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Epidemiological, Clinical and Prognostic Profiles of Measles in Children in the Pediatric Ward of the University Hospital of Conakry

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Open Journal of Pediatrics 2024年第6期14卷 965-972页

作者： Salématou Hassimiou Camara Kaba Bangoura Ouo Ouo Kolié aissata barry Fatoumata Binta Diallo Mohamed Lamine Diallo Emmanuel Camara Department of Paediatrics Donka National Hospital Conakry Guinea.

Introduction: Measles is a highly contagious viral infectious disease. It is one of the major causes of infant morbidity and mortality in developing countries. The general objective was to study the epidemiological, clinical and prognostic aspects of measles in the paediatric department of Conakry University Hospital. Methods: This was a prospective descriptive study lasting six months, from 01 October 2021 to 31 March 2022, in the paediatric wards of Conakry University Hospital. It included all patients aged between 0 and 15 years, received in consultation and/or hospitalised for measles and whose parents agreed to participate in the study. Results: Out of 3916 cases of paediatric pathology, we collected 380 cases of measles, i.e., 9.7%. The 0 - 4 age group was the most affected, accounting for 60.8%, with an average age of 26.6 ± 18.8 months and extremes of 3 months and 150 months. Females predominated in 53.2% of cases, with a sex ratio of 0.9. Non-vaccinated children accounted for 226 cases (59.5%). Fever was the most common clinical sign in the study (97.11%), followed by oculonasal catarrh (83.9%) and maculopapular lesions (82.1%). A notion of contagion was noted in 254 patients, i.e., a rate of 66.8%. The main complications were ocular in 229 cases (60.3%), pulmonary in 139 cases (36.6%) and digestive in 124 cases (32.6%). Malnutrition was noted in only 15 patients (3.93%). Treatment was symptomatic. The outcome was favourable in 92.3% of cases. We recorded 20 cases of death (5.3%) and 9 cases of escape (2.4%). Conclusion: Despite progress in the control and management of measles, much remains to be done to improve vaccination coverage with the aim of eradicating this disease.

关键词： Measles Child Conakry University Hospital

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Management of Acute Diarrhoea in Children Aged 0 - 59 Months in the Paediatric Ward of the Ratoma CMC (Guinea)

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Open Journal of Pediatrics 2024年第6期14卷 1108-1116页

作者： Camara Salématou Hassimiou Bah Fatoumata Binta barry aissata Diallo Mohamed Lamine Bangoura M’mah Aminata Bangoura Kaba Diallo Fatoumata Binta Kolié Ouo Ouo Department of Paediatrics Donka National Hospital Conakry Guinea Paediatric Emergency Department Donka National Hospital Conakry Guinea

Introduction: Acute diarrhoea is a real public health problem worldwide and is responsible for considerable mortality in developing countries. The aim of this study was to evaluate the management of acute diarrhoea in children aged 0 - 59 months hospitalised in the paediatric ward of the Ratoma CMC. Material and Methods: This was a descriptive cross-sectional study lasting 6 months, from 01 July to 31 December 2023, including all children aged 0-59 months admitted for diarrhoea lasting no more than 14 days and whose parents agreed to take part in the study. Sociodemographic, clinical, therapeutic and evolutionary data were studied. Results: 79 children were seen for acute diarrhoea out of 330 consulted, i.e., a frequency of 23.9%. The age group 0 - 11 months was the most represented, at 54.4%. Males predominated: 62% with a sex ratio of 1.6. The average consultation time was 3 days, with extremes of 0 to 10 days. The number of bowel movements per day varied from 3 to 12. The stools were liquid in 82.27% of cases. All hospitalised children were dehydrated, with 68.4% suffering from moderate dehydration, 21.5% from mild dehydration and 10.1% from severe dehydration. Malaria was the condition most frequently associated with diarrhoea (27.8%). Malnutrition was found in only 2.5%. 82% of the children had received oral rehydration with ORS and 18% intravenous rehydration. Almost all the children (93.67%) had a favourable outcome. We recorded one case of death, a rate of 1.26%. Conclusion: Acute diarrhoea in children is one of the most frequent reasons for consultation in the paediatric department of the Ratoma CMC. Often accompanied by fever and vomiting, it is frequently observed in children aged 0 to 11 months, with a predominance of males. The overall management of acute diarrhoea in children involves improving people’s standard of living, combating faecal peril, drinking water consumption, promoting vaccination, the use of oral rehydration solutions and zinc, and trai

关键词： Diarrhoea Child Ratoma Guinea

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Glomerular Filtration Rate of Children with Sickle Cell Disease Compared to Non-Sickle Cell Patients in Donka Pediatric Emergencies and SOS Drepano-Guinea Center

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Open Journal of Pediatrics 2023年第4期13卷 562-567页

