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WMO TYPHOON LANDFALL FORECAST DEMONSTRATION PROJECT(WMO-TLFDP) PROGRESS AND FUTURE PLANS

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Tropical Cyclone Research and Review 2016年第3期5卷 72-84页

作者： Xiaotu Lei Hui Yu Guomin Chen Barbara Brown Sai Tick Chan ajit Tyagi Shanghai Typhoon Institute National Center for Atmospheric Research Hongkong Observatory Indian Meteorological Society Shanghai Typhoon Institute National Center for Atmospheric Research Hongkong Observatory Indian Meteorological Society

The "WMO Typhoon Landfall Forecast Demonstration Project(TLFDP)" was started in May 2010 in conjunction with the start of the Shanghai World Expo 2010. The project was successful in terms of assisting the local forecasters in providing an efficient tropical cyclone(TC) forecast service for World Expo 2010, demonstrating the performance of the most up-to-date techniques in TC forecasting, and enhancing the ability of forecasters to effectively use products based on advanced TC forecasting techniques. The first phase was completed in December 2012 and the second phase was completed in December 2015. The third phase(TLFDP-III) started in *** its first(2010-2012) and second(2013-2015) phases, TLFDP collected real-time TC forecast products from 15 Typhoon Forecast Product Providers(TFPPs). The products include deterministic track and intensity forecasts, ensemble track and intensity forecasts, deterministic wind radii forecasts, wind probability forecasts, and gridded model outputs. The products were disseminated through the project's website and the operational website of the Shanghai Typhoon Warning *** has made significant progress in TC forecast verification, including setting up the tools for both realtime and post-season TC forecast verification, developing and integrating several new verification techniques, carrying out a survey on the operational status of TC forecast verification in the western North Pacific region, and contributing to the WMO document "Verification of tropical cyclone forecasts". The post-season forecast verification was reported to the Session of the UNESCAP/WMO Typhoon Committee since 2013. New consensus methods for TC track and intensity forecasts were also proposed either based on Ensemble Prediction Systems(EPSs) products or multiple deterministic NWP model products. Two training workshops on TC forecasting were organized by the TLFDP and held in Shanghai, China, in May 2010 and June 2012, respectively, and seven research

关键词： WMO Forecast Demonstration Project typhoon landfall evaluation and assessment

On Numerical Simulation of Black Carbon (Soot) Emissions from Non-Premixed Flames

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Journal of Geoscience and Environment Protection 2014年第4期2卷 15-24页

作者： ajit Patki Xianchang Li Daniel Chen Helen Lou Peyton Richmond Vijaya Damodara Lan Liu kader Rasel Arokiaraj Alphones Jenny Zhou Dan F. Smith Department of Chemical Engineering Lamar University Beaumont TX USA Department of Mechanical Engineering Lamar University Beaumont TX USA

Soot emissions (PM 2.5) from land-based sources pose a substantial health risk, and now are subject to new and tougher EPA regulations. Flaring produces significant amount of particulate matter in the form of soot, along with other harmful gas emissions. A few experimental studies have previously been done on flames burning in a controlled condition. In these lab-experiments, great effort is needed to collect, sample, and analyze the soot so that the emission rate can be calculated. Soot prediction in flares is tricky due to variable conditions such as radiation and surrounding air available for combustion. Work presented in this paper simulates some lab-scale flares in which soot yield for methane flame mixture was measured under different conditions. The focus of this paper is on soot modeling with various flair operating conditions. The computational fluid dynamics software ANSYS Fluent 13 is used. Different soot models were explored along with other chemistry mechanisms. The effect of radiation models, quantity of air supplied, different fuel mixture and its effect over soot formations were also studied.

