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Low temperature-mediated repression and far-red light-mediated induction determine morning FLOWERING LOCUS T expression levels

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Journal of Integrative Plant Biology 2024年第1期66卷 103-120页

作者： Hayeon Kim Hye Won Kang Dae Yeon Hwang Nayoung Lee akane Kubota Takato Imaizumi Young Hun Song Department of Agricultural Biotechnology Seoul National UniversitySeoul 08826Korea Department of Biology Ajou UniversitySuwon 16499Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea Graduate School of Science and Technology Nara Institute of Science and TechnologyIkomaNara 630‐0192Japan Department of Biology University of WashingtonSeattleWA 98195USA Institute of Agricultural Life Sciences Seoul National UniversitySeoul 08826Korea

In order to flower in the appropriate season,plants monitor light and temperature changes and alter downstream pathways that regulate florigen genes such as Arabidopsis(Arabidopsis thaliana)FLOWERING LOCUS T(FT).In Arabidopsis,FT messenger RNA levels peak in the morning and evening under natural long-day conditions(LDs).However,the regulatory mechanisms governing morning FT induction remain poorly *** morning FT peak is absent in typical laboratory LDs characterized by high red:far-red light(R:FR)ratios and constant ***,we demonstrate that ZEITLUPE(ZTL)interacts with the FT repressors TARGET OF EATs(TOEs),thereby repressing morning FT expression in natural *** LDs with simulated sunlight(R:FR=1.0)and daily temperature cycles,which are natural LD-mimicking environmental conditions,FT transcript levels in the ztl mutant were high specifically in the morning,a pattern that was mirrored in the toe1 toe2 double *** night-to-morning temperatures increased the inhibitory effect of ZTL on morning FT expression by increasing ZTL protein levels early in the ***-red light counteracted ZTL activity by decreasing its abundance(possibly via phytochrome A(phyA))while increasing GIGANTEA(GI)levels and negatively affecting the formation of the ZTL-GI complex in the ***,the phyA-mediated high-irradiance response and GI play pivotal roles in morning FT *** findings suggest that the delicate balance between low temperature-mediated ZTL activity and the far-red light-mediated functions of phyA and GI offers plants flexibility in fine-tuning their flowering time by controlling FT expression in the morning.

关键词： far-red light FLOWERING LOCUS T flowering time GIGANTEA low night-to-morning temperature natural long days phytochrome A red to far-red ratio ZEITLUPE

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<i>Vibrio vulnificus</i>septicemia and necrotizing fasciitis in the patients with liver cirrhosis and diabetes mellitus

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Journal of Diabetes Mellitus 2012年第1期2卷 122-125页

作者： Hiroyuki Ito akane shibayama Mariko Abe Shinichi Antoku Hiroko Nawata Miyuki Isonishi Masaki Fujita Shojiro Kato Department of Diabetes Metabolism and Kidney Disease Edogawa Hospital Tokyo Japan

Vibrio vulnificus (V. vulnificus) infection is a rare disease in Japan but the leading cause of death related to raw seafood consumption. We hereby reported a successfully treated case of V. vulnificus septicemia, severe necrotizing fasciitis, disseminated intravascular coagulation and multiple organ failure after raw perch consumption with underlying alcoholic liver cirrhosis and diabetes mellitus. It is the first report of a case of V. vulnificusinfection caused by eating raw perch, whereas V. vulnificus infection should be suspected in all of middle-aged to elderly men with underlying immunosuppressive diseases, who have recent consumption of raw seafood or contact with seawater, especially in the summer. The levels of HbA1c and glycoalbumin were not high in the present case, however, obvious hyperglycemia was found even after the infection had completely healed. On reviewing 166 case of V. vulnificus infection in Japan including ours, the complication of diabetes mellitus, one of immunocompromised condition, was found only in 11%, although it had been reported that individuals strongly suspected of having diabetes were 17.2% among the Japanese male population aged from 40 to 74 years. Because diabetes mellitus might be underdiagnosed in the previous reports, intensive examinations are considered to be necessary in order to correctly diagnose diabetes mellitus in patients with severe V. vulnificus infection.

