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Quantitative prediction and ranking of the shock sensitivity ofexplosives via reactive molecular dynamics simulations

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Defence Technology（防务技术） 2022年第5期18卷 843-854页

作者： kun Yang Lang chen Dan-yang liu De-shen Geng jian-ying Lu Jun-ying wu State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China

A deep understanding of explosive sensitivities and their factors is important for safe and reliable ***,quantitative prediction of the sensitivities is ***,reactive molecular dynamics simulation models for high-speed piston impacts on explosive supercells were *** were also performed to investigate shock-induced reactions of various high-energy *** fraction of reacted explosive molecules in an initial supercell changed linearly with the propagation distance of the shock-wave *** corresponding slope could be used as a reaction rate for a specific shock-loading *** rates that varied with the shock-loading pressure exhibited two-stage linearities with different *** two inflection points corresponded to the initial and accelerated reactions,which respectively correlated to the thresholds of shock-induced ignition and ***,the ignition and detonation critical pressures could be *** sensitivity could then be a quantitative prediction of the critical *** accuracies of the quantitative shock sensitivity predictions were verified by comparing the impact and shock sensitivities of common explosives and the characteristics of anisotropic shock-induced *** dynamics simulations quantitatively predict and rank shock sensitivities by using only crystal structures of the ***,this method will enable the design and safe use of explosives.

关键词： Explosive Shock sensitivity Quantitative prediction Reactive molecular dynamics simulation

Scanning tunneling spectroscopic study of monolayer 1T-TaS2 and 1T-TaSe2

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Nano Research 2020年第1期13卷 133-137页

作者： Haicheng Lin Wantong Huang kun Zhao Shuang Qiao Zheng liu jian wu Xi chen Shuai-Hua Ji State Key Laboratory of Low Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing100084China Institute for Advanced Studies Tsinghua UniversityBeijing100084China

The isostructural and isoelectronic transition-metal-dichalcogenides 1T-TaS2 and 1T-TaSe2 are layered materials with intricate electronic *** the molecular beam epitaxy growth,scanning tunneling microscopy measurements and first-principles calculations,we prepare monolayer 1T-TaS2 and TaSe2 and explore their electronic structures at the atomic *** two-dimensional(2D)compounds exhibit commensurate charge density wave phase at low *** conductance mapping identifies the contributions from different Ta atoms to the local density of states with spatial and energy *** 1T-TaS2 and 1T-TaSe2 monolayer are shown to be insulators,while the former has a Mott gap and the latter is a regular band insulator.

关键词： monolayer 1T-TaS2 1T-TaSe2 commensurate charge density wave(CCDW) Mott gap band insulator

Intervention effects and related mechanisms of glycyrrhizic acid on zebrafish with Hirschsprung-associated enterocolitis

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World Journal of Gastrointestinal Surgery 2023年第7期15卷 1317-1330页

作者： Ming-kun liu Ying-jian chen Fei chen Zhi-Xiong Lin Zi-cheng Zhu Yu Lin Yi-Fan Fang Dian-Ming wu Department of Pediatric Surgery Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Pediatric Surgery Fujian Children’s Hospital(Fujian Branch of Shanghai Children’s Medical Center)College of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Pediatric Surgery Fujian Children’s HospitalFuzhou 350001Fujian ProvinceChina Department of Clinical Medicine Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina

BACKGROUND The prevention and treatment of Hirschsprung-associated enterocolitis(HAEC)is a serious challenge in pediatric *** the mechanism of HAEC is conducive to the prevention of this *** To explore the possible mechanism of glycyrrhizic acid(GA)and its therapeutic effect on *** We developed a model of enteritis induced by trinitrobenzenesulfonic acid(TNBS)in zebrafish,and treated it with different concentrations of *** analyzed the effect of GA on the phenotype and inflammation of *** After treatment with TNBS,the area of the intestinal lumen in zebrafish was significantly increased,but the number of goblet cells in the intestinal lumen was significantly reduced,but these did not increase the mortality of zebrafish,indicating that the zebrafish enteritis model was successfully *** concentrations of GA protected zebrafish with *** particular,high concentrations of GA were important for the prevention and control of HAEC because it significantly reduced the intestinal luminal area,increased the number of goblet cells in the intestinal lumen,and reduced the levels of interleukin(IL)-1βand *** GA significantly reduced the intestinal luminal area,increased the number of intestinal goblet cells,and decreased IL-1βand IL-8 in zebrafish,and is important for prevention and control of HAEC.

