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Association of the Platelet Glycoprotein Ia C807T Gene Polymorphism With Risk of Myocardial Infarction in Chinese

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South China Journal of Cardiology 2007年第2期8卷 87-91,86页

作者： Zhao Qingbin ma aiqun Sun Chaofeng Department of Cardiology The First Affiliated Hospital Xi＇an Jiao Tong University Xi＇an 710061 China

Objectives To investigate the relationship of the GPIa C807T dimorphism to the risk of myocardial infarction （MI） in Chinese. Methods We did a case-control study including 100 patients and 110 controls with same race. An allele-specific polymerase chain reaction （PCR） was used for genotyping of C807T polymorphism. Results An apparent association was found between the T807 allele and MI among individuals younger than the mean age of 60 years （odds ratio, 2. 49 ; 95 % confidence interval, 1.08 - 6.22 ）. The T807 allele remained an independent risk factor for MI when age, sex, smoking, hypertension, diabetes, bodymass index, LDL-cholesterol and HDL-cholesterol were adjusted by logistic regression. Conclusions GPIa T807 appears to be an independent risk factor for MI.

关键词： Platelet glycoprotein Gene polymorphism Myocardial infarction

A Class of Two-mode Nonclassical State via Generalize Super Positions of Two-mode Coherent States

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量子光学学报 2006年第B8期12卷 82-82页

作者： aiqun ma City Construction College of Guangzhou University Guangzhou 510900 China

Clinical evaluation of Technetium-99m sestamibi myocardial perfusion SPECT in diabetes with suspected coronary artery diseases

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Journal of Medical Colleges of PLA(China) 2010年第4期25卷 220-225页

作者： Deng Huixing ma aiqun Yang Aimin Cheng Hu Ran Hongde Department of Nuclear Medicine First Affiliated Hospital Medical College Xi 'an Jiaotong University Xi 'an 710061 China Department of Cardiology First Affiliated Hospital Medical College Xi 'an Jiaotong University Xi'an 710061 China

Objective:To study the clinical value of Technetium-99m sestamibi myocardial perfusion single photon emission computed tomography(SPECT) in diabetes with suspected coronary artery ***:Seventy-eight diabetic patients complicated with cardiac symptoms or electrocardiogram(ECG) abnormalities and suspected coronary heart disease hospitalized in the department of endocrinology from January,2008 to December,2008 were ***-99m sestamibi myocardial perfusion SPECT was performed in all *** stress test was done in 35 cases(group A).Adenosine stress test was done in 43 cases(group B).Results:The positive rates in the two groups were 54.29%(19/35) and 53.48%(23/43),*** was no statistic difference between the 2 groups(P>0.05).The abnormality rates in male and female groups were 63.04% and 28.13%,respectively(Pmality were detected in 38 positive *** segments of fixed defect were found in 4 ***:As non-invasive method,myocardial perfusion SPECT can play an important role in the treatment of diabetes with suspected coronary artery disease.

关键词： Technetiurn-99m sestamibi Single photon emission computed tomography Coronary artery disease Diabetes

Using dementia rating scales in the diagnosis of Alzheimer’s disease

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Journal of Nanjing Medical University 2006年第2期20卷 109-112页

作者： Jin Qiao Jianbo Yang Qiumin Qu Jianfeng Han Guogang Luo aiqun ma Department of Neurology the First Hospital of Xi＇ an Jiaotong University Xi＇ an 710061 China

