medical Oncology University of Iowa Hospitals and ClinicsIowaIA 52242United States

BACKGROUND The burden of cannabis use disorder(CUD)in the context of its prevalence and subsequent cardiopulmonary outcomes among cancer patients with severe sepsis is *** To address this knowledge gap,especially due to rising patterns of cannabis use and its emerging pharmacological role in *** By applying relevant International Classification of Diseases,Ninth and Tenth Revision,Clinical Modification codes to the National Inpatient Sample database between 2016-2020,we identified CUD(+)and CUD(-)arms among adult cancer admissions with severe *** the two cohorts,we examined baseline demographic characteristics,epidemiological trends,major adverse cardiac and cerebrovascular events,respiratory failure,hospital cost,and length of *** used the Pearsonχ^(2) d test for categorical variables and the Mann-Whitney U test for continuous,non-normally distributed *** regression analysis was used to control for potential confounders.A P value≤0.05 was considered for statistical *** We identified a total of 743520 cancer patients admitted with severe sepsis,of which 4945 had ***,the CUD(+)cohort was more likely to be younger(median age=58 vs 69,P<0.001),male(67.9%vs 57.2%,P<0.001),black(23.7%vs 14.4%,P<0.001),Medicaid enrollees(35.2%vs 10.7%,P<0.001),in whom higher rates of substance use and depression were ***(+)patients also exhibited a higher prevalence of chronic pulmonary disease but lower rates of cardiovascular *** was no significant difference in major adverse cardiac and cerebrovascular events between CUD(+)and CUD(-)cohorts on multivariable regression ***,the CUD(+)cohort had lower all-cause mortality(adjusted odds ratio=0.83,95%confidence interval:0.7-0.97,P<0.001)and respiratory failure(adjusted odds ratio=0.8,95%confidence interval:0.69-0.92,P=0.002).Both groups had similar median length of stay,though CUD(+)patients were more likely to have

关键词： Cannabis/marijuana Sepsis Cardiovascular outcomes Major adverse cardiac and cerebrovascular events Pulmonological complications Cancer

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Impact of D-dimer on in-hospital mortality following aortic dissection:A systematic review and meta-analysis

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World Journal of Cardiology 2024年第6期16卷 355-362页

作者： Sashwath Srikanth Shabnam Abrishami Lakshmi Subramanian Ashwini Mahadevaiah Ankit Vyas akhil jain Sangeetha Nathaniel Subramanian Gnanaguruparan Rupak Desai Department of Medicine ECU Health Medical CenterGreenvilleNC 27834United States Department of Research Independent Outcomes ResearchLos AngelesCA 90036United States Harvard T.H.Chan School of Public Health Harvard UniversityBostonMA 02115United States Department of Vascular Medicine Ochsner Clinic FoundationNew OrleansLA 70121United States Department of Leukemia The University of Texas MD Anderson Cancer CenterHoustonTX 77079United States Department of Cardiology Heart and Vascular ClinicNewarkDE 19713United States Independent Researcher AtlantaGA 30079United States

BACKGROUND The utility of D-dimer(DD)as a biomarker for acute aortic dissection(AD)is ***,its predictive value for in-hospital mortality remains uncertain and subject to conflicting *** To conduct a meta-analysis of AD-related in-hospital mortality(ADIM)with elevated DD *** We searched PubMed,Scopus,Embase,and Google Scholar for AD and ADIM literature through May *** was assessed using I2 statistics and effect size(hazard or odds ratio)analysis with random-effects *** size,study type,and patients’mean age were used for subgroup *** significance threshold was P60 *** and larger sample size studies(n>250)demonstrated a heightened likelihood of ADIM associated with elevated DD levels(effect size:2.57,95%CI:1.30-5.08,P<0.01 vs effect size:1.05,95%CI:1.00-1.11,P=0.05,respectively).CONCLUSION Our meta-analysis shows elevated DD increases in-hospital mortality risk in AD patients,highlighting the need for larger,prospective studies to improve risk prediction models.

