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CAR-T cell therapy in neuro-oncology: applications and toxicity

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Neuroimmunology and Neuroinflammation 2018年第10期5卷 15-26页

作者： akanksha sharma Gustavo De Leon Alyx Porter Marie F Grill Allison Rosenthal Christine E Brown Kristin Swanson Maciej M Mrugala Department of Neurology Mayo ClinicPhoenixAZ 85054USA Division of Hematology-Oncology Mayo ClinicPhoenixAZ 85054USA Mathematical Neuro-Oncology Lab Mayo ClinicPhoenixAZ 85054USA Department of Hematology and Hematopoietic Cell Transplantation T Cell Therapeutics Research LaboratoryCity of Hope Beckman Research InstituteDuarteCA 91010USA.

A new era for cancer treatment has been ushered in with the field of cancer immunotherapy. After initial success with systemic malignancies, several of these promising treatments are being investigated for efficacy with primary and secondary brain tumors. Chimeric antigen receptor (CAR) T cells are being studied, both with systemic infusion and direct administration to the tumor and into the cerebrospinal fluid, with promising early results. Systemic CAR-T treatment can have serious systemic and neurological toxicities that are important for the practicing neurologist and neuro-oncologist to know and understand. This review aims to discuss adoptive cell therapies with a focus on CAR-T treatment. We review use of this therapy in brain cancers, particularly malignant glioma, and provide an overview of the toxicity of CAR-T treatment and its appropriate management.

关键词： CAR-T cell immunotherapy brain tumor cytokine release syndrome

Gasification kinetic studies of low volatile weakly caking coal

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International Journal of Coal Science & Technology 2023年第2期10卷 159-168页

作者： akanksha Mishra Shalini Gautam Tripurari sharma Department of Mechanical Engineering Sharda School of Engineering and TechnologySharda UniversityG.NoidaIndia Department of Fuel Minerals and Metallurgical EngineeringIndian Institute of Technology(ISM)DhanbadIndia

Present investigation focuses on the fractional conversion of low volatile weakly caking coal(LVWC)under the standard set of operating conditions for *** this purpose,samples of LVWC of different ash content have been collected from Kusunda Area of Bharat Coking Coal *** results were validated using Homogenous and Shrinking Core kinetic models and the suitability of selected samples for gasification was assessed by estimating the activation *** values of activation energy for LVWC samples were obtained in the range of 25.17-44.09 kJ/***,empirical models were developed to correlate the response of interest with the input variables(temperature,residence time and CO_(2) flow rate).The significance of these developed empirical models was checked using analysis of variance(ANOVA).

关键词： LVWC Gasification CO_(2) Activation energy

Effect of operating parameters on coal gasification

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International Journal of Coal Science & Technology 2018年第2期5卷 113-125页

作者： akanksha Mishra Shalini Gautam Tripurari sharma Department of Mechanical Engineering Sharda UniversityGreater Noida India Department of Fuel and Mineral Engineering Indian Institute of Technology (Indian School of Mines) Dhanbad India

Coal combustion and gasification are the processes to utilize coal for production of electricity and many other applications. Global energy demand is increasing day by day. Coal is an abundant source of energy but not a reliable source as it results into high CO2 emissions. Energy industries are expected to decrease the CO2 emission to prevent global warming. Coal gasification is a process that reduces the CO2 emission and emerges as a clean coal technology. Coal gasification process is regulated by several operating parameters. A Number of investigations have been carried out in this direction. A critical review of the work done by several researchers in the field of coal gasification has been compiled in this paper. The effect of several operating parameters such as coal rank, temperature, pressure, porosity, reaction time and catalyst on gasification has been presented here.

