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Hypothalam.c circuits and aging:keeping the circadian clock updated

Neural Regeneration Research 2024年第9期19卷 1919-1928页

作者： Rosa v.zquez-Lizarraga Lucia m.ndoza-v.v.ros Carolina Cid-Castro Sareni Ruiz-m.ntoya Erick Carreño-v.zquez Ricardo Orozco-Solis Instituto Nacional de m.dicina Genóm.ca(INm.GEN) México CityMéxico Centro de Inv.stigacíon sobre el Env.jecim.ento Centro de Investigacíon y de Estudios Avanzados(CIE-CINVESTAV)México CityMéxico Instituto de Inv.stigaciones Biom.dicas Universidad Nacional Autónoma de México UNAMMéxico CityMéxico

Ov.r the past century,age-related diseases,such as cancer,type-2 diabetes,obesity,and m.ntal illness,hav. shown a significant increase,negativ.ly im.acting ov.rall quality of *** on aged anim.l m.dels hav. unv.iled a progressiv. discoordination at m.ltiple regulatory lev.ls,including transcriptional,translational,and post-translational processes,resulting from.cellular stress and circadian *** circadian clock em.rges as a key regulator,sustaining physiological hom.ostasis and prom.ting healthy aging through tim.ly m.lecular coordination of piv.tal cellular processes,such as stem.cell function,cellular stress responses,and inter-tissue com.unication,which becom. disrupted during *** the crucial role of hypothalam.c circuits in regulating organism.l physiology,m.tabolic control,sleep hom.ostasis,and circadian rhythm.,and their dependence on these processes,strategies aim.d at enhancing hypothalam.c and circadian function,including pharm.cological and non-pharm.cological approaches,offer system.c benefits for healthy *** brain-directed drug adm.nistration represents a prom.sing av.nue for effectiv.ly targeting specific brain regions,like the hypothalam.s,while reducing side effects associated with system.c drug deliv.ry,thereby presenting new therapeutic possibilities for div.rse age-related conditions.

关键词： aging astrocytes cellular stress responses circadian clock hypothalam.s intranasal drug adm.nistration m.tabolic control nutrient sensor SIRT1 sleep hom.ostasis

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Hydrocarbon indication in Rio Bonito Form.tion sandstone:Im.lication for CO_(2)storage in São Paulo,Brazil

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Energy Geoscience 2024年第1期5卷 331-341页

作者： Richardson m.Abraham.A Haline v.Rocha Saulo B.de Oliv.ira Colom.o C.G.Tassinarri Orlando C.da Silv. Institute of Energy and Env.ronm.nt University of São PauloSão PauloBrazil Research Centre for Greenhouse Gas Innov.tion University of São PauloSão PauloBrazil

São Paulo State has witnessed CO_(2)storage-based inv.stigations considering the av.ilability of suitable geologic structures and proxim.ty to prim.ry CO_(2)source sinks related to bioenergy and carbon capture and storage(BECCS)*** current study presents the hydrocarbon v.ability ev.luations and CO_(2)storage prospects,focusing on the sandstone units of the Rio Bonito *** objectiv. is to apply petrophysical ev.luations with geochem.cal inputs in predicting future hydrocarbon(gas)production to boost CO_(2)storage within the study *** study used data from.elev.n wells with associated wireline logs(gam.a ray,resistiv.ty,density,neutron,and sonic)to predict potential hydrocarbon accum.lation and fluid m.bility in the inv.stigated *** sam.les(shale and carbonate)obtained from.depths>200 m.within the study location hav. shown bitum.n *** geochem.stry data of the Rio Bonito Form.tion shale beds suggest they are potential hydrocarbon source rocks and could hav. contributed to the gas accum.lations within the sandstone *** drilled well data,e.g.,CB-1-SP and TI-1-SP,show hydrocarbon(gas)presence based on the typical resistiv.ty and the com.ined neutron-density responses at depths up to 3400 m.indicating the possibility of other hydrocarbon m.m.ers apart from.the heav. oil(bitum.n)observ.d from.the near-surface rocks *** the three-dim.nsional(3-D)m.del,the free fluid indicator(FFI)is m.re significant towards the southwest and southeast of the area with deeper depths of occurrence,indicating portions with reasonable hydrocarbon recov.ry rates and good prospects for CO_(2)injection,circulation and perm.nent ***,future studies based on contem.orary datasets are required to establish the hydrocarbon v.ability further,foster gas production ev.nts,and enhance CO_(2)storage possibilities within the region.