关键词： D-dimer Aortic dissection Mortality Biomarker Systematic review Meta-analysis

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EGFR mutation--a commonly neglected mutation in squamous cell lung carcinoma

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 253-254页

作者： Rajeev Saini Ullas Batra akhil jain Chaturbhuj Agrawal Department of Medical Oncology Rajiv Gandhi Cancer Institute and Research CentreSector 5RohiniNew Delhi 110085India

Lung cancer is the leading cause of cancer-related death *** in molecular biology have unveiled various targetable mutations with epidermal growth factor receptor(EGFR)being most *** testing is recommended for all locally advanced or metastatic adenocarcinoma lungs but recommendation in squamous histology is ***,just on the basis of histology,EGFR testing should not be withheld in patients diagnosed as squamous cell cancer on small biopsy,in females,never smokers and *** report two cases with squamous cell lung cancer diagnosed on small biopsy,in non smoker females with EGFR mutations emphasizing the importance of testing in such population.

关键词： Epidermal growth factor receptor mutation squamous cell lung carcinoma never smoker small biopsy

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Elevated cardiovascular risk and acute events in hospitalized colon cancer survivors:A decade-apart study of two nationwide cohorts

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World Journal of Clinical Oncology 2024年第4期15卷 548-553页

作者： Rupak Desai Avilash Mondal Vivek Patel Sandeep Singh Shaylika Chauhan akhil jain Independent Researcher AtlantaGA 30079United States Department of Internal Medicine Nazareth HospitalPhiladelphiaPA 19152United States Department of Clinical Epidemiology Biostatistics and Bio-informaticsAmsterdam UMCAmsterdam 7057Netherlands Department of Internal Medicine Geisinger Health SystemWikes-BarrePA 18702United States Division of Leukemia The University of Texas MD Anderson Cancer CenterHoustonTX 77079United States

BACKGROUND Over the years,strides in colon cancer detection and treatment have boosted survival rates;yet,post-colon cancer survival entails cardiovascular disease(CVD)*** on CVD risks and acute cardiovascular events in colorectal cancer survivors has been *** To compare the CVD risk and adverse cardiovascular outcomes in current colon cancer survivors compared to a decade *** We analyzed 2007 and 2017 hospitalization data from the National Inpatient Sample,studying two colon cancer survivor groups for CVD risk factors,mortality rates,and major adverse events like pulmonary embolism,arrhythmia,cardiac arrest,and stroke,adjusting for confounders via multivariable regression *** Of total colon cancer survivors hospitalized in 2007(n=177542)and 2017(n=178325),the 2017 cohort often consisted of younger(76 vs 77 years),male,African-American,and Hispanic patients admitted non-electively vs the 2007 ***,the 2017 cohort had higher rates of smoking,alcohol abuse,drug abuse,coagulopathy,liver disease,weight loss,and renal *** in the 2017 cohort also had higher rates of cardiovascular comorbidities,including hypertension,hyperlipidemia,diabetes,obesity,peripheral vascular disease,congestive heart failure,and at least one traditional CVD(P<0.001)vs the 2007 *** adjusted multivariable analysis,the 2017 cohort had a significantly higher risk of pulmonary embolism(PE)(OR:1.47,95%CI:1.37-1.48),arrhythmia(OR:1.41,95%CI:1.38-1.43),atrial fibrillation/flutter(OR:1.61,95%CI:1.58-1.64),cardiac arrest including ventricular tachyarrhythmia(OR:1.63,95%CI:1.46-1.82),and stroke(OR:1.28,95%CI:1.22-1.34)with comparable all-cause mortality and fewer routine discharges(48.4%vs 55.0%)(P<0.001)vs the 2007 *** Colon cancer survivors hospitalized 10 years apart in the United States showed an increased CVD risk with an increased risk of acute cardiovascular events(stroke 28%,PE 47%,arrhythmia 41%,and cardiac arres

关键词： Colon cancer Colorectal cancer Cardiovascular diseases Cardiovascular disease risk Cardiac events Stroke

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单纳米粒子表面的甲醇电催化氧化过程

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Chinese Journal of Catalysis 2024年第2期57卷 59-67页

