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COVID-19 associated diabetes mellitus: A review

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World Journal of Diabetes 2022年第9期13卷 729-737页

作者： ajay m gavkare Neeta Nanaware Abhijit S Rayate Sachin mumbre Basavraj S Nagoba Physiology Maharashtra Institute of Medical Sciences&Research(Medical College)Latur 413531MaharashtraIndia Physiology Vilasrao Deshmukh Government Medical CollegeLatur 413512MaharashtraIndia Surgery Maharashtra Institute of Medical Sciences&Research(Medical College)Latur 413531MaharashtraIndia Community medicine Ashwini Rural Medical CollegeSolapur 413006MaharashtraIndia microbiology Maharashtra Institute of Medical Sciences&Research(Medical College)Latur 413531MaharashtraIndia

A significantly higher rate of new-onset diabetes in many coronavirus disease 2019(COVID-19)patients is a frequently observed *** resultant hyperglycemia is known to influence the clinical outcome,thereby increasing the cost of treatment and stay in *** will also affect the post-hospitalization *** has been observed that new-onset diabetes in COVID-19 patients is associated with considerable increase in morbidity and may be associated with increased mortality in some *** mini-review focuses on the possible causes to understand how COVID-19-related diabetes develops,various associated risk factors,and possible mechanism to understand the natural history of the disease process,clinical outcome,associated morbidities and various treatment options in the mana-gement of post COVID-19 diabetes.A literature search was performed in Pubmed and other online database using appropriate keywords.A total of 80 articles were found,among which,53 of the most relevant were evaluated/analyzed and relevant data were *** studies show that patients who have had severe acute respiratory syndrome coronavirus 2 infection leading to development of COVID-19 may manifest not only with new-onset diabetes but also worsening of pre-existing *** effect and autoimmune destruction of insulin-secreting pancreatic beta cells,cytokine storm during the active phase of infection causing impaired insulin secretion and resistance,druginduced hyperglycemia,undetected pre-existing hyperglycemia/diabetic condition,and stress-induced impairment of glucose metabolism are some of the possible potential mechanisms of COVID-19-associated new-onset diabetes *** studies published in recent times have found a significantly higher rate of new-onset diabetes mellitus in many COVID-19 *** it is an inflammatory or immune-mediated response,direct effect of virus or combination of these is *** resultant hyperglycemia is known t

关键词： Coronavirus disease 2019 Coronavirus disease 2019 associated diabetes Coronavirus disease 2019 related diabetes Hyperglycemia in coronavirus disease 2019 patients New-onset diabetes Postcoronavirus disease 2019 diabetes

Current scenario of traditional medicines in management of diabetic foot ulcers:A review

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World Journal of Diabetes 2023年第1期14卷 1-16页

作者： Abhijit S Rayate Basavraj S Nagoba Sachin S mumbre Hardi B mavani ajay m gavkare Advait S Deshpande Department of Surgery Maharashtra Institute of Medical Sciences&Research(Medical College)Latur 413531India Department of microbiology Maharashtra Institute of Medical Sciences&Research(Medical College)Latur 413531India Department of Community medicine Ashwini Rural Medical CollegeSolapur 413006India Department of Physiology Maharashtra Institute of Medical Sciences&Research(Medical College)Latur 413531India

Diabetic foot infections and diabetic foot ulcers(DFU)cause significant suffering and are often *** have three important pathogenic factors,namely,microangiopathy causing local tissue anoxia,neuropathy making the foot prone to injuries from trivial trauma,and local tissue hyperglycaemia favouring infection and delaying the wound *** have been the leading cause for non-traumatic amputations of part or whole of the *** medicines focus mainly on euglycaemia,antimicrobials,debridement and wound cover with grafts,and off-loading *** in euglycaemic control,foot care and footwear,systemic antimicrobial therapy,and overall health care access and delivery,have resulted in an overall decrease in ***,the process of wound care after adequate debridement remains a major cost burden globally,especially in developing *** process revolves around two basic concerns regarding control/eradication of local infection and promotion of faster healing in a chronic DFU without *** modulation with various dressings and techniques are often a costly *** aspects of the topical therapy with modern/Western medicines are frequently not *** of and compliance to these therapies are important as both the wounds and their treatment are“chronic.”Naturally occurring agents/medications from traditional medicine systems have been used frequently in different cultures and nations,though without adequate clinical base/*** Chinese medicine involves restoring yin-yang balance,regulating the‘chi’,and promoting local blood *** medicines from India have been emphasizing on‘naturally’available products to control wound infection and promote all the aspects of wound *** is one more group of chemicals which are not pharmaceutical agents but can create acidic milieu in the wound to satisfy the above-mentioned basic *** natural and plant derived products(e.g

关键词： Diabetic foot infections Diabetic foot ulcers management Traditional medicines Topical agents Wound healing

Understanding serum inflammatory markers in pediatric mycoplasma pneumoniae pneumonia

