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Linking stemness with colorectal cancer initiation, progression, and therapy

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World Journal of Stem Cells 2019年第8期11卷 519-534页

作者： Deepak narayanan Iyer Wai-Yan Sin Lui Ng Department of Surgery Li Ka Shing Faculty of Medicine The University of Hong Kong

The discovery of cancer stem cells caused a paradigm shift in the concepts of origin and development of colorectal cancer. Several unresolved questions remain in this field though. Are colorectal cancer stem cells the cause or an effect of the disease? How do cancer stem cells assist in colorectal tumor dissemination to distant organs? What are the molecular or environmental factors affecting the roles of these cells in colorectal cancer? Through this review, we investigate the key findings until now and attempt to elucidate the origins, physical properties, microenvironmental niches, as well as the molecular signaling network that support the existence, self-renewal, plasticity, quiescence, and the overall maintenance of cancer stem cells in colorectal cancer. Increasing data show that the cancer stem cells play a crucial role not only in the establishment of the primary colorectal tumor but also in the distant spread of the disease. Hence, we will also look at the mechanisms adopted by cancer stem cells to influence the development of metastasis and evade therapeutic targeting and its role in the overall disease prognosis. Finally, we will illustrate the importance of understanding the biology of these cells to develop improved clinical strategies to tackle colorectal cancer.

关键词： Cancer stem cell Colorectal cancer Tumor microenvironment Metastasis Extracellular matrix Tumor heterogeneity Resistance Stemness Quiescence Recurrence

Nonylphenol in bivalves and sediments in the northeast coast of China

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Journal of Environmental Sciences 2010年第11期22卷 1735-1740页

作者： Juan Wang Won-joon Shim Un-hynk Yim narayanan Kannan Donghao Li Key Laboratory of Nature Resources of Changbai Mountain and Functional Molecular Ministry of Education of China Yanbian University Yanji 133002 China. Oil and POPs Research Group Korea Ocean Research and Development Institute Geoje-shi 656-834 Korea

To understand nonylphenol （NP） contamination in the northeast coastal environment in China, NP was determined in 19 sediment and 20 bivalve samples collected during November 2005. NP was identified in all sediment samples in the range of 8.8 to 1.0 × 10^3 ng/g dw （dry weight）, with an average of 0.12 × 10^3 ng/g dw. Most of the bivalve samples （oysters and mussels） contained detectable amounts of NP that ranged from ND （not detected） to 7.6 × 10^3 ng/g dw, with an average value of 0.79 × 10^3 ng/g dw. These results indicated that NP is ubiquitous in sediments and bivalves from the northeast coast of China, and are even present in bivalves sold as seafood. Serious contamination with NP was recorded off the coast of Bohai Strait and in semi-enclosed coastal environment such as Jiaozhou Bay and Liaodong Bay. Possible environmental and human health implications were understood in this study.

关键词： nonylphenol Yellow Sea Bohai Sea sediment bivalve

High Throughput Scheduling Algorithms for Input Queued Packet Switches

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Computers, Materials & Continua 2022年第1期70卷 1527-1540页

作者： R.Chithra Devi D.Jemi Florinabel narayanan Prasanth Department of IT Dr.Sivanthi Aditanar College of EngineeringTiruchendur628205India Department of CSE Dr.Sivanthi Aditanar College of EngineeringTiruchendur628205India School of CSE Vellore Institute of TechnologyVellore632014India

The high-performance computing paradigm needs high-speed switching fabrics to meet the heavy traffic generated by their *** switching fabrics are efficiently driven by the deployed scheduling *** this paper,we proposed two scheduling algorithms for input queued switches whose operations are based on ranking *** first,we proposed a Simple 2-Bit(S2B)scheme which uses binary ranking procedure and queue size for scheduling the ***,the Virtual Output Queue(VOQ)set with maximum number of empty queues receives higher rank than other VOQ’*** simulation,we showed S2B has better throughput performance than Highest Ranking First(HRF)arbitration under uniform,and non-uniform traffic *** further improve the throughput-delay performance,an Enhanced 2-Bit(E2B)approach is *** approach adopts an integer representation for rank,which is the number of empty queues in a VOQ *** simulation result shows E2B outperforms S2B and HRF scheduling algorithms with maximum throughput-delay ***,the algorithms are simulated under hotspot traffic and E2B proves to be more efficient.

