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Clinical observation of Qushi Xiezhuo formula in reducing monosodium urate crystal deposition in patients with axial spondyloarthritis

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Journal of Traditional Chinese Medicine 2019年第5期39卷 722-729页

作者： li aiwu Huang Yinger Zheng Songyuan Tang Cuiping Zhu Junqing li Juan Department of Internal Medicine of Traditional Chinese Medicine College of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China Department of Rheumatology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China

OBJECTIVE: To investigate effect of Qushi Xiezhuo formula (QSXZF) on axial spondyloarthritis (AxSpA) with a high incidence of monosodium serum urate (MSU) crystal ***: In this prospective cohort study, 62 Ax- SpA patients diagnosed with MSU crystal deposition from October 2012 to July 2015 were recruited for follow-up observation for 1 year after discharge from the hospital. Patients were divided into a case group with QSXZF treatment and a control group without any interventions. X-ray and dual-energy computed tomography were used to assess structural damage in the pelvis and sacroiliac joint and the volume of the MSU crystals. The Wilcoxon rank-sum test and Fisher's exact test were used to compare the proportion and distribution between the groups. RESULTS: A decrease in C-reactive protein (CRP) level, relief from back pain, and an increase in MSU crystal depositions were found in control patients. Compared with the control group, QSXZF reduced CRP levels and back pain to a greater extent, as well as reduced erythrocyte sedimentation rate levels, serum uric acid levels, Ankylosing Spondylitis Disease Activity Score, morning stiffness and MSU crystal deposition. CONCLUSION: QSXZF can lower progress of radiogrphaic grade at sacroiliac joint in AxSpA/AS patients with MSU crystal deposition by decreasing the inflammation response and reducing the serum uric acid and volume of MSU crystal deposition in sacroiliac joint. The above process may be attributed to the relieving the Qi-movement disturbance in the body, and eliminating turbidity and dampness by QSXZF.

关键词： Spondylitis, ankylosing Uric acid Hyperuricemia Sacroiliac joint Qushi Xiezhuo formula

Preparation of Large-area Controllable Patterned Silver Nanocrystals for High Sensitive and Stable Surface-enhanced Raman Spectroscopy

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Chemical Research in Chinese Universities 2016年第3期32卷 428-432页

作者： XU Weiwei OKAMOTO Toshihiro li aiwu WANG Jiping HARAGUCHI Masanobu Department of Optical Science and Technology Faculty of Engineering Tokushima University 2-1 Minamijosanjima Tokushima 7708506 Japan State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering Jilin University Changchun 130012 P. R. China The First Hospital of Jilin University Changchun 130021 P. R. China

A novel and facile method for fabricating large-area pattemed silver nanocrystals was introduced and the investigation on the high sensitive and stable surface-enhanced Raman spectroscopy（SERS） of the nanocrystals was carried out. Nanostructured silicon substrate was processed by laser interference and used as a template for growing silver nanocrystals via galvanic battery reaction method. The substrate with large area for violent chemical reaction was tailored into a nanocell array. The limited reaction area hindered the growth of silver nanocrystals and made their size uniform and controllable. The size and gaps of the nanocrystals could be controlled by template period and ratio, which were easily reproduced by laser interference. Taking 10^-8 to 10^-11 mol/L RhoG for example, the optimized silver arrays exhibited great potential for ultrasensitive molecular sensing in terms of its high SERS enhancement ability, favorable stability, and excellent reproducibility.

关键词： Surface-enhanced Raman spectroscopy Laser interference Silver nanocrystal Galvanic battery reaction

Simultaneous Photoreduction and Nitrogen Doping of Graphene Oxide for Supercapacitors by Direct Laser Writing

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Chemical Research in Chinese Universities 2019年第5期35卷 879-883页

作者： FU Xiuyan XU Shuai LUO Yang li aiwu YANG Han State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012P.R.China

Graphene-based supercapacitors have attracted tremendous attention owing to their outstanding electrochemical performance. In terms of material, nitrogen(N)-doped graphene(NDG) displays enhanced specific capaci-tance and rate performance compared with bare graphene used as a supercapacitor electrode. However, it still remains a challenge to develop a facile and simple method of NDG in cost-effective manner. Here, we used a simple direct laser writing technique to accomplish the simultaneous photoreduction and N-doping of graphene oxide(GO) using urea as a N source. The N content of the resultant reduced N-doped graphene oxide(NGO) reached a maximum value of 6.37%. All reduced NGO(NRGO)-based supercapacitors exhibited a higher specific capacitance than those based on pure reduced GO(RGO). Interestingly, the electrochemical performance of NRGO-based supercapacitors varied with different contents ofN species. Therefore, we can control the properties of the obtained NRGOs by adjusting the doping ratios, an important step in developing effective graphene-based energy storage devices.

