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A Systematic Review and Meta-Analysis of Randomized Control Trials to Check Role of Non-Steroidal Anti-inflammatory Drugs as Protective Factor in Alzheimer Disease Subjects

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Advances in Alzheimer's Disease 2023年第1期12卷 1-16页

作者： akash asthana Shashank Tripathi Rachna Agarwal Department of Statistics University of Lucknow Lucknow India Department of Neurochemistry Institute of Human Behavior and Allied Sciences New Delhi India

Background: Alzheimer’s disease is the major neurodegenerative disease, affecting more than two third cases of dementia in the world. NSAIDs are widely used anti-inflammatory analgesic agents representing 7.7% of worldwide prescriptions of which 90% are in patients over 65 years old. Based on mixed findings observed by different RCTs, a systematic review and meta-analysis were conducted to develop a better understanding of the protective role of Non-steroidal anti-inflammatory drugs (NSAIDs) in AD. Methods: Database search was Pubmed, WebScience, and Embase. RCTs investigating the effect of NSAIDs on AD or test scores assessing cognitive function in people without AD at baseline were included. Three indicators were MMSE Score, ADAS-cog score, and CDR-sob. 10 studies were included in the present Meta-analysis. Results: For the ADAS-cog score, the pooled effect size was -0.31 with 95% CI -0.06 to 0.02, which was statistically significant (p = 0.03). MMSE score difference, the pooled effect size was -0.06 with 95% CI -0.22 to 0.10, which was statistically insignificant (p-value = 0.47). For the MMSE average score, the pooled effect size was -0.002 with 95% CI -0.03 to 0.07, which was statistically insignificant (p-value = 0.87). For the CDR-sob score difference, the pooled effect size calculated using the random effect model was -0.06 with 95% CI -0.39 to 0.05 which was statistically insignificant (p = 0.14). For CDR-sob average score, the pooled effect size calculated using the random effect model was 0.21 with 95% CI -0.09 to 0.51, which was statistically insignificant (p-value = 0.17). Conclusion: Present Meta-analysis shows that NSAIDs in general are not effective in the treatment of AD. They also have no protective effect against the development of AD on their sustained use.

关键词： NSAIDs Alzheimer’s Disease Meta-Analysis Hazard Ratio

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Non-Steroidal Anti-Inflammatory Drugs as Protective Factor in Alzheimer’s Diseases: A Systematic Review and Meta-Analysis Protocol

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Advances in Alzheimer's Disease 2023年第2期12卷 17-28页

作者： akash asthana Rachna Agarwal Shashank Tripathi Department of Statistics University of Lucknow Lucknow India Department of Neurochemistry Institute of Human Behavior and Allied Sciences New Delhi India

Introduction: NSAIDs inhibit COX-2, which is responsible for regulating neurons leading to neurodegeneration in Alzheimer’s disease. Alzheimer’s disease is a neurodegenerative disease affecting the geriatric population, as it affects more than two third cases of dementia in the sphere. Results obtained from experimental and observational studies were unclear regarding the protective role of NSAIDs in AD, therefore this justifies the need for meta-analysis. Methods: Database search was PubMed, Web of Science, and Embase. Experimental studies and Observational studies investigating the effect of NSAIDs on AD. For experimental studies indicators used were MMSE score, ADAS-cog score, CDR-sob score, NPI score, and Hazard ratio. Similarly for Observational studies, Odds Ratio and Relative Risk are used. Results: As this is the study protocol, therefore it is not possible to write the results of the study in the study protocol. There is a total of 06 (MMSE, ADAS-cog, CDR-sob, HR, RR, and OR) indicators used in the study, so 06 results will be obtained showing the pooled effect size which will indicate the use of NSAIDs as a protective factor for Alzheimer’s disease. Discussion: The present systematic review will improve the understanding of the relative efficacies of NSAIDs in AD and possibly guide clinical practices by providing the current best evidence on the efficacy of various regimens of NSAIDs in the management of AD subjects. Conclusion: Conclusion can be drawn only after the final meta-analysis using three study design (RCT, Cohort and Case-control study designs) and six indicators.