关键词： Crossbar switch input queued switch virtual output queue scheduling algorithm high performance computing

Properties of Sustainable High Strength Concrete with Waste Copper Slag

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Journal of Wuhan University of Technology(Materials Science) 2023年第4期38卷 815-822页

作者： JAGAN Sivamani KARUPASAMY narayanan DHARMARAJ R THIYANESWARAN Periyasamy KARTHIKEYAN Selvarajan NAVANEETHAN Kumaravalasu Subramaniam Department of Civil Engineering Sona College of TechnologySalem636005India Department of Civil Engineering KPR Institute of Engineering and TechnologyCoimbatore641407India Kongu School of Architecture Perundurai638060India Department of Civil Engineering Kongu Engineering CollegePerundurai638060India

The present work investigates copper slag as a substitute for river sand in high-strength *** concrete mixtures were manufactured with 10%,30%,50%,70%,and 100%of copper slag to evaluate the mechanical and durability *** experimental results indicate that replacing copper slag above 50%affects the performance characteristics of the concrete due to its high angularity and lower water absorption *** strength of concrete with 50%copper slag is improved by 5.6%,whereas the strength of concrete with 100%copper slag is reduced by 2.75%at 28 ***,increased curing to 90days improves the strength of the former by 7.16%and reduces the latter by only 0.23%.The water absorption,porosity,and rapid chloride penetration of the concrete mixtures with 100%copper slag are increased by 10.44%,13.20%,and 19.56%compared to control ***-structural investigations through SEM infer higher replacement of copper results in higher void formation due to its reduced water absorption.

关键词： copper slag high strength concrete strength water absorption porosity

Frequency regularization of a linked wind- diesel system using dual structure fuzzy with ultra-capacitor

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Protection and Control of Modern Power Systems 2022年第1期7卷 165-173页

作者： Gulshan Sharma K.narayanan T.Adefarati Sachin Sharma Department of Electrical Engineering Technology University of JohannesburgJohannesburg 2006South Africa Department of Electrical and Elec-tronics Engineering SASTRA DEEMED UNIVERSITYThanjavurIndia Department of Electrical and Electronic Engineering Federal University Oye EkitiOye EkitiNigeria Department of Electrical Engineering Graphic Era(Deemed to be University)DehradunIndia

Microgrids(μ-grids)are gaining increased interest around the world for supplying cheap and clean *** this paper,aμ-grid comprising a wind turbine generator(WTG)and diesel generator(DG)is *** is one of most practical and demanding systems suitable for the present energy crisis in isolated or rural ***,wind energy is intermittent in nature while load demand changes ***,aμ-grid can experience large frequency and power *** speed governor of the DG tries to minimize the frequency and power deviations inμ-grid though its operation is slow and cannot adequately minimize system *** paper proposes a novel arrangement based on a dual structured fuzzy(DSF)whose structure changes according to the switching limit with a reduced rule *** has the capability to switch between proportional and integral actions and hence improves the frequency regularization of theμ-*** proposed strategy is tested in aμ-grid and the results considering step load alteration,load alteration at different instants of time,nonstop changing load request are compared with some of the well published methods to validate the effectiveness and simplicity of the present *** addition,it shows that ultra-capacitor establishment in aμ-grid has a positive impact in minimizing system deviations with DSF for the studied cases.

关键词： Microgrid Wind generation Diesel generation Frequency control Dual mode fuzzy

Optimization of microwave-assisted extraction for picroside I and picroside II from Picrorrhiza kurroa using Box-Behnken experimental design

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Frontiers of Chemical Science and Engineering 2014年第4期8卷 445-453页

作者： Pravin WAKTE ajit PATIL Bhusari SACHIN Munnaza QUAZI Shraddha JABDE Devanand SHINDE Pharmaceutical Technology Division Department of Chemical Technology Dr. Babasaheb Ambedkar Marathwada University Aurangabad 431004 India

The response surface methodology was employed to study the optimization of microwave-assisted extraction of picroside I and picroside II from Picrorrhiza kurroa Royle rhizomes. The effects of solid to solvent ratio, and extraction temperature, time and solvent on the yields ofpicroside I and picroside II have been investigated using Box-Behnken experimental design. The experimen- tal data were fitted to second-order polynomial equations using multiple regression analysis and analyzed using the appropriate statistical method. By solving the regression equation and analyzing 3-D plots, the optimum extraction conditions were found to be： solid to solvent ratio, 10 ： 90 （w/v）; temperature, 60 ~C; and extraction time, 60 s. Under the optimal conditions, the yields of picroside I and picroside II are 41.23 and 6.12 *** feed respectively, which are in good agreement with the predicted values. The ratio of solid to solvent significantly affects the yields of picroside I and picroside II. Application of microwave- assisted extraction of picroside I and picroside II from P kurroa would dramatically reduce extraction time and solvent consumption.