关键词： Vibrio Vulnificus Primary Septicemia Necrotizing Fasciitis Liver Cirrhosis Diabetes Mellitus

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Stage at diagnosis of colorectal cancer through diagnostic route:Who should be screened?

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World Journal of Gastroenterology 2024年第10期30卷 1368-1376页

作者： Nobukazu Agatsuma Takahiro Utsumi Yoshitaka Nishikawa Takahiro Horimatsu Takeshi Seta Yukitaka Yamashita Yukari Tanaka Takahiro Inoue Yuki Nakanishi Takahiro Shimizu Mikako Ohno akane Fukushima Takeo Nakayama Hiroshi Seno Department of Gastroenterology and Hepatology Kyoto University Graduate School of MedicineKyoto 606-8507Japan Department of Gastroenterology and Hepatology Japanese Red Cross Wakayama Medical CenterWakayama 640-8558Japan Department of Health Informatics Kyoto University School of Public HealthKyoto 606-8501Japan Institute for Advancement of Clinical and Translational Science(iACT) Kyoto University HospitalKyoto 606-8507Japan Medical Support Section Medical Affairs DivisionKyoto University HospitalKyoto 606-8507Japan

BACKGROUND Colorectal cancer(CRC)is a global health concern,with advanced-stage diagnoses contributing to poor *** efficacy of CRC screening has been well-established;nevertheless,a significant proportion of patients remain unscreened,with>70%of cases diagnosed outside *** identifying specific subgroups for whom CRC screening should be particularly recommended is crucial owing to limited resources,the association between the diagnostic routes and identification of these subgroups has been less *** the Japanese cancer registry,the diagnostic routes for groups discovered outside of screening are primarily categorized into those with comorbidities found during hospital visits and those with CRC-related *** To clarify the stage at CRC diagnosis based on diagnostic *** We conducted a retrospective observational study using a cancer registry of patients with CRC between January 2016 and December 2019 at two *** diagnostic routes were primarily classified into three groups:Cancer screening,follow-up,and *** early-stage was defined as Stages 0 or *** and univariate logistic regressions were exploited to determine the odds of early-stage diagnosis in the symptomatic and cancer screening groups,referencing the follow-up *** adjusted covariates were age,sex,and tumor *** Of the 2083 patients,715(34.4%),1064(51.1%),and 304(14.6%)belonged to the follow-up,symptomatic,and cancer screening groups,*** the 2083 patients,CRCs diagnosed at an early stage were 57.3%(410 of 715),23.9%(254 of 1064),and 59.5%(181 of 304)in the follow-up,symptomatic,and cancer screening groups,*** symptomatic group exhibited a lower likelihood of early-stage diagnosis than the follow-up group[P<0.001,adjusted odds ratio(aOR),0.23;95%confidence interval(95%CI):0.19-0.29].The likelihood of diagnosis at an early stage was similar between the follow-up and cancer screening gro

关键词： Colorectal neoplasms Cancer registry Diagnostic route Cancer screening Stage at diagnosis

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Osteopontin is a biomarker for early autoimmune uveoretinitis

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Neural Regeneration Research 2022年第7期17卷 1604-1608页

作者： Jeongtae Kim Meejung Ahn Yuna Choi Jiyoon Chun Kyungsook Jung akane Tanaka Hiroshi Matsuda Taekyun Shin Department of Anatomy Kosin University College of MedicineBusanRepublic of Korea Department of Animal Science College of Life ScienceSangji UniversityWonjuRepublic of Korea Department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJejuRepublic of Korea Functional Biomaterials Research Center Korea Research Institute of Bioscience and BiotechnologyJeonbukRepublic of Korea Laboratory of Comparative Animal Medicine Division of Animal Life ScienceInstitute of AgricultureTokyo University of Agriculture and TechnologyTokyoJapan

Osteopontin(OPN)is an extracellular matrix protein with a diverse range of functions,including roles in cell adhesion,migration,and immunomodulation,which are associated with the modulation of neuroinflammation in the central nervous *** present study was performed to evaluate the involvement of OPN in the eyes of an experimental autoimmune uveoretinitis(EAU)*** EAU model was developed by immunization of Lewis rats with interphotoreceptor retinoid-binding *** results showed the OPN level was remarkably upregulated in the eye of EAU rats on day 9 *** level of CD44,a ligand of OPN,was increased in the ciliary body of EAU ***,OPN was also detected in the ciliary body and activated microglia/macrophages in the EAU *** results suggest that OPN was significantly upregulated in the eyes of EAU rats,and that it may be useful as an early biomarker of ocular autoimmune *** animal experiments were approved by the Institutional Animal Care and Use Committee of Jeju National University(approval No.2020-0012)on March 11,2020.

