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Chlorella sp.-ameliorated undesirable microenvironment promotes diabetic wound healing

Acta Pharmaceutica Sinica B 2023年第1期13卷 410-424页

作者： Hangyi Wu Pei Yang aiqin li Xin Jin Zhenhai Zhang HuiXia Lv Department of Pharmaceutics China Pharmaceutical UniversityNanjing 211198China The Affiliated Suqian First People's Hospital of Nanjing Medical University Suqian 223800China Jiangsu Province Academy of Traditional Chinese Medicine Nanjing 210023China Affiliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing 210028China

Chronic diabetic wound remains a critical challenge suffering from the complicated negative microenvironments,such as high-glucose,excessive reactive oxygen species(ROS),hypoxia and malnutrition.Unfortunately,few strategies have been developed to ameliorate the multiple microenvironments simultaneously.In this study,Chlorella sp.(Chlorella)hydrogels were prepared against diabetic wounds.In vitro experiments demonstrated that living Chlorella could produce dissolved oxygen by photosynthesis,actively consume glucose and deplete ROS with the inherent antioxidants,during the daytime.At night,Chlorella was inactivated in situ by chlorine dioxide with human-body harmless concentration to utilize its abundant contents.It was verified in vitro that the inactivated-Chlorella could supply nutrition,relieve inflammation and terminate the oxygen-consumption of Chlorella-respiration.The advantages of living Chlorella and its contents were integrated ingeniously.The abovementioned functions were proven to accelerate cell proliferation,migration and angiogenesis in vitro.Then,streptozotocininduced diabetic mice were employed for further validation.The in vivo outcomes confirmed that Chlorella could ameliorate the undesirable microenvironments,including hypoxia,high-glucose,excessiveROS and chronic inflammation,thereby synergistically promoting tissue regeneration.Given the results above,Chlorella is considered as a tailor-made therapeutic strategy for diabetic wound healing.

关键词： Chlorella sp. Diabetic wound healing Oxygen production Glucose consumption ROS depletion Nutrition supplement Anti-inflammation

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拉曼光谱结合光谱特征区间筛选算法快速定量鉴别植物调和油品质

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食品科学 2024年第6期45卷 244-253页

作者：吴升德姜鑫李爱琴郭志明朱家骥盐城市产品质量监督检验所江苏盐城224056 盐城工学院电气工程学院江苏盐城224051 江苏大学食品与生物工程学院江苏镇江212013

本研究提出了一种基于拉曼光谱与光谱特征区间筛选算法实现植物调和油中高价值植物油含量快速定量检测的方法。首先,将粒子群优化(particle swarm optimization,PSO)算法与灰狼优化(grey wolf optimization,GWO)算法融合构建混合智能优... 详细信息

本研究提出了一种基于拉曼光谱与光谱特征区间筛选算法实现植物调和油中高价值植物油含量快速定量检测的方法。首先,将粒子群优化(particle swarm optimization,PSO)算法与灰狼优化(grey wolf optimization,GWO)算法融合构建混合智能优化算法,即PSOGWO算法。其次,将PSOGWO与组合移动窗口(combined moving window,CMW)策略结合构建新型的拉曼光谱特征区间筛选算法,即PSOGWO-CMW算法。然后,将玉米油(corn oil,CO)和特级初榨橄榄油(extra virgin olive oil,EVOO)以不同比例配制为CO-EVOO植物调和油,并采集其拉曼光谱。将拉曼光谱输入偏最小二乘回归、PSO-CMW、GWO-CMW和PSOGWO-CMW模型预测EVOO含量,并比较建模效果。结果表明,PSOGWO-CMW模型具有最佳的预测性能。采用本方法与气相色谱-质谱法分别检测真实的CO-EVOO植物调和油样本中EVOO含量,结果表明两者的检测性能无显著差异。本方法快速、准确,亦可用于其他植物调和油中高价值植物油含量的快速定量检测。