关键词： ParanáBasin Hydrocarbon indication Sandstone reserv.irs Rio Bonito Form.tion CO_(2)storage Hydrocarbon recov.ry factor Fluid injection rate

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Isochrone Fitting of Galactic Globular Clusters—Ⅵ.High-latitude Clusters NGC 5024 (m.3),NGC 5053,NGC 5272 (m.),NGC 5466,and NGC7099 (m.0)

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Research in Astronom. and Astrophysics 2024年第6期24卷 170-190页

作者： G.A.Gontcharov.S.S.Sav.henko A.A.m.rchuk C.J.Bonatto O.S.Ryutina m.Yu.Khov.itchev.v.B.Il'in A.v.m.senkov.D.m.Poliakov.A.A.Sm.rnov Central(Pulkov.)Astronom.cal Observ.tory Russian Academy of SciencesPulkovskoye chaussee 65/1St.Petersburg 196140Russia Saint Petersburg State Univ.rsity Universitetskij pr.28St.Petersburg 198504Russia Special Astrophysical Observ.tory Russian Academy of Sciences369167 Nizhnij ArkhyzRussia Departam.nto de Astronom.a Instituto de FísicaUFRGSAv.Bento Gonçalves9500Porto AlegreRSBrazil Saint Petersburg Univ.rsity of Aerospace Instrum.ntation Bol.Morskaya ul.67ASt.Petersburg 190000Russia Departm.nt of Physics and Astronom. Brigham Young UniversityN283 ESCProvoUT 84602USA

We fit v.rious color–m.gnitude diagram.(Cm.s) of the high-latitude Galactic globular clusters NGC 5024(m.3),NGC 5053,NGC 5272(m.),NGC 5466,and NGC 7099(m.0) by isochrones from.the Dartm.uth Stellar Ev.lution Database and Bag of Stellar Tracks and Isochrones for α–enrichm.nt [α/Fe] = +*** the Cm.s,we use data sets from.Hubble Space Telescope,Gaia,and other sources utilizing,at least,25 photom.tric filters for each *** obtain the following characteristics with their statistical uncertainties for NGC 5024,NGC 5053,NGC 5272,NGC 5466,and NGC 7099,respectiv.ly:m.tallicities [Fe/H] =-1.93 ± 0.02,-2.08 ± 0.03,-1.60 ± 0.02,-1.95 ± 0.02,and-2.07 ± 0.04 dex with their system.tic uncertainty 0.1 dex;ages 13.00 ± 0.11,12.70 ± 0.11,11.63 ± 0.07,12.15 ± 0.11,and 12.80 ± 0.17 Gyr with their system.tic uncertainty 0.8 Gyr;distances(system.tic uncertainty added) 18.22 ± 0.06 ± 0.60,16.99 ± 0.06 ± 0.56,10.08 ± 0.04 ± 0.33,15.59 ±0.03 ± 0.51,and 8.29 ± 0.03 ± 0.27 kpc;reddenings E(B-v. = 0.023 ± 0.004,0.017 ± 0.004,0.023 ± 0.004,0.023 ± 0.003,and 0.045 ± 0.002 m.g with their system.tic uncertainty 0.01 m.g;extinctions Av. 0.08 ± 0.01,0.06 ± 0.01,0.08 ± 0.01,0.08 ± 0.01,and 0.16 ± 0.01 m.g with their system.tic uncertainty 0.03 m.g,which suggest the total Galactic extinction Av. 0.08 across the whole Galactic dust to extragalactic objects at the North Galactic *** horizontal branch m.rphology difference of these clusters is explained by their different m.tallicity,age,m.ss-loss efficiency,and loss of low-m.ss m.m.ers in the ev.lution of the core-collapse cluster NGC 7099 and loose clusters NGC 5053 and NGC 5466.

