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Chinese pangolins (Manis pentadactyla) are not functionally extinct in China

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Zoological Research(Diversity and Conservation) 2024年第1期1卷 79-81页

作者： Zhi-cheng liu Peng Cen jian-kun Sun Fu-Hua Zhang Amna Mahmood chen Lei Shi-Bao wu School of Life Sciences South China Normal UniversityGuangzhouGuangdong 510631China

DEAR EDITOR,The key features of functional extinction include continuous reproductive failure,lack of new recruitment,and persistent population decline(Jarićet al.,2016;Roberts et al.,2017).However,the conclusion of functional extinction for the Chinese pangolin(Manis pentadactyla)by the China Biodiversity Conservation and Green Development Foundation(CBC-GDF)based on preliminary field information is unconvincing as they did not assess reproductive function or new individual recruitment of Chinese pangolin populations(Supplementary Materials).

关键词： extinction Roberts Manis

Risk factors for renal outcomes in children with antineutrophil cytoplasmic antibody-associated vasculitis:a nationwide retrospective study in China

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World Journal of Pediatrics 2024年第5期20卷 506-516页

作者： Li-Wen Tan Jun-Li Wan Chun-Hua Zhu Hong Xu Zheng-kun Xia Li-Zhi chen Xiao-Chuan wu Fang Wang Xiao-Rong liu cheng-Guang Zhao Xiao-Zhong Li jian-Hua Mao Xiao-Wen Wang Wen-Yan Huang Yu-Hong Li jian-jiang Zhang Shi-Pin Feng Jun Yang Jiao-Jiao liu Chun-Lin Gao Li-Ping Rong Lan-Jun Shuai Ke Xu He-Jia Zhang Qiu Li Ai-Hua Zhang Mo Wang Department of Nephrology Children’s Hospital of Chongqing Medical UniversityZhongshan 2nd Rd.136Chongqing400014China Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChildren’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Pediatrics Children’s Hospital of Chongqing Medical UniversityChongqingChina Department of Nephrology Children’s Hospital of Nanjing Medical University72 Guangzhou RoadNanjing210008China Department of Nephrology Children’s Hospital of Fudan UniversityNational Paediatric Medical Center of ChinaShanghaiChina Department of Pediatrics Jinling HospitalNanjing Medical UniversityNanjingChina Department of Pediatrics Jinling HospitalThe First School of Clinical MedicineSouthern Medical UniversityNanjingChina Department of Pediatrics Jinling HospitalMedical School of Nanjing UniversityNanjingChina Department of Pediatric Nephrology and Rheumatology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouChina Department of Pediatrics The Second Xiangya Hospital of Central South UniversityChangshaChina Department of Pediatrics Peking University First HospitalBeijingChina Department of Nephrology Beijing Children’s HospitalCapital Medical UniversityBeijing100045China National Center for Children’s Health BeijingChina Department of Pediatrics Shengjing Hospital of China Medical UniversityShenyangChina Department of Nephrology and Immunology Children’s Hospital of Soochow UniversitySuzhouChina Department of Nephrology Children HospitalZhejiang University School of MedicineHangzhouChina Department of Nephrology Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science&TechnologyWuhanChina Department of Nephrology and Rheumatology Shanghai Children’s HospitalSchool

Background Pediatric antineutrophil cytoplasmic antibody-associated vasculitis(AAV)is a life-threatening systemic vasculitis featured by liability to renal ***,there are few studies on the risk factors and predictive models for renal outcomes of AAV in *** Data from 179 AAV children in multiple centers between January 2012 and March 2020 were collected *** risk factors and predictive model of end-stage renal disease(ESRD)in AAV were *** Renal involvement was the most typical manifestation(95.5%),and the crescent was the predominant pathological lesion(84.9%).The estimated glomerular filtration rate(eGFR)was evaluated in 114 patients,of whom 59.6%developed ESRD,and the median time to ESRD was 3.20 *** eGFR[P=0.006,odds ratio(OR)=0.955,95%confidence interval(CI)=0.924–0.987]and the percentages of global glomerulosclerosis(pGGS;P=0.018,OR=1.060,95%CI=1.010–1.112)were independent risk factors for ESRD of renal *** on the pGGS and eGFR at renal biopsy,we developed three risk grades of ESRD and one predictive *** Kaplan‒Meier curve indicated that renal outcomes were significantly different in different risk grades(P<0.001).Compared with serum creatinine at baseline,the predictive model had higher accuracy(0.86 versus 0.58,P<0.001)and a lower coefficient of variation(0.07 versus 0.92)in external *** Renal involvement is the most common manifestation of pediatric AAV in China,of which more than half deteriorates into *** predictive model based on eGFR at renal biopsy and the pGGS may be stable and accurate in speculating the risk of ESRD in AAV children.

