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Enzyme-linked immunosorbent assay of 3 Screen Islet Cell Autoantibody in patients with autoimmune thyroid disease

World Journal of Diabetes 2024年第5期15卷 935-944页

作者： Eiji Kawasaki Hidekazu Tamai Takahiro Fukuyama Yoko Sagara Ryutaro Hidaka aira uchida Masayuki Tojikubo Narihito Tatsumoto Yuko Akehi Yuji Hiromatsu The Diabetes Thyroid and Endocrine CenterShin-Koga HospitalKurume 830-8577Japan

BACKGROUND In recent years,the emergence of multiplex technology that can simultaneously measure multiple anti-islet autoantibodies has become particularly valuable for the staging and early diagnosis of immune-mediated type 1 diabetes(T1D).While it has been established that 20%-30%of T1D patients suffer from autoimmune thyroid disease(AITD),there is limited available data regarding the presence of anti-islet autoantibodies in AITD *** commercially available anti-islet autoantibodies,glutamic acid decarboxylase 65 autoantibodies(GADAs)are often the first marker measured in general clinical *** To investigate the frequency of anti-islet autoantibodies in AITD *** Our study involved four hundred ninety-five AITD patients,categorized into three distinct groups:AITD with T1D(n=18),AITD with phenotypic type 2 diabetes(T2D)(n=81),and AITD without diabetes(n=396),and the enzyme-linked immunosorbent assay(ELISA)was employed to determine the frequencies of 3 Screen Islet Cell Autoantibody(3 Screen ICA),GADA,insulinoma-associated antigen-2 autoantibodies(IA-2As),and zinc transporter 8 autoantibodies(ZnT8As)within these *** The frequency of 3 Screen ICA in AITD patients with T1D,T2D,and those without diabetes were 88.9%,6.2%,and 5.1%,respectively,with no significant difference seen between the latter two ***,the frequency of 3 Screen ICA was 11.1%higher in AITD patients with T1D,1.3%higher in AITD patients with T2D,and 1.1%higher in AITD patients without diabetes compared to GADA,***,12.5%,20.0%,and 20.0%of the 3 Screen ICA-positive patients were negative for ***,1.3%of the AITD patients who tested negative for 3 Screen ICA in both the AITD with T2D and non-diabetic AITD groups were found to be positive for individual *** the 3 Screen ICA-positive patients,there was a significantly higher proportion of individuals with multiple autoantibodies in AITD patients with T1D com

关键词： Anti-islet autoantibodies Autoimmune thyroid disease Real-world practice Retrospective study Type 1 diabetes

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Efficacy of omarigliptin,once-weekly dipeptidyl peptidase-4 inhibitor,in patients with type 2 diabetes

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World Journal of Diabetes 2021年第12期12卷 2087-2095页

作者： Eiji Kawasaki Yuko Nakano Takahiro Fukuyama aira uchida Yoko Sagara Hidekazu Tamai Masayuki Tojikubo Yuji Hiromatsu Nobuhiko Koga Department of Diabetes and Endocrinology Shin-Koga HospitalKurume 830-8577Japan

BACKGROUND Omarigliptin is one of several once-weekly dipeptidyl peptidase-4 inhibitors(DPP-4is).Despite the high frequency of switching from various daily DPP-4is to omarigliptin in actual clinical practice,data regarding its efficacy in patients with type 2 diabetes(T2D)after switching are *** To analyze the efficacy of omarigliptin in Japanese patients with T2D who had previously received treatment with other glucose-lowering *** Forty-nine T2D patients treated for the first time with omarigliptin were recruited retrospectively and divided into four groups defined as either add-on or switched from daily DPP-4is:switched from linagliptin,switched from sitagliptin,and switched from *** a 3-mo follow-up,the clinical parameters among these groups were assessed and compared,with the impact of the switch on glycemic variability as measured by continuous glucose monitoring also being evaluated in the switched *** Hemoglobin A1c levels saw a significant decrease of-0.32%±0.41%in the add-on group(P=0.002).However,the other groups’variables depended on the preswitch daily DPP-4i:switched from linagliptin,-0.05%±0.22%;switched from sitagliptin,-0.17%±0.33%;and switched from vildagliptin,0.45%±0.42%,which saw significant worsening(P=0.0007).Multivariate logistic regression analysis revealed that switching from vildagliptin to omarigliptin was independently associated with worsening glycemic control(P=0.0013).The mean and standard deviation of sensor glucose value,the mean amplitude of glycemic excursions,and the mean of daily difference significantly improved when switching the patient from either linagliptin or sitagliptin to ***,in patients switched from vildagliptin,not only did the glucose variability indices see no improvements,the mean of daily difference even underwent significant *** Administering omarigliptin as add-on therapy or switching to it from sitagliptin and linagliptin,but not v