关键词： Hirschsprung-associated enterocolitis High mobility group box 1 protein Toll-like receptor 4 Interleukin-1β Interleukin-8 Glycyrrhizic acid

Infection,pathology and interferon treatment of the SARS-CoV-2 Omicron BA.1 variant in juvenile,adult and aged Syrian hamsters

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Cellular & Molecular Immunology 2022年第12期19卷 1392-1399页

作者： Lunzhi Yuan Huachen Zhu Peiwen chen Ming Zhou jian Ma Xuan liu kun wu Rirong chen Qiwei liu Huan Yu Lifeng Li Jia Wang Yali Zhang Shengxiang Ge Quan Yuan Qiyi Tang Tong cheng Yi Guan Ningshao Xia State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious DiseasesSchool of Life SciencesSchool of Public HealthXiamen UniversityXiamenFujianChina State Key Laboratory of Emerging Infectious Diseases School of Public HealthLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina Guangdong-Hong Kong Joint Laboratory of Emerging Infectious Diseases/Joint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases Joint Institute of Virology(STU/HKU)Shantou UniversityShantouGuangdongChina EKIH Pathogen Research Institute Futian DistrictShenzhenGuangdongChina Department of Microbiology Howard University College of MedicineWashingtonDCUSA

The new predominant circulating SARS-CoV-2 variant,Omicron,can robustly escape current vaccines and neutralizing *** Omicron has been reported to have milder replication and disease manifestations than some earlier variants,its pathogenicity in different age groups has not been well ***,we report that the SARS-CoV-2 Omicron BA.1 sublineage causes elevated infection and lung pathogenesis in juvenile and aged hamsters,with more body weight loss,respiratory tract viral burden,and lung injury in these hamsters than in adult *** hamsters show a reduced interferon response against Omicron BA.1 infection,whereas aged hamsters show excessive proinflammatory cytokine expression,delayed viral clearance,and aggravated lung *** inhaled IFN-α2b treatment suppresses Omicron BA.1 infection and lung pathogenesis in juvenile and adult ***,the data suggest that the diverse patterns of the innate immune response affect the disease outcomes of Omicron BA.1 infection in different age groups.

关键词： SARS-CoV-2 Omicron Lung pathology Innate immune response Interferon treatment

A novel robust nomogram based on peripheral monocyte counts for predicting lymph node metastasis of prostate cancer

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Asian Journal of Andrology 2021年第4期23卷 409-414页

作者： Jia-Wei Zhou Yun-Hua Mao Yang liu Hai-Tao Liang Chandni Chandur Samtani Yue-wu Fu Yun-Lin Ye Gang Xiao Zi-Ke Qin Cun-Dong liu jian-kun Yang Qi-Zhao Zhou Wen-Bin Guo Kang-Yi Xue Shan-Chao Zhao Ming-kun chen Department of Urology The Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510630China Department of Urology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Urology Cancer Center of Sun Yat-sen UniversityGuangzhou 510060China Department of International Medical Education The Southern Medical UniversityGuangzhou 510515China Department of Surgery The First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Department of Laboratory Medicine The Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510630China Department of Urology Nanfang Hospital of Southern Medical UniversityGuangzhou 510515China

Accurate methods for identifying pelvic lymph node metastasis(LNM)of prostate cancer(PCa)prior to surgery are still *** aimed to investigate the predictive value of peripheral monocyte count(PMC)for LNM of PCa in this *** hundred and ninety-eight patients from three centers were divided into a training set(n=125)and a validation set(n=173).In the training set,the independent predictors of LNM were analyzed using univariate and multivariate logistic regression analyses,and the optimal cutoff value was calculated by the receiver operating characteristic(ROC)*** sensitivity and specificity of the optimal cutoff were authenticated in the validation ***,a nomogram based on the PMC was constructed for predicting *** analyses of the training cohort demonstrated that clinical T stage,preoperative Gleason score,and PMC were independent risk factors for *** subsequent ROC analysis showed that the optimal cutoff value of PMC for diagnosing LNM was 0.405×10^(9)l^(−1)with a sensitivity of 60.0%and a specificity of 67.8%.In the validation set,the optimal cutoff value showed significantly higher sensitivity than that of conventional magnetic resonance imaging(MRI)(0.619 vs 0.238,P<0.001).The nomogram involving PMC,free prostate-specific antigen(fPSA),clinical T stage,preoperative Gleason score,and monocyte-to-lymphocyte ratio(MLR)was generated,which showed a robust predictive capacity for predicting LNM before the *** results indicated that PMC as a single agent,or combined with other clinical parameters,showed a robust predictive capacity for LNM in *** can be employed as a complementary factor for the decision of whether to conduct pelvic lymph node dissection.