关键词： CD44 ciliary body experimental autoimmune uveoretinitis macrophage Müller cell osteopontin photoreceptor cell retina

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Current status of disparity in liver disease

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World Journal of Hepatology 2022年第11期14卷 1940-1952页

作者： Tomoki Sempokuya Josh Warner Muaataz Azawi akane Nogimura Linda L Wong Division of Gastroenterology and Hepatology Department of Internal MedicineUniversity of Nebraska Medical CenterOmahaNE 68198United States Department of Internal Medicine University of Nebraska Medical CenterOmahaNE 68198United States Division of Gastroenterology and Hepatology Sanford Center for Digestive HealthSioux Falls 57105SDUruguay Department of Public Health Nagoya City University Graduate School of Medical SciencesNagoya 467-8601AichiJapan Division of Psychiatry and Cognitive-Behavioral Medicine Nagoya City University Graduate School of Medical SciencesNagoya 467-8601AichiJapan Department of Surgery John A.Burns School of MedicineUniversity of Hawaii at ManoaHonoluluHI 96813United States

Disparities have emerged as an important issue in many aspects of healthcare in developed countries and may be based on race,ethnicity,sex,geographical location,and socioeconomic *** liver disease specifically,these potential disparities can affect access to care and outcome in viral hepatitis,chronic liver disease,and hepatocellular *** in hepatologists and medical providers versed in liver disease may amplify these disparities by compromising early detection of liver disease,surveillance for hepatocellular carcinoma,and prompt referral to subspecialists and transplant *** the United States,continued efforts have been made to address some of these disparities with better education of healthcare providers,use of telehealth to enhance access to specialists,reminders in electronic medical records,and modifying organ allocation systems for liver *** review will detail the current status of disparities in liver disease and describe current efforts to minimize these disparities.

关键词： Disparity Transplant Race Age Gender Hepatitis

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Synchronous multiple lung cancers with hilar lymph node metastasis of small cell carcinoma:A case report

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世界临床病例杂志 2023年第25期11卷 5919-5925页

作者： Ryusei Yoshino Nana Yoshida Shunsuke Yasuda akane Ito Masaki Nakatsubo Sayaka Yuzawa Masahiro Kitada Thoracic Surgery and Breast Surgery Asahikawa Medical UniversityAsahikawa 078-8510Japan Diagnostic Pathology Asahikawa Medical University HospitalHokkaido 078-8510Japan

BACKGROUND Synchronous multiple lung cancers are rare and refer to the simultaneous presence of two or more primary lung tumors,which present significant challenges in terms of diagnosis and *** SUMMARY We report a case of multiple synchronous lung cancers with hilar lymph node metastasis of small cell carcinoma of unknown origin in a 73-year-old *** lung biopsy revealed squamous cell *** enlargement of lymph node 12u was detected,no distant metastases were *** patient was preoperatively diagnosed with T1cN0M0 and underwent thoracoscopic right upper lobectomy with nodal dissection(ND2a).Based on histopathological findings,the primary lesion was squamous cell carcinoma.A microinvasive adenocarcinoma was also observed on the cranial side of the primary *** were detected in two resected lymph nodes(#12u and#11s).Both tumors were pathologically diagnosed as small cell *** primary lesion of the small cell carcinoma could not be identified even by whole-body imaging;however,chemotherapy was initiated for hilar lymph node metastasis of the small cell carcinoma of unknown *** Multiple synchronous lung cancers can be accompanied by hilar lymph node metastasis of small cell carcinomas of unknown origin.