关键词： Numerical Modeling Soot Emission Flames

Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse model

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Translational Neurodegeneration 2023年第1期12卷 70-89页

作者： Carolyn Tallon Benjamin J.Bell Medhinee M.Malvankar Pragney Deme Carlos Nogueras-Ortiz Erden Eren ajit G.Thomas kristen R.Hollinger Arindom Pal Maja Mustapic Meixiang Huang kaleem Coleman Tawnjerae R.Joe Rana Rais Norman J.Haughey Dimitrios kapogiannis Barbara S.Slusher Johns Hopkins Drug Discovery Johns Hopkins University School of MedicineBaltimoreMD 21205USA Neurology Johns Hopkins University School of MedicineBaltimoreMD 21205USA Cell Biology Johns Hopkins University School of MedicineBaltimoreMD 21205USA Oncology Johns Hopkins University School of MedicineBaltimoreMD 21205USA Medicine Johns Hopkins University School of MedicineBaltimoreMD 21205USA Pharmacology and Molecular Sciences Johns Hopkins University School of MedicineBaltimoreMD 21205USA Psychiatry and Behavioral Science Johns Hopkins University School of Medicine855 N.Wolfe StreetRangos 278BaltimoreMD 21205USA Intramural Research Program Laboratory of Clinical InvestigationNational Institute on AgingNational Institutes of Health251 Bayview BlvdSte 8C228BaltimoreMD 21224USA Johns Hopkins University School of Medicine 600 N.Wolfe StreetPathology 517BaltimoreMD 21287USA

Background Cognitive decline in Alzheimer’s disease(AD)is associated with hyperphosphorylated tau(pTau)propagation between neurons along synaptically connected networks,in part via extracellular vesicles(EVs).EV biogenesis is triggered by ceramide enrichment at the plasma membrane from neutral sphingomyelinase2(nSMase2)-mediated cleavage of *** report,for the first time,that human tau expression elevates brain ceramides and nSMase2 *** To determine the therapeutic benefit of inhibiting this elevation,we evaluated PDDC,the first potent,selective,orally bioavailable,and brain-penetrable nSMase2 inhibitor in the transgenic PS19 AD mouse ***,we directly evaluated the effect of PDDC on tau propagation in a mouse model where an adeno-associated virus(AAV)encoding P301L/S320F double mutant human tau was stereotaxically-injected unilaterally into the *** contralateral transfer of the double mutant human tau to the dentate gyrus was *** examined ceramide levels,histopathological changes,and pTau content within EVs isolated from the mouse *** Similar to human AD,the PS19 mice exhibited increased brain ceramide levels and nSMase2 activity;both were completely normalized by PDDC *** PS19 mice also exhibited elevated tau immunostaining,thinning of hippocampal neuronal cell layers,increased mossy fiber synaptophysin immunostaining,and glial activation,all of which were pathologic features of human *** treatment reduced these *** plasma of PDDC-treated PS19 mice had reduced levels of neuronal-and microglial-derived EVs,the former carrying lower pTau levels,compared to untreated *** the tau propagation model,PDDC normalized the tau-induced increase in brain ceramides and significantly reduced the amount of tau propagation to the contralateral *** PDDC is a first-in-class therapeutic candidate that normalizes elevated brain ceramides and nSMase2 activity,leading to the slo

关键词： Alzheimer’s disease Extracellular vesicles Neutral sphingomyelinase 2 Tau Ceramide

Effect of Projectile Break-Up Threshold Energy on Incomplete Fusion at Energy ≈ 4 - 7 MeV/Nucleon

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Journal of Modern Physics 2014年第18期5卷 2063-2074页

作者： Sabir Ali Tauseef Ahmad kamal kumar Isar Ahmad Rizvi Avinash Agarwal Sandeep S. Ghugre ajit kumar Sinha Ashok kumar Chaubey Department of Physics Aligarh Muslim University Aligarh India Department of Physics Bareilly College Bareilly India UGC-DAE Consortium for Scientific Research Kolkata India Department of Physics Addis Ababa University Addis Ababa Ethiopia

Complete and incomplete fusion cross sections have been measured for the 20Ne + 51V system to investigate the influence of projectile break-up at or above the barrier energies. The excitation function of the individual reaction channel measured using off-line γ-ray spectroscopy has been compared with those estimated theoretically using the statistical model code PACE4. A significant fraction of incomplete fusion has been found in the production of residues involving α-particle in the exit channel. In order to understand the energy dependence of incomplete fusion reactions, incomplete fusion fraction has been deduced, which has also been compared with the earlier data available for 12C and 16O projectiles to look for the projectile structure dependence.