关键词： Omarigliptin Once-weekly dipeptidyl peptidase-4 inhibitor Real-world practice Retrospective study Type 2 diabetes

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Visual grading criteria for Japanese larch ( Larix kaempferi ) structural timber from Spain

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Journal of Forestry Research 2020年第6期31卷 2605-2614页

作者： Mari-Jose Barriola José-Ramón aira Edgar Lafuente Tknika LHri Aplikatutako Ikerketa eta Berrikuntzako EAEko zentroaZamalbide Auzoa z/g20100 ErrenteriaGipuzkoaSpain Escuela de Ingeniería de la Industria Forestal Agronómica y de la BioenergíaUniversidad de ValladolidUVa-Campus Duques de Sorias/n42005 SoriaSpain Cesefor Centro de Servicios y Promoción Forestal y de su Industria de Castilla y LeónCalle C42005 SoriaSpain

Larch wood is structurally classifi ed in many countries as one of conifers with the highest load-bearing capacity(strength class of C30).The Spanish visual classifi cation regulation only assigns a strength class to 4 pine woods:Laricio pine(Pinus nigra ***),Silvestre pine(Pinus sylvestris L.),Radiata pine(Pinus radiata ***),and Pinaster pine(Pinus pinaster Ait.).This work adds to the number of structurally characterised species by creating a visual classifi cation table for Japanese larch wood(Larix kaempferi(Lamb.)Carr.)which diff erentiates between 2 visual classes,MEG-1 and *** strength values were calculated for each class(fk,MEG-1=31.80 MPa,f k,MEG-2=24.55 MPa),mean module of elasticity(E 0,mean,MEG-1=13,082 MPA,E 0,mean,MEG-2=12,320 MPA)and density(ρk,MEG-1=456.6 kg m−3,ρk,MEG-2=469.1 kg m−3),before fi nally assigning a strength class of C30 to visual class MEG-1,and a strength class of C24 to visual class MEG-2.

关键词： Japanese larch wood Visual grading Strength class Mechanical properties Density

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Soil under dead or live organic matter systems:Effect of European shag(Phalacrocorax aristotelis L.)nesting on soil nematodes and nutrient mineralization

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Soil Ecology Letters 2020年第1期2卷 40-46页

作者： Manuel aira Jorge Dominguez Grupo de Ecoloxia Animal(GEA) Facultade de CienciasUniversidad de VigoVigo E-36310Espana

Here we studied whether soil systems differ if they are under the influence of live(plants)or dead organic matter systems(nest)in terms of C and N mineralization,microbiological characteristics and nematode trophic group *** analyzed physicochemical and microbiological properties of soils inside and outside nests of the European shag(Phalacrocorax aristotelis L.)on the Cies Islands(NW Spain).We sampled fresh soil below dead(nests)and live organic matter(plants)(paired samples,n=7).Soil of nests had lower organic matter and higher electric conductivity and dissolved organic C and extractable N contents than the soil of *** biomass and activity were greater in soil of nests than in soil of *** abundance of nematode trophic groups(bacterivores,fungivores,omnivores and herbivores)differred between soils of nests and plants,and the soil of plants supported a more abundant and diverse nematode *** present results points to that source of organic matter promote differences in the decomposer community,being more efficient in soil of nests because C mineralization is ***,this occurred independently of the complexity of the systems,higher in the soil of plants with more groups of nematodes.