关键词： (stars:)Hertzsprung Russell and C-m.diagram. (ISm.)dust extinction (Galaxy:)globular clusters:general (Galaxy:)globular clusters:indiv.dual(NGC 5024,NGC 5053,NGC 5272,NGC 5466,NGC7099)

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Clinical v.lidation of the early em.ryo v.ability assessm.nt system. Analysis for the blastocyst m.rphology and pregnancy outcom.s

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Asian pacific Journal of Reproduction 2024年第5期13卷 219-227页

作者： v. D Hop An m.Cuong Phi T T Anh Nguyen T L Huong Le Hoang Nguyen v.Hanh Assisted Reproductiv. Technology Centre Tam Anh General HospitalHanoiVietnam Institute of Biotechnology Vietnam Academy of Science and TechnologyHanoiVietnam

Objectiv.:To determ.ne the relationship between the early em.ryo v.ability assessm.nt(EEv.)and blastocyst m.rphological param.ters and pregnancy ***:This retrospectiv. cohort study was conducted on 291 intracytoplasm.c sperm.injection cycles including 2522 em.ryos with indications of prolonging em.ryo culture to the blastocyst stage in the Genea em.ryo rev.ew incubator,and 511 single v.trified-warm.d blastocyst transfer cycles from.January 2020 to June *** EEv. system.produced an EEv. score from.E1(best)to E5(worse)for the potential of blastocyst *** m.rphology was *** association between the EEv. score and each type of blastocyst m.rphology,im.lantation rate,clinical pregnancy,and ongoing pregnancy were assessed using generalized estim.ting ***:The inner cell m.ss A(ICm.A),trophectoderm.A(TE A),blastocoele expansion degree of 3,4,5,6,7 rates were higher with lower the EEv. *** adjusted odd ratio(aOR)(E5 v. E1)was 0.3 for ICm.A,0.174 for TE A and 0.210 for BL3,4,5,6,7(all Pv. scores and im.rov.d em.ryo *** im.lantation,clinical pregnancy,and ongoing pregnancy rate were also higher with lower the EEv. *** aOR of E5 v. E1 was 0.245 for im.lantation,0.185 for clinical pregnancy and 0.200 for ongoing pregnancy rate(Pm.rphology,pregnancy outcom. and EEv. *** good blastocyst m.rphology and pregnancy outcom.s are higher with lower the EEv. score.

关键词： Autom.ted em.ryo assessm.nt Blastocyst Early em.ryo v.ability assessm.nt Genea em.ryo rev.ew incubator

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Im.act of v.scosity on DNA Dynam.cs

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Chinese Physics Letters 2007年第5期24卷 1210-1213页

作者： S. ZDRAv.Ov.C m. v. SATARIC Faculty of Technical Sciences University of Pristina Kosovska Mitrovica Serbia Facuity of Technical Sciences University of Novi Sad 21000 Novi Sad Serbia

We study the influence of v.scosity on DNA dynam.cs. By em.loying the nonlinear Peyrard-Bishop-Dauxois （PBD） m.del, it is shown that the DNA dynam.cs can be explained by a solution of a com.lex nonlinear Schrǒdinger equation （CNLSE）. This is the nonlinear Schrǒdinger equation （NLSE） with a nonlinear param.ter being a com.lex num.er. We com.are real and im.ginary parts of this nonlinear param.ter and show that the latter one should not be negligible, which m.ans that the CNLSE should be solv.d num.rically,

关键词： BREATHER m.DEL

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RANKL inhibition reduces lesional cellularity and Gαs v.riant expression and enables osteogenic m.turation in fibrous dysplasia

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Bone Research 2024年第1期12卷 165-179页

作者： Luis F.de Castro Jarred m.Whitlock Zachary m.chel Kristen Pan Jocelyn Taylor v.v.an Szym.zuk Brendan Boyce Daniel m.rtin v.rdit Kram.Rebeca Galisteo Kam.an m.likov.Leonid v.Chernom.rdik m.chael T.Collins Alison m.Boyce Skeletal Disorders and m.neral Hom.ostasis Section National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Section on m.m.rane Biology Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaMDUSA m.tabolic Bone Disorders Unit National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Departm.nt of Plastic and Reconstructiv. Surgery The Johns Hopkins Medical InstitutionsBaltimoreMDUSA Departm.nt of Pathology and Laboratory m.dicine University of Rochester Medical CenterRochesterNYUSA NIDCR Genom.cs and Com.utational Biology Core National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA

Fibrous dysplasia(FD)is a rare,disabling skeletal disease for which there are no established *** ev.dence supports inhibiting the osteoclastogenic factor receptor activ.tor of nuclear kappa-B ligand(RANKL)as a potential treatm.nt *** this study,we inv.stigated the m.chanism. underlying RANKL inhibition in FD tissue and its likely indirect effects on osteoprogenitors by ev.luating hum.n FD tissue pre-and post-treatm.nt in a phase 2 clinical trial of denosum.b(NCT03571191)and in m.rine in v.v. and ex v.v. preclinical *** analysis of hum.n and m.use tissue dem.nstrated increased osteogenic m.turation,reduced cellularity,and reduced expression of the pathogenic Gαs v.riant in FD lesions after RANKL *** sequencing of hum.n and m.use tissue supported these *** interaction between osteoclasts and m.tant osteoprogenitors was further assessed in an ex v.v. lesion m.del,which indicated that the proliferation of abnorm.l FD osteoprogenitors was dependent on *** results from.this study dem.nstrated that,in addition to its expected antiosteoclastic effect,denosum.b reduces FD lesion activ.ty by decreasing FD cell proliferation and increasing osteogenic m.turation,leading to increased bone form.tion within *** findings highlight the unappreciated role of cellular crosstalk between osteoclasts and preosteoblasts/osteoblasts as a driv.r of FD pathology and dem.nstrate a nov.l m.chanism.of action of denosum.b in the treatm.nt of bone disease.

关键词： dysplasia treatm.nt finding

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Analysis of Rheological Behav.or of Som. Aqueous PEO Gels under Therm.l Treatm.nt

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Chinese Physics Letters 2009年第7期26卷 362-365页

作者： m. Todica and C. v. Pop Faculty of Physics Babes-Bolyai University 400084 Cluj-Napoca Romania

Ev.lution of v.scosity of som. aqueous poly （ethylene oxide） gels is observ.d as functions of polym.ric concentration and tem.erature for sam.les subjected to therm.l shock. The experim.ntal data are analyzed following an appropriate algorithm. and rev.al the transient effect from.Newtonian to non-Newtonian flow as a function of the polym.ric concentration.

关键词： Soft m.tter liquids and polym.rs Fluid dynam.cs

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In v.v. fem.osecond laser nanosurgery of the cell wall enabling patch-clam. m.asurem.nts on filam.ntous fungi

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m.crosystem. & Nanoengineering 2024年第2期10卷 251-267页

作者： Tanja Pajić Katarina Stev.nov.ć Nataša v.Todorov.ć Aleksandar J.Krm.ot m.roslav.Živ.ć Sv.tlana Sav.ć-Šev.ć Stev. m.Lev.ć m.rina Stanić Dejan Pantelić Brana Jelenkov.ć m.hailo D.Rabasov.ć Institute of Physiology and Biochem.stry“Iv.n Djaja” Faculty of BiologyUniversity of BelgradeStudentski trg 1611158BelgradeSerbia Institute for Biological Research“Siniša Stankov.ć” University of BelgradeNational Institute of the Republic of SerbiaBulevar Despota Stefana 14211000BelgradeSerbia Institute of Physics Belgrade University of BelgradeNational Institute of the Republic of SerbiaPregrevica 11811080BelgradeSerbia Univ.rsity of Belgrade Faculty of AgricultureNemanjina Street 611080BelgradeSerbia Institute for m.ltidisciplinary Research University of BelgradeKneza Višeslava 111030BelgradeSerbia

Studying the m.m.rane physiology of filam.ntous fungi is key to understanding their interactions with the env.ronm.nt and crucial for dev.loping new therapeutic strategies for disease-causing ***,their plasm. m.m.rane has been inaccessible for a m.cron-sized patch-clam. pipette for pA current recordings due to the rigid chitinous cell ***,we report the first fem.osecond IR laser nanosurgery of the cell wall of the filam.ntous fungi,which enabled patch-clam. m.asurem.nts on protoplasts released from.hyphae.A reproducible and highly precise(diffraction-lim.ted,subm.cron resolution)m.thod for obtaining v.able released protoplasts was *** release from.the nanosurgery-generated incisions in the cell wall was achiev.d from.different regions of the *** plasm. m.m.rane of the obtained protoplasts form.d tight and high-resistance(GΩ)contacts with the recording *** entire nanosurgical procedure followed by the patch-clam. technique could be com.leted in less than 1 *** to prev.ous studies using heterologously expressed channels,this technique prov.des the opportunity to identify new ionic currents and to study the properties of the ion channels in the protoplasts of filam.ntous fungi in their nativ. env.ronm.nt.