关键词： microwave-assisted extraction picroside I,picroside II Picrorrhiza kurroa Box-Behnken design

Impact of surgery for chronic pancreatitis on the risk of pancreatic cancer:Untying the Gordian knot

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World Journal of Gastroenterology 2021年第27期27卷 4371-4382页

作者： Raja Kalayarasan Sankar narayanan Jayaprakash Sahoo Pazhanivel Mohan Department of Surgical Gastroenterology JIPMERPuducherry 605006India Department of Endocrinology JIPMERPuducherry 605006India Department of Medical Gastroenterology JIPMERPuducherry 605006India

Pancreatic ductal adenocarcinoma is an aggressive tumor with poor long-term *** pancreatitis(CP)is considered a risk factor for the development of pancreatic cancer(PC).Persistent pancreatic inflammation and activation of pancreatic stellate cells play a crucial role in the pathogenesis of CPrelated PC by activating the oncogene *** genetic mutations increase the possibility of recurrent and persistent pancreatic inflammation,they are not directly associated with the development of *** studies suggest that early surgical intervention for CP might have a protective role in the development of CP-related ***,the physician faces the clinical question of whether early surgical intervention should be recommended in patients with CP to prevent the development of ***,the varying relative risk of PC in different subsets of CP underlines the complex gene-environment interactions in the disease ***,it is essential to stratify the risk of PC in each individual *** review focuses on the complex relationship between CP and PC and the impact of surgical intervention on PC *** proposed risk stratification based on the genetic and environmental factors could guide future research and select patients for prophylactic surgery.

关键词： Chronic pancreatitis Pancreatic adenocarcinoma Pancreatic cancer Surgery Hereditary pancreatitis Pancreatitis

Comparison of Performances of Turbines for Wave Energy Conversion

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Journal of Thermal Science 2003年第4期12卷 323-327,343页

作者： Yoichi Kinoue Toshiaki Setoguchi Tomohiko Kuroda Kenji Kaneko Manabu Takao ajit Thakker Department of Mechanical Engineering Saga University 1 Honjo Saga 840-8502 Japan Dept. of Control Eng. Matsue National College of Tech. 14-4 Nishiikuma Matsue Shimane 690-8518 Japan Department of Mechanical & Aeronautical Engineering University of Limerick Limerick Ireland

The Wells turbine for a wave power generator is a self-rectifying air turbine that is available for an energy conversion in an oscillating water-air column without any rectifying valve. The objective of this paper is to compare the performances of the Wells turbines in which the profile of blade are NACA0020, NACA0015, CA9 and HSIM15-262123-1576 in the small-scale model testing. The running characteristics in the steady flow, the start and running characteristics in the sinusoidal flow and the hysteretic characteristics in the sinusoidal flow were investigated for four kinds of turbine. As a conclusion, the turbine in which the profile of blade is NACA0020 has the best performances among 4 turbines for the running and starting characteristics in the small-scale model testing.

关键词： fluid machinery Wells turbine airfoil wave energy conversion ocean energy.

Evaluation of root traits and water use efficiency of different cotton genotypes in the presence or absence of a soil-hardpan

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The Crop Journal 2021年第4期9卷 945-953页

作者： Ricardo St Aime Grace Rhodes Michael Jones BTodd Campbell Sruthi narayanan Department of Plant and Environmental Sciences Clemson UniversityClemsonSC 29634USA Medical University of South Carolina SC 29425USA Pee Dee Research and Education Center Clemson UniversityFlorenceSC 29506USA USDA-ARS Coastal Plain SoilWater and Plant Conservation ResearchFlorenceSC 29501USA

Cotton(Gossypium spp.) is an important fiber and oil crop grown worldwide. Water and nutrient stresses are major issues affecting cotton production globally. Root traits are critical in improving water and nutrient uptake and maintaining plant productivity under optimal as well as drought ***, root traits have rarely been utilized in cotton breeding programs, a major reason being the lack of information regarding genetic variability for root traits. The objective of this research was to evaluate ten selected cotton genotypes for root traits and water use efficiency. The tested genotypes included germplasm lines(PD 1 and PD 695) and cultivars that are currently grown in the southeastern USA(PHY 499 WRF, PHY 444 WRF, PHY 430 W3 FE, DP 1646 B2 XF, DP 1538 B2 XF, DP 1851 B3 XF, NG5007 B2 XF, and ST 5020 GLT). Experiments were conducted under controlled environmental conditions in 2018 and 2019. A hardpan treatment was included in the second year to evaluate the effect of a soil hardpan on root traits and water use efficiency. Genotype PHY 499 WRF ranked at the top and NG5007 B2 XF ranked at the bottom for root morphological traits(total and fine root length, surface area,and volume) and root weight. PHY 499 WRF was also one of the best biomass producers and had high water use efficiency. PHY 444 WRF, PHY 430 W3 FE, and PD-1 were the other best genotypes in terms of root traits and water use efficiency. All genotypes had higher values for root traits and water use efficiency under hardpan conditions. This trend indicates a horizontal proliferation of root systems when they incur a stress imposed by a hardpan. The genotypic differences identified in this research for root traits and water use efficiency would be valuable for selecting genotypes for cotton breeding programs.

关键词： Cotton Root traits Water use efficiency Hardpan Genetic variability