关键词： Small cell carcinoma Synchronous multiple lung cancers Squamous cell carcinoma Adenocarcinoma Chemotherapy Case report

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Throughfall and stemflow chemical dynamics of Satoyama, a traditional secondary forest system under threat in Japan

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Journal of Forestry Research 2022年第3期33卷 813-826页

作者： Satoshi Asaoka Fuyuhiko Sumikawa Yoshifumi Watanabe Waqar Azeem Jadoon Masaki Ohno Nobumichi Shutoh Yuki Wakamatsu Lawrence M.Liao akane Kanazawa Yuka Sato Natsumi Fujiwara Graduate School of Integrated Sciences for Life Hiroshima University1-4-4 KagamiyamaHigashi-Hiroshima739-8528Japan Research Center for Inland Seas Kobe University5-1-1 FukaeminamiHigashinadaKobe658-0022Japan Naragakuen Senior High School 430 YamadaYamatokoriyamaNara639-1093Japan Department of Environmental Sciences Faculty of Natural and Computational SciencesHazara UniversityDhodiaMansehra21130Khyber PakhtunkhwaPakistan Niigata University of Pharmacy and Applied Life Sciences 265-1 HigashijimaAkihaNiigata956-8603Japan Faculty of Science and Engineering Kindai University3-4-1 KowakaeHigashi-OsakaOsaka577-8502Japan Department of Maritime Science and Technology Japan Coast Guard Academy5 WakabaKureHiroshima737-8512Japan

The term 'Satoyama' refers to traditional and unique secondary forests in Japan that occupy intermediate zones between villages ('sato') and hills or mountains ('yama'). Satoyama landscapes help sustain ecosystem services and the diversity of secondary natural environments. As Japan relies more heavily on foreign timber imports, the traditional role of Satoyama in providing forest products has diminished, and this has led to their abandonment and poor management. The chemical behavior of cations, anions, and dissolved organic matter in throughfall and stemflow from one such threatened Satoyama system in central Japan was investigated. From autumn to winter, the atmospheric deposition of sulfates and nitrates was 2.5–6.0 times higher compared to the amounts in summer due to the intrusion of air masses from the Asian continent. The dissolved organic matter in the throughfall and stemflow was composed mainly of humic substances and protein derivatives. The deposition fluxes of dissolved organic carbon from throughfall (7.31–10.1 g m^(−2) a^(−1)) and stemflow (1.79–3.84 g m^(−2) a^(−1)) in this study were within ranges seen in temperate forests in previous studies. The deposition flux of sulfates was low compared to that in other forest types because canopy interaction was lower, suggesting higher canopy openness than in primary forests. If a shift from a mixed species Satoyama forest to a conifer-dominated forest occurs after the mass mortality of oak, the deposition flux of dissolved organic carbon and K^(+) might decrease by 33% and 62%, respectively, while NO_(3)^(−) might increase by 20%. In the near future, the degradation of Satoyama landscapes might change the levels of dissolved organic carbon and nitrogen loads, resulting in imbalances in river-ocean linkages affecting forested catchments and aquatic ecosystems in Japan.

关键词： Atmospheric deposition Dissolved organic matter Humic substance Mass mortality Oak trees Sustainable development goals

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Lead Removal from Aqueous Solutions Using Novel Gel Adsorbent Synthesized from Natural Condensed Tannin

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Chinese Journal of Chemical Engineering 2003年第4期11卷 426-430页

作者：占新民赵璇 akane Miyazaki YOSHIO Nakano State Key Joint Laboratory on Environment Simulation and Pollution Control Department of Environmental Science and Engineering Tsinghua University Beijing 100084 China Section of Environmental Technology Institute of Nuclear Energy Technology Tsinghua University Beijing 100084China Department of Environmental Chemistry and Engineering Interdisciplinary Graduate School of Science and Engineering Tokyo Institute of Technology Nagatsuta 4259 Midori-ku Yokohama 226-8502 Japan

