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Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期68卷 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma jia Liu Xiang Xia Ning Xu Wen Sun jianjun Du jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

关键词： NIR fluorescent probe ER viscosity hepatic fibrosis gender difference estrogen

Photosynthetic reaction pathways of natural and artificial systems

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Science China Chemistry 2025年

作者： Shixing Lei Liting Bi Lingxuan Chen Zhanting Li jia Tian State Key Laboratory of Organometallic Chemistry and Shanghai Hong Kong Joint Laboratory in Chemical Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences

Photosynthesis converts solar energy into chemical energy through highly coordinated photosynthetic *** by natural systems,artificial photosynthesis aims to develop an efficient,sustainable,and cost-effective pathway for solar-tochemical *** review examines natural photosynthetic pathways,including retinal/rhodopsin-,bacteriochlorophyll-,and chlorophyll-based systems,highlighting their key components and ***,we outline reaction pathways in artificial photosynthetic systems constructed via heterogeneous,homogeneous,self-assembly,and semi-artificial strategies,focusing on water splitting,carbon fixation,and nitrogen ***,we offer insights into future directions for artificial photosynthesis,emphasizing the importance of using self-assembly strategies and the potential of using primitive phototrophic microorganisms as models.

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Li,Na,and Cs-based metal-organic frameworks for room temperature phosphorescence applications

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Science China Chemistry 2025年

作者： jiaqi Ma Rui Feng Yanyuan jia Mingshi Zhang Shuo Guo College of Chemistry and Chemical Engineering Inner Mongolia University School of Materials Science and Engineering Smart Sensing Interdisciplinary Science Center Nankai University & TKL of Metal and Molecule Based Material Chemistry Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University Department of Chemistry and Biochemistry University of California San Diego

The conventional design of metal-organic frameworks (MOFs) with room-temperature phosphorescence (RTP) mostly relies on using heavy metals,as the heavy atom effect can effectively increase the efficiency of intersystem crossing (ISC) to get a better phosphorescence *** the first time,we reported the highly efficient RTP of a lithium-based MOF IMU-101 with a lifetime (τ) of 299 ms and a quantum yield (QY) of 4.91%.In addition,MOFs IMU-102 and IMU-103,with sodium and cesium as metal nodes,were successfully *** phosphorescence properties of this series of alkali metal MOFs were systematically studied and *** crystallography and computational calculation show that the mechanism for achieving RTP for this material lies in the ultrashort coordination bond of Li,which enables the reduction of non-radiative ***-101,as a cheap and environmentally friendly room-temperature phosphorescent material,has been further developed into composite polymer inks and bulk *** makes them promising for applications in anti-counterfeiting and information encryption.

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Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning Li Yakun Gu Wei Ma Yuying Guan Mengyuan Guo Qianqian Shao Xunming Ji jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin Dai Lei Ye Tao Song Shuai Huang jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

双核镁配合物[Mg_2(μ-OH_2)_2(H_2O)_4(OPPh_3)_4]Br_4的合成与分子结构

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安徽工业大学学报（自然科学版） 2013年第4期30卷 395-398页

作者：刘景龙吴秀丽贾爱铨陈群张千峰安徽工业大学分子工程与应用化学研究所安徽马鞍山243002 常州大学石油化工学院江苏常州213164

溴化镁与三苯基膦氧在乙醇溶液中反应生成新的可用于MgO粒子制备前驱体的双核镁化合物[Mg2(μ-OH2)2(H2O)4-(OPPh3)4]Br4。单晶X射线衍射分析表明:该双核镁配合物结构由一个均氧配位的双核镁阳离子基团与4个溴离子所组成,两对溴离子参... 详细信息

溴化镁与三苯基膦氧在乙醇溶液中反应生成新的可用于MgO粒子制备前驱体的双核镁化合物[Mg2(μ-OH2)2(H2O)4-(OPPh3)4]Br4。单晶X射线衍射分析表明:该双核镁配合物结构由一个均氧配位的双核镁阳离子基团与4个溴离子所组成,两对溴离子参与形成分子间的O H Br氢键,并组成了由[Mg2(μ-O)2(O)4]核所共享的高度扭曲立方烷构型,其中每个镁原子与2个μ-OH2、2个OH2和2个OPPh3中的6个氧原子组成了八面体的空间结构,Mg O(PPh3)、Mg O(OH2)和MgμO(OH2)的平均键长分别为198.3(2),206.1(2)和226.0(2)pm。

