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Reactive uveitis, retinal vasculitis and scleritis as ocular end-stage of Acanthamoeba keratitis: a histological study

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International Journal of Ophthalmology(English edition) 2019年第12期12卷 1966-1971页

作者： Lei Shi Tobias Hager Fabian Norbert Fries Loay Daas Leonard Holbach Carmen Hofmann-Rummelt Elena Zemova Berthold Seitz Nóra Szentmáry Department of Ophthalmology Saarland University Medical CenterHomburg/Saar 66424Germany Department of Ophthalmology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvincePR.China Department of Ophthalm ology Friedrich-A lexander University Erlangen-NiimbergErlangen 91052Germany Department of Ophthalmology Semmelweis UniversityBudapest 1093Hungary

We analysed histologically two Acanthamoeba keratitis(ak) eyes with anterior and posterior segment inflammation and blindness. Two enucleated eyes of 2 patients(age 45 and 51y) with ak(PCR of epithelial abrasion positive) were analysed. Histological analysis was performed using hematoxylin-eosin, periodic acid-Schiff and G?m?rimethenamine silver staining. We could not observe Acanthamoeba trophozoites or cysts neither in the cornea nor in other ocular tissues. Meanwhile, we found uveitis, retinal vasculitis and scleritis in these eyes, due to the long-standing, recalcitrant ak. So in this stage of ak, systemic immune suppression may be necessary for a longer time period.

关键词： Acanthamoeba keratitis enucleation uveitis retinal vasculitis scleritis

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采用强化降压方案后,美国成年人潜在死亡率减少,但严重不良事件发生率增加——美国国家健康和营养调查的预测

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中华高血压杂志 2017年第4期25卷 307-307页

作者：刘莉叶鹏 Bress AP Kramer H Khatib R Beddhu S Cheung ak Hess R Bansal VK Cao G Yee J Moran AE Durazo-Arvizu ra Muntner P Cooper RS

收缩压干预试验（systolic blood pressure intervention trial,SPRINT）结果显示,在有高心血管病风险,但无糖尿病、脑卒中或心力衰竭的美国成年人中,相对于收缩压〈140mmHg（1mmHg=0.133kPa）的目标,以收缩压〈120mmHg为目标时的全因... 详细信息

收缩压干预试验（systolic blood pressure intervention trial,SPRINT）结果显示,在有高心血管病风险,但无糖尿病、脑卒中或心力衰竭的美国成年人中,相对于收缩压〈140mmHg（1mmHg=0.133kPa）的目标,以收缩压〈120mmHg为目标时的全因死亡率可降低27%。

关键词：营养调查国家健康降压目标干预试验 SPRINT systolic 心血管病抗高血压药物急性肾损伤标准应用

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Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study

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Journal of Clinical and Translational Hepatology 2021年第6期9卷 818-827页

作者： Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi CHESS Center Institute of Portal HypertensionThe First Hospital of Lanzhou UniversityLanzhouGansuChina CHESS Center The Sixth People’s Hospital of ShenyangShenyangLiaoningChina Department of Infectious Disease Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Microbiology and Infec-tious Disease Center School of Basic Medical SciencesPeking University Health Science CenterBeijingChina Depart-ment of radiology Zhongda HospitalMedical School of Southeast UniversityNanjingJiangsuChina Istanbul Health and Technology University Zytinburnu/İstanbulTurkey CHESS Working Party Xingtai People’s HospitalXingtaiHebeiChina Department of Hepatobiliary Surgery The Third People’s Hospital of ShenzhenShenzhenGuangdongChina Department of radiology Fifth Medical Center of PLA General HospitalBeijingChina Department of Gastroenterol-ogy Shandong Provincial Hospital Affiliated to Shandong UniversityJinanShandongChina Department of radiology IRCCS Azienda Ospedaliero-Universitaria di BolognaUniversity of BolognaItaly Department of radiology Ankara University School of MedicineAnkaraTurkey Department of Gastroenterology Ankara University School of MedicineAnkaraTurkey Department of Hepatobiliary Surgery People’s Hospital of Ningxia Hui Autonomous RegionYinchuanNingxiaChina

Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in ***:In this international multicenter,diagnostic study(***,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November *** segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface ***:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(praining and validation cohorts,*** area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,*** intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,***:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive ***,this score could be used to detect CSPH in patients with cirrhosis.

关键词： Liver cirrhosis Advanced chronic liver disease Hepatic venous pressure gradient Liver surface nodularity Imaging

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肺泡死腔分数可区分儿童急性呼吸窘迫综合征病死率

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中国小儿急救医学 2016年第2期23卷 141-141页

作者：方伯梁 Yehya N Bhalla ak Thomas NJ 首都医科大学附属北京儿童医院

目的生理死腔与急性呼吸窘迫综合征（acute respiratory distress syndrome,ARDS）病死率有关,但测量极为困难。肺泡死腔分数（alveolar dead space fraction,AVDSf）可根据动脉及呼气末二氧化碳分压差计算[AVDSf=(PaCO;-P;CO;)/PaCO;)]。本研究旨在评估同时满足ARDS（2012柏林及1994 AECC急性肺损伤标准）及儿童ARDS（pediatric ARDS,PARDS,2015 PALICC制定）诊断标准的患儿AVDSf与病死率之间的关系。PICU内哪些患儿需讨论限制及停止生命支持/Limiting and withdrawing life support in the pediatric intensive care unit:for whom are these options discussed?Keele L,Meert KL,Berg ra,et *** Crit Care Med,2016,17（2）:110-120.关键词做决定;死亡;FICU;婴儿;儿童摘要目的美国PICU内多数患儿死亡发生于决定限制或停止生命支持之后（limit or withdraw life support,LWLS）。本研究旨在描述PICU住院期间家属及医生讨论LWLS患儿的临床特点及预后,并确定LWLS讨论相关因素。设计既往曾随机抽取儿童重症监护研究合作网（Collaborative Pediatric Critical Care Research Network,CPCCRN）附属PICUs内2011年12月4日到2013年4月7日间住院患儿并前瞻性收集其相关数据资料,本次研究对所获数据进行二次分析。场所七家CPCCRN附属临床基地。对象10078例18岁以下、于PICU住院且住院时非濒死

关键词：儿童急性呼吸窘迫综合征 ARDS PARDS 肺泡死腔分数 AVDSf

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