作者：周湘淇李丽丽王俊刚李展波邵希吉程付鹏张林娟王建强 akhil jaing 林涛静超中国科学院上海应用物理研究所中国科学院微观界面物理与探测重点实验室中国上海201800 上海应用技术大学化学与环境工程学院中国上海201418 深圳技术大学新材料与新能源学院中国广东深圳518118 山东大学晶体材料国家重点实验室晶体材料研究院中国山东济南250100 湖南师范大学化学化工学院化学生物学及中药分析教育部重点实验室中国湖南长沙410081 韶关学院智能工程学院物理系中国广东韶关512005 诺丁汉大学药学院再生医学与细胞诊疗生物电子实验室英国诺丁汉中国科学院大学中国北京100049

由于全球资源短缺和环境污染等问题日益加剧,开发利用洁净高效的新能源已成为当今社会研究热点.其中,直接甲醇燃料电池(DMFC)具有低温启动、无需重整制氢、洁净环保和体积小巧等特性,展现出较好的应用前景.DMFC的阳极反应为甲醇氧化反应... 详细信息

由于全球资源短缺和环境污染等问题日益加剧,开发利用洁净高效的新能源已成为当今社会研究热点.其中,直接甲醇燃料电池(DMFC)具有低温启动、无需重整制氢、洁净环保和体积小巧等特性,展现出较好的应用前景.DMFC的阳极反应为甲醇氧化反应,甲醇的完全氧化涉及到复杂的六步电子转移反应过程.揭示甲醇氧化的反应路径与机理,阐明催化剂的真实活性中心以及毒化效应,对于高效催化剂的设计和制备至关重要.随着纳米技术的发展,在单颗粒水平对纳米催化剂进行表征受到了越来越多的关注.因此,亟需发展具有高灵敏度的原位界面表征方法,实现纳米尺度的精准测量,排除催化剂平均效应,获取纳米表界面真实的催化反应信息.本文结合纳米等离子共振散射光谱与电化学技术,获得了单个纳米催化剂的同步光电响应信号,实现单颗粒水平纳米粒子表面化学、电化学反应过程(如电荷转移、分子吸附等)的高灵敏监测,揭示纳米尺度表界面催化反应机制.利用这一技术,动态监测了单个金/铂包金纳米颗粒表面的甲醇氧化过程.结果表明,在金纳米颗粒表面,甲醇氧化主要通过HCOOH路径,生成产物为HCOOH或CO_(2).其中,反应中间体与羟基离子的竞争性吸附起到重要作用,反应决速步为Au-OH和Au-CHO的共吸附.而铂催化甲醇氧化主要经过CO路径,决速步为Pt-OH和Pt-CO氧化生成Pt-COOH过程.此外,观测到金和铂氢氧化物为催化反应的活性物种,进一步证实了金属氧化物对于催化活性的钝化作用.结合密度泛函理论模拟,明确了甲醇氧化反应中间体吸附与金属氢氧化物演变之间的内在联系.综上,本文利用纳米等离子共振散射光谱,原位监测了单个纳米粒子表面的甲醇电催化氧化过程,实现了催化剂真实活性物种演变与失活过程的直接观测,揭示了不同催化剂表面的决速步骤,为提高催化反应效率提供了更加准确的反应信息.本文将有益于纳米等离子共振散射光谱在电催化反应高灵敏监测方面的广泛应用,并为高效甲醇催化剂的制备提供参考.

关键词：单个纳米粒子检测暗场显微镜等离子体共振散射光谱甲醇氧化反应纳米电化学

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Link between irritable bowel syndrome,depression,and colorectal cancer risk in young patients:Age-matched nationwide populationbased study

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World Journal of Gastrointestinal Pathophysiology 2024年第3期15卷 1-8页