Lead has caused serious environmental pollution due to its toxicity, accumulation in food chains and persistence in nature. In this paper, removal of lead from aqueous solutions is investigated using a novel gel adsorbent synthesized from natural condensed tannin. The novel adsorbent performs in aqueous solutions as a weak base with valid basic groups of 1.2mmol·g^-1 tannin gel particles and therefore results in the elevation of pH value of aqueous solutions. Even when initial pH is 3.6, final pH at equilibrium can climb up to 6.5 that is above the pH value for Pb(OH)2 precipitation formation and then lead can be removed from wastewater by this so-called surface precipitation. The adsorption isotherm can be expressed by the Langmuir equation and the maximum capacity for adsorption of Pb is up to 92mg·g^-l(based on dry adsorbent) when initial pH value is 3.6. Hence, the adsorbent does offer favorable properties in lead removal with respect to its high adsorption capacity at low initial pH value,which is advantageous to lead removal from acidic wastewater. A model is put forward to describe the individual adsorption phenomenon of the tannin gel adsorbent.

关键词：天然浓缩丹宁合成凝胶吸附剂表面沉淀水溶液铅分离

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Preparation,characterization and catalytic behavior of Pt-Cu nanoparticles in methane combustion

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Journal of Natural Gas Chemistry 2011年第5期20卷 537-542页

作者： Florica Papa Catalin Negrila Gianina Dobrescu akane Miyazaki Ioan Balint Institute of Physical Chemistry of the Romanian Academy Spl.Independentei 202 National Institute of Material Physics Department of Chemical and Biological Sciences Faculty of Science Japan Women's University

Fine and well dispersed Pt-Cu bimetallic nanoparticles stabilized by polyvinyl pyrrolidone （PVP） were synthesized by alkaline polyol method. The molar ratio of Pt to Cu was 1 ： 1. Further, the Pt-Cu bimetallic nanoparticles were supported on alumina and their catalytic behavior in methane combustion was investigated. The as-prepared as well as the supported Pt-Cu nanoparticles were characterized by transmission elec- tron microscopy （TEM）, X-ray photoelectron spectroscopy （XPS）, fractal analysis and X-ray diffraction （XRD）. The dependence of methane combustion on the morphology and surface composition of Pt-Cu nanoparticles was analyzed based on the experimental results.

关键词： Pt-Cu bimetallic catalyst methane combustion polyol method Pt-Cu nanoparticle

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Rapid Decrease and Subsequent Increase in the Serum Triglycerides Accompanied by CD36 Transcript Increase in an Acute Stress Mice Model

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Journal of Biosciences and Medicines 2022年第10期10卷 98-107页

作者： Reiko Seki Riku Miyawaki akane Matsuda Kazuhisa Nishizawa Teikyo University School of Medical Technology Tokyo Japan Biomolecular Logic Research Laboratory Tokyo Japan

In this article, we report the changes in serum triglyceride (TG) levels that occurred during repeated tail blood sampling using a mouse restrainer. We used three groups of mice, namely, “PBS-restrained” “PBS-unrestrained” and “mock-restrained”. The mice in the PBS-restrained and PBS-unrestrained groups were intraperitoneally (i.p.) injected with 100 mL PBS and tail blood sampling was performed at 1, 5, 8, 24, and 48 h after i.p. injection. For the mock-restrained group, no i.p. injection was performed whereas the subsequent tail blood sampling was similarly performed. During the tail blood sampling, the mice of the two “restrained” groups were placed inside the restrainer designed from an open-ended 50 mL conical tube. The blood from the mice in the PBS-unrestrained group mice was sampled from the tail held by the operator’s hands while being allowed to move on a stage. Strikingly, in all of the three groups, the serum TG level initially decreased to remarkably low levels (approximately 30 mg/dL) after several blood samplings were performed over 8 h. This decrease was followed by a 2 - 3-fold increase in the levels relative to that in the control mice in the subsequent 24 - 48 h time period. We concluded that the acute stress associated with blood sampling caused alterations in TG levels. Serum levels of free fatty acid showed only modest changes. Changes in TG levels were not associated with serum corticosterone levels but with a dramatic increase in CD36 transcript levels in the liver. The relevance of this finding to the previously reported release of lipoprotein lipase (LPL) from white fatty tissue into the plasma during acute stress is also discussed.

关键词： Acute Stress Lipoprotein Lipase CD36 Plasma Triglyceride

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