关键词： Antineutrophil cytoplasmic antibody End-stage renal disease Glomerulonephritis Pediatric nephrology Vasculitis

Quantitative prediction and ranking of the shock sensitivity ofexplosives via reactive molecular dynamics simulations

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Defence Technology（防务技术） 2022年第5期18卷 843-854页

作者： kun Yang Lang chen Dan-yang liu De-shen Geng jian-ying Lu Jun-ying wu State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China

A deep understanding of explosive sensitivities and their factors is important for safe and reliable ***,quantitative prediction of the sensitivities is ***,reactive molecular dynamics simulation models for high-speed piston impacts on explosive supercells were *** were also performed to investigate shock-induced reactions of various high-energy *** fraction of reacted explosive molecules in an initial supercell changed linearly with the propagation distance of the shock-wave *** corresponding slope could be used as a reaction rate for a specific shock-loading *** rates that varied with the shock-loading pressure exhibited two-stage linearities with different *** two inflection points corresponded to the initial and accelerated reactions,which respectively correlated to the thresholds of shock-induced ignition and ***,the ignition and detonation critical pressures could be *** sensitivity could then be a quantitative prediction of the critical *** accuracies of the quantitative shock sensitivity predictions were verified by comparing the impact and shock sensitivities of common explosives and the characteristics of anisotropic shock-induced *** dynamics simulations quantitatively predict and rank shock sensitivities by using only crystal structures of the ***,this method will enable the design and safe use of explosives.

关键词： Explosive Shock sensitivity Quantitative prediction Reactive molecular dynamics simulation

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四川省公共卫生医师对处方权认知的调查

现代预防医学 2024年第9期51卷 1649-1653+1707页

作者：王卓邹锟曾智查雨欣何予晋胡狄慧秦小雲左根永唐尚峰刘毅杨艾茜陈建李佳圆陈芙君杨珉吴先萍钟波四川省疾病预防控制中心四川大学华西第二医院/华西妇产儿童医院中国疾病预防控制中心山东大学公共卫生学院/山东大学卫生管理和政策研究中心华中科技大学医药卫生管理学院四川大学华西公共卫生学院/华西第四医院成都医学院公共卫生学院

目的了解公共卫生医师群体对处方权的态度，为进一步探索赋予公共卫生医师处方权的政策制定和推动提供支撑和参考。方法采用关键人物法和滚雪球法，对四川省各级疾病预防控制中心、医院、妇幼保健院、基层医疗机构、专业公共卫生等多... 详细信息

目的了解公共卫生医师群体对处方权的态度，为进一步探索赋予公共卫生医师处方权的政策制定和推动提供支撑和参考。方法采用关键人物法和滚雪球法，对四川省各级疾病预防控制中心、医院、妇幼保健院、基层医疗机构、专业公共卫生等多类机构的公共卫生医师开展在线横断面问卷调查。对246份问卷关于公卫医师对处方权现状、认知、影响、态度和建议进行定性、定量分析。结果约95%的参与者支持赋予公共卫生医师处方权，认为赋予处方权是对公共卫生“医师”身份认同的标志，可以促进防治结合，提升公共卫生体系的工作效率和质量，促进公共卫生医师医学专业能力提升，从而改善公共卫生工作的质量和效果；而没有处方权会降低医学同行对公共卫生医师医学专业性的认可以及公共卫生医师开展公共卫生工作的效果。对不同形式的处方权获得方式，多数参与者表示愿意接受。结论公共卫生医师群体对处方权的需求意愿高，认为推行公共卫生医师处方权是改善公共卫生医师医防分离现状，推动公共卫生医师高质量发展的一项重要措施。