关键词：拉曼光谱植物调和油智能优化算法光谱特征区间筛选定量鉴别

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农村大龄未婚男青年非常态婚姻策略及其形成机制研究——基于苏北H村的田野调查

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河北青年管理干部学院学报 2024年第4期36卷 13-19页

作者：李爱芹江苏师范大学公共管理与社会学院江苏徐州221116

通过对苏北H村的田野调查发现,在婚姻挤压背景下,农村大龄未婚男青年为达成婚姻诉求而采取的非常态婚姻策略主要包括入赘、娶有婚史女性、买婚或骗婚、撬别人媳妇、与在婚女性构建事实婚姻等。究其原因,规避养老危机与满足情感需求、婚... 详细信息

通过对苏北H村的田野调查发现,在婚姻挤压背景下,农村大龄未婚男青年为达成婚姻诉求而采取的非常态婚姻策略主要包括入赘、娶有婚史女性、买婚或骗婚、撬别人媳妇、与在婚女性构建事实婚姻等。究其原因,规避养老危机与满足情感需求、婚姻支付成本高涨与家庭偿付能力不足、村庄公共舆论默许与基层治理失序、传统婚姻观念嬗变与婚姻的伦理性危机等成为激发农村大龄未婚男青年采取非常态婚姻策略的重要影响因素。

关键词：农村大龄未婚男青年非常态婚姻策略形成机制

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急性呼吸窘迫综合征肺纤维化中巨噬细胞和成纤维细胞相互作用的研究进展

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实用医学杂志 2024年第4期40卷 571-574页

作者：李爱琴张震徐雅楠朱金源张旭宁夏医科大学总医院医学研究院银川750004 宁夏医科大学总医院日间病房银川750004 宁夏医科大学总医院老年与特需医学科银川750004 宁夏医科大学总医院重症医学科银川750004

急性呼吸窘迫综合征(acute respimtory distress syndrome,ARDS)主要是由于各种肺内外损伤因素所导致的急性弥漫性炎症性肺损伤。其发病机制复杂,起病急且病死率高,严重危害人类生命健康。肺纤维化是ARDS发生发展的重要病理过程之一,是... 详细信息

急性呼吸窘迫综合征(acute respimtory distress syndrome,ARDS)主要是由于各种肺内外损伤因素所导致的急性弥漫性炎症性肺损伤。其发病机制复杂,起病急且病死率高,严重危害人类生命健康。肺纤维化是ARDS发生发展的重要病理过程之一,是导致ARDS患者死亡的重要原因。ARDS中肺纤维化的严重程度一定程度上由巨噬细胞-成纤维细胞相互作用的动态平衡决定。因此,本文旨在综述巨噬细胞-成纤维细胞在ARDS肺纤维化过程中相互作用的机制,为ARDS肺纤维化的诊疗提供新的方法和思路。

关键词：急性呼吸窘迫综合征肺纤维化巨噬细胞成纤维细胞

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Cobalt doping amount determines dominant reactive species in peroxymonosulfate activation via porous carbon catalysts co-doped by cobalt and nitrogen

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Journal of Environmental Sciences 2024年第4期138卷 212-226页

作者： Xiang li limeng Wu aiqin Zhang Shaohua Wu Yan lin Chunping Yang Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063China Academy of Environmental and Resource Sciences School of Environmental Science and EngineeringGuangdong University of Petrochemical TechnologyMaoming 525000China College of Environmental Science and Engineering Hunan University and Key Laboratory of Environmental Biology and Pollution Control(Hunan University)Ministry of EducationChangsha 410082China