关键词： Simultaneous photoreduction and nitrogen-doping Graphene based supercapacitor Direct laser writing

Effect of Shengmai Yin on the DNA methylation status of nasopharyngeal carcinoma cell and its radioresistant strains

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Journal of Pharmaceutical Analysis 2021年第6期11卷 783-790页

作者： Shiya liu Zhiyuan Wang Daoqi Zhu Jiabin Yang Dandan Lou Ruijiao Gao Zetai Wang aiwu li Ying Lv Qin Fan School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou510515China Nan Fang Hospital Guangzhou510515China

Shengmai Yin(SMY)is a Chinese herbal decoction that effectively alleviates the side effects of radiotherapy in various cancers and helps achieve radiotherapy’s clinical *** this study,we explored the interaction mechanism among SMY,DNA methylation,and nasopharyngeal carcinoma(NPC).We identified differences in DNA methylation levels in NPC CNE-2 cells and its radioresistant cells(CNE-2R)using the methylated DNA immunoprecipitation array and found that CNE-2R cells showed genomewide changes in methylation status towards a state of *** may restore its original DNA methylation status,and thus,enhance ***,we confirmed that the differential gene Tenascin-C(TNC)was overexpressed in CNE-2R cells and that SMY downregulated TNC *** downregulation of TNC inhibited NPC cell radiation resistance,migration,and ***,we found that TNC was hypomethylated in CNE-2R cells and partially restored to a hypermethylated state after SMY *** methyltransferases 3 a may be the key protein in DNA methylation of TNC.

关键词： Nasopharyngeal carcinoma DNA methylation Radiosensitization Shengmai Yin

Opening of Band Gap of Graphene with High Electronic Mobility by Codoping BN Pairs

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Chemical Research in Chinese Universities 2019年第6期35卷 1058-1061页

作者： REN Xiangyang XIA Sha ZHANG Zhiguo MENG Xing YU Hongmei WU Qi ZHANG Wenyi li aiwu YANG Han State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012P.R.China Shenyang Acadamy of Instrumentation Science Co. Ltd.Shenyang 110043P.R.China College of Physics Jilin UniversityChangchun 130012P.R.China College of Computer Science and Technology Jilin UniversityChangchun 130012P.R.China Systems Engineering Research Institute Beijing 100036P.R.China

Two-dimensional(2D)materials with a high density and low power consumption have become the most popular candidates for next-generation semiconductor electronic *** a prototype 2D material,graphene has attracted much attention owing to its stability and ultrahigh ***,zero band gap of graphene leads to very low on-off ratios and thus limits its applications in electronic devices,such as *** some new 2D materials and doped graphene have nonzero band gaps,the electronic mobility is *** this study,to open the band gap of graphene with high electronic mobility,the structure and property of BN-doped graphene were evaluated using first-principles *** formation energies indicate that the six-membered BN rings doped graphene has the most favorable *** band structures show that the band gaps can be opened by such type of ***,the Dirac-cone-like band dispersion of graphene is mostly inhibited,ensuring high electronic ***,codoping BN into graphene might provide 2D materials with nonzero band gaps and high electronic mobility.

关键词： First-principle calculation Doping Optoeletronic property Mobility

Tunable protein microlens array

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Chinese Optics Letters 2019年第6期17卷 65-68页

作者： Zhishan Hou Jiaji Cao aiwu li Han Yang State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering Jilin University

Based on natural protein materials,a series of lenses with different heights and focal lengths were assembled on glass substrates by femtosecond laser non-contact,masking,and cold *** lens array itself possesses unique and characteristic optical performance in three-dimensional parallel imaging and bending *** is more profound is that by using equilibrium swelling of protein-hydrogel,once the lens array was placed in a liquid environment,with the change of ion concentration(e.g.,pH),the refractive index and curvature of the protein-hydrogel would change,which leads to the flex of the focal plane of the lens,finally realizing the dynamical tunability of a protein *** smart stress devices may have great potential in optical biosensing and microfluidic chip integration fields.

