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Emergency and Critical Care Medicine 2024年第2期4卷 97-99页

作者： Sarfaraz Ahmad Neeraj kumar ajeet kumar Saravanan Palasevam Department of Anaesthesiology All India Institute of Medical Sciences PatnaBiharIndia

Introduction:Awake fiberoptic bronchoscopy has long been considered the criterion standard for the management of difficult airways because of large thyroid malignancies.After an unsuccessful attempt to intubate with a fiberoptic bronchoscope in the supine position,the decision to switch to the left lateral position was made.We present this case to propose the utilization of the lateral position for awake intubation.Case presentation:We report a rare case of a patient with a large papillary carcinoma of the thyroid planned for surgical excision.The patient presented to our hospital with complaints of difficulty breathing while lying down in the supine position and oozing blood from the necrotic tissue.The breathing difficulties subsided in the lateral position.Conclusion:We demonstrated how the left lateral position with an adjunct maneuver facilitates intubation in large thyroid malignancies.

关键词： Awake intubation Case report Lateral position Thyroid malignancy

Boosting the energy harvesting performance of cantilever structured magneto-mechano-electric generator by controlling magnetic flux intensity on magnet proof mass

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Journal of Materiomics 2023年第4期9卷 735-744页

作者： Deepak R.Patil Seungah Lee Atul Thakre ajeet kumar Hyunseok Song Dae-Yong Jeong Jungho Ryu School of Materials Science and Engineering Yeungnam UniversityGyeongsan38541South Korea Centre for Functional Materials Vellore Institute of TechnologyVellore632014TamilnaduIndia Department of Materials Science&Engineering Inha UniversityIncheon22212South Korea Institute of Materials Technology Yeungnam UniversityDaehak-roGyeongsan38541South Korea

A cantilever-structured magneto-mechano-electric(MME)generator comprising a magnetoelectric composite with a magnet proof mass is a potential candidate for powering autonomous wireless sensor networks.Recently,the concept of a magnetic flux concentrator(MFC)to enhance the output performance of the MME generator by focusing the ultralow-intensity magnetic field into the MME generator was introduced.However,the MFC-concentrated magnetic flux mostly focused on the end tip of the MME cantilever rather than at the magnet proof mass located on the cantilever beam.Considering that the torque generated by the magnet proof mass contributes more than half of the output power of an MME generator,optimizing the volume and position of the proof-mass with MFC is crucial for better performance.Furthermore,a smaller proof-mass is desirable for the long-term reliability of cantilevertype harvesters.Hence,we investigated the effect of the position and weight(volume)of the magnet proof mass with respect to the MFC on the output performance of the MME generator through finite element analysis and experiments.The MME generator with the lighter magnet proof mass at the optimized position generated a maximum power of 5.35 mW under a 10 Oe magnetic field,which was 210%of that of the MME configuration used in our previous study.Furthermore,the MME generator showed broadband characteristics around the practical frequency of 60 Hz,which could provide more freedom to design the harvester with high performance.

关键词： Magneto-mechano-electric Magnetic flux concentrator Magnet proof mass Broadband IoT sensor

AN EFFICIENT METHOD FOR MULTIOBJECTIVE OPTIMAL CONTROL AND OPTIMAL CONTROL SUBJECT TO INTEGRAL CONSTRAINTS

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Journal of Computational Mathematics 2010年第4期28卷 517-551页

作者： ajeet kumar Alexander Vladimirsky Department of Theoretical & Applied Mechanics Cornell University Department of Mathematics Cornell University

We introduce a new and efficient numerical method for multicriterion optimal control and single criterion optimal control under integral constraints. The approach is based on extending the state space to include information on a ＂budget＂ remaining to satisfy each constraint; the augmented Hamilton-Jacobi-Bellman PDE is then solved numerically. The efficiency of our approach hinges on the causality in that PDE, i.e., the monotonicity of characteristic curves in one of the newly added dimensions. A semi-Lagrangian ＂marching＂ method is used to approximate the discontinuous viscosity solution efficiently. We compare this to a recently introduced ＂weighted sum＂ based algorithm for the same problem [25]. We illustrate our method using examples from flight path planning and robotic navigation in the presence of friendly and adversarial observers.