关键词： C and N mineralization Decomposer food web Nematode trophic structure Microbial biomass

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Geochemistry of the Batang Group in the Zhaokalong Area, Yushu, Qinghai： Implications for the Late Triassic Tectonism in the Northern Sanjiang Region, China

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Acta Geologica Sinica(English Edition) 2016年第2期90卷 704-721页

作者： LI Huan XI Xiaoshuang SUN Huashan KONG Hua WU Qianhong WU Chengming Jillian aira S.GABO-RATIO Department of Resources Science and Engineering Faculty of Earth Resources China University of Geosciences Wuhan 430074 China MOE Key Laboratory of Non-ferrous Metal Ore Forecast School of Geosciences and Info-physics Central South University Changsha 410083 China Guangxi Land and Resources Planning Institute Nanning 530022 China National Institute of Geological Sciences University of the Philippines Diliman Quezon City 1101 Philippines

The Batang Group in the Zhaokalong area not only hosts an important Fe-Cu polymetallic deposit but also reveal important insights for the Late Triassic tectonism in the northern Sanjiang region. In order to delineate the tectonic setting and evolutionary process of the paleo arc-basin system, geochemical studies on the Batang Group strata have been carried out. The results suggest that andesite in the Zhaokalong area mainly belongs to the tholeiite series and is characterized by obvious fractionation of LREE and HREE, enrichment in LILE and depletion in HFSE, and a distinctly elevated δ^（34）SCDT average of 10.5‰. The sandstone is classified as lithic sandstone, which is also characterized by obvious fractionation of LREE and HREE, as well as weak negative Ce and Eu anomalies. The limestone displays positive Eu anomalies, with δ^（13）CPDB ranging from-1.3‰ to 4.4‰ and δ^（18） OSMOW ranging from 14.6‰ to 22.5‰. These results indicate that the andesite has a dual signature of both arc andesite and rift volcanic rocks, whereas the sandstone may be formed in an active continental margin, and the limestone could be deposited in a weak oxidizing shallow sea. The sandstone in the Zhaokalong area represents sedimentation in a platform slope facies, corresponding to the main stage of the Jinshajing oceanic basin subduction during the middle period of Late Triassic. The continental arc volcanic activity resulted from subsequent strengthened subduction, forming the andesite in the North Qiangtang backarc basin. Afterwards, the limestone was formed after the cessation of magmatic activity. The information gleaned from the Batang Group strata helped constrain the evolution of the paleo-Jomda island arc and Jinshajiang oceanic subduction in the Late Triassic.

关键词： arc-basin system Triassic Batang Group Zhaokalong Sanjiang Orogen

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Gender differences in the efficacy of cardiovascular rehabilitation in patients after cardiac surgery procedures

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Journal of Geriatric Cardiology 2015年第5期12卷 575-579页

作者： Mauro Feola Sonia Garnero Beatrice Daniele Claudia Memo Fabio Dell'aira Giuliana Chizzolini Marzia Testa Cardiovascular Rehabilitation-Heart Failure Unit Ospedale SS Trinita-Fossano Italy School of Geriatry Universita degli Studi di Torino Torino Italy

Cardiac rehabilitation （CR） programs are well known to improve patients＇ functional status after cardiac surgery and are recommended by current guideline. In fact, they pro- mote not only structured physical exercises but also a complete secondary prevention determining an overall reduction in recurrent cardiac events and an improvement in functional, psychosocial status and survival.