关键词：公共卫生医师处方权横断面调查

斑鳢ghr基因克隆、表达分析及性类固醇激素诱导的响应

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农业生物技术学报 2024年第6期32卷 1371-1384页

作者：吴玉霞张啸天张扬赵建罗青刘海洋费树站陈昆慈欧密中国水产科学研究院珠江水产研究所/农业农村部热带亚热带水产种质资源利用与养殖重点实验室上海海洋大学水产与生命学院湖南科技大学生命科学与健康学院

生长激素(growth hormone, GH)-胰岛素样生长因子(insulin-like growth, IGF)轴是调控鱼类生长的主要内分泌轴线。为探讨生长激素受体(growth hormone receptor, GHR)在斑鳢(Channa maculata)雌、雄生长差异中的调控机制，本研究克隆了... 详细信息

生长激素(growth hormone, GH)-胰岛素样生长因子(insulin-like growth, IGF)轴是调控鱼类生长的主要内分泌轴线。为探讨生长激素受体(growth hormone receptor, GHR)在斑鳢(Channa maculata)雌、雄生长差异中的调控机制，本研究克隆了斑鳢ghr基因序列，分析了基因结构，解析了ghr在成鱼不同组织和不同发育时期肝脏中的表达模式及其对外源性类固醇激素刺激的响应表达。结果表明，斑鳢ghr基因cDNA序列全长2 602 bp，包括100 bp 5'-UTR,1 872 bp开放阅读框，编码623个氨基酸，630 bp 3'-UTR。斑鳢ghr基因组序列长18 118 bp，包含9个外显子和8个内含子，在5'-端上游鉴定到899 bp的侧翼序列，经分析发现，ghr 5'-端侧翼序列含有雄激素受体(androgen receptor, AR)、含溴结构域蛋白4 (bromodomaincontaining protein 4, BRD4)和抑制元素-1-沉默转录因子(repressor element-1-silencing transcription factor,REST)等多种转录因子结合位点。成鱼组织表达分析证实ghr在斑鳢肝脏中高表达，且在雄性中的表达极显著高于雌性(P<0.01)；不同发育时期表达分析表明，ghr基因在365 d的雄性斑鳢肝脏中表达量最高，且极显著高于同时期雌性斑鳢(P<0.01)。激素诱导实验显示，长期注射17α-乙炔基雌二醇(17α-ethynylestradiol, EE2)会抑制雌、雄斑鳢ghr基因的表达；长期注射17α-甲基睾丸酮(17α-methyltestosterone, MT)会抑制雌性斑鳢ghr的表达，但在一定时间内会促进雄性斑鳢ghr的表达。以上结果表明，GHR可能在斑鳢雌雄生长二态性中发挥作用，其表达受性类固醇激素调控，本研究为进一步探究GHR调控斑鳢生长发育的分子机理研究提供参考。

关键词：斑鳢生长激素受体基因(ghr) 基因克隆表达分析激素诱导

Intervention effects and related mechanisms of glycyrrhizic acid on zebrafish with Hirschsprung-associated enterocolitis

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World Journal of Gastrointestinal Surgery 2023年第7期15卷 1317-1330页

作者： Ming-kun liu Ying-jian chen Fei chen Zhi-Xiong Lin Zi-cheng Zhu Yu Lin Yi-Fan Fang Dian-Ming wu Department of Pediatric Surgery Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Pediatric Surgery Fujian Children’s Hospital(Fujian Branch of Shanghai Children’s Medical Center)College of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Pediatric Surgery Fujian Children’s HospitalFuzhou 350001Fujian ProvinceChina Department of Clinical Medicine Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina

BACKGROUND The prevention and treatment of Hirschsprung-associated enterocolitis(HAEC)is a serious challenge in pediatric *** the mechanism of HAEC is conducive to the prevention of this *** To explore the possible mechanism of glycyrrhizic acid(GA)and its therapeutic effect on *** We developed a model of enteritis induced by trinitrobenzenesulfonic acid(TNBS)in zebrafish,and treated it with different concentrations of *** analyzed the effect of GA on the phenotype and inflammation of *** After treatment with TNBS,the area of the intestinal lumen in zebrafish was significantly increased,but the number of goblet cells in the intestinal lumen was significantly reduced,but these did not increase the mortality of zebrafish,indicating that the zebrafish enteritis model was successfully *** concentrations of GA protected zebrafish with *** particular,high concentrations of GA were important for the prevention and control of HAEC because it significantly reduced the intestinal luminal area,increased the number of goblet cells in the intestinal lumen,and reduced the levels of interleukin(IL)-1βand *** GA significantly reduced the intestinal luminal area,increased the number of intestinal goblet cells,and decreased IL-1βand IL-8 in zebrafish,and is important for prevention and control of HAEC.

关键词： Hirschsprung-associated enterocolitis High mobility group box 1 protein Toll-like receptor 4 Interleukin-1β Interleukin-8 Glycyrrhizic acid

Infection,pathology and interferon treatment of the SARS-CoV-2 Omicron BA.1 variant in juvenile,adult and aged Syrian hamsters

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Cellular & Molecular Immunology 2022年第12期19卷 1392-1399页

作者： Lunzhi Yuan Huachen Zhu Peiwen chen Ming Zhou jian Ma Xuan liu kun wu Rirong chen Qiwei liu Huan Yu Lifeng Li Jia Wang Yali Zhang Shengxiang Ge Quan Yuan Qiyi Tang Tong cheng Yi Guan Ningshao Xia State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious DiseasesSchool of Life SciencesSchool of Public HealthXiamen UniversityXiamenFujianChina State Key Laboratory of Emerging Infectious Diseases School of Public HealthLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina Guangdong-Hong Kong Joint Laboratory of Emerging Infectious Diseases/Joint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases Joint Institute of Virology(STU/HKU)Shantou UniversityShantouGuangdongChina EKIH Pathogen Research Institute Futian DistrictShenzhenGuangdongChina Department of Microbiology Howard University College of MedicineWashingtonDCUSA

The new predominant circulating SARS-CoV-2 variant,Omicron,can robustly escape current vaccines and neutralizing *** Omicron has been reported to have milder replication and disease manifestations than some earlier variants,its pathogenicity in different age groups has not been well ***,we report that the SARS-CoV-2 Omicron BA.1 sublineage causes elevated infection and lung pathogenesis in juvenile and aged hamsters,with more body weight loss,respiratory tract viral burden,and lung injury in these hamsters than in adult *** hamsters show a reduced interferon response against Omicron BA.1 infection,whereas aged hamsters show excessive proinflammatory cytokine expression,delayed viral clearance,and aggravated lung *** inhaled IFN-α2b treatment suppresses Omicron BA.1 infection and lung pathogenesis in juvenile and adult ***,the data suggest that the diverse patterns of the innate immune response affect the disease outcomes of Omicron BA.1 infection in different age groups.

关键词： SARS-CoV-2 Omicron Lung pathology Innate immune response Interferon treatment

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乌鳢三种性腺组织的转录组比较分析

农业生物技术学报 2024年第2期32卷 379-395页

作者：黄苏静吴玉霞夏威威张啸天赵建李凯彬罗青刘海洋费树站陈昆慈欧密中国水产科学研究院珠江水产研究所/农业农村部热带亚热带水产种质资源利用与养殖重点实验室上海海洋大学水产与生命学院

乌鳢(Channa argus)是我国重要的淡水经济鱼类，具有显著的性别二态性。为了研究乌鳢性别分化和性腺发育的分子机制，挖掘精、卵巢差异表达的功能基因和信号通路，本研究采用Illumina HiSeq 2000测序平台对6月龄乌鳢XX雌鱼(XX-F)、XY雄... 详细信息

