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New U-Pb-Hf zircon isotope data for the Paleoproterozoic Ubendian belt in the Chimala area,SW Tanzania

Geoscience Frontiers 2019年第6期10卷 1993-2006页

作者： Robert j.thomas joachim jacobs Marlina A.Elburg Abdul Mruma Godson Kamihanda Anthony Kankila Alex Masanja Hamisi Saidi Council for Geoscience 3 Oos StreetBellvilleCape Town7535South Africa Department of Earth Science University of BergenPO Box 7803Norway Department of Geology University of JohannesburgPO Box 524Auckland Park2006South Africa Geological Survey of Tanzania DodomaTanzania

We present new U-Pb and Hf zircon isotope data on a suite of granitoids from a hitherto unstudied area of the Palaeoproterozoic Lupa terrane of the Ubendian belt in SW *** major part of the area comprises a sequence of upper amphibolite grade paragneisses and ***,the field relations show a complex history of granitoid emplacement from early pre-tectonic strongly foliated diorite-tonalite-granodiorite orthogneiss to late tectonic,weakly deformed ellipsoidal granitoid *** were followed by emplacement of undeformed K-feldspar rich porphyritic alkali granite.U-Pb zircon data on the granitoids show their emplacement ages span the period^1925 Ma to 1890 Ma and constrain the culmination of the Ubendian orogeny in the Lupa terrane to about 1900 *** undeformed K-feldspar rich Chimala granite,previously considered to be unconformably overlain by the Buanji Group volcano-sedimentary rocks(recently shown to be^1675 Ma,not Neoproterozoic as originally thought)was dated at^1407 Ma showing that it must intrude the sedimentary rocks,although the age relationships are not exposed in the mapping *** is the first record of early Irumide/Kibaran-aged post-tectonic granites in this part of East *** isotope data from the zircons show that the granitoids have a long crustal pre-history stretching back to as far as^3.9 Ga,and showing that the Lupa terrane may form part of the"metacratonic"margin of an originally much more extensive Tanzania Craton.

关键词： Ceochronology Tanzania Ubendian Palaeoproterozoic Mesoprorerozoic

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幼体生长发育特征可导致橙腹田鼠的单配体制吗?(英文)

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兽类学报 2014年第2期34卷 122-128页

作者： Timothy Bushyhead j.thomas Curtis Department of Pharmacology and Physiology Oklahoma State University Center for Health Sciences

橙腹田鼠(Microtus ochrogaster)和草原田鼠(***)是两种亲缘关系很近,但有着完全不同交配体制的田鼠。本文试图通过他们头骨的形态学比较来验证幼体生长发育(paedomorphosis)可以印证单配制交配体制进化的假说。通过几种头骨的测量,我... 详细信息

橙腹田鼠(Microtus ochrogaster)和草原田鼠(***)是两种亲缘关系很近,但有着完全不同交配体制的田鼠。本文试图通过他们头骨的形态学比较来验证幼体生长发育(paedomorphosis)可以印证单配制交配体制进化的假说。通过几种头骨的测量,我们发现草原田鼠头骨的长与宽比例大于橙腹田鼠,说明前者具有相对狭长的头骨。进一步的测量发现,这种不同是由于草原田鼠具有相对较长的鼻骨造成的。最后,我们对同种内成年和幼年的头骨进行了比较,发现单配制的橙腹田鼠相对于多配制的草原田鼠,其成年的头骨与幼年的头骨更相似。这些测量结果说明与多配制的田鼠相比,单配制的田鼠在形态及行为上保留更多的幼年状态,而这种行为很可能与其交配体制有关。

关键词：橙腹田鼠草原田鼠幼体生长发育头骨形态单配制

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Omega-6支撑身体,Omega-3支撑大脑:均衡摄入对儿童大脑发育的影响