关键词： Cardiac rehabilitation Cardiovascular disease Gender differences

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Characterization of the proto-Philippine Sea Plate:Evidence from the emplaced oceanic lithospheric fragments along eastern Philippines

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Geoscience Frontiers 2020年第1期11卷 3-21页

作者： Carla B.Dimalanta Decibel V.Faustino-Eslava Jillian aira S.Gabo-Ratio Edanjarlo J.Marquez Jenielyn T.Padrones Betchaida D.Payot Karlo L.Queano Noelynna T.Ramos Graciano P.Yumul Jr. Rushurgent Working Group National Institute of Geological SciencesCollege of ScienceUniversity of the PhilippinesDilimanQuezon CityPhilippines School of Environmental Science and Management University of the PhilippinesLos BañosLagunaPhilippines Department of Physical Sciences and Mathematics University of the Philippines-ManilaPadre FauraManilaPhilippines Institute of Renewable Natural Resources University of the PhilippinesLos BañosLagunaPhilippines Department of Environmental Science Ateneo de Manila UniversityQuezon CityPhilippines Itogon-Suyoc Resources Inc. OrtigasPasig CityPhilippines Apex Mining Company Inc. OrtigasPasig CityPhilippines

The proto-Philippine Sea Plate(pPSP)has been proposed by several authors to account for the origin of the Mesozoic supra-subduction ophiolites along the Philippine *** this paper,a comprehensive review of the ophiolites in the eastern portion of the Philippines is *** data on the geology,ages and geochemical signatures of the oceanic lithospheric fragments in Luzon(Isabela,Lagonoy in Camarines Norte,and Rapu-Rapu island),Central Philippines(Samar,Tacloban,Malitbog and Southeast Bohol),and eastern Mindanao(Dinagat and Pujada)are *** of the Halmahera Ophiolite to the south of the Philippines are also reviewed for *** all of the crust-mantle sequences preserved along the eastern Philippines share Early to Late Cretaceous *** geochemical signatures of mantle and crustal sections reflect both mid-oceanic ridge and suprasubduction *** paleomagnetic information is currently limited to the Samar Ophiolite,results indicate a near-equatorial Mesozoic supra-subduction zone *** general,correlation of the crust-mantle sequences along the eastern edge of the Philippines reveal that they likely are fragments of the Mesozoic pPSP.

关键词： Eastern Philippines Ophiolites Proto-Philippine Sea Plate

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Screening for Drought-Tolerant and Low-Input Responsive Upland Rice Landraces

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American Journal of Plant Sciences 2014年第22期5卷 3432-3439页

作者： Roberto B. Barba Jr. Nicca aira A. Marquez Ruben P. Tablizo College of Agriculture and Fisheries Catanduanes State University Virac Catanduanes Philippines

Productivity potentials of upland rice landraces (URLs) are continuously compromised by scanty water supply due to competing priorities for irrigations and fluctuations in agro-ecological conditions peculiar to low-input farming systems. A growing demand for rice amidst decline in productive agricultural areas plunges into an urgent contribution of marginal areas critical in attaining food sufficiency among Filipino households. Agronomic performances of URLs locally found in Catanduanes province, Philippines were evaluated in a replicated trial utilizing three URLs: Kamanang [1], Kadari [2] and Bulaw [3]. The experimental set-up was closely monitored for consistent dry moisture content and zero fertilizer application. Results were significant for traditional upland landraces: Kamanang and Kadari, scored in terms of higher germination rate, increment plant height and the number of tillers during the vegetative stage. Leaf color gradations, although statistically not significant across cultivars, were suggestive of varying adaptive performance between traditional cultivars subjected to low-input system. Putative low-input responsive lines indicated by the higher survival percentage and overall agronomic responses were selected from the study site. Screened lines took part of the advance population which would be potentially able to tolerate poor soil conditions (i.e. poor storehouse of water and nutrients) especially in areas with edaphological constraints and changing rainfall distribution pattern. The development of putative drought tolerant lines among URLs forms the most economical solution implicated to areas with limited access to agricultural interventions.

关键词： Upland Rice Landraces Low-Input System Edaphological Constraints

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红外线激光疗法对处理和未经处理刺激点的疗效

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国外医学（中医中药分册） 1991年第2期13卷 36-38页

作者： aira.,O 王刚

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风景画家的片段人生

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作者： (阿根廷)塞萨尔·艾拉(César aira)

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