关键词： Optimal control Multiobjective optimization Pareto front Vector dynamic programming Hamilton-Jacobi equation Discontinuous viscosity solution Semi-Lagrangian discretization.

COVID-19 presentation as acute pancreatitis:A case report

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Journal of Acute Disease 2022年第5期11卷 199-201页

作者： Abhyuday kumar A.Valiyaparambath Neeraj kumar Amarjeet kumar ajeet kumar Department of Anaesthesiology AIIMS PatnaBiharIndia801505 Departments of Trauma&Emergency AIIMS PatnaBiharIndia801505

Rationale:The gastrointestinal manifestations of COVID-19 include anorexia,nausea,vomiting,abdominal pain,and diarrhea.However,pancreatitis as the presentation of COVID-19 is rarely reported.Patient’s Concern:A 63-year-old COVID-19 patient presented with complaints of abdominal pain and difficulty breathing for 5 d.Diagnosis:Contrast-enhanced computed tomography of the abdomen suggested acute interstitial pancreatitis without any biliary tract obstruction.Interventions:The patient was resuscitated with intravenous fluids based on dynamic parameters of fluid responsiveness.The patient was started on enteral feeding,analgesics,antibiotics,dexamethasone,low molecular weight heparin,and supportive therapy.Outcomes:The patient developed severe acute respiratory distress syndrome and died 6 days after admission.Lessons:Management of COVID-19 in the presence of pancreatitis is challenging.Adequate early fluid resuscitation is an important aspect of medical management for COVID-19 patients with pancreatitis and restrictive strategies must be followed.Increased liver enzymes and renal dysfunction in acute pancreatitis can also limit the use of specific therapies like remdesivir.Dexamethasone,even though it has shown a beneficial effect in treating COVID-19,can have an additive effect in causing hyperglycemia in these cases.Clinicians should be aware of this atypical presentation of COVID-19 with pancreatitis and adjust their management strategies,keeping in mind the considerations for both diseases.

关键词： Pancreatitis COVID-19 APACHE II Remdesivir Fluid

Effect of flaxseed supplementation on metabolic state,endocrine profiles,body composition and reproductive performance of sows

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Asian pacific Journal of Reproduction 2021年第3期10卷 127-136页

作者： Sukhjinder Kaur Ashwani kumar Singh Mrigank Honparkhe ajeet kumar Prahlad Singh Udeybir Singh Department of Veterinary Gynaecology and Obstetrics Guru Angad Dev Veterinary and Animal Sciences UniversityLudhianaPunjabIndia Department of Animal Nutrition Guru Angad Dev Veterinary and Animal Sciences UniversityLudhianaPunjabIndia

Objective:To assess the effect of flaxseed supplementation on metabolic profile,endocrine concentrations,non-esterified fatty acids(NEFA),body composition variables,and reproductive performance of sows.Methods:All the 21 crossbred Large White Yorkshire sows were considered in the study period starting at day 1 of current farrowing when the feeding of specific supplemental ration was started until the day of subsequent farrowing(days 150-155)and were equally allocated into three groups.Group 1 served as the control group and followed their normal feeding schedule.Group 2 and group 3,in addition to their normal feeding schedule,were supplemented with flaxseed at a rate of 0.5%and 1.0%of the dry matter,respectively.Blood samples were collected 15 days prior to farrowing,on the day of farrowing(day 0),at weekly intervals until day 28 of lactation and at monthly intervals during gestation to harvest the plasma.Plasma was used to assess the metabolic and endocrine status of sows.Body weight of each sow and individual birth weight of all piglets born were measured.Results:Flaxseed supplementation led to decrease in plasma cholesterol and triglyceride levels in the supplemented groups than in the control group(P0.05).Conclusions:Flaxseed improves endocrine profiles,NEFA concentrations and body weight,resulting in better pregnancy rate and litter size.