作者： Mohamed Lamine Diallo Emmanuel Camara Mamadou Moustapha Diop Mamadou Cire barry Fatoumata Binta Diallo aissata barry Saliou Bellanrcisse Diallo Narcisse Idohou Ganin Paul Ulrich N’dri N’gotta Mamdy Dramé Telly Sy Mohamed Lamine Kaba Paediatric Emergency Donka National Hospital Conakry Guinea Paediatrics Department Donka National Hospital Conakry Guinea Department of Paediatrics H&#244pital National Ignace Deen Conakry Guinea Centre SOS Drépano-Guinée Conakry Guinea Department of Gynaecology and Obstetrics H&#244pital National Ignace Deen Conakry Guinea Haemodialysis Department Donka National Hospital Conakry Guinea

Introduction: Our study focused on the evaluation of renal function in children with sickle cell disease compared to children without sickle cell disease at the pediatric emergency unit of the Donka National Hospital and SOS Drepano-Guinea center. Patients and Methods: This was a cross-sectional descriptive and analytical study lasting 3 months (October 1 to December 31, 2020). Were included, all sickle cell and non-sickle cell children aged 0 to 15 received on an outpatient basis and had undergone an exploration of renal function (serum creatinine and urine dipstick). Results: We performed the urine dipstick and serum creatinine in 75 children, 45 of whom were sickle cell and 30 were not sickle cell. 27 of our patients or 36% had a reduction in GFR, among them 9 or 20% were sickle cell and 18 or 60% were not sickle cell. The most affected age group was 5 to 9 years in sickle cell (66.7%) and non-sickle cell (38.9%). In sickle cell patients, 9 cases (100%) had mild renal failure (IRL). Non-sickle cell patients, had 14 cases or 77.8% of IRL and 4 cases (22.2%) of moderate IR. Sickle cell disease and antibiotics which had the respective p-value (0.01);(0.02), were statistically significant with the onset of renal failure. Conclusion: Several factors including sickle cell anemia and antibiotics are believed to be involved in lowering GFR. It would be essential to detect early the children received in consultation.

关键词： Flow Filtration Glomerular Child Sickle Cell Disease

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Evaluation of Glomerular Filtration Rate and Urinary Abnormalities in Children with Cancer before Chemotherapy

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Open Journal of Pediatrics 2023年第4期13卷 594-603页

作者： Mamadou Moustapha Diop aissata barry Ouo Ouo Kolié Emanuel Camara Mohamed Lamine Diallo Kaba Bangoura Mamadou Aliou Doukouré Pé Neabel Beimy Dienab Diallo Moustapha Kouyate Mohamed Lamine Kaba Department of Pediatrics Faculty of Health Sciences and Technologies Gamal Abdel Nasser University Conakry Republic of Guinea Pediatric Emergency CHU Donka Ministry of Higher Education Scientific Research and Innovation Conakry Republic of Guinea Hemodialysis Department CHU Donka Ministry of Higher Education Scientific Research and Innovation Conakry Republic of Guinea

Introduction: Glomerular filtration is an important elimination pathway for many types of chemotherapy. Accurate estimation of glomerular filtration is essential in the management of children with cancer. Methodology: This was a prospective cross-sectional study of the descriptive type extending over a period of 6 months from July 01 to December 31, 2021 on all children with cancer followed in the pediatric hemato-oncology unit of the HND with a renal, blood and urinary assessment associated with the GFR calculated by the SCHWARTZ formula during the study period. Results: During the study period, we registered 41 new cases of cancer in the pediatric oncology unit. The age group of 0 - 5 years was the most represented, i.e. 65.85% and the average age was 5.6 ± 4 years. The most cited clinical signs were fever ie 56.10% followed by abdominal pain 34.15% and anemia 26.83%. The most represented diagnosis was Burkitt’s Lymphoma, i.e. 26.83% followed by Retinoblastoma 24.39%. Mean serum creatinine was 70.65 ± 68.93 μmol/L. In our series, patients whose normal glomerular filtration rate were more represented, i.e. 70.73% and 29.27% had an abnormal GFR with an average of 87.28 ± 70 mL/min/1.73m2. Proteinuria and leukocyturia were observed in 31.71% and 19.51% respectively. Glycosuria and hematuria with common frequencies of 2.44% of patients. Conclusion: The prevention of renal toxicity of anticancer drugs always involves the precise evaluation of renal function using the Schwartz formula in children. .