关键词： Alzheimer’s Disease NSAIDs Meta-Analysis RCT OR RR

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Irreversible electroporation for metastatic pancreatic carcinoma with liver metastasis:What does the evidence say

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World Journal of Clinical Cases 2025年第3期13卷 30-34页

作者： Ranit Seal akash Bararia Bitan Kumar Chattopadhyay Nilabja Sikdar Department of General Surgery IPGME&R and SSKM HospitalKolkata 700020West BengalIndia Human Genetics Unit Indian Statistical InstituteKolkata 700108West BengalIndia Estaurine and Coastal Studies Foundation Howrah 711101India

Irreversible electroporation is a promising non-thermal ablation method that has been shown to increase overall survival in locally advanced pancreatic cancer in some ***,higher quality studies with proper controls and randomization are required to establish its superiority when added with neoadjuvant chemotherapy over the current management of choice,which is chemotherapy *** studies are required before establishment of any survival benefit in metastatic pancreatic carcinoma,and such evidence is lacking at present.

关键词： Irreversible electroporation Locally advanced pancreatic carcinoma Metastatic pancreatic carcinoma Advanced pancreatic carcinoma Chemotherapy

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High performance 20 nm GaSb/InAs junctionless tunnel field effect transistor for low power supply

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Journal of Semiconductors 2015年第2期36卷 56-61页

作者： Pranav Kumar asthana Department of Electrical Engineering Indian Institute of Technology Kanpur

We present a GaSb/In As junctionless tunnel FET and investigate its static device characteristics. The proposed structure presents tremendous performance at a very low supply voltage of 0.4 V. The key idea is to the present device architecture, which can be exploited as a digital switching device for sub 20 nm *** simulations resulted in an IOFF of 8×10^-17A/ m, ION of 9 A/ m, ION/IOFF of 1×10^11,subthreshold slope of 9.33 m V/dec and DIBL of 87 m V/V for GaSb/InAs JLTFET at a temperature of 300 K,gate length of 20 nm, HfO2 gate dielectric thickness of 2 nm, film thickness of 10 nm, low-k spacer thickness of 10 nm and VDD of 0.4 V.

关键词： band tunneling (BTBT) tunnel field effect transistor (TFET) junctionless tunnel field effect transistor(JLTFET) ION/IOFF ratio low power digital switching

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Influence of A-site cation disorder on structural and magnetocaloric properties of Nd_(0.7–x)La_xSr_(0.3)MnO_3(x=0.0, 0.1, 0.2 & 0.3)

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Journal of Rare Earths 2015年第10期33卷 1072-1080页

作者： Sudharshan Vadnala Prem Pal Saket asthana Department of Physics Indian Institute of Technology Hyderabad

In the present research, the influence of A-site ionic size disorder on structural, magnetic and magnetocaloric properties of Ndo.7_xtaxSr0.3MnO3 （for x=0.0, 0.1, 0.2 ＆ 0.3） compounds were investigated. These compounds were synthesized by solid state reaction route and crystallized in orthorhombic structure with Pnma space group. An average ionic radius 〈rA〉 increased with La-substitution which influenced the physical properties such as the magnetic entropy varying from 4.78 J/kg.K （for x-=0.0） to 3.55 J/kg.K （for x=0.3） and the maximum magnetization at 5 K changing from 3.92 μB （for x=0.0） to 3.59 μB （for x=0.3）. The change in maximum magnetic entropy decreased with increase of A-site average ionic radius. The decrease in magnetic entropy indicated the suppression of lattice disorder that influenced the spin-lattice coupling. The ferromagnetic transition temperature shifted toward room temperature with La substitution. As 〈rA〉 increased, the phase transition changed from first order （for x-=0.0） to second order （for x≥ 0.1） and the refrigeration capacity increased to a significant level. The modest change in magnetic entropy over a wide range of transition temperature might be useful for future active magnetic refrigeration technology.

