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Draft Genome of White-blotched River Stingray Provides Novel Clues for Niche Adaptation and Skeleton Formation

Genomics, Proteomics & Bioinformatics 2023年第3期21卷 501-514页

作者： Jingqi Zhou ake liu Funan He Yunbin Zhang Libing Shen Jun Yu Xiang Zhang School of Public Health Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Life Sciences Changzhi UniversityChangzhi 046011China Greehey Children’s Cancer Research Institute UT Health San AntonioSan AntonioTX 78229USA State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China International Human Phenome Institutes(Shanghai) Shanghai 200433China Institute of Neuroscience Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Beijing Institute of Genomics Chinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Shanghai Nanmulin Biotechnology Company Limited Shanghai 200031China

The white-blotched river stingray(Potamotrygon leopoldi)is a cartilaginous fish native to the Xingu River,a tributary of the Amazon River *** a rare freshwater-dwelling cartilaginous fish in the Potamotrygonidae family in which no member has the genome sequencing information available,*** provides the evolutionary details in fish phylogeny,niche adaptation,and skeleton *** this study,we present its draft genome of 4.11 Gb comprising 16,227 contigs and 13,238 scaffolds,with contig N50 of 3937 kb and scaffold N50 of 5675 kb in *** analysis shows that *** is a slow-evolving fish that diverged from elephant sharks about 96 million years ***,two gene families related to the immune system(immunoglobulin heavy constant delta genes and T-cell receptor alpha/delta variable genes)exhibit expansion in *** *** also identified the Hox gene clusters in *** and discovered that seven Hox genes shared by five representative fish species are missing in *** RNA sequencing data from *** and other three fish species demonstrate that fishes have a more diversified tissue expression spectrum when compared to *** functional studies suggest that lack of the gc gene encoding vitamin D-binding protein in cartilaginous fishes(both *** and Callorhinchus milii)could partly explain the absence of hard bone in their ***,this genome resource provides new insights into the niche adaptation,body plan,and skeleton formation of ***,as well as the genome evolution in cartilaginous fishes.

关键词： White-blotched river stingray Potamotrygon leopoldi De novo genome assembly Vitamin D-binding protein Niche adaptation

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Netrin蛋白家族的进化分析

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复旦学报（自然科学版） 2017年第1期56卷 106-116页

作者：陈丹丹张朝刘阿克邹央云谷迅复旦大学生命科学学院上海200438

神经突起生长导向因子(Netrin)蛋白家族是分泌型蛋白质,其通过与不同的受体相互作用,在神经发育过程中起轴突导向和细胞迁移中发挥着双重导向功能.本文分别对涉及到细胞相互作用的Netrin基因家族的起源与进化进行研究.以进化史不同阶段... 详细信息

神经突起生长导向因子(Netrin)蛋白家族是分泌型蛋白质,其通过与不同的受体相互作用,在神经发育过程中起轴突导向和细胞迁移中发挥着双重导向功能.本文分别对涉及到细胞相互作用的Netrin基因家族的起源与进化进行研究.以进化史不同阶段的代表物种作为研究对象,通过使用MEGA的邻接法和似释然法分别对Netrin基因家族构建系统发育树;使用PAML 4.7工具以核苷酸序列作为分析材料进行选择压分析,筛选出发生正选择作用的位点;使用DIVERGE3.0软件对Netrin氨基酸序列进行功能分化分析,筛选出Ⅰ型和Ⅱ型功能分化位点.

关键词： Netrin 基因家族功能分化选择压力细胞黏连

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EQUILIBRIUM SAMPLING THROUGH MEMBRANES(ESTM) FOR DETERMINATION OF FREELY DISSOLVED FRACTIONS OF ORGANIC AND INORGANIC POLLUTANTS

EQUILIBRIUM SAMPLING THROUGH MEMBRANES(ESTM) FOR DETERMINATI...

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第十一届北京分析测试学术报告会暨展览会(BCEIA 2005)

作者： Jan ake Jnsson Jingfu liu Philipp Mayer Analytical Chemistry Lund University State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for EcoEnvironmental SciencesChinese Academy of Sciences

Membrane assisted extraction facilitates the integration of classical liquid-liquid extraction(LLE)chemistry to automated instrumental *** shortcomings of classical LLE are overcome by the membrane separation of sampl...