作者： Sai Priyanka Mellacheruvu Sai Prasanna Lekkala Sukhjinder Chauhan Adil Sarvar Mohammed Sravya R Mundla Ankita Shenoy Bilal Khan Mohammed Jerrin Bawa Shantha Nallapothula Priyatham Gurram akhil jain Rupak Desai Mohammed Mustafa Nayeem Department of Public Health University of MassachusettsLowellMA 01854United States Department of Internal Medicine Mamata Medical CollegeTelanganaKhammam 507002India Department of Internal Medicine Mountainview HospitalLas VegasNV 89128United States Department of Internal Medicine Central Michigan University College of MedicineSaginawMI 48602United States Department of Public Health Apollo Institute of Medical Sciences and ResearchTelanganaHyderabad 500090India Department of Medicine Dr D.Y.Patil University School of MedicineMaharashtraNavi Mumbai 400706India Department of Medicine Northwestern University Feinberg School of MedicineChicagoIL 60611United States Department of Internal Medicine Flushing Hospital Medical CenterQueensNY 11355United States Department of Internal Medicine PES Institute of Medical Sciences and ResearchAndhra PradeshKuppam 517425India Department of Gastroenterology Mayo ClinicScottsdaleAZ 85259United States Division of Leukemia The University of Texas MD Anderson Cancer CenterHoustonTX 77079United States Independent Researcher AtlantaGA 30079United States Department of Internal Medicine Parkview Medical CenterPuebloCO 81003United States

BACKGROUND There exists a link between irritable bowel syndrome(IBS)and ***,chronic depression is known to increase the risk of cancer in *** this population-based analysis,we investigated the prevalence and the odds of colorectal cancer(CRC)in young-depressed patients with *** To investigate the relationship between IBS and CRC in young,depressed patients using a nationally representative United States inpatient *** The 2019 National Inpatient Sample was used to identify young(18-44 years)patients admitted with comorbid depression in the presence vs absence of IBS using relevant International Classification of Diseases,Tenth Revision,Clinical Modification *** endpoint was the prevalence and odds of CRC in age matched(1:1)youngdepressed cohort hospitalized with IBS(IBS+)vs without IBS(IBS-).Multivariable regression analysis was performed adjusting for potential *** Age-matched(1:1)young-depressed IBS+(83.9%females,median age 36 years)and IBS-(65.8%females,median age 36 years)cohorts consisted of 14370 patients in each ***+cohort had higher rates of hypertension,uncomplicated diabetes,hyperlipidemia,obesity,peripheral vascular disease,chronic obstructive pulmonary disease,hypothyroidism,prior stroke,prior venous thromboembolism,anxiety,bipolar disorder,and borderline personality disorder(P<0.005)vs the ***,prior myocardial infarction,acquired immunodeficiency syndrome,dementia,smoking,alcohol abuse,and drug abuse(P<0.005)are high in *** rate of CRC was comparable in both cohorts[IBS+n=25(0.17%)vs IBS-n=35(0.24%)].Compared to the IBS-cohort,the odds ratio(OR)of developing CRC was not significantly higher[OR 0.71,95% confidence interval(CI)0.23-2.25]in IBS+***,adjusting for baseline sociodemographic and hospital characteristics and relevant comorbidities,the OR was found to be non-significant(OR 0.89,95%CI 0.21-3.83).CONCLUSION This nationwide propensity-matched ana

关键词： Colorectal cancer Depression Irritable bowel syndrome Young patients National inpatient sample Comorbidities

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A Comprehensive Survey on Federated Learning Applications in Computational Mental Healthcare

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 49-90页

作者： Vajratiya Vajrobol Geetika jain Saxena Amit Pundir Sanjeev Singh Akshat Gaurav Savi Bansal Razaz Waheeb Attar Mosiur Rahman Brij B.Gupta Institute of Informatics and Communication University of DelhiDelhi110021India Maharaja Agrasen College University of DelhiDelhi110096India Computer Engineering Ronin InstituteMontclairNJ 07043USA Department of Research and Innovation Insights2TechinfoJaipur302001India University Centre for Research and Development(UCRD) Chandigarh UniversityChandigarh140413India Management Department College of Business AdministrationPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia CCRI&Department of Computer Science and Information Engineering Asia UniversityTaichung413Taiwan Symbiosis Centre for Information Technology(SCIT) Symbiosis International UniversityPune411057India Center for Interdisciplinary Research University of Petroleum and Energy Studies(UPES)Dehradun248007India

Mental health is a significant issue worldwide,and the utilization of technology to assist mental health has seen a growing *** aims to alleviate the workload on healthcare professionals and aid *** applications have been developed to support the challenges in intelligent healthcare ***,because mental health data is sensitive,privacy concerns have *** learning has gotten some *** research reviews the studies on federated learning and mental health related to solving the issue of intelligent healthcare *** explores various dimensions of federated learning in mental health,such as datasets(their types and sources),applications categorized based on mental health symptoms,federated mental health frameworks,federated machine learning,federated deep learning,and the benefits of federated learning in mental health *** research conducts surveys to evaluate the current state of mental health applications,mainly focusing on the role of Federated Learning(FL)and related privacy and data security *** survey provides valuable insights into how these applications are emerging and evolving,specifically emphasizing FL’s impact.