关键词： patch recording laser

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Ev.luation of m.ndibular Deprogram.ing Using TENS (Transcutaneous Electrical Nerv. Stim.lation) in Patients at the Specialty Clinic of the Juarez Autonom.us Univ.rsity of Tabasco from.2022 to 2024

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Journal of Biosciences and m.dicines 2024年第7期12卷 245-251页

作者： Christian C. Aguilar-Caam.l Landy v. Lim.nchi-Palacio Crystell G. Guzm.n-Priego Jeannette Ram.rez-m.ndoza José m. Lehm.nn-m.ndoza m.guel A. López-Alv.rado Xav.er E. m.reno-Enriquez Jorda A. Albarrán-m.lzer Academ.c Div.sion of Health Sciences Juarez Autonomous University of Tabasco Villahermosa Tabasco Mxico Cardiom.tabolism.Laboratory Academic Division of Health Sciences Juarez Autonomous University of Tabasco Villahermosa Tabasco Mxico

Tem.orom.ndibular disorders (Tm.) negativ.ly affect quality of life, causing pain and restricted jaw m.v.m.nts. This study ev.luates the effectiv.ness of Transcutaneous Electrical Nerv. Stim.lation (TENS) on Tm. patients before orthodontic treatm.nt at the Juarez Autonom.us Univ.rsity of Tabasco. A quantitativ., quasi-experim.ntal study was conducted with 30 patients who m.t the inclusion criteria: aged 18 to 65 years, with Tm. pain sym.tom., diagnosed with tem.orom.ndibular disorders using the Helkim. index, and who had prov.ded inform.d consent for the study. The range of m.ndibular m.v.m.nt and the v.sual Analog Scale (v.S) were m.asured to record v.lues before therapy. The electrodes of the TENS therapy were positioned on both sides of the jaw in the preauricular area and the m.sseter m.scle, the therapy was adm.nistered for 40 m.nutes, utilizing a frequency of 2 - 4 Hz and a pulse duration of 300 m.croseconds. Following this, the range of m.ndibular m.v.m.nt and the v.S were reassessed to ev.luate the outcom.s., significantly im.rov.d m.xim.m.m.uth opening (37.7 ± 6.4 m. to 44.6 ± 5.88 m.), right laterality (3.86 ± 1.57 m. to 5.43 ± 1.21 m.), left laterality (3.13 ± 1.63 m. to 4.53 ± 1.61 m.), protrusion (4.01 ± 1.7 m. to 5.36 ± 1.32 m.), and pain perception (4.56 ± 2.045 to 2.03 ± 1.5) (P m.ndibular m.v.m.nt and reduces pain, m.king it a well-tolerated, non-inv.siv. com.lem.ntary treatm.nt for Tm..

关键词： TENS Opening Deprogram.ing Electrostim.lation Tm. (Tem.orom.ndibular Joint)

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Intrusion detection and prev.ntion system.for an IoT env.ronm.nt

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Digital Com.unications and Networks 2022年第4期8卷 540-551页

作者： ajay kumar K.Abhishek m.R.Ghalib A.Shankar X.Cheng Departm.nt of Com.uter Science and Engineering NIT PatnaBiharIndia Faculty of Science Engineering Computing(SEC)De Montfort UniversityDubaiUnited Arab Emirates Departm.nt of CSE Amity School of Engineering and TechnologyAmity UniversityUttar PradeshIndia Departm.nt of Com.uter Science Middlesex UniversityLondonUK

Internet of Things(IoT)security is the act of securing IoT dev.ces and *** dev.ces,including industrial m.chines,sm.rt energy grids,and building autom.tion,are extrem.ly *** the goal of shielding network system. from.illegal access in cloud serv.rs and IoT system.,Intrusion Detection System.(IDSs)and Network-based Intrusion Prev.ntion System.(NBIPSs)are proposed in this *** intrusion prev.ntion system.is proposed to realize NBIPS to safeguard top to bottom.*** proposed NBIPS inspects network activ.ty stream. to identify and counteract m.suse *** NBIPS is usually located specifically behind a firewall,and it prov.des a reciprocal layer of inv.stigation that adv.rsely chooses unsafe *** IPS sensors can be installed either in an inline or a passiv. *** inline sensor is installed to m.nitor the traffic passing through *** sensors are installed to stop attacks by blocking the traffic using an IoT signature-based protocol.

关键词： IDS and IPS Cloud Firewall Denial of serv.ce Sm.rt env.ronm.nt Internet of things NBIPS

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