关键词： Endocrine profile Flaxseed Non-esterified fatty acids Piglet mortality Pregnancy rate Sow

Improvement in cryosurvival of buffalo bull (Bubalus bubalis) sperm by altering freezing rate within critical temperature range

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Asian pacific Journal of Reproduction 2018年第2期7卷 72-78页

作者： Jasmer Dalal ajeet kumar Pradeep kumar Mrigank Honparkhe Vijay Singh Malik Sumit Singhal Simarjeet Kaur Parkash Singh Brar Department of Veterinary Gynaecology and Obstetrics Guru Angad Dev Veterinary and Animal Sciences UniversityLudhiana141004Punjab India Department of Buffalo Physiology and Reproduction Central Institute for Research on BuffaloHisar125001HaryanaIndia Livestock Farms Complex Guru Angad Dev Veterinary and Animal Sciences UniversityLudhiana141004Punjab India

Objective:To optimize the cryopreservation of buffalo bull semen by altering freezing rates within critical temperature range (4℃ to -60℃). Methods: A total of 20 ejaculates each from 5 Murrah buffalo bulls were cryopreserved using programmable biofreezer in 2 phases. In the 1st phase, 9 freezing rates were applied at -2, -5, -10, -20, -30, -40, -50, -60 or -4℃/min (control) from 4℃ to -15℃;at -40℃/min from -15℃ to -60℃. In the 2nd phase, a fixed freezing rate was applied at -30℃/min from 4℃ to -15℃. Six freezing rates were applied at -10, -20, -30, -40 (control), -50 or -60℃/min from -15℃ to -60℃. The freezing from -60℃ to -140℃ were fixed at -50℃/min in both the phases. Post thaw semen quality was assessed in terms of motility, viability, membrane integrity (hypo-osmotic swelling test), sperm abnormalities, and active mitochondria. Data were arc sine transformed and analyzed through one-way analysis of variance using SPSS software. Results: In the 1st phase, percent individual motility, progressive motility and viability were similar among various protocols. Percent hypo-osmotic swelling reactive sperm was higher with freezing at -30℃/min. In the 2nd phase, percent individual motility, viability and hypo-osmotic swelling reactive sperm was higher with freezing at -50℃/min. Sperm head abnormalities were lower at -30℃/min in the 1st phase, but were similar among the protocols of the 2nd phase. Percent active mitochondria were higher at -30℃/min in the 1st phase and at -50℃/min in the 2nd phase.Conclusions:The optimum post thaw semen quality of buffalo bull could be obtained by applying freezing rate at -30℃/min (4℃ to -15℃) and at -50℃/min (-15℃ to -140℃), followed by plunging of straws in into liquid nitrogen for storage.

关键词： Buffalo bulls Freezing rate Critical temperature range Programmed freezing

Reserpine Improves Working Memory

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Journal of Behavioral and Brain Science 2016年第3期6卷 107-112页

作者： Raghuraman Vasantharaja ajeet kumar Ashok kumar Jamuna R. Subramaniam Department of Biological Sciences and Bioengineering Indian Institute of Technology Kanpur India Center for Preclinical and Translational Medicine Research Central Research Facility Sri Ramachandra University Chennai India

Despite exhaustive search, no drug is in sight for AD. Earlier, we reported that reserpine, an antihypertensive and antipsychotic drug, ameliorates Amyloid beta (Aβ-AD causing peptide) toxicity and confers several positive enhancements in the C. elegans model system. Here, we evaluate whether reserpine can provide protection against working memory and against AD in the mouse model. Reserpine (0.08 mg) was administered orally on alternate days to the non-Tg and accelerated Aβ deposition (at 2 months of age)and cognitive deficit (4 months of age) developing 5XFAD AD Tg mouse model expressing mutant human APP (3 familial mutations) and human Presenilin1(2 familial mutations) in the neurons, and follow their working memory for 2 months using the spontaneous Y-maze alteration behavioral paradigm. Reserpine enhanced working memory in non-Tg mice and improved the cognitive deficit in the 5XFAD AD Tg mice. Hence, reserpine can be considered for a detailed evaluation in the 3X Tg AD mouse model and a pilot study in AD patients.