关键词： GFR Child Cancer Chemotherapy

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Frequency of Group A Beta-Hemolytic Streptococcal Angina in Children in the Department of Pediatrics of Donka National Hospital

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Open Journal of Pediatrics 2020年第4期10卷 610-616页

作者： Mamadou Moustapha Diop aissata barry Emmanuel Camara Mohamed Lamine Diallo M’mah Aminata Bangoura Hasmiou Dia Saliou Bella Diallo Mamadou Aliou Doukouré Moustapha Kouyaté Narcisse Viani Gateu Tadjom Mamadou Pathé Diallo Pediatrics Department Donka National Hospital Conakry Republic of Guinea Paediatric Medical Emergency Donka National Hospital Conakry Republic of Guinea Institute of Nutrition and Child Health Conakry Republic of Guinea Paediatrics Department Ignace Deen National Hospital Conakry Republic of Guinea Medical Centre and Health Counselling Conakry Guinea

Background: Angina is a common paediatric condition. It has certain peculiarities in children, particularly with regard to the frequency of bacterial germs and the use of diagnostic tests. The aim of this study was to determine the place of the rapid diagnostic test in the management of group A beta-hemolytic streptococcal angina in children in the paediatric ward at Donka National Hospital. Methods: This was a prospective descriptive study lasting 6 months from 1st February to 31st July 2019 concerning children aged between 3 and 15 years old who were diagnosed with angina. Epidemiological, clinical, para-clinical and therapeutic variables were studied. Results: Out of 1494 registered children, we collected 116 cases of angina (7.76%). Out of 52 patients who benefited from the rapid diagnostic test, we recorded 13 cases of angina due to group A beta-hemolytic strptococcus. The male sex was the most dominant with 31 cases (59.69%) and a G/F sex ratio of 1.47. The age group most affected was between 3 and 5 years old (50%). The average age of ou

关键词： Angina Frequency Clinic Treatment Pediatrics Donka

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Transient Diabetes Induced by L-Asparaginase

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Open Journal of Pediatrics 2023年第6期13卷 862-865页

作者： Mamadou Moustapha Diop M’mah Aminata Bangoura aissata barry Emmanuel Camara Kolié Ouo Ouo Pé Neabei Beimy Mohamed Lamine Diallo Kaba Bangoura Moustapha Kouyate Mohamed Lamine Kaba Aka Nbga Department of Paediatrics Faculty of Health Sciences and Techniques Gamal Abdel Nasser University Conakry Republic of Guinea Urgence Pédiatrique CHU Donka Ministère de l’enseignement de la recherche scientifique et de l’innovation Conakry Republic of Guinea Haemodialysis Department CHU Donka Ministry of Education Scientific Research and Innovation Conakry Republic of Guinea

Background: Although hyperglycaemia is one of the known side effects of L-asparaginase, its contribution to the development of diabetic ketoacidosis (DKA) is less well known in the literature. Asparaginase is an essential component of treatment protocols for acute lymphoblastic leukaemia (ALL) in combination with other chemotherapeutic drugs. On further evaluation, she was found to have high anion gap metabolic acidosis, hyperglycaemia and ketonuria. In recent decades, the use of these chemotherapeutic agents has led to a decrease in mortality and disease-free survival in ALL. L-asparaginase is one of the chemotherapy protocols used in the treatment of acute lymphoblastic leukaemia (ALL) and can induce hyperglycaemia which is aggravated by the concomitant use of corticosteroids. We report the observation of a 14-year-old girl treated with chemotherapy (GFA LAL protocol) who developed transient diabetes following the use of L-asparaginase. She was treated at the Donka paediatric haemato-oncology unit by a multidisciplinary team including a paediatric oncologist, a psychologist and a diabetologist. The aim of this study was to highlight blood glucose monitoring before and after the use of asparaginase in acute lymphoblastic leukaemia. Conclusion: We conclude that the occurrence of ketoacidosis following the use of asparaginase is a rare event. We recommend close monitoring of blood glucose levels for hyperglycaemia in patients with ALL receiving L-asparaginase.

关键词： Asparaginase Diabetes ALL Donka

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Macroscopic Congenital Malformations at the Institute of Nutrition and Child Health (INSE)

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Open Journal of Pediatrics 2023年第6期13卷 879-893页

作者： M’mah Aminata Bangoura aissata barry Salimatou Hassimiou Camara Sory Diallo Kadiatou Péthé Diallo Amadou Oury Toure Mariama Sadio Diallo Ouo Ouo Kolié Fatoumata Binta Diallo Moustapha Kouyaté Kaba Bangoura Mamadou Aliou Doukouré Emmanuel Camara Mamadou Moustapha Diop Ibrahima Sory Diallo Institute of Nutrition and Child Health Donka National Hospital-CHU Conakry University of Conakry Conakry Guinea Service of Pediatrics HN Donka-CHU Conakry University of Conakry Conakry Guinea