关键词： Iymph node metastasis magnetic resonance imaging monocyte nomogram prostate cancer

Feedback on a shared big dataset for intelligent TBM PartⅠ:Feature extraction and machine learning methods

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Underground Space 2023年第4期11卷 1-25页

作者： jian-Bin Li Zu-Yu chen Xu Li liu-Jie Jing Yun-Pei Zhangf Hao-Han Xiao Shuang-Jing Wang Wen-kun Yang Lei-Jie wu Peng-Yu Li Hai-Bo Li Min Yao Li-Tao Fan China Railway Group Co.Ltd. Beijing 100089China Department of Geotechnical Engineering China Institute of Water Resources and Hydropower ResearchBeijing 100038China Key Laboratory of Urban Underground Engineering Ministry of EducationBeijing Jiaotong UniversityBeijing 100044China China Railway Engineering Equipment Group Co. Ltd.ZhengzhouHenan 450016China School of Civil Engineering Southeast UniversityNanjing 211189China Xi’an University of Technology Xi’an 710048China

This review summarizes the research outcomes and findings documented in 45 journal papers using a shared tunnel boring machine(TBM)dataset for performance prediction and boring efficiency optimization using machine learning *** big dataset was col-lected during the Yinsong water diversion project construction in China,covering the tunnel excavation of a 20 km-section with 199 items of monitoring metrics taken with an interval of one *** research papers were the result of a call for contributions during a TBM machine learning contest in 2019 and covered a variety of topics related to the intelligent construction of *** review com-prises two *** I is concerned with the data processing,feature extraction,and machine learning methods applied by the *** review finds that the data-driven and knowledge-driven approaches in extracting important features applied by various authors are diversified,requiring further studies to achieve commonly accepted *** techniques for cleaning and amending the raw data adopted by the contributors were summarized,indicating some highlights such as the importance of sufficiently high fre-quency of data acquisition(higher than 1 second),classification and standardization for the data preprocessing process,and the appro-priate selections of features in a boring *** review finds that both supervised and unsupervised machine learning methods have been utilized by various *** ensemble and deep learning methods have found wide *** I highlights the impor-tant features of the individual methods applied by the contributors,including the structures of the algorithm,selection of hyperparam-eters,and model validation approaches.

关键词： Big data Machine learning method TBM construction Data extraction Machine learning contest

Feedback on a shared big dataset for intelligent TBM Part Ⅱ:Application and forward look

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Underground Space 2023年第4期11卷 26-45页

作者： jian-Bin Li Zu-Yu chen Xu Li liu-Jie Jing Yun-Pei Zhang Hao-Han Xiao Shuang-Jing Wang Wen-kun Yang Lei-Jie wu Peng-Yu Li Hai-Bo Li Min Yao Li-Tao Fan China Railway Group Co.Ltd Beijing 100089China Department of Geotechnical Engineering China Institute of Water Resources and Hydropower ResearchBeijing 100038China Key Laboratory of Urban Underground Engineering Ministry of EducationBeijing Jiaotong UniversityBeijing 100044China China Railway Engineering Equipment Group Co. LtdZhengzhouHenan 450016China School of Civil Engineering Southeast UniversityNanjing 211189China Xi’an University of Technology Xi’an 710048China

This review discusses the application scenarios of the machine learning-supported performance prediction and the optimization effi-ciency of tunnel boring machines(TBMs).The rock mass quality ratings,which are based on the Chinese code for geological survey,were used to provide"labels"suitable for supervised *** a result,the generation of machine prediction for rock mass grades reason-ably agreed with the ground truth documented in geological *** contrast,the main operational parameters,i.e.,thrust and torque,can be reasonably predicted based on historical ***,18 collapse sections of the Yinsong project have been successfully predicted by several *** studies on the selection of the optimal penetration rate and cost were *** review also presents a summary of the main achievements in response to the initiatives of the Lotus Pool Contest in *** the first time,large and well-documented TBM performance data has been shared for joint scientific ***,the review discusses the technical problems that require further study and the perspectives in the future development of intelligent TBM construction based on big data and machine learning.