Switching the reaction routes in peroxymonosulfate(PMS)-based advanced oxidation processes have attracted much attention but remain challenging.Herein,a series of Co-N/C catalysts with different compositions and structures were prepared by using bimetallic zeolitic imidazolate frameworks based on ZIF-8 and ZIF-67(x Zn/Co-ZIFs).Results show that Co doping amount could mediate the transformation of the activation pathway of PMS over CoN/C.When Co doping amount was less than 10%,the constructed x Co-N/C/PMS system(x≤10%)was singlet oxygen-dominated reaction;however further increasing Co doping amount would lead to the generation and coexistence of sulfate radicals and high-valent cobalt,besides singlet oxygen.Furthermore,the nitrogen-coordinated Co(Co-NX)sites could serve as main catalytically active sites to generate singlet oxygen.While excess Co doping amount caused the formation of Co nanoparticles from which leached Co ions were responsible for the generation of sulfate radicals and high-valent cobalt.Compared to undoped N/C,Co doping could significantly enhance the catalytic performance.The 0.5%Co-N/C could achieve the optimum degradation(0.488 min^(-1))and mineralization abilities(78.4%)of sulfamethoxazole among the investigated Co-N/C catalysts,which was superior to most of previously reported catalysts.In addition,the application prospects of the two systems in different environmental scenarios(pH,inorganic anions and natural organic matter)were assessed and showed different degradation behaviors.This study provides a strategy to regulate the reactive species in PMS-based advanced oxidation process.

关键词： Peroxymonosulfate Sulfate radical Singlet oxygen Cobalt Zeolitic imidazolate framework Advanced oxidation process

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A PROVABLY SECURE PROXY SIGNATURE SCHEME FROM BIliNEAR PAIRINGS

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Journal of Electronics(China) 2010年第3期27卷 298-304页

作者： Wang aiqin li Jiguo Wang Zhijian College of Computer ＆ Information Engineering Hohai University Nanjing 210098 China

A proxy signature allows an entity, called original signer, to delegate its signing power to another entity, called proxy signer, to sign messages on its behalf. Proxy signatures have many practical applications and are very important cryptographic protocol. In this paper, we propose an efficient proxy signature scheme from bilinear pairings. We prove it secure in the random oracle model and analyze computation cost of our scheme. Our scheme satisfies all the properties required for proxy signatures.

关键词： Proxy signature Bilinear pairings Provably security

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Natural attapulgite supported nano-Ni catalysts for the efficient reductive amination of biomass-derived aldehydes and ketones

Green Synthesis and Catalysis

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Green Synthesis and Catalysis 2024年第1期5卷 42-50页

作者： Jia Zhang Jian Yang Xuemei li Bin Mu Hailong liu Chungu Xia aiqin Wang Zhiwei Huang State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Key Laboratory of Clay Mineral Applied Research of Gansu Province Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

The efficient synthesis of useful primary amines via reductive amination of biomass-based aldehydes and ketones over earth-abundant base metal catalysts is an attractive biomass value-adding technology yet facing lots of challenges.Herein,natural attapulgite(ATP)was applied as support for the fabrication of active Ni catalysts with different Ni loadings(5–30 wt%)by the deposition-precipitation method.The Ni/ATP-550 catalyst with 10–15 wt%Ni loadings was found to present the highest catalytic performance for the synthesis of valuable 5-amino-1-pentanol(5-AP)via reductive amination of biofurfural-derived 2-hydroxytetrahydropyran among a variety of commonly used oxide supports loaded Ni catalysts,as well as ATP supported nickel catalysts with other loadings,achieving 5-AP yield up to 94%.The intrinsic activity of the Ni/ATP catalysts was found to depend strongly on the Ni^(0) crystallite size and Ni^(0) fraction of the catalysts,which generally increased with increasing Ni^(0) crystallite size and fraction,owing probably to the hydrogenation of imine intermediate is a structure-sensitive reaction.The efficient 10Ni/ATP-550 catalyst also exhibited good activity and stability in the reductive amination of several other biomass-derived aldehydes and ketones to their corresponding primary amines with good to excellent yields(81%–99%).This work provided a clean and efficient natural ATP-supported non-noble metal nickel-based catalytic system for the reductive amination of aldehydes and ketones to synthesize high-value-added primary amines,which could be a promising candidate for the industrial production of amines.

关键词： Attapulgite Nano-Ni catalyst Reductive amination 5-Amino-1-pentanol Structure-activity relationship

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Discussion on internal control of account receivable of small and medium-sized enterprises

Discussion on internal control of account receivable of smal...