关键词： Depression emotional recognition intelligent healthcare systems mental health federated learning stress detection sleep behaviour

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Image smog restoration using oblique gradient profile prior and energy minimization

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Frontiers of Computer Science 2021年第6期15卷 147-153页

作者： Ashok KUMAR Arpit jain College of Computing Science and Information Technogy TeerthankerMahaveer UniversityMoradabad 244001India

Removing the smog from digital images is a challenging pre-processing tool in various imaging ***,many smog removal(i.e.,desmogging)models are proposed so far to remove the effect of smog from *** desmogging models are based upon a physical model,it means it requires efficient estimation of transmission map and atmospheric veil from a single smoggy ***,many prior based restoration models are proposed in the literature to estimate the transmission map and an atmospheric ***,these models utilized computationally extensive minimization of an energy ***,the existing restoration models suffer from various issues such as distortion of texture,edges,and ***,in this paper,a convolutional neural network(CNN)is used to estimate the physical attributes of smoggy *** gradient channel prior(OGCP)is utilized to restore the smoggy ***,a dataset of smoggy and sunny images are ***,we have trained CNN to estimate the smog gradient from smoggy ***,based upon the computed smog gradient,OGCP is utilized to restore the still smoggy *** analyses reveal that the proposed CNN-OGCP based desmogging model outperforms the existing desmogging models in terms of various performance metrics.

关键词： convolutional neural networks desmogging smog oblique gradient channel prior

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DNA-guided hepatitis B treatment:Viral load is insufficient with few exceptions

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World Journal of Gastroenterology 2009年第12期15卷 1530-1531页

作者： Pankaj jain Consultant Gastroenterology Apollo Modi HospitalSwami vivekanan dnagarKota-324010RajasthanIndia

In DNA-guided hepatitis B treatment, viral load is insufficient, and requires other viral markers for treatment of hepatitis B patients as in patients with acute exacerbation of chronic hepatitis B, end-stage renal disease on dialysis, human immunodeficiency virus co-infected patients. There are exceptions to this rule： a residual level hepatitis B virus （HBV） DNA at 24 wk predicts beneficial outcome and reduced resistance at i year. The genotypic viral resistance to antiviral agents and occult HBV infection can be determined by HBV-DNA levels.

关键词： DNA Hepatitis B Viral load

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＂NEW＂ resource recovery from wastewater using bioelectrochemical systems： Moving forward with functions

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Frontiers of Environmental Science & Engineering 2018年第4期12卷 3-15页

作者： Akshay jain Zhen He Department of Civil and Environmental Engineering Virginia Polytechnic Institute and State University Blacksburg VA 24061 USA

Bioelectrochemical systems （BES） have been extensively studied ｜br resource recovery from wastewater. By taking advantage of interactions between microorganisms and electrodes, BES can accomplish wastewater treatment while simultaneously recovering various resources including nutrients, energy and water （＂NEW＂）. Despite much progress in laboratory sit, dies, BES have not been advanced to practical applications. This paper aims to provide some subjective opinions and a concise discussion of several key challenges in BES-based resource recovery and help identil- the potential application niches that may guide further technological development. In addition to further increasing recovery efficiency, it is also important to have more lbcus on the applications of the recovered resources such as how to use the harvested electricity and gaseous energy and how to separate the recovered nutrients in an energy-efficient way. A changc in mindset fur energy performance of BES is necessary to understand overall energy production and consumption. Scaling up BES can go through laboratory scale, transitional scale, and then pilot scale. Using functions as driving forces lbr BES research and development will better guide the investment of efforts.

关键词： Bioelectrochemical systemsResource recoveryWastewater treatmentEnergy Nutrients

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