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On the Cultural＂Other＂and＂Self＂of Chinese Culture Going Abroad

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学术界 2017年第9期 288-295页

作者： He Hongli liu Wenyuan Hengyang Normal University Hengyang Hunan 421002 Tianjin Normal University Tianjin 300387

Under the conditions of globalization,it is a m ission in the new era for C hinese culture going abroad.H ow ever,during the period of post-colonialism,w estern scholars have studied C hinese culture based on the w estern culture and *** a result,C hinese culture has becom e cultural "other ". T hrough analyzing the cultural "other " and"self",the demonstration of Chinese culture from the perspective of post-colonialism proves not to be *** is an inevitable choice for C hina's developm ent to m ake the C hinese culture go abroad and m ake an equal dialogue betw een C hinese and w estern cultures.

关键词：中国文化后殖民主义西方文化西方学者全球化价值观

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Automatic Keyphrase Extraction from Scientific Chinese Medical Abstracts Based on Character-Level Sequence Labeling

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Journal of Data and Information Science 2021年第3期6卷 35-57页

作者： Liangping Ding Zhixiong Zhang Huan liu Jie Li GaihongYu National Science Library Chinese Academy of SciencesBeijing 100190China University of Chinese academy of sciences Beijing 100049China Wuhan Library Chinese Academy of SciencesWuhan 430071China

Purpose:Automatic keyphrase extraction(ake)is an important task for grasping the main points of the *** this paper,we aim to combine the benefits of sequence labeling formulation and pretrained language model to propose an automatic keyphrase extraction model for Chinese scientific ***/methodology/approach:We regard ake from Chinese text as a character-level sequence labeling task to avoid segmentation errors of Chinese tokenizer and initialize our model with pretrained language model BERT,which was released by Google in *** collect data from Chinese Science Citation Database and construct a large-scale dataset from medical domain,which contains 100,000 abstracts as training set,6,000 abstracts as development set and 3,094 abstracts as test *** use unsupervised keyphrase extraction methods including term frequency(TF),TF-IDF,TextRank and supervised machine learning methods including Conditional Random Field(CRF),Bidirectional Long Short Term Memory Network(BiLSTM),and BiLSTM-CRF as *** are designed to compare word-level and character-level sequence labeling approaches on supervised machine learning models and BERT-based ***:Compared with character-level BiLSTM-CRF,the best baseline model with F1 score of 50.16%,our character-level sequence labeling model based on BERT obtains F1 score of 59.80%,getting 9.64%absolute *** limitations:We just consider automatic keyphrase extraction task rather than keyphrase generation task,so only keyphrases that are occurred in the given text can be *** addition,our proposed dataset is not suitable for dealing with nested *** implications:We make our character-level IOB format dataset of Chinese Automatic Keyphrase Extraction from scientific Chinese medical abstracts(Cake)publicly available for the benefits of research community,which is available at:https://***/possible1402/***

关键词： Automatic keyphrase extraction Character-level sequence labeling Pretrained language model Scientific chinese medical abstracts

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中药雾化吸入预防放射性口腔黏膜反应35例

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中医外治杂志 2006年第5期15卷 20-21页

作者：刘雪华王阿克李铁红辽宁省阜新市中心医院辽宁阜新123000

头颈部肿瘤由于其特定的解剖位置和对放射线的敏感性,通常使用放射线治疗,由于口腔和颈部接受较高的照射,口腔黏膜反应难以避免放射线口腔黏膜反应多在照射剂量达到10GY－30GY时出现,可有口、咽干痛,下咽痛,随着放射剂量增加而加重,严... 详细信息

头颈部肿瘤由于其特定的解剖位置和对放射线的敏感性,通常使用放射线治疗,由于口腔和颈部接受较高的照射,口腔黏膜反应难以避免放射线口腔黏膜反应多在照射剂量达到10GY－30GY时出现,可有口、咽干痛,下咽痛,随着放射剂量增加而加重,严重者可致滴水难咽,需终止放疗.因此,预防和减轻放疗所致口腔黏膜反应,不仅能提高患者生活质量,而且对治疗效果及其预后均具有重要意义:笔者自2004年始对我院35例头颈部恶性肿瘤行放疗的患者,采用鱼腥草、丹参注射液雾化吸人预防口腔黏膜反应,收到良好效果,现报道如下:[第一段]

关键词：口腔黏膜反应鱼腥草注射液丹参注射液中药雾化吸入

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沿海地区能源供需保障与解决途径研究

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地理学报 1999年第6期54卷 509-517页

作者：刘毅中国科学院地理研究所北京100101

东部沿海地区面向２１世纪的可持续发展面临资源、环境等突出矛盾，其中能源供需保障是关系到社会经济能否持续发展的重大问题之一。本文在分析能源供需特点、问题及需求预测基础上，提出下世纪初能源持续发展的主要途径应当是强化... 详细信息

东部沿海地区面向２１世纪的可持续发展面临资源、环境等突出矛盾，其中能源供需保障是关系到社会经济能否持续发展的重大问题之一。本文在分析能源供需特点、问题及需求预测基础上，提出下世纪初能源持续发展的主要途径应当是强化煤电运系统的能力建设，利用国内外两种资源，保障能源的有效供给；合理的开发本地能源资源，保持能源供给的支持能力，缓解能源供需的紧张状况；调整产业结构及其空间布局，节能降耗，

关键词：沿海地区能源供给途径能源供需保障

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Engineering of Allosteric Adenylate Kinase into ATP-Switched Antioxidant Selenoenzyme

Engineering of Allosteric Adenylate Kinase into ATP-Switched...