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第四届人文科学、管理和教育技术国际学术会议

作者： li aiqin Department of Business Management Wuhan Business University

There are a large number of the SME in China,which occupy the majority of the enterprise.The SME are usually composed of individuals,a few people or families.The number of employee is small.Most of the production and operation of enterprises are directly managed by the owners and are less affected by the outside world.Therefore,there are many problems in internal control.At the same time,SME have a wide range of business scope,high operating costs,difficult economic benefits,poor ability to withstand operational risks,weak funds,and poor fundraising capabilities.On the one hand,account receivable can help enterprises expand sales and reduce inventory;on the other hand,the occurrence of bad debt in account receivable is not uncommon,and it greatly occupies corporate funds.Therefore,the study on the problems existing in the management of account receivable of SME is necessary.And the effective improvement strategy can help SME make full use of account receivable to improve the economic benefits of enterprises.

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利拉鲁肽治疗2型糖尿病合并颈动脉斑块患者1例

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中华糖尿病杂志 2022年第S1期14卷 257-259页

作者：李爱琴金星任鑫河南省开封市中心医院内分泌科开封475000

报道1例利拉鲁肽治疗2型糖尿病患者颈动脉斑块的诊疗经过。患者为64岁男性,主因“发现血糖升高4年,乏力1月余”入院,完善相关检查,结合病史,患者最终明确诊断为2型糖尿病、2型糖尿病性周围血管疾病、2型糖尿病周围神经病变等。应用利拉... 详细信息

报道1例利拉鲁肽治疗2型糖尿病患者颈动脉斑块的诊疗经过。患者为64岁男性,主因“发现血糖升高4年,乏力1月余”入院,完善相关检查,结合病史,患者最终明确诊断为2型糖尿病、2型糖尿病性周围血管疾病、2型糖尿病周围神经病变等。应用利拉鲁肽联合二甲双胍治疗2年,患者颈动脉斑块得到逆转。利拉鲁肽具有高效安全降糖、减轻体重、改善心血管不良结局等综合获益。该文就其临床应用及可能的改善作用进行报道,希望能够帮助临床医师更为合理地应用此类药物,减少或延缓糖尿病并发症的发生发展,改善患者的临床结局。

关键词：糖尿病,2型颈动脉斑块利拉鲁肽

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基于夜间灯光影像的太原市城市扩张特征及驱动力分析

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测绘通报 2022年第11期 79-83,105页

作者：张娜张会霞李艾琴太原师范学院地理科学学院山西榆次030619

随着城市化进程的推进,城市建成区范围不断扩大,在此过程中也出现了诸多问题。为更好地了解城市发展规律,本文选取1992、1997、2002、2007、2012年5期的DMSP/OLS数据和2017、2019年2期的NPP-VIIRS两种夜间灯光影像作为数据源,采用统计... 详细信息

随着城市化进程的推进,城市建成区范围不断扩大,在此过程中也出现了诸多问题。为更好地了解城市发展规律,本文选取1992、1997、2002、2007、2012年5期的DMSP/OLS数据和2017、2019年2期的NPP-VIIRS两种夜间灯光影像作为数据源,采用统计数据比较法提取太原市建成区范围,通过对太原市建成区形态扩张指数的分析,得出城市扩张规律。研究结果表明:(1)太原市建成区从1992—2019年太原市建成区面积增长了249.73 km~2,扩大了2.7倍,且建成区增长的面积主要集中在太原市的东南部。(2)2002—2012年和2017—2019年进入加速型扩张模式,扩张的速度快;1992—2019年太原市重心偏移距离为5676.42 m,平均偏移速度为202.73 m/a,重心位置总体向东南方偏移。(3)太原城市扩张的驱动力主要是受经济发展因素、人口因素、交通因素和政策规划因素的影响。本文为太原城市规划和空间结构调整提供理论依据和数据支撑。

关键词：夜间灯光影像建成区提取城市扩张特征分析

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