乌鳢(Channa argus)是我国重要的淡水经济鱼类，具有显著的性别二态性。为了研究乌鳢性别分化和性腺发育的分子机制，挖掘精、卵巢差异表达的功能基因和信号通路，本研究采用Illumina HiSeq 2000测序平台对6月龄乌鳢XX雌鱼(XX-F)、XY雄鱼(XY-M)和YY超雄鱼(YY-M)的性腺组织进行了转录组测序(RNA-seq)分析。性腺组织两两样品的表达量相关性分析显示，XY-M精巢和YY-M精巢具有相似的表达模式，与XX-F卵巢表达模式相差甚远，与性腺的组织学结果一致。三种性腺组织的基因差异表达分析显示，XY-M vs XX-F中有12 317个差异表达基因(differentially expressed genes, DEGs)，其中5 427个上调、6 890个下调；XY-M vs YY-M中有212个DEGs，其中59个上调、153个下调；YY-M vs XX-F中有11 282个DEGs，其中5 038个上调、6 244个下调。利用qRT-PCR对性别分化和性腺发育相关的DEGs进行验证，发现抗缪勒管激素2型受体(anti-müllerian hormone receptor type 2, Amhr2)、抗缪勒管激素(anti-müllerian hormone, Amh)、double sex和mab3相关转录因子1(double sex and mab3-related transcription factor1,Dmrt1)、性腺体细胞衍生因子(gonadal somatic cell-derived factor, Gsdf)等10个基因在XY-M和YY-M精巢中高表达，骨形态发生蛋白15(bone morphogenetic protein 15, Bmp15)、性腺型芳香化酶基因Cyp19a1a(cytochrome P450 family 19 subfamily A member 1a)、叉头框转录因子2(forkhead transcription factor gene 2, Foxl2)等9个基因在XX-F卵巢中高表达。qRT-PCR验证结果与转录组分析结果一致，说明Amhr2、Amh、Dmrt1和Gsdf等基因与乌鳢精巢发育调控相关，Bmp15、Cyp19a1a和Foxl2等基因与乌鳢卵巢发育调控相关。另外，对DEGs进行KEGG代谢通路富集分析，发现较多的DEGs富集在性别分化和代谢相关通路，如丝裂原活化蛋白激酶(mitogen-activated protein kinase, MAPK)、无翅型MMTV整合位点家族成员(wingless-type MMTV integration site family, Wnt)以及转化生长因子-β(transforming growth factor-β, TGF-β)信号通路等。本研究筛选出了大量乌鳢性别分化和性腺发育相关的候选基因和信号通路，为后续深入研究乌鳢的性别分化和性腺发育的分子机制及性别相关基因的功能提供了基础资料。

关键词：乌鳢转录组差异表达基因(DEG) 性别分化性腺发育

Scanning tunneling spectroscopic study of monolayer 1T-TaS2 and 1T-TaSe2

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Nano Research 2020年第1期13卷 133-137页

作者： Haicheng Lin Wantong Huang kun Zhao Shuang Qiao Zheng liu jian wu Xi chen Shuai-Hua Ji State Key Laboratory of Low Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing100084China Institute for Advanced Studies Tsinghua UniversityBeijing100084China

The isostructural and isoelectronic transition-metal-dichalcogenides 1T-TaS2 and 1T-TaSe2 are layered materials with intricate electronic *** the molecular beam epitaxy growth,scanning tunneling microscopy measurements and first-principles calculations,we prepare monolayer 1T-TaS2 and TaSe2 and explore their electronic structures at the atomic *** two-dimensional(2D)compounds exhibit commensurate charge density wave phase at low *** conductance mapping identifies the contributions from different Ta atoms to the local density of states with spatial and energy *** 1T-TaS2 and 1T-TaSe2 monolayer are shown to be insulators,while the former has a Mott gap and the latter is a regular band insulator.

关键词： monolayer 1T-TaS2 1T-TaSe2 commensurate charge density wave(CCDW) Mott gap band insulator