关键词： Heavy Ion Induced Reaction Complete Fusion Incomplete Fusion Break-Up Reaction

Cardiovascular risk factors among older persons with cognitive frailty in middle income country

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World Journal of Clinical Cases 2024年第17期12卷 3076-3085页

作者： Azianah Mohamad Ibrahim Devinder kaur ajit Singh Arimi Fitri Mat Ludin Noor Ibrahim Mohamed Sakian Nurul Fatin Malek Rivan Suzana Shahar Centre for Healthy Ageing and Wellness Faculty of Health SciencesUniversiti Kebangsaan MalaysiaWilayah Persekutuan Kuala Lumpur 50300Malaysia Basic Medical Sciences University of CyberjayaSelangor Darul EhsanMalaysia 63000Malaysia

BACkGROUND Cognitive frailty,characterized by the coexistence of cognitive impairment and physical frailty,represents a multifaceted challenge in the aging *** role of cardiovascular risk factors in this complex interplay is not yet fully *** To investigate the relationships between cardiovascular risk factors and older persons with cognitive frailty by pooling data from two cohorts of studies in *** A comprehensive approach was employed,with a total of 512 communitydwelling older persons aged 60 years and above,involving two cohorts of older persons from previous *** related to cardiovascular risks,namely sociodemographic factors,and cardiovascular risk factors,including hypertension,diabetes,hypercholesterolemia,anthropometric characteristics and biochemical profiles,were pooled for *** frailty was defined based on the Clinical Dementia Rating scale and Fried frailty *** risk was determined using Framingham risk *** analyses were conducted using SPSS version *** Of the study participants,46.3%exhibited cognitive *** risk factors including hypertension(OR:1.60;95%CI:1.12-2.30),low fat-free mass(OR:0.96;95%CI:0.94-0.98),high percentage body fat(OR:1.04;95%CI:1.02-1.06),high waist circumference(OR:1.02;95%CI:1.01-1.04),high fasting blood glucose(OR:1.64;95%CI:1.11-2.43),high Framingham risk score(OR:1.65;95%CI:1.17-2.31),together with sociodemographic factors,i.e.,being single(OR 3.38;95%CI:2.26-5.05)and low household income(OR 2.18;95%CI:1.44-3.30)were found to be associated with cognitive *** Cardiovascular-risk specific risk factors and sociodemographic factors were associated with risk of cognitive frailty,a prodromal stage of *** identification and management of cardiovascular risk factors,particularly among specific group of the population might mitigate the risk of cognitive frailty,hence preventing dementia.

关键词： Cognitive frailty Older persons Cardiovascular risk factors Frailty Mild cognitive impairment

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钢框架非比例损伤识别

钢结构(中英文) 2010年第3期 86-87页

作者： Eric M. Lui ajit C. khanse

提出能够鉴别损伤位置和截面损伤严重程度的钢框架非比例破坏监测方法。所提出的方法由两部分组成,一是损伤识别,二是损伤严重程度分析。损伤识别和严重程度分析均以结构动力性质的变化作为损伤的判据,以此来确定损伤位置和严重程度。... 详细信息

提出能够鉴别损伤位置和截面损伤严重程度的钢框架非比例破坏监测方法。所提出的方法由两部分组成,一是损伤识别,二是损伤严重程度分析。损伤识别和严重程度分析均以结构动力性质的变化作为损伤的判据,以此来确定损伤位置和严重程度。所提方法中损伤判别的重要特点是能够在损伤严重程度分析之前,精确地区分不同的损伤区域。与整个结构尺寸相比,损伤区域相对较小,因此,确定损伤严重程度的计算量更小。检测方法的另一个特点是有些特征值或振型对噪声相对不敏感。采用所提检测方法对几个框架进行验证,结果表明,该方法能够成功地检测及量化截面的损伤。

关键词：损伤识别钢框架截面损伤结构动力学有限元

Diphtheria and Tetanus Antibody Persistence in Indian Pre-school Children and Response to a Booster Dose of DT Vaccine.

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World Journal of Vaccines 2011年第1期1卷 5-9页

作者： ajit M. Satwekar Shireen S. Telang Nilesh A. Ghorpade Prajakt J. Barde Moreshwar R. Patwardhan Prasad S. kulkarni 不详

Despite effective vaccines, diphtheria (D) resurged recently in the former socialistic block, and tetanus (T) still occurs in less privileged countries. We studied the antibody persistence for D and T in Indian pre-school children who had received four doses of DTP vaccine and subsequently, the response to a booster dose. Anti-D and anti-T IgG antibodies prior to and one month after a DT vaccine were measured by ELISA in 223 healthy children of 4-6 years who had previously received four doses of the triple vaccine. Adverse reactions were monitored for one month. While 30% and 14% of subjects were susceptible to D and T, respectively, 98% and 100% of them attained seroprotection post-vaccination. Both responses were significant. Local, but not systemic reactions except fever were rather common. A high proportion of the Indian pre-school population is susceptible to D and T, despite of receiving four doses. The current policy of giving the fifth dose at this age is appropriate.