关键词： TBM performance prediction TBM rock mass quality rating TBM-supported machine learning Rock mass classification ensemble Tunnel collapse

Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1369-1376页

作者： Lunzhi Yuan Huachen Zhu Ming Zhou jian Ma Rirong chen Yao chen Liqiang chen kun wu Minping Cai Junping Hong Lifeng Li Che liu Huan Yu Yali Zhang Jia Wang Tianying Zhang Shengxiang Ge Jun Zhang Quan Yuan Yixin chen Qiyi Tang Honglin chen Tong cheng Yi Guan Ningshao Xia State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious DiseasesSchool of Life SciencesSchool of Public HealthXiamen UniversityXiamenP.R.China State Key Laboratory of Emerging Infectious Diseases The University of Hong KongHong KongP.R.China Joint Institute of Virology(Shantou University and The University of Hong Kong) Guangdong-Hongkong Joint Laboratory of Emerging Infectious DiseasesShantou UniversityShantouP.R.China Department of Microbiology Howard University College of MedicineWashingtonDCUSA Research Unit of Frontier Technology of Structural Vaccinology Chinese Academy of Medical SciencesXiamenFujianChina

Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung *** experimentally demonstrate the epidemiological results,we performed animal studies to infect male and female Syrian hamsters with ***,high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss,weakness,piloerection,hunched back and abdominal respiration,as well as severe pneumonia,pulmonary edema,consolidation,and *** contrast with the males,the female hamsters showed much lower shedding viral titers,moderate symptoms,and relatively mild lung *** obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender.

关键词： pathogenesis lung infection

Therapeutic effect of an injectable sustained-release sinomenine hydrochloride and sodium hyaluronate compound in a rabbit model of osteoarthritis

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Chinese Medical Journal 2012年第14期125卷 2543-2547页

作者： liu Wen-guang LING Pei-xue LIN Xiu-kun chen jian-ying WANG Shao-jin LI Peng wu Xiao-juan ZHAO Dong-mei liu Sheng-hou Institute of Biopharmaceuticals of Shandong Province JinanShandong 250101 China Institute of Oceanology Chinese Academy of Sciences QingdaoShandong 266071 China Department of Pathology Shandong University School ofMedicine Jinan Shandong 250014 China

Background While intra-articular injection of sinomenine hydrochloride has a therapeutic effect on osteoarthritis, it has a short half-life, and is thermolabile and photolabile. The aim of this research was to evaluate the sustained-release of sinomenine hydrochloride from an injectable sinomenine hydrochloride and sodium hyaluronate compound （CSSSI） and its therapeutic effect in a rabbit model of osteoarthritis following intra-articular injection. Methods An injectable compound consisting of 1% sodium hyaluronate and 2.5% sinomenine hydrochloride was prepared and kept as the experiment group, and 2.5% sinomenine hydrochloride was prepared and kept as the control group. The cumulative mass release was measured at different time points in each group in vitro. Sixty-five male Zelanian rabbits were randomly divided into five groups： 15 （30 knees） each for the control, sodium hyaluronate, sinomenine hydrochloride, and CSSSI groups respectively, and five （10 knees） for the modeling group. Papain was injected into both knees of each rabbit for model establishment. Subsequently, 0.2 ml of the corresponding drugs was injected into the articular cavities of the remaining experiment groups, while the control group was treated with 0.2 ml normal saline. All groups were treated once a week for 4 weeks. Seven days after the last treatment, knees were anatomized to perl^orm pathological observations and Mankin＇s evaluation of the synovium. Four groups were compared using the SPSS 13.0 software package. Results In the in vitro sustained-release experiments, 90% of the drug was released in the experiment group 360 minutes following the injection. Comparison of the Mankin＇s evaluations of the four groups illustrated statistical discrepancies （P 〈0.05）. In further paired comparisons of the CSSSI group vs. modeling control/sodium hyaluronate/sinomenine hydrochloride groups, statistical significance was uniformly obtained. Moreover, sodium hyaluronate and sinomenine hydrochloride treat

关键词： sinomenine osteoarthritis sodium hyaluronate articular cavity injection