关键词： manganites magnetocaloric effect relative cooling Curie temperature rare earths

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Scaling behavior of different shapes of hysteresis loops and recoverable energy storage density in Na_(0.5)Bi_(0.5)TiO_(3), K_(0.5)Bi_(0.5)TiO_(3), and Na_(0.25)K_(0.25)Bi_(0.5)TiO_(3) ferroelectrics

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Journal of Materiomics 2022年第4期8卷 918-927页

作者： Krishnarjun Banerjee Saket asthana Advanced Functional Materials Laboratory Department of PhysicsIndian Institute of Technology HyderabadKandiTelangana502284India

In this work,the dependency of the polarization(P)-electric field(E)loop area A of lead free ferro-electrics Na_(0.5)Bi_(0.5)TiO_(3)(NBT), K_(0.5)Bi_(0.5)TiO_(3)(KBT),and Na_(0.25)K_(0.25)Bi_(0.5)TiO_(3)(NKBT)on the amplitude(E0)of the electric field is *** on the nature of the hysteresis loop with increasing E0,the lnA versus lnE0 graph is divided into three stages and the scaling exponents of each stage are *** the third stage,NBT,KBT,and NKBT show different shapes of P-E loops(square,slanted and pinched,respectively).Although,almost similar slopes in the third stage are obtained from the lnA versus lnE0 graphs of KBT and NKBT,the formation of pinched P-E loop of NKBT is discussed based on the current-time curve under a complete cycle of the applied electric *** shape of the P-E loop also affects the recoverable energy storage density(Wrec)of the *** to the scaling of A,the variation of lnWrec with lnE0 of NBT,KBT and NKBT are ***,three stages are only noticed in the lnWrec-lnE0 curve of pinched P-E loop(NKBT),whereas lnWrec linearly increases with lnE0 for square and slanted P-E *** type of behavior of Wrec of NKBT is explained based on the reversible domain switching mechanism of the pinched P-E loop.

关键词： Scaling Recoverable energy storage density Lead free ferroelectric

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Boulder-induced form roughness and skin shear stresses in a gravel-bed stream

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Journal of Mountain Science 2024年第1期21卷 346-360页

作者： DAS Ratul DATTA akash Civil Engineering Department National Institute of Technology AgartalaAgartala-799046India

Boulder spacing in mountain rivers and near-wake flow zones within the boulder array is very useful for fish habitat and growth of aquatic *** present study aims to investigate how the boulder array and spacing influence the near-bed flow structures in a gravel-bed *** are staggered over a gravel-bed stream with three different inter-boulder spacing namely(a)large(b)medium and(c)small *** acoustic Doppler velocimeter was used for flow measurements in a rectangular channel and the results were compared with those acquired from numerical *** time-averaged velocity profiles at the near-wake flow zones of boulders experience maximum flow retardation which is an outcome of the boulder-induced form *** ratio of velocity differences associated to form and skin roughness and its positive magnitude reveals the dominance of form roughness closest to the *** roughness computed is 1.75 to 2 times higher than the skin roughness at the near-wake flow *** particular,the collective immobile boulders placed at different inter-boulder spacings developed high and low bed shear stresses closest to the *** low bed shear stresses characterised by a secondary peak developed at the trough location of the boulders is attributed to the skin shear ***,the spatial averaging of time-averaged flow quantities gives additional impetus to present an improved illustration of fluid shear *** formation of form-induced shear stress is estimated to be 17%to 23%of doubleaveraged Reynolds shear stress and partially compensates for the damping of time-averaged Reynolds shear stress in the interfacial *** quadrant analysis of spatial velocity fluctuations depicts that the form-induced shear stresses are dominant in the interfacial sub-layer and have no significance above the gravel-bed surface.