关键词： Diphtheria tetanus antibodies India preschool children DT vaccine

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超轻质全复合材料桁架结构的弯曲性能研究

超轻质全复合材料桁架结构的弯曲性能研究

Breeding and biotechnological efforts in Jatropha curcas *** sustainable yields

第十六届全国复合材料学术会议

作者：鞠苏江大志肖加余 R ajit Shenoi 国防科学技术大学航天与材料工程学院南安普顿大学工程科学学院

利用人工引导预浸渍纤维束缠绕工艺整体成型三角形截面玻璃纤维/环氧全复合材料桁架;采用三点弯曲方式对桁架进行整体弯曲性能测试;利用数值计算方法对桁架的弯曲特性进行模拟。结果表明,该工艺制得的超轻质全复合材料桁架弯曲刚度达到3... 详细信息

利用人工引导预浸渍纤维束缠绕工艺整体成型三角形截面玻璃纤维/环氧全复合材料桁架;采用三点弯曲方式对桁架进行整体弯曲性能测试;利用数值计算方法对桁架的弯曲特性进行模拟。结果表明,该工艺制得的超轻质全复合材料桁架弯曲刚度达到33.75N/mm,失效载荷为405N;数值模拟的结果与实验结果偏差不大于7%。

关键词：超轻质结构复合材料桁架弯曲性能数值计算

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Oil Crop Science 2021年第4期6卷 180-191页

作者： S.Arockiasamy Jyothirmayi kumpatla Sainath Hadole Vijay Yepuri Manoj Patil Vineeta Shrivastava Chandrasekhara Rao Nagesh kancharla Saakshi Jalali Alok Varshney Neeta Madan Sai Pothakani Vinod Nair Sridhar Peyyala Vishwnadharaju Mudunuri Ananthan Gopal Niranjan S.kumar Jawahar Pachiyannan Satyanarayana Seelamanthula J.V.Narasimham Makarand Phadke Anindya B ajit Sapre Santanu Dasgupta Agronomy Division Reliance Technology GroupReliance Industries LtdGhansoliNavi Mumbai400701India Jatropha Breeding Station Reliance Industries LtdIDA-PeddapuramADB Road SamalkotaAndhra Pradesh533440India

Jatropha is a non-edible,important bioenergy plant,which can grow in marginalized *** seeds possess about 36%oil and this would be converted into biodiesel or *** provides an option for sustainable feed and fuel production due to its inherent qualities including hardy nature,drought tolerance and surviving with limited amount of water,tolerance to unfavorable conditions and excessive ***,heterozygosity,low productivity and poor understanding of its genome are the major impediments to elite line ***,classical breeding and advanced technological investments remain limited owing to long juvenile phase and breeding *** technologies that lead to identification of elite genotypes and development of high yielding elite Jatropha lines and effective methods of detoxification of seeds needs immediate *** tissue culture system,doubled haploids(DH)and genomic tools are increasingly made available to improve the seed yield and its oil quantity through the development of geminivirus disease resistant *** application of advanced,sequencing technologies has presented a repertoire of genomic information for this important yet orphan *** the present investigation,we highlight the achievements made in Jatropha towards development of high yielding,virus resistant elite lines and hybrids with yield potential ranging from 3 to 5 tons per hectare in a year,which is a first ever report in the *** also developed potential biotechnological tools such as genetic transformation,genome editing and next generation genomics tools including linkage maps and QTLs for accelerating breeding efforts through marker assisted *** of our concerted and continuous efforts during the past 15 years,we have overcome all the obstacles and developed high yielding,disease resistant hybrids/lines,advanced cultivation technologies with thorough knowledge on Agronomy of the Jatropha *** Jatropha cultivat

关键词： Breeding Hybrids Micropropagation Transformation Sequencing Mapping QTLs CRISPR