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World Journal of Clinical Pediatrics 2024年第4期13卷 1-4页

作者： Basavraj S Nagoba Shree V Dhotre ajay m gavkare Sachin S mumbre Pradnya S Dhotre Department of microbiology Maharashtra Institute of Medical Sciences and Research(Medical College)Latur 413531India Department of microbiology Ashwini Rural Medical CollegeSolapur 413001India Department of Physiology Maharashtra Institute of Medical Sciences and Research(Medical College)Latur 413531India Department of Community medicine Ashwini Rural Medical CollegeSolapur 413006India Department of Biochemistry Ashwini Rural Medical CollegeSolapur 413001India

This editorial reflects on the research,which investigates the potential of serum markers to predict the severity of mycoplasma pneumoniae *** pneumoniae pneumonia(mPP)is a prevalent cause of respiratory infections in children,often leading to significant *** the severity of mPP can significantly enhance patient management and *** editorial reviews the role of specific laboratory markers:(1)Lactate dehydrogenase;(2)Interleukin(IL)-6;(3)IL-10;(4)Tumor necrosis factor-α;and(5)D-dimer in predicting the severity of mPP in pediatric *** levels of these markers are strongly associated with severe cases of mPP,providing clinicians with valuable tools for early diagnosis and targeted intervention.

关键词： mycoplasma pneumoniae pneumonia Pediatric Severity prediction Laboratory markers Clinical management

Impact of vitamin D on COVID-19 and other viral diseases

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World Journal of Virology 2024年第4期13卷 1-6页

作者： Basavraj S Nagoba ajay m gavkare Abhijit S Rayate Neeta Nanaware Sachin Bhavthankar Department of microbiology Maharashtra Institute of Medical Sciences and ResearchLatur 413531India Department of Physiology Maharashtra Institute of Medical Sciences and ResearchLatur 413531India Department of Surgery Maharashtra Institute of Medical Sciences and ResearchLatur 413531India Department of Physiology Vilasrao Deshmukh Government Medical CollegeLatur 413512MaharashtraIndia Department of Biochemistry MIMSR Medical CollegeLatur 413512India

This editorial aims to elucidate the intricate relationship between vitamin D and viral *** explores the anticipated role of vitamin D as a modulator in the immune response against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and other viral *** editorial comments are based on the review article by Engin et *** potential role of vitamin D in modulating immune responses has been highlighted by several studies,suggesting that it may influence both the risk and severity of *** D receptors are present in immunocompetent cells,which indicates that vitamin D can potentially modulate innate and adaptive immune *** context is relevant in the pathophysiology of coronavirus disease 2019(COVID-19),where the immune response to the virus can significantly impact the disease progression and *** immunomodulatory effects of vitamin D can protect against SARSCoV-2 infection by enhancing innate and adaptive immune *** also maintains the integrity of the body's physical barriers and modulates inflammatory responses,thereby preventing entry and replication of the *** studies have suggested that adequate vitamin D levels help alleviate morbidity and mortality associated with ***,vitamin D supplementation has been linked with a lower risk of severe disease and mortality in COVID-19 patients,particularly in those with a deficiency during seasons with less sunlight exposure.

关键词： COVID-19 Immunomodulation Pandemic Severe acute respiratory syndrome coronavirus 2 Vitamin D

Role of an acidic environment in the treatment of diabetic foot infections:A review

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World Journal of Diabetes 2021年第9期12卷 1539-1549页

作者： Basavraj Nagoba ajay gavkare Abhijit Rayate Sachin mumbre Arunkumar Rao Basavraj Warad Neeta Nanaware Nawab Jamadar Department of microbiology MIMSR Medical CollegeLatur 413512MaharashtraIndia Department of Physiology MIMSR Medical CollegeLatur 413512MaharashtraIndia Department of Surgery MIMSR Medical CollegeLatur 413512MaharashtraIndia Department of Community medicine Ashwini Rural Medical CollegeSolapur 413001MaharashtraIndia Department of Orthopedics MIMSR Medical CollegeLatur 413512India Department of Physiology Government Medical CollegeLatur 413512MaharashtraIndia Department of Anesthesiology MIMSR Medical CollegeLatur 413512MaharashtraIndia

management of diabetic foot ulcers is the biggest challenge to the clinician,as conventional antibiotic therapies and local wound care have their own *** are not effective for control of infections and promotion of healing because of cytotoxic *** view of cytotoxicity of routinely used topical antiseptic agents,this article focuses on the search of an ideal topical antiseptic agent that is safe and effective in controlling infectious agents and also in promoting the healing *** review focuses on the use of various acids such as citric,acetic,hyaluronic,and hypochlorous acids as topical agents in diabetic foot *** article also focuses on the different roles of acids in the treatment of diabetic foot infections.