关键词：镁配合物氧配位合成晶体结构

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不同烹饪方式对红薯食用品质的影响

家电科技 2022年第S1期 694-698页

作者：吴勇郑健李彩云张明明贾爱全孙秀娇青岛海尔智慧厨房电器有限公司山东青岛266100 数字化家电国家重点实验室山东青岛266100 青岛海尔电冰箱有限公司山东青岛266100

红薯营养丰富,具有比较独特的风味,深受消费者的喜爱。在中国,烹饪方法多样,菜肴也就有更多的选择性。烹饪方式的不同,食材烹饪的品质也差别较大。以红薯为研究对象,对比单独蒸制、蒸烤组合、单独烤制3种烹饪方式对红薯食用品质的影响... 详细信息

红薯营养丰富,具有比较独特的风味,深受消费者的喜爱。在中国,烹饪方法多样,菜肴也就有更多的选择性。烹饪方式的不同,食材烹饪的品质也差别较大。以红薯为研究对象,对比单独蒸制、蒸烤组合、单独烤制3种烹饪方式对红薯食用品质的影响。分析不同烹饪方式,对红薯水分、可溶性糖、淀粉含量、质构、感官评价等品质的影响。结果表明:从理化指标分析,水分含量从高到低依次为:单独蒸制>蒸烤组合>单独烤制;可溶性糖含量从高到低依次为:单独烤制>蒸烤组合>单独蒸制;淀粉含量从高到低依次为:单独蒸制>蒸烤组合>单独烤制;从质构数据看,蒸烤组合烹饪的红薯在质地、口感上显示出较大的优势;从感官评价角度进行分析,单独烤制的红薯更受用户喜欢。3种不同的烹饪方式各有特点,用户应根据不同需求,合理选择不同的烹饪加工方式。

关键词：烹饪方式食用品质理化指标质构感官评价

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具有类蜻蜓状双核铜-联吡啶水簇配合物

化学通报 2021年第1期84卷 58-62页

作者：刘娥董晓光刘小婧贾爱铨郭子瑜刘会玲郭晓爽张千峰安徽工业大学材料科学与工程学院马鞍山243002 河南科技大学化工与制药学院洛阳471023 河科大再生循环能源有限公司洛阳471023

本文介绍了一种合成[Cu_(2)(bipy)_(2)(H_(2)P_(2)O_(7))(OH)_(2)]·7H_(2)O双核铜水簇配合物的简单方法,晶体结构解析表明7个结晶水相互之间形成丰富的二维水簇聚合物[(H_(2)O)_(7)]n,水簇再与主体结构中的羟基形成强的氢键作用,整个... 详细信息

本文介绍了一种合成[Cu_(2)(bipy)_(2)(H_(2)P_(2)O_(7))(OH)_(2)]·7H_(2)O双核铜水簇配合物的简单方法,晶体结构解析表明7个结晶水相互之间形成丰富的二维水簇聚合物[(H_(2)O)_(7)]n,水簇再与主体结构中的羟基形成强的氢键作用,整个配合物结构从仿生学角度考虑类似蜻蜓状。通过对这种水簇聚合物的研究,有助于改善无法解释的含结晶水的某些配合物性质的模型,更好地理解水分子在化学和生物过程中的结构和行为。

关键词：焦磷酸盐水簇联吡啶氢键蜻蜓状结构

二烷基二硫代氨基甲酸酯钼和银配合物的合成与结构表征

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安徽工业大学学报（自然科学版） 2020年第4期37卷 341-344,378页

作者：张彩霞方多文钱冰峯贾爱铨张千峰安徽工业大学分子工程与应用化学研究所安徽马鞍山243002

将配体二烷基二硫代氨基甲酸酯(DTC)分别与三氧化钼和硝酸银在不同条件下反应得到配合物Mo[S2CN(iPr)2]4PF6(1)和Ag6[S2CN(nPr)2]6(2),采用紫外-可见吸收光谱和X射线单晶衍射对配合物1和2的结构进行表征。结果表明:配合物1和2的紫外可... 详细信息

将配体二烷基二硫代氨基甲酸酯(DTC)分别与三氧化钼和硝酸银在不同条件下反应得到配合物Mo[S2CN(iPr)2]4PF6(1)和Ag6[S2CN(nPr)2]6(2),采用紫外-可见吸收光谱和X射线单晶衍射对配合物1和2的结构进行表征。结果表明:配合物1和2的紫外可见谱中最大吸收峰为配体到过渡金属的特征峰(LMCT跃迁);配合物1为以钼原子为中心、周围连接8个S原子形成的十二面体结构;配合物2为由两个Ag3S3六元环组成的六核结构。

关键词：二烷基二硫代氨基甲酸酯钼配合物银配合物