关键词： Coal gasification Temperature and pressure Porosity Rank

Update on the preclinical and clinical assessment of Withania somnifera: from ancient Rasayana to modern perspectives

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Traditional Medicine Research 2022年第5期7卷 50-64页

作者： akanksha Rashmi Singh Atiqul Islam Rimpi Arora Harjeet Singh Alok sharma Department of Pharmacognosy ISF College of PharmacyMogaPunjab 142001India Department of Pharmacology ISF College of PharmacyMogaPunjab 142001India CCRAS Ministry of AYUSHJhansiUttar Pradesh 212658India

The Rasayana plant Withania somnifera(***)Dunal,also known as“Ashwagandha”,has been mentioned in various classical Ayurvedic texts,such as Charaka Samhita,Sushruta Samhita,and *** Ayurvedic drug has been referred to as a tonic that renews the body,provides physical and mental vigor in weakened states,and promotes endurance and *** possesses notable biological activity in many ailments,such as diabetes,conjunctivitis,insomnia,senile dementia,Parkinson’s disease,nervous system disorders,rheumatism,and *** pharmacological activities are due to the presence of diverse active components and their *** lead compounds are found to be effective against anxiety and other central nervous system *** has been proven to be effective and safe for a wide range of ailments from ancient to modern *** reported properties represent the traditional use of *** as indicated in the literature;furthermore,*** is one of the most important prescribed drugs in Ayurveda for its multimodal *** current review highlights the bioactive present and provides an overview of the toxicological and pharmacological studies on ***,including preclinical and clinical *** its earliest utilization to its current application,*** has been recognized to be effective at clinical levels for human health and *** attention to the safety and efficacy of *** would provide more scientific evidence,promoting global acceptance of the Ayurvedic plant.

关键词： Withania somnifera Ayurveda Rasayana pharmacological profile preclinical study clinical study

Implications of metabolic dysfunction associated fatty liver disease in COVID-19

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World Journal of Clinical Cases 2023年第6期11卷 1275-1286页

作者： Raja Chakraborty Deepak sharma Devesh U Kapoor akanksha Dwivedi Rakhi Khabiya Saikat Sen Institute of Pharmacy Assam Don Bosco UniversityGuwahati 782402AssamIndia School of Medical Sciences Adamas UniversityKolkata 700126West BengalIndia Department of Pharmacy Dr.Dayaram Patel Pharmacy CollegeBardoli 394601GujaratIndia Department of Pharmacy Acropolis Institute of Pharmaceutical Education&ResearchIndore 453771Madhya PradeshIndia Faculty of Pharmaceutical Science Assam down town UniversityGuwahati 781026AssamIndia

Metabolic associated fatty liver disorder(MAFLD)characterizes the contributing etiologies(i.e.,type 2 diabetes mellitus,metabolic syndrome,overweight)of individuals with fatty liver disease that affects 1/3rd of the world *** 2020,the coronavirus disease 2019(COVID-19)crisis was unprecedented,and people with different comorbidities became more susceptible to the infection caused by severe acute respiratory syndrome coronavirus *** patients are frequently obese with added metabolic menace like diabetes,hypertension,and dyslipidemia leading to greater jeopardy of *** patients are 4 to 6-fold more prone towards ***-19 induces liver injury with elevated levels of aspartate aminotransferase and alanine aminotransferase and insignificantly elevated ***,MAFLD in COVID-19 patients worsens the condition *** evidence highlighting the interaction between MAFLD and altered liver functioning in COVID-19 suggested that COVID-19 patients with pre-existing MAFLD are at greater risk of morbidity or intensive care unit *** hepatic injury,enhanced levels of inflammatory cytokines,declined hepatic mitochondrial activity,and compromised immunity are considered as some underlying *** main focus of this review is to discuss the implications of metabolic dysfunction associated with fatty liver disease in COVID-19 *** review systematically analyzes the effect of striking two worldwide pandemics(MAFLD and COVID-19)together in the present era.