Introduction: A congenital malformation is defined as a morphological abnormality of an organ or body region resulting from an abnormal developmental process during the formation of the embryo or fetus. Depending on their type, location and size, malformations can cause functional, psychological and aesthetic defects. The aim of this study is to document the frequency of congenital malformations, describe the characteristics of malformed newborns and their biological mothers, and identify the different types of malformations presented by newborns at the INSE. Methods: Descriptive cross-sectional study of clinically visible malformed newborns. It was carried out from January 1, 2021 to January 1, 2022 at the INSE neonatology unit. Epi info version 3.1 software was used for data entry and analysis. Results: Of a total of 2332 neonates hospitalized during the study period, 81 (3.5%) cases had at least one clinically visible congenital malformation. Nearly 84% had an age ≤ 7 days at the time of admission. The male sex was most concerned (60.5%). Newborns referred by a health facility accounted for 84%. Malformations of the digestive system accounted for 30.9% of cases, followed by those of the limbs (19.8%) and poly malformative syndrome (19.8%). Conclusion: This study shows that congenital malformations exist and are frequent in Guinea. Our results could therefore be the starting point for the future establishment of a national register of congenital malformations.

关键词： Congenital Malformation Institute Nutrition Child Heath

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Ecotoxicological assessment of diffuse pollution using biomonitoring tool for sustainable land use in Thailand

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Journal of Environmental Sciences 2010年第6期22卷 858-863页

作者： Chuleemas Boonthai Iwai barry Noller Department of Plant Sciences and Agricultural Resources Land Resourcesand Environment SectionFaculty of AgricultureKhon Kaen University The University of Queensland Centre for Mined Land Rehabilitation (CMLR)

As a developing country, Thailand has a significant issue with diffuse pollution of the soil ecosystem due to an indiscriminate use of agrichemicals and poorly regulated disposal of a wide variety of hazardous wastes. Practical risk assessment tools based on locallyoccurring species are needed to assess the effects of diffuse pollutants on the soil ecosystem in Thailand because reliance on soil criteria developed for overseas conditions may provide inadequate protection. Native soil organisms in Thailand may be more or less sensitive to contaminants compared to overseas test species. This article described a biological indicator approach for ecological risk assessment of diffuse pollution in the soil ecosystem of Thailand from pesticide application with the aim of developing standardized protocols using native species and locally generated data to better evaluate the ecological risks of non-point source soil pollution. It was found that ecotoxicological assessment provided a better understanding of the ecological impacts that diffuse pollution induced on Thai environmental conditions. Thai soil biota species were more sensitive to soil contaminants than similar species overseas. Soil series also had an influence on the ecotoxicology of contaminants to soil biota. Collembolan, Cyphoderus sp., was demonstrated as a useful alternative test species to Folsomia candida （international test species） for terrestrial ecotoxicological testing of Thai soils. In addition, the soil biota activities such as soil respiration and earthworm avoidance including soil biodiversity and the litter bag decomposition technique are also good tools to assess the effects of diffuse pollution by pesticides on the soil ecosystem of Thailand.

关键词： ecotoxicological assessments diffuse pollution biomonitoring soil ecosystem

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Non-Uniformity and Generalised Sacks Splitting

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Acta Mathematica Sinica,English Series 2002年第2期18卷 327-334页

作者： COOPER S.barry Department of Pure Mathematics School of Mathematics University of Leeds Leeds UK Institute of Software Chines Academy of Sciences Beijing P. R. China

We show that there do not exist computable fimetions f_1(e,i).f_2(e,i).g_1(e,i),g_2(e,i)such that for all e,i ∈ω, (1)(W_(f_1)(e,i)-W_(f_2)(e,i))≤T(W_e-W_1): (2)(W_(g_1)(e,i)-W_(g_2)(e,i))≤T(W_e-W_i): (3)(W_w-W_i)≤T(W_(f_1)(e,i)-W_(f_2)(e,i))⊕(W_(g_1)(e,i)-W_(g_2)(e,i)): (4)(W_e-W_i)T(W_(f_1)(e,i)-W_(f_2)(e,i))uuless(W_e-W_i)≤T:and (5)(W_e-W_i)T(E_(g_1)(e,i)-W_(g_2)(e,i))unless(W_w-W_i)≤T. It follows that the splitting theorems of Sacks and Cooper cannot be combined uniformly.

关键词： Computably enumerable(c.e.) Difference of computably enumerable sets(d.c.e.,or 2-c.e.) Turing degrees Splitting and nonsplitting

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WHAT I LEARNED FROM BRITTON CHANCE

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 223-226页

作者： barry R.MASTERS Department of the History of Science Harvard UniversityCambridgeMA 02138USA Department of Biological Engineering Massachusetts Institute of Technology CambridgeMA 02139USA

In this personal and reflective article,I honor the memory of Britton Chance and explain how his mentorship during my tenure at the Johnson Research Foundation greatly impacted my scientific career.I emphasize the critical role of mentors on the development of scientists and present some wonderful and remarkable attributes that characterized Britton Chance's scientific and personal style.

关键词： Britton Chance mentorship scientific attributes and style

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