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Naked-eye visualization of lymph nodes using fluorescence nanoprobes in non-human primate-animal models

Nano Research 2024年第8期17卷 7404-7414页

作者： Xiaoyuan Ji Binbin Chu Xiaofeng Wu Zhiming Xia airui jiang Chenyu Wang Zhiming Chen Danni Zhong Qiaolin Wei Bin Song Wanlin Li Yiling Zhong Houyu Wang Fenglin Dong Min Zhou Yao He Suzhou Key Laboratory of Nanotechnology and Biomedicine Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesInstitute of Functional Nano and Soft Materials(FUNSOM)Soochow UniversitySuzhou 215123China School of Public Health Shanghai Jiao Tong University School of MedicineShanghai 200025China Zhejiang University-University of Edinburgh Institute(ZJU-UoE Institute) Zhejiang UniversityHaining 314400China Department of Ultrasound the First Affiliated Hospital of Soochow UniversitySuzhou 215006China State Key Laboratory(SKL)of Biobased Transportation Fuel Technology Zhejiang UniversityHangzhou 310027China School of Pharmacy Hangzhou Normal UniversityHangzhou 311121China Macao Translational Medicine Center Macao University of Science and TechnologyTaipa 999078MacaoChina Macao Institute of Materials Science and Engineering Macao University of Science and TechnologyTaipa 999078MacaoChina

Despite sufficient studies performed in non-primate animal models,there exists scanty information obtained from pilot trials in non-human primate animal models,severely hindering nanomaterials moving from basic research into clinical *** herein present a pioneering demonstration of nanomaterials based optical imaging-guided surgical operation by using macaques as a typical kind of non-human primate-animal ***,taking advantages of strong and stable fluorescence of the small-sized(diameter:~5 nm)silicon-based nanoparticles(SiNPs),lymphatic drainage patterns can be vividly visualized in a real-time manner,and lymph nodes(LN)are able to be sensitively detected and precisely excised from small animal models(e.g.,rats and rabbits)to non-human primate animal models(e.g.,cynomolgus macaque(Macaca fascicularis)and rhesus macaque(Macaca mulatta)).Compared to clinically used invisible near-infrared(NIR)lymphatic tracers(i.e.,indocyanine green(ICG);etc.),we fully indicate that the SiNPs feature unique advantages for naked-eye visible fluorescence-guided surgical operation in long-term *** toxicological analysis in macaque models further provides confirming evidence of favorable biocompatibility of the SiNPs *** expect that our findings would facilitate the translation of nanomaterials from the laboratory to the clinic,especially in the field of cancer treatment.

关键词： fluorescent silicon nanoparticles lymph node real-time naked-eye visualization macaque models

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Doxorubicin-loaded silicon nanoparticles impregnated into red blood cells featuring bright fluorescence, strong photostability, and lengthened blood residency

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Nano Research 2018年第4期11卷 2285-2294页

作者： airui jiang Bin Song Xiaoyuan Ji Fei Peng Houyu Wang Yuanyuan Su Yao He Laboratory of Nanoscale Biochemical Analysis Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano & Soft Materials (FUNSOM) and Collaborative Innovation Center of Suzhau Nano Science and Technology (NANO-CIC) Soochow University Suzhou 215123 China

Based on the unique advantages of fluorescent silicon nanoparticles （SiNPs）, long circulation red blood cells （RBCs）, and anti-cancer drug molecules （i.e., doxorubicin （DOX））, we developed multifunctional DOX-loaded SiNPs impregnated into RBCs. Importantly, the resulting drug delivery systems （DDSs） simultaneously exhibited bright fluorescence coupled with robust photostability （i.e., - 24% loss of fluorescent intensity after 25 min continuous laser irradiation） and significantly lengthened blood residency （i.e., t1/2 = 7.31 ± 0.96 h, 3.9-fold longer than pure DOX-loaded SiNPs）. Therefore, this novel DDS featuring multi-functionalities shows high potential for cancer diagnosis and therapy, particularly for tumor imaging and chemotherapy in a synchronous manner.

关键词： fluorescent silicon nanoparticles mulfi-function red blood cells drug delivery system

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Fluorescent silicon nanoparticles-based nanotheranostic agents for rapid diagnosis and treatment of bacteria-induced keratitis

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Nano Research 2021年第1期14卷 52-58页

作者： Lu Zhang Xiaoyuan Ji Yuanyuan Su Xia Zhai Hua Xu Bin Song airui jiang Daoxia Guo Yao He Laboratory of Nanoscale Biochemical Analysis Institute of Functional Nano and Soft Materials(FUNSOM)and Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhou 215123China Department of Ophthalmology Childrens Hospital ofSoochow UniversitySoochow UniversitySuzhou 215123China

Recommended as a medical emergency,infectious keratitis with an acute and rapid disease progression can lead to serious damage of vision and even ***,we present a kind of theranostic agents,which are made of vancomycin(Van)-modified fluorescent silicon nanoparticles(SiNPs-Van),enabling rapid and non-invasive diagnosis and treatment of Gram-positive bacteria-induced keratitis in a simultaneous ***,the resultant SiNPs-Van nanoagents have an ability of imaging bacteria in a short time both in vitro(5 min)and in vivo(10 min),making them an efficacious diagnostic agent for the detection of bacterial *** addition,the SiNPs-Van feature distinct antimicrobial activity,with superior activity of 92.5%at a concentration of 0.5 ng/mL against Staphylococcus aureus(***);comparatively,the antimicrobial rate of free vancomycin is 23.3%at the same *** further explore the SiNPs-Van agents as eye drops for therapy of ***-induced bacterial keratitis on rat *** by slit-lamp scores,the keratitis severity of SiNPs-Van-treated corneas is 3.4,which is 59.6%and 77.3%slighter than vancomycin-(8.2 score)and PBS-treated corneas(15.0 score),*** infected corneas recover to normal(1 score)after 7-d of SiNPs-Van *** results suggest that the SiNPs-Van could serve as a new kind of high-quality nanotheranostic agents,especially suitable for simultaneous diagnosis and therapy of Gram-positive bacteria keratitis.

关键词： bacterial keratitis bio-imaging theranostic probe silicon nanoparticles

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植物样品中痕量碘的测定

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广东微量元素科学 2011年第3期18卷 28-31页

作者：付爱瑞陈庆芝姜云军国土资源部保定矿产资源监督检验中心河北保定071051

研究了植物样品中痕量碘的测定条件。样品用艾斯卡熔剂于550℃灰化分解,以乙酸-乙酸钠缓冲体系,控制适当的酸度,利用4,4′-四甲基二胺基甲烷（简称四碱）-氯胺T体系进行催化比色测定,通过对实验温度的严格控制,以及增加样量,较大地改善... 详细信息

研究了植物样品中痕量碘的测定条件。样品用艾斯卡熔剂于550℃灰化分解,以乙酸-乙酸钠缓冲体系,控制适当的酸度,利用4,4′-四甲基二胺基甲烷（简称四碱）-氯胺T体系进行催化比色测定,通过对实验温度的严格控制,以及增加样量,较大地改善了催化光度法测定痕量碘的稳定性和灵敏度。结果表明,在选定实验条件下,测定精密度（n=12）RSD=4.93%~9.88%,检出限0.066μg/g,快速、灵敏、实用,用国家一级标准物质进行验证,测试结果令人满意。

关键词：植物样品碘艾斯卡熔剂催化光度法

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