关键词： Diabetic foot ulcer Infection management Topical agents Acids Role of acids

Nanoindentation and Wear Characteristics of Al 5083/SiC_p Nanocomposites Synthesized by High Energy Ball milling and Spark Plasma Sintering

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Journal of materials Science & Technology 2012年第11期28卷 969-975页

作者： Sivaiah Bathula Saravanan m ajay Dhar metals and Alloys Group Materials Physics and Engineering Division CSIR-National Physical Laboratory

AI 5083//10 wt% SiCp nano composites have been synthesized by means of high energy ball milling followed by spark plasma sintering （SPS）. Nano composites produced via this method exhibited near-theoretical density while retaining the nano-grained features. X-ray diffraction （XRD） analysis indicated that the crystalline size of the ball milled AI 5083 matrix was observed to be～25 nm and it was coarsened up to～30 nm after SPS. Nano indentation results of nano composites demonstrated a high hardness of～280 HV with an elastic modulus of 126 GPa. Wear and friction characteristics with addition of SiCp reinforcement exhibited significant improvement in terms of coefficient of friction and specific wear rate to that of nano structured AI 5083 alloy. The reduction in specific wear rate in the nanocomposite was mainly due to the change of wear mechanism from adhesive to abrasive wear with the addition of SiCp which resulted in high hardness associated with nano-grained microstructure.

关键词： metal matrix nano composites Friction/wear mechanical properties Highresolution transmission electron microscopy Spark plasma sintering Nanoindentation

GA and PSO culled hybrid technique for economic dispatch problem with prohibited operating zones

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第6期8卷 896-903页

作者： SUDHAKARAN m. ajay-D-VImALRAJ P. PALANIVELU T.G. ECE Department of Pondicherry University College Pondicherry University Pondicherry 605014 India

This paper presents an efficient and reliable genetic algorithm (GA) based particle swarm optimization (PSO) tech- nique (hybrid GAPSO) for solving the economic dispatch (ED) problem in power systems. The non-linear characteristics of the generators, such as prohibited operating zones, ramp rate limits and non-smooth cost functions of the practical generator operation are considered. The proposed hybrid algorithm is demonstrated for three different systems and the performance is compared with the GA and PSO in terms of solution quality and computation efficiency. Comparison of results proved that the proposed algo- rithm can obtain higher quality solutions efficiently in ED problems. A comprehensive software package is developed using mATLAB.

关键词： Economic dispatch (ED) Genetic algorithm (GA) Particle swarm optimization (PSO) Hybrid GAPSO Prohibited operating zone Crossover mutation Velocity

Intrusion detection and prevention system for an IoT environment

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Digital Communications and Networks 2022年第4期8卷 540-551页

作者： ajay Kumar K.Abhishek m.R.Ghalib A.Shankar X.Cheng Department of Computer Science and Engineering NIT PatnaBiharIndia Faculty of Science Engineering Computing(SEC)De Montfort UniversityDubaiUnited Arab Emirates Department of CSE Amity School of Engineering and TechnologyAmity UniversityUttar PradeshIndia Department of Computer Science Middlesex UniversityLondonUK

Internet of Things(IoT)security is the act of securing IoT devices and *** devices,including industrial machines,smart energy grids,and building automation,are extremely *** the goal of shielding network systems from illegal access in cloud servers and IoT systems,Intrusion Detection Systems(IDSs)and Network-based Intrusion Prevention Systems(NBIPSs)are proposed in this *** intrusion prevention system is proposed to realize NBIPS to safeguard top to bottom *** proposed NBIPS inspects network activity streams to identify and counteract misuse *** NBIPS is usually located specifically behind a firewall,and it provides a reciprocal layer of investigation that adversely chooses unsafe *** IPS sensors can be installed either in an inline or a passive *** inline sensor is installed to monitor the traffic passing through *** sensors are installed to stop attacks by blocking the traffic using an IoT signature-based protocol.

关键词： IDS and IPS Cloud Firewall Denial of service Smart environment Internet of things NBIPS

Spectroscopic investigation of light strange S=−1Λ and Σ and S=−2Ξbaryons

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Chinese Physics C 2021年第6期45卷 91-108页

作者： Chandni menapara ajay Kumar Rai Department of Physics Sardar Vallabhbhai National Institute of TechnologySurat-395007GujaratIndia

The present study is dedicated to light-strange∧with strangeness S=−1 and isospin I=0,with S=−1 and I=1,andΞbaryon with S=−2 andI=1/*** this study,the hypercentral constituent quark model with linear confining potential has been employed along with a first order correction term to obtain the resonance masses up to approximately 4 *** calculated states include 1S-5S,1P-4P,1D-3D,1F-2F,and 1G(in a few cases)along with all possible spin-parity *** trajectories have been explored for the linearity of the calculated masses for(n,m^(2))and(J,m^(2)).magnetic moments have been intensively studied for ground state spin 1/2 and,3/2 in addition to the configuration mixing of the first negative parity state ***,the transition magnetic moments and radiative decay widths have been presented.

关键词： mass spectra strange baryon Regge trajectory magnetic moment