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粮油食品科技 2022年第3期30卷 7-15页

作者： j.thomas BRENNA 德克萨斯大学奥斯汀分校戴尔医学院美国奥斯汀TX 78723 康奈尔大学伊萨卡美国纽约NY 14853

人体大脑和身体的发育,需要从食物中摄取均衡的营养物质。人类大脑是区分人类和其他动物的特征。食物中的必需脂肪酸是机体组织结构和功能的必要组成部分。Omega-6(O6)亚油酸(LA6)是皮肤组织的组成成分,且是炎症、血栓形成、免疫和其他... 详细信息

人体大脑和身体的发育,需要从食物中摄取均衡的营养物质。人类大脑是区分人类和其他动物的特征。食物中的必需脂肪酸是机体组织结构和功能的必要组成部分。Omega-6(O6)亚油酸(LA6)是皮肤组织的组成成分,且是炎症、血栓形成、免疫和其他信号分子的前体;Omega-3(O3)α-亚麻酸(ALA3),特别是其长链代谢产物——二十二碳六烯酸(DHA3),是大脑、视网膜和部分神经组织中的关键组分。从富含LA6脂肪酸(缺乏O3脂肪酸)的植物籽中提取出的廉价而优质油脂,是20世纪的西方国家食品工业生产的主要脂肪来源。在代谢通路中,高浓度的LA6脂肪酸可拮抗O3脂肪酸代谢,造成O3脂肪酸不足,因此,在给怀孕动物的饲料中,只提供富含LA6但缺乏O3脂肪酸的油脂作为唯一的脂肪来源,会导致幼崽大脑发育不良。过去20~30年的研究表明,低含量LA6且含DHA3的油脂可改善大脑的功能。近年来的研究较多集中在营养因素对大脑发育的影响,最新研究数据表明,脂肪酸平衡对营养不良儿童的大脑发育尤为重要。世界卫生组织(WHO)越来越重视大脑的营养健康,通过其下属的食品法典委员会,建议用于治疗严重急性营养不良儿童的即食治疗食品中,使用含有均衡脂肪酸组成/构成的脂肪。同样,脂肪酸均衡对老年人可能也很重要。目前,业界已经有了调整油脂成分的方法,以确保脂肪酸均衡,从而维持人体整个生命周期的大脑健康。

关键词：大脑发育二十二碳六烯酸 Omega-3脂肪酸 Omega-6脂肪酸高油酸油严重急性营养不良即食治疗性食品脂肪酸平衡

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Overview of Clostridium difficile infection:implications for China

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Gastroenterology Report 2013年第3期1卷 153-158页

作者： Xinhua Chen j.thomas Lamont Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

The incidence and severity of Clostridium difficile infection(CDI)have dramatically increased in the Western world in recent *** contrast,CDI is rarely reported in China,possibly due to *** article briefly summarizes CDI incidence,management and preventive *** authors intend to raise awareness of this disease among Chinese physicians and health workers,in order to minimize the medical and economic burden of a potential epidemic in the future.

关键词： Clostridium difficile C.difficile infection(CDI) treatment prevention

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单配制啮齿动物PairBond形成的神经调节机制(英文)

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兽类学报 2004年第2期24卷 160-172页

作者： Brandon j.Aragona j.thomas Curtis 刘彦汪作新 Department of Psychology and Program in Neuroscience Florida State University

单配制啮齿动物社会结构的神经生物学原理可以通过实验室研究Socialbonding而获得。在本文中,我们探讨了如何利用单配制的草原田鼠(Microtusochrogaster)作为研究模型揭示pairbond形成的神经调控机制。我们进而探讨了单配制与多配制田... 详细信息

单配制啮齿动物社会结构的神经生物学原理可以通过实验室研究Socialbonding而获得。在本文中,我们探讨了如何利用单配制的草原田鼠(Microtusochrogaster)作为研究模型揭示pairbond形成的神经调控机制。我们进而探讨了单配制与多配制田鼠之间神经解剖学的差异以及神经化学物质的调节是怎样影响pairbond的。本篇综述还讨论了与pairbond形成有关的神经化学系统之间的相互影响以及pairbond形成过程中的两性差异。最后,我们预测了这一研究领域的未来研究方向以及研究socialbonding的神经调控对人类健康的重要性。

关键词：多巴胺加压素催产素肾上腺皮质素单配制田鼠 Pair bond 神经调节机制

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Adjuvant therapy for gastric cancer:What have we learned since INT0116?