Objective： To study the significance of dementia rating scales in the diagnosis of Alzheimer＇ s disease（AD）. Methods： Probable AD patients（118 cases） diagnosed according to NINCDS-ADRDA criteria and the normal controls（100 cases） were examined with a battery of neuropsychological tests and the dementia severity of AD patients was determined with clinical dementia rating （CDR）. Changed neuropsychological characteristics of different AD dementia severities were analyzed. The discriminant analysis and ROC curve analysis were perfomed to analyze the specificity, the sensitivity, and the general accuracy of various dementia rating scales in the diagnosis of AD, and the area under the ROC curve. Results： The total cognition function in mild （CDR = 1 ）, moderate（CDR = 2） and severe stages（CDR=3） of AD had an obvious trend of continuous decline, with the MMSE values 17.44±2.64, 13.90±4.32, and 5.50 ± 3.90 respectively. The trend of decline of the verbal fluency function in AD was same as that of total cognition function. The visuospatial function was reduced in early stage of AD （CDR = 1 ） and completely lost in moderate and severe AD. Delay memory function began to show decline in the early stage of AD, and the decline turned apparent in moderate and severe AD. Immediate memory function showed unchanged in early stage of AD, while showed decline in moderate AD, and the decline became very quick in severe AD. The impairment of daily living ability and social activity function developed with the severity degree of AD. But the decline of social activity function was very quick in moderate stage of AD. In general, the leading scale to diagnose AD was FOM, followed by RVR, POD, MMSE, BD,ADL and DS. When MMSE was combined with one or more of FOM, RVR, BD, DS, the general accuracy in distinguishing AD from the normal controls was improved. Conclusion： Neuropsychological test is useful in the diagnosis of AD, especially in the early stage. The validity is improved when dementia ra

关键词： alzheimer''s disease neuropsychological dementia rating scale diagnosis

Bisoprolol reverses down-regulation of potassium channel proteins in ventricular tissues of rabbits with heart failure

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The Journal of Biomedical Research 2011年第4期25卷 274-279页

作者： Xi Li Tingzhong Wang Ke Han Xiaozhen Zhuo Qun Lu aiqun ma Department of Cardiovascular Medicine the First Affiliated Hospital of Medical School Xi＇an Jiaotong University Xi ＇an Shaanxi 710061 China Key Laboratory of Molecular Cardiology of Shaanxi Province Xi ＇an Shaanxi 710061 China Key Laboratory of Enwronment and Genes Related to Diseases Xi＇an Jiaotong University Xi＇an Shaanxi 710061 China Department of Cardiovascular Medicine the Second Affiliated Hospital of Medical School Ningxia Medical University Yinehuan Ningxia Hui Autonomous Region 750001 China

Remodeling of ion channels is an important mechanism of arrhythmia induced by heart failure （HF）. We investigated the expression of potassium channel encoding genes in the ventricles of rabbit established by volumeoverload operation followed with pressure-overload. The reversible effect of these changes with bisoprolol was also evaluated. The HF group exhibited left ventricular enlargement, systolic dysfunction, prolongation of corrected QT interval （QTc）, and increased plasma brain natriuretic peptide levels in the HF rabbits. Several potassium channel subunit encoding genes were consistently down-regulated in the HF rabbits. After bisoprolol treatment, heart function was improved significantly and QTc was shortened. Additionally, the mRNA expression of potassium channel subunit genes could be partially reversed. The down-regulated expression of potassium channel subunits Kv4.3, Kv1.4, KvLQT1, minK and Kir 2.1 may contribute to the prolongation of action potential duration in the heart of rabbits induced by volume combined with pressure overload HF. Bisoprolol could partially reverse these down-regulations and improve heart function.

关键词： heart failure potassium channel down-regulation animal models

新型冠状病毒肺炎影响心血管系统的可能机制及治疗对策

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中华心血管病杂志 2021年第12期49卷 1261-1266页

作者：冯云飞董彩娟马爱群西安交通大学医学院西安交通大学医学院第一附属医院心内科西安交通大学心血管研究所陕西省分子心脏病学重点实验室环境与疾病相关基因教育部重点实验室710061

既往并存疾病,如心血管疾病、糖尿病等,与新型冠状病毒肺炎(COVID-19)的严重程度和病死率有关。同时,COVID-19也会导致心血管并发症,包括心肌损伤、心律失常、心力衰竭、心原性休克等。COVID-19导致的心血管损伤与细胞因子风暴及微血栓... 详细信息

既往并存疾病,如心血管疾病、糖尿病等,与新型冠状病毒肺炎(COVID-19)的严重程度和病死率有关。同时,COVID-19也会导致心血管并发症,包括心肌损伤、心律失常、心力衰竭、心原性休克等。COVID-19导致的心血管损伤与细胞因子风暴及微血栓形成有密切关系。治疗上需要考虑心血管方面的一些特殊因素,合理应用肾素-血管紧张素-醛固酮系统抑制剂、抗凝、免疫抑制/调节及机械循环支持等是必要的。

关键词：新型冠状病毒肺炎心血管疾病治疗