关键词： Array of boulders Near wake flow zones Velocity distributions Skin roughness Form induced shear stresses

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Modeling and optimization of a wide-band piezoelectric energy harvester for smart building structures

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International Journal of Modeling, Simulation, and Scientific Computing 2020年第2期11卷 31-38页

作者： Prateek asthana Gargi Khanna Electronics and Communication Engineering Department National Institute of Technology Hamirpur Himachal PradeshIndia

Piezoelectric energy harvesting refers to conversion of mechanical energy into usable electrical *** the modern connected world,wireless sensor nodes are scattered around the *** nodes are powered by *** require regular replacement,hence energy harvesters providing continuous autonomous power are used to power these sensor *** work provides two different fixation modes for the resonant frequency for the two *** in geometric parameter and their effect on resonant frequency and output power have been *** harvesters capture a wide-band of ambient vibrations and convert them into usable electrical *** capture random ambient vibrations,the harvester used is a wide-band energy harvester based on conventional seesaw *** proposed structure operates on first two resonant frequencies in comparison to the conventional cantilever system working on first resonant *** frequency,as well as response to a varying input vibration frequency,is carried out,showing better performance of seesaw cantilever *** this work,modeling of wide-band energy harvester with proof mass is being *** of proof mass plays a key role in determining the resonant frequency of the *** the proof mass near or away from fixed end results in increase and decrease in stress on the piezoelectric ***,to avoid the breaking of cantilever,the position of proof mass has been analyzed.

关键词： Finite element modeling optimization seesaw energy harvester wide-band energy harvester piezoelectric

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Strategic recommendations for financing green and sustainable energy projects

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Clean Energy 2023年第5期7卷 1069-1077页

作者： Arindam Dutta akash Samanta Department of Energy Management Indian Institute of Social Welfare and Business ManagementIndia

The main hindrances to the large-scale development of renewable-energy projects are the lack of bankability and the inability to align investments and investors with suitable financial instruments or robust policy *** illustrate a bankable project,this paper presents a research-based case study on the installation of solar photovoltaic panels on the rooftops of 195 trains of the Indian *** information on the annual running hours,exposure to sunlight,efficiency of solar photovoltaic generation and electrical power demands of each rail coach is considered to conduct a quantitative measure of the tentative amount of fossil fuel *** purpose is to provide insight into the types of renewable-energy projects that can be highly attractive to financial institutions and promoters due to their lucrative internal return on *** seen in this case study,there are annual savings in diesel of 12323088 litres and a CO_(2) reduction of 32755 tonnes,with return on investment of 1.3 ***,this study conducts a com-prehensive analysis of the limitations of existing renewable-energy project financing mechanisms in ***,three policy measures are recommended to develop a robust financial mechanism that can effectively meet the needs of investors and *** measures include increasing equity injection through a buy-and-hold strategy,providing direct tax benefits to promoters and financing through real-estate investment *** findings are highly relevant to address the challenges associated with bridging the financial gap between access to finance and capital investment in the renewable-energy sector,especially for Asian countries.

关键词： rooftop solar railways fuel saving return on investment bankable project equity funding debt funding renewable energy

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Investigation of structural,magnetic and optical properties of rare earth substituted bismuth ferrite

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Journal of Rare Earths 2013年第4期31卷 370-375页

作者： T.Durga Rao T.Karthik Saket asthana Advanced Functional Materials Laboratory Department of PhysicsIndian Institute of Technology Hyderabad Department of Materials Science and Engineering Indian Institute of Technology Hyderabad

Polycrystalline BiFeO3 and rare earth substituted ***3 （BRFO, R=Y, Ho and Er） compounds were prepared by rapid solid state sintering technique. Structural phase analysis indicated that all the compounds stabilized in rhombohedral structure （R3c space group） and a small orthorhombic phase fraction was observed in BRFO compounds. From the Raman spectra results, the changes in the phonon frequencies （A1） and line widths suggested lattice distortion in the BRFO compounds as was evidenced in the XRD analysis. Compared to the linear variation of magnetization with magnetic field （M-H） shown by BFO, an obvious M-H loop was observed in BRFO compounds which could be due to the suppression of space modulated spin structure and was explained on the basis of weak ferromagnetism and field induced spin reorientation. UV-Vis spectroscopy evidenced a change in local FeO6 envi- ronment due to shift in the 6Alg→4T2g energy transition band. BRFO compounds with improved remnant magnetization and coercive field are applicable for magnetoelectric devices.

关键词： structural distortion spin-reorientation G-type antiferromagnet rare earths

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