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Shunting,optic nerve sheath fenestration and dural venous stenting for medically refractory idiopathic intracranial hypertension:systematic review and meta-analysis

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Annals of Eye Science 2018年第1期3卷 169-183页

作者： Daniel B.Scherman Adam A.Dmytriw Gia Thanh Nguyen Nhan Thi Nguyen Nana Tchantchaleishvili Julian Maingard Hamed Asadi Mark Brooks Christoph Griessenauer Christopher Ogilvy ajith J.thomas Justin M.Moore Kevin Phan NeuroSpine Surgery Research Group(NSURG) Prince of Wales Private HospitalSydneyAustralia Department of Neurosurgery Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonUSA Hue University of Medicine and Pharmacy Hue CityVietnam University of Medicine and Pharmacy Ho Chi Minh CityVietnam Interventional Neuroradiology Service Department of RadiologyAustin HospitalMelbourneAustralia Interventional Neuroradiology Unit Monash ImagingMonash HealthMelbourneAustralia Faculty of Health School of MedicineDeakin UniversityWaurn PondsAustralia Department of Neurosurgery Geisinger Health SystemDanvilleUSA Department of Neurosurgery Stanford UniversityStanfordUSA

Background:Cerebrospinal fluid(CSF)-diversion procedures have traditionally been the standard of treatment for patients with medically refractive idiopathic intracranial hypertension(IIH).However,dural venous sinus stent(VSS)placement has been described as a safe and effective procedure for the management of medically refractive *** performed a meta-analysis comparing outcomes and complications of CSF-diversion procedures,VSS and optic nerve sheath fenestration(ONSF)for the treatment of medically refractive ***:Electronic searches were performed using six databases from 1988 to January *** was extracted and meta-analysed from the identified ***:From 55 pooled studies,there were 538 CSF-diversion cases,224 dural venous stent placements,and 872 ONSF *** improvements were found in terms of postoperative headaches(CSF *** ***:84%vs.78%vs.62%,P=0.223),papilledema(CSF *** ***:71%vs.86%vs.77%,P=0.192),whilst visual acuity changes favored venous stenting(CSF *** ***:55%vs.69%vs.44%,P=0.037).There was a significantly lower rate of subsequent procedures with venous stent placement(CSF *** ***:37%vs.13%vs.18%,P<0.001),but other complication rates were similar(CSF *** ***:13%vs.8%vs.14%,P=0.28).Subgroup analysis of lumbar-peritoneal *** shunts found no differences in symptom improvements,complications and subsequent procedure ***:Our findings suggest that dural venous sinus stenting may be a viable alternative to traditional surgical interventions in patients who are refractory to medical treatment.

关键词： Cerebrospinal fluid diversion procedures(CSF-diversion procedures) idiopathic intracranial hypertension(IIH) optic nerve sheath fenestration(ONSF) venous sinus stent placement(VSS)

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Common polymorphisms of protein tyrosine phosphate non-receptor type 2 gene are not associated with risk of Crohn’s disease in Indian

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World Journal of Gastrointestinal Pathophysiology 2022年第4期13卷 114-123页

作者： Kaushik Chatterjee Amit Kumar Dutta Ashish Goel Rekha Aaron Vijayalekshmi Balakrishnan ajith thomas Anoop John Rajeeb Jaleel Deepu David Reuben thomas Kurien SD Chowdhury Ebby George Simon AJ Joseph Prasanna Premkumar Anna B Pulimood Department of Gastrointestinal Sciences Christian Medical College and HospitalVellore 632004Tamil NaduIndia Department of Gastroenterology Christian Medical CollegeVellore 632004Tamil NaduIndia Departments of Biostatistics Christian Medical CollegeVellore 632004Tamil NaduIndia

BACKGROUND Multiple genetic risk factors for Crohn’s disease(CD)have been ***,these observations are not consistent across different *** protein tyrosine phosphate non-receptor type 2(PTPN2)gene plays a role in various aspects of host defense including epithelial barrier function,autophagy,and innate and adaptive immune *** common polymorphisms in the PTPN2 gene(rs2542151 and rs7234029)have been associated with risk of CD in Western *** To evaluate the association of PTPN2 gene polymorphisms with risk of CD in Indian *** We conducted a prospective case-control *** with CD were recruited,and their clinical and investigation details were *** were patients without organic gastrointestinal disease or other comorbid *** common polymorphisms in the PTPN2 gene(rs2542151 and rs7234029)were *** was extracted from peripheral blood samples of cases and controls and target DNA was amplified using specific sets of *** amplified fragments were digested with restriction enzymes and the presence of polymorphism was detected by restriction fragment length *** frequency of alleles was *** frequencies of genotypes and alleles were compared between cases and controls to look for significant *** A total of 108 patients with CD(mean age 37.5±12.7 years,females 42.6%)and 100 controls(mean age 39.9±13.5 years,females 37%)were *** the single nucleotide polymorphism(SNP)rs7234029,the overall frequency of G variant genotype(AG or GG)was noted to be significantly lower in the cases compared to controls(35.2%vs 50%,P=0.05).For the SNP rs2542151,the overall frequency of G variant genotype(GT or GG)was noted to be similar in cases compared to controls(43.6%vs 47%,P=0.73).There were no significant differences in minor allele(G)frequency for both polymorphisms between the cases and *** the SNPs had no significant association with a

关键词： PTPN2 gene Crohn’s disease Genetic polymorphism Case-control study Asia Risk factor

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