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World journal of Gastroenterology 2015年第13期21卷 3850-3859页

作者： Alexandre A jácome ajith K Sankarankutty josé Sebastiao dos Santos Department of Medical Oncology Hospital Mater DeiBelo Horizonte 30190-131Minas GeraisBrazil Department of Surgery and Anatomy University of Sao Paulo at Ribeirao PretoSchool of MedicineRibeirao Preto14049-900Sao PauloBrazil

Gastric cancer is one of the main cancer-related causes of death worldwide. The curative treatment of gastric cancer consists of tumor resection and lymphadenectomy. However, surgical treatment alone is associated with high recurrence rates. Adjuvant treatment strategies have been studied over the last decades, but there have been controversial results from the initial studies. The pivotal INT0116 study demonstrated that the use of adjuvant chemoradiotherapy with 5-fluorouracil increases relapse-free and overall survival, and it has been adopted across the Western world. The high toxicity of radiochemotherapy and suboptimal surgical treatment employed, with fewer than 10% of the patients submitted to D2 lymphadenectomy, were the main study limitations. Since its publication, other adjuvant treatment modalities have been studied, and radiochemotherapy is being refined to improve its efficacy and safety. A multimodal approach has been demonstrated to significantly increase relapsefree and overall survival, and it can be offered in the form of perioperative chemotherapy, adjuvant chemoradiotherapy or adjuvant chemotherapy, regardless of the extent of lymphadenectomy. The objective of the present review is to report the major advances obtained in the last decades in the adjuvant treatment of gastric cancer as well as the perspectives of treatment based on recent knowledge of the molecular biology of the disease.

关键词： Stomach neoplasms Adjuvant radiotherapy Adjuvant chemotherapy Histology Genes erbB-2

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Reporting of longitudinal pancreatojejunostomy with partial pancreatic head resection(the Frey procedure) for chronic pancreatitis: A systematic review

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Hepatobiliary & Pancreatic Diseases International 2021年第2期20卷 110-116页

作者： Minas Baltatzis Santhalingam jegatheeswaran ajith K Siriwardena Regional Hepato-Pancreato-Biliary Surgery Unit Manchester Royal InfirmaryOxford RoadManchester M139WLUK Faculty of Biology Medicine and HealthUniversity of ManchesterManchesterUK

Background:Longitudinal pancreatojejunostomy with partial pancreatic head resection(the Frey procedure)is accepted for surgical treatment of painful chronic ***,conduct and reporting are not standardized and thus,making comparisons *** study assesses the reporting standards of this *** sources:A systematic literature review was performed between january 1987 and january *** keyword and Medical Subject Heading"chronic pancreatitis"was used together with the individual operation term"Frey pancreatojejunostomy".Reports were included if they provided original information on conduct and ***-three papers providing information on 1205 patients constituted the study *** of bias in included reports was ***:Etiology of chronic pancreatitis(alcohol)was reported in 26 of 28(93%)studies,duration of symptoms prior to surgery in 19(58%)studies and pre-operative opiate use in 12(36%)*** terms of morphology,pancreatic duct diameter was reported in 17(52%)studies and diameter of the pancreatic head in 13(39%)*** terms of technique,three(9%)studies reported weight of excised *** were 9(0.7%)procedure-related ***-operative follow-up ranged from 6 to 82.5 *** studies reported post-operative portal ***:There is substantial heterogeneity between studies in reporting of clinical baseline,morphology of the diseased pancreas,operative detail and outcome after longitudinal pancreatojejunostomy with partial pancreatic head *** critically compromises the comparison between centers and between *** reporting is necessary for clinicians to assess choice of procedure and for patients to make informed choices when seeking treatment for painful chronic pancreatitis.