关键词： Alzheimer’s Disease Amyloid-β-Aβ Reserpine Cognitive Deficits Transgenic Mice Working Memory

Post Operative Sensorineural Hearing Loss Following Middle Ear Surgery—A Study of 100 Cases

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International Journal of Otolaryngology and Head & Neck Surgery 2018年第3期7卷 67-74页

作者： Antony Abraham Paulose ajeet kumar Nishi Sonkhya Department of Otorhinolaryngology & Head and Neck Surgery SMS Medical College & Hospital Jaipur Rajasthan India

Background: Drill and surgical tools can cause noise induced hearing loss when used on or adjacent to the ossicular chain and stapes footplate or while working on the mastoid bone. Therefore the drill generated noise has been incriminated as a cause of sensorineural hearing loss in the operated ear. Objective: This study has been undertaken to estimate the proportion of sensorineural hearing loss following middle ear surgery and to assess the bone conduction thresholds of operated ear following middle ear surgery at different follow up periods. Methods: 100 cases of chronic suppurative otitis media posted for middle ear exploration surgery were included in the study. Results: Sensorineural hearing loss was present in 3 cases out of 100 cases (3%) after undergoing mastoid surgery. There was a mean increase in bone conduction thresholds of 0.75 dB at 500 Hz, 1.4 dB at 1 kHz, 1.7 dB at 2 kHz and 2.7 dB at 4 kHz at 6th month of follow up period after surgery with statistical significance at 2 kHz (p = 0.011) and 4 kHz (p Conclusion: Post mastoidectomy hearing loss is of high frequency in nature.

关键词： Chronic Otitis Media Mastoidectomy Drill Induced Acoustic Trauma SNHL

Smart electrochemical sensing of amyloid-beta to manage total Alzheimer's diseases

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Neural Regeneration Research 2024年第6期19卷 1185-1186页

作者： ajeet Kaushik School of Engineering University of Petroleum and Energy Studies (UPES) NanoBioTech Laboratory Department of Environmental Engineering Florida Polytechnic University

Need for Alzheimer ’s disease progression monitoring: Alzheimer ’s disease(AD) is an irreversible progressive brain disorder that causes severe and incurable neuro-impairment. The World Health Organization estimates that 55 million people are affected by AD dementia by 2020 which may exceed 78 million by 2030 and 139 in 2050. The estimated cost to manage AD is above US$ 1.3 trillion, which will further increase to US$ 2.8 trillion by 2030.

关键词： IMMUNOSENSOR

Numerical modelling of post-failure behaviors of coal specimens

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 514-531页

作者： ajeet Yadav Bhaskara Behera Gauri Shankar Prasad Singh Sanjay kumar Sharma Department of Mining Engineering Indian Institute of Technology(Banaras Hindu University)VaranasiUttar Pradesh221005India

A modelling approach consisting of best-fit relations to estimate the post-yield strength parameters is presented for simulating post-peak behavior beyond the point of residual strength of coal pillars having different w/h ratios.The model was developed based on back-analysis of the complete stress-strain behavior of specimens belonging to six different Indian coal seams with different w/h ratios of 0.5 e13.5.It was found that the simultaneous degradation of the cohesion and friction angle of the Mohr-Coulomb rock material characterizes the post-peak strength behavior of the rock.The resulting expressions are simplistic as they require parameters that can be easily determined using uniaxial and triaxial compression results.Eventually,the developed model was validated by simulating the triaxial tests of coal specimens with different sizes under varying confining stresses and comparing its findings with the published test results.The study showed that its implementation in the numerical model could reproduce laboratory-observed mechanical response,deformation behavior,and failure mechanism very closely.

关键词： Strain softening Dilatancy Interface Shape effect Residual strength