关键词： Metabolic associated fatty liver disorder COVID-19 Metabolic dysfunction Hepatic damage Cytokine storm

Polymers in Drug Delivery

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Journal of Biosciences and Medicines 2016年第1期4卷 69-84页

作者： Apurva Srivastava Tejaswita Yadav Soumya sharma Anjali Nayak akanksha akanksha Kumari Nidhi Mishra Department of Applied Science Indian Institute of Information Technology Deoghat Jhalwa Allahabad India

Polymers are being used extensively in drug delivery due to their surface and bulk properties. They are being used in drug formulations and in drug delivery devices. These drug delivery devices may be in the form of implants for controlled drug delivery. Polymers used in colloidal drug carrier systems, consisting of small particles, show great advantage in drug delivery systems because of optimized drug loading and releasing property. Polymeric nano particulate systems are available in wide variety and have established chemistry. Non toxic, biodegradable and biocompatible polymers are available. Some nano particulate polymeric systems possess ability to cross blood brain barrier. They offer protection against chemical degradation. Smart polymers are responsive to atmospheric stimulus like change in temperature;pressure, pH etc. thus are extremely beneficial for targeted drug delivery. Some polymeric systems conjugated with antibodies/specific biomarkers help in detecting molecular targets specifically in cancers. Surface coating with thiolated PEG, Silica-PEG improves water solubility and photo stability. Surface modification of drug carriers e.g. attachment with PEG or dextran to the lipid bilayer increases their blood circulation time. Polymer drug conjugates such as Zoladex, Lupron Depot, On Caspar PEG intron are used in treatment of prostate cancer and lymphoblastic leukemia. Polymeric Drug Delivery systems are being utilized for controlled drug delivery assuring patient compliance.

关键词： Polymeric Drug Delivery Biocompatible Polymers Smart Polymers Polymeric Implants Polymeric Drug Formulations

Sitagliptin,sitagliptin and metformin,or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats

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The Journal of Biomedical Research 2012年第3期26卷 200-210页

作者： Ashish Kumar sharma Akash sharma Rita Kumari Kunal Kishore Divya sharma Bharthu Parthsarthi Srinivasan Ashok sharma Santosh Kumar Singh Samir Gaur Vijay Singh Jatav Prashant sharma Varnika Srivastava Sneha Joshi Megha Joshi Prashant Kumar Dhakad Davender Singh Kanawat akanksha Mishra Anil sharma Dharmendra Singh Ravinder Pal Singh Himmat Singh Chawda Rambir Singh Sachin Kumar Raikwar Muneem Kumar Kurmi Pankaj Khatri Ashutosh Agarwal Arshee Munajjam Department of Pharmacology Gyan Vihar School of PharmacySuresh Gyan Vihar UniversityJagatpuraJaipur(Rajasthan)302025India Department of Pharmacology Delhi Institute of Pharmaceutical Sciences&ResearchPushpviharNew Delhi 110017India Department of Pharmacology Kota Collage of PharmacyRIICO Industrial AreaRanpurKota(Rajasthan)Pincode 302025India

Diabetic neuropathies are a family of nerve disorders caused by diabetes. Symptoms of the disease include nerve palsy, mononeuropathy, mononeuropathy multiplex, diabetic amyotrophy, painful polyneuropathy, autonomic neu- ropathy, and thoracoabdominal neuropathy. In this study, type 2 diabetes in rats was induced with nicotinamide- streptozotocin. Drug treatment was initiated on the d 15, with the combination regimen of metformin, pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin, amitriptyline and sitagliptin and led to significantly im- proved glycemic control, increased grip strength and paw jumping response on d 21, 28 and 35 （P 〈 0.001）. Signif- icant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21, 28 and 35 （P 〈 0.001）. Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells, while administration of metformin and sitagliptin showed tissue regen- eration and no body weight gain. In conclusion, treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain, but causes an increase in grip strength and pain sensitivity, exhibits neural protection, and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes.

关键词： diabetic neuropathy nicotinamide-streptozotocin metformin pioglitazone glimipiride sitagliptin amitriptyline