关键词： Chronic pancreatitis Frey procedure Reporting Longitudinal pancreatojejunostomy

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论述延长空气预热器使用寿命的方法步骤

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锅炉技术 1989年第7期20卷 17-20页

作者： j.thomas Neff 田安平 C-E预热器公司山东电力职工大学

由于空气预热器是整个电站运行工作的组成部分,在研究延长电站使用寿命的同时也必须把它考虑进去。本文论述:在延长回转再生式空气预热器使用寿命时,应遵循的主要方法步骤。

关键词：电站空气预热器使用寿命

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Neoadjuvant chemoradiotherapy before resection of perihilar cholangiocarcinoma: A systematic review

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Hepatobiliary & Pancreatic Diseases International 2020年第2期19卷 103-108页

作者： Minas Baltatzis Santhalingam jegatheeswaran ajith K.Siriwardena Regional Hepato-Pancreato-Biliary Surgery Unit Manchester Royal InfirmaryOxford RoadManchester M139WLUK Faculty of Biology Medicine and HealthUniversity of ManchesterManchester M139WLUK

Background: Treatment with neoadjuvant chemoradiotherapy followed by liver transplantation yields promising results in perihilar cholangiocarcinoma (PH-CCA). This study reviews the literature to assess whether there is evidence to justify modern phase Ⅱ studies of neoadjuvant chemoradiotherapy prior to resection of *** sources: A systematic review of the literature for reports of patients undergoing resection of PH- CCA after neoadjuvant chemoradiotherapy was performed using MEDLINE and EMBASE databases for the period between 1990 and 2019. The keywords and MeSH headings "hilar cholangiocarcinoma", "Klatskin", "chemoradiotherapy" and "chemotherapy" were used. Data were extracted on demographic profile, dis- ease staging, chemoradiotherapy protocols, complications and outcome. Risks of bias were assessed using Cochrane methodology. Results: There were seven reports on this topic, with median recruitment period of 14 (range 4–31) years. The total number of patients in these studies was 87. Interval from completion of neoadjuvant treatment to surgery varied from 3 days to 6 months. Resection was by hepatectomy with three studies reporting an R0 rate of 100%, 24% and 63%, respectively. Three studies reported histopathological evidence of prior treatment response. There were two treatment related deaths at 90 days. Median survival was 19 (95% CI: 9.9–28) months and 5-year survival 20%. Conclusions: There are potential benefits of treatment on both R0 rate and complete response in resected specimens. Scientific equipoise exists in relation to neoadjuvant chemoradiotherapy for PH-CCA.

关键词： Perihilar cholangiocarcinoma Neoadjuvant Chemotherapy Radiotherapy Surgery

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Multidisciplinary management of patients with post-inflammatory pancreatic necro

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Hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 1-3页

作者： Santhalingam jegatheeswaran joe Geraghty ajith K Siriwardena Regional Hepato-Pancreato-Biliary Surgery Unit Manchester Royal InfirmaryOxford RoadManchester M139WLUK Department of Gastroenterology Manchester Royal InfirmaryOxford RoadManchester M139WLUK Faculty of Biology Medicine and HealthUniversity of ManchesterManchester M139PLUK

Current knowledge of the pathophysiology of acute pancreatitis indicates that pancreatic injury originates at the acinar cell level and then extends through a spectrum of damage ranging from mild peri-acinar inflammatory infiltration and edema to extensive pancreatic parenchymal and peri-pancreatic necrosis[1,2].Clinical acute pancreatitis correlates closely with this range of injury with the majority of patients experiencing mild disease,some having transient organ dysfunction which typically recovers after adequate resuscitation(moderate acute pancreatitis)and a variable minority exhibiting sustained organ failure together with radiological evidence of pancreatic necrosis(severe acute pancreatitis)[2,3].Worldwide,the management of this latter category of patients with severe acute pancreatitis remains a *** is no effective direct medical treatment and there is no role for early pancreatic debridement[3,4].This article provides a concise summary of current multidisciplinary management of patients with post-inflammatory pancreatic necrosis.

关键词： acute patients sustained

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