关键词： Based on natural protein materials different heights chip integration fields

殿后锁固坡体剪断边坡变形能释放与滑体起动速度关系分析

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岩石力学与工程学报 2011年第8期30卷 1522-1530页

作者：潘岳李爱武青岛理工大学土木工程学院山东青岛266520

通过对锁固坡体应力场和位移场所作的能量分析表明:在殿后锁固坡体厚度大,且为坚硬岩体构成的情况下,中、后部坡体在巨大推力作用下边坡系统聚集了巨大的剪切变形能,使殿后锁固坡体被剪断,边坡系统临滑时释放的剪切变形能远大于潜滑带... 详细信息

通过对锁固坡体应力场和位移场所作的能量分析表明:在殿后锁固坡体厚度大,且为坚硬岩体构成的情况下,中、后部坡体在巨大推力作用下边坡系统聚集了巨大的剪切变形能,使殿后锁固坡体被剪断,边坡系统临滑时释放的剪切变形能远大于潜滑带岩体破裂需要的能量,所超过的变形能部份,将转换为滑体弹冲的动能,造成剧动式滑坡。推导蕴涵丰富信息量的殿后锁固坡体剪切变形能变化率曲线及其表达式,通过该曲线和锁固坡体潜滑带荷载–变形曲线,用直观的几何方式对边坡系统的剪切变形能聚集、临滑变形能释放量与滑体起程弹冲速度关系进行阐述,并给出滑体弹冲速度算例。

关键词：边坡工程锁固段聚能变形能释放剧动式滑坡起动速度弹冲效应

Gefitinib in the treatment of 41 cases with refractory non-small cell lung cancer

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The Chinese-German Journal of Clinical Oncology 2009年第6期8卷 314-316页

作者： Jianfang Xu Caicun Zhou aiwu li Department of Oncology Shanghai Pulmonary Hospital Tongji University Shanghai 200433 China

Objective： We observe the curative effect, median survival time, time to progression, quality of life and adverse effect of patients with advanced refractory non-small cell lung cancer （NSCLC） after gefitinib （Iressa） treatment. Methods： Forty-one patients with grade Ⅲb to Ⅳ NSCLC previously treated with two chemotherapy including 85.4% of patients after second line therapy were chosen. The regimen was oral intake of gefitinib 250 mg once daily until the disease progression or toxic reaction has become intolerable. The patients were required to receive tumor evaluation before the treatment, one month, two month and every three months after Iressa administration. Results： All of 41 patients were evaluable for therapeutic effect. Without complete regression being observed, partial response rate （PR）, stable disease （SD） and progression of disease （PD） were 43.9% （18/41）, 34.1% （14/41） and 22.1% （9/41）, respectively. The overall response rate was 43.9% （18141） and disease control rate （PR ＋ SD） was 78% （32/41）. The response rate in male was 42.1%, while it in female was 45.5% （P 〉 0.05）. Twenty-two of them （53.7%, 22/41） were still alive with 10.1 months of MST when the follow-up ended in November 2006. TTP and MST of patients who died was 2.7 and 5.0 months, respectively. The rate of symptom improvement was 78% of all patients with 13 months of MST of PR patients. The Karnofsky enhanced 20 ＋ 5 after 28 days treatment without 3-4 degree of reactive toxicity. Conclusion： Iressa has significant antitumor activity in advanced NSCLC patients who have previously failed in second or third line chemotherapy. Iressa is effective and safe for patients with poor performance status.

关键词： gefitinib non-small cell lung cancer (NSCLC) epidermal growth factor receptor

腹腔镜下胆总管囊肿切除术中肝总管狭窄或者胆总管远端蛋白栓的处理方法与技巧

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临床小儿外科杂志 2019年第7期18卷 545-547页

作者：李爱武山东大学齐鲁医院小儿外科

随着腔镜技术的发展,腹腔镜胆总管囊肿切除Roux-en-Y胆肠吻合术已经成为治疗胆总管囊肿的标准术式,在国内许多医院已经广泛开展,但该术式在操作的过程中往往会遇到一些特殊情况(如伴肝总管狭窄、副肝管、肝右动脉畸形、胆总管远端蛋白栓... 详细信息

随着腔镜技术的发展,腹腔镜胆总管囊肿切除Roux-en-Y胆肠吻合术已经成为治疗胆总管囊肿的标准术式,在国内许多医院已经广泛开展,但该术式在操作的过程中往往会遇到一些特殊情况(如伴肝总管狭窄、副肝管、肝右动脉畸形、胆总管远端蛋白栓等),笔者旨在结合自身临床经验,对伴肝总管狭窄或胆总管远端蛋白栓的术中处理经验及技巧进行总结。

关键词：腹腔镜胆总管囊肿/外科学