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第十届全国化学生物学学术会议

作者： Quan Luo Junqiu liu State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryJilin University

Rational redesign of allosteric protein offers an efficient strategy to develop switchable biocatalysts. By combining the computational design and protein engineering, a glutathione peroxidase（GPx）-like active center that contains the catalytic selenocysteine（Sec） residue and substrate-binding Arg residue was precisely incorporated into the allosteric domain of adenylate kinase（ake）. The engineered selenoenzyme shows not only high GPx activity but also adenosine triphosphate（ATP）-responsive catalytic property, which is regulated by its opened to closed conformational change upon ATP binding. Theoretical and mutational analysis reveals that the synergistic effect of electrostatic interactions and van der Waals（vdW） interactions for substrate recognition is a major contribution to the high activity. The mitochondrial oxidative damage experiment further demonstrated its antioxidant ability at the subcellular level, offering a potential application toward controllable catalysis in vivo.

关键词： artificial selenoenzyme enzyme design adenylate kinase allosteric switches antioxidant

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高质量发展背景下的人口老龄化应对——论“十五五”时期我国积极应对人口老龄化的战略重点

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人口与发展 2024年第5期30卷 7-14页

作者：刘尚君北京大学人口研究所北京100871

“十四五”期间我国已搭建积极应对人口老龄化基础性制度框架并取得一定成效,但距离《国家积极应对人口老龄化中长期规划》中制度安排更加科学有效、成熟稳定等目标仍有不足。研究在总结“十四五”政策效果和梳理“十五五”人口发展新... 详细信息

“十四五”期间我国已搭建积极应对人口老龄化基础性制度框架并取得一定成效,但距离《国家积极应对人口老龄化中长期规划》中制度安排更加科学有效、成熟稳定等目标仍有不足。研究在总结“十四五”政策效果和梳理“十五五”人口发展新需求的基础上,学习贯彻党的二十届三中全会精神,分析提出“十五五”时期贯彻落实积极应对人口老龄化国家战略的基本思路和战略重点。研究指出,面对更加紧迫的超常规人口老龄化压力和亟须解决的不平衡、不充分矛盾,要以高质量发展为核心,继续践行积极老龄观和健康老龄化观念,促进“以为促养”;坚持系统观念,持续深化供给侧结构性改革的同时发掘需求侧潜力,从组织体系、政策体系和制度创新三方面完善制度安排;加强创新驱动,创新老龄工作模式,增强积极应对人口老龄化的要素支撑,以更高效的管长远制度运行机制、系统协同的要素支撑,共同推进我国养老服务体系高质量发展和老龄事业产业协同发展,服务中国式现代化目标最终实现。

关键词：积极应对人口老龄化高质量发展 “十五五”

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Chaotic maps and biometrics-based anonymous three-party authenticated key exchange protocol without using passwords

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Chinese Physics B 2015年第11期24卷 163-170页

作者：谢琪胡斌陈克非刘文浩谭肖 Hangzhou Key Laboratory of Cryptography and Network Security Hangzhou Normal University

In three-party password authenticated key exchange （ake） protocol, since two users use their passwords to establish a secure session key over an insecure communication channel with the help of the trusted server, such a protocol may suffer the password guessing attacks and the server has to maintain the password table. To eliminate the shortages of password- based ake protocol, very recently, according to chaotic maps, Lee et al. [2015 Nonlinear Dyn. 79 2485] proposed a first three-party-authenticated key exchange scheme without using passwords, and claimed its security by providing a well- organized BAN logic test. Unfortunately, their protocol cannot resist impersonation attack, which is demonstrated in the present paper. To overcome their security weakness, by using chaotic maps, we propose a biometrics-based anonymous three-party ake protocol with the same advantages. Further, we use the pi calculus-based formal verification tool ProVerif to show that our ake protocol achieves authentication, security and anonymity, and an acceptable efficiency.

关键词： chaos Chebyshev chaotic maps anonymous authenticated key exchange

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