检索结果-南通市图书馆

Effect of Guanxin Danshen Dripping Pills on Coronary Heart Disease Comorbid with Depression or Anxiety: The ADECODE-Real World Study

引用

Chinese Journal of Integrative Medicine 2024年第5期30卷 443-448页

作者： WU shi-hao shi Wei-qi LI Yu-hang LIU Ru-hui HU Da-yi ZHENG Li-qiang MA Wen-lin Department of Geriatric Medicine Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China Department of Cardiology Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China Department of Cardiology Peking University People's HospitalBeijing 100044China School of Public Health Shanghai Jiao Tong UniversityShanghai 200030China

Objective: To evaluate the efficacy of Guanxin Danshen Dripping Pill(GXDSDP) in treating anxiety and depression in patients with coronary heart disease(CHD). Methods: A total of 1,428 patients diagnosed with CHD screened for anxiety, depression, and quality of life(QOL) at baseline received 0.4 g of GXDSDP treatment 3 times per day and returned for monthly reassessment. Patients were recruited after stable treatment for CHD and received assessment of General Anxiety Disorder-7(GAD-7), Patient Health Questionnaire-9(PHQ-9), and Seattle Angina Questionnaire(SAQ) for evaluating anxiety, depression, and QOL.Patients were followed up 3 times, once every 4 weeks, during outpatient visits for 12 weeks. Results: At the third follow-up(F3), the anxiety symptom of 63.79%(673/1,055) of the patients improved to sub-clinical level, and the GAD-7 score improved significantly(8.11 vs. 3.87, P<0.01);57.52%(585/1,017) patients' depressive symptoms improved to sub-clinical level, with a significant improvement in PHQ-9 score(8.69 vs. 4.41, P<0.01) at F3. All aspects of QOL significantly improved at the end of treatment compared to those at baseline(all P<0.01) as assessed by SAQ: physical limitation(31.17 vs. 34.14), anginal stability(2.74 vs. 4.14), anginal frequency(8.16vs. 9.10), treatment satisfaction(13.43 vs. 16.29), and disease perception(8.69 vs. 11.02). Conclusions: A fixed dosage of GXDSDP may be a potential treatment option for CHD patients comorbid with anxiety or depression.(Registration No. ChiCTR2100051523)

关键词： Guanxin Danshen Dripping Pill coronary heart disease depression anxiety quality of life Chinese medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ELABELA-derived peptide ELA13 attenuates kidney fibrosis by inhibiting the Smad and ERK signaling pathways

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 341-353页

作者： Zhibin YAN Ying shi Runling YANG Jijun XUE Caiyun FU Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhou310018China State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou University Lanzhou 730000China Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical Sciences2019RU066Lanzhou UniversityLanzhou 730000China

Kidney fibrosis is an inevitable result of various chronic kidney diseases(CKDs)and significantly contributes to end-stage renal failure.Currently,there is no specific treatment available for renal fibrosis.ELA13(amino acid sequence:RRCMPLHSRVPFP)is a conserved region of ELABELA in all vertebrates;however,its biological activity has been very little studied.In the present study,we evaluated the therapeutic effect of ELA13 on transforming growth factor-β1(TGF-β1)-treated NRK-52E cells and unilateral ureteral occlusion(UUO)mice.Our results demonstrated that ELA13 could improve renal function by reducing creatinine and urea nitrogen content in serum,and reduce the expression of fibrosis biomarkers confirmed by Masson staining,immunohistochemistry,real-time polymerase chain reaction(RT-PCR),and western blot.Inflammation biomarkers were increased after UUO and decreased by administration of ELA13.Furthermore,we found that the levels of essential molecules in the mothers against decapentaplegic(Smad)and extracellular signal-regulated kinase(ERK)pathways were reduced by ELA13 treatment in vivo and in vitro.In conclusion,ELA13 protected against kidney fibrosis through inhibiting the Smad and ERK signaling pathways and could thus be a promising candidate for anti-renal fibrosis treatment.

关键词： ELA13 Kidney fibrosis Inflammation Smad Extracllular signal-regulated kinase(ERK)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Loyal wingman task execution for future aerial combat:A hierarchical prior-based reinforcement learning approach

引用

Chinese Journal of Aeronautics 2024年第5期37卷 462-481页

作者： Jiandong ZHANG Dinghan WANG Qiming YANG Zhuoyong shi Longmeng JI Guoqing shi Yong WU School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710129China

In modern Beyond-Visual-Range(BVR)aerial combat,unmanned loyal wingmen are pivotal,yet their autonomous capabilities are limited.Our study introduces an advanced control algorithm based on hierarchical reinforcement learning to enhance these capabilities for critical missions like target search,positioning,and relay guidance.Structured on a dual-layer model,the algorithm’s lower layer manages basic aircraft maneuvers for optimal flight,while the upper layer processes battlefield dynamics,issuing precise navigational commands.This approach enables accurate navigation and effective reconnaissance for lead aircraft.Notably,our Hierarchical Prior-augmented Proximal Policy Optimization(HPE-PPO)algorithm employs a prior-based training,prior-free execution method,accelerating target positioning training and ensuring robust target reacquisition.This paper also improves missile relay guidance and promotes the effective guidance.By integrating this system with a human-piloted lead aircraft,this paper proposes a potent solution for cooperative aerial warfare.Rigorous experiments demonstrate enhanced survivability and efficiency of loyal wingmen,marking a significant contribution to Unmanned Aerial Vehicles(UAV)formation control research.This advancement is poised to drive substantial interest and progress in the related technological fields.

关键词： Beyond-visual-range Loyal wingmen Hierarchical prior-augmented proximal policy optimization Unmanned aerial vehicles Warfare

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Combining TDLAS and multi-fusion algorithms for methane gas concentration detection

引用

Optoelectronics Letters 2024年第6期20卷 353-359页

作者： shi Guojun SONG Xinmin DONG Taiji School of Information&Electrical Engineering Heilongjiang Bayi Agricultural UniversityDaqing 163319China College of Electrical and Information Engineering Northeast Petroleum UniversityDaqing 163318China

High-precision methane gas detection is of great importance in industrial safety, energy production and environmental protection, etc. However, in the existing measurement techniques, the methane gas concentration information is susceptible to noise, which leads to its useful signal being drowned by noise. A fusion algorithm of variational modal decomposition(VMD) and improved wavelet threshold filtering is proposed, which is used in combination with tunable diode laser absorption spectroscopy(TDLAS) to implement a non-contact, high-resolution methane gas concentration detection. The fusion algorithm can perform noise reduction and further segmentation of the methane gas detection signal. And the simulation and experiment verify the effectiveness of the fusion algorithm, and the experimental results show that for the detection of air containing 10 ppm, 30 ppm, 60 ppm, 80 ppm, and 99 ppm methane, the errors are 12.75%, 8.18%, 3.37%, 2.46%, and 1.78%, respectively.

关键词： Combining TDLAS and multi-fusion algorithms for methane gas concentration detection TDLAS

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multi-Stream Temporally Enhanced Network for Video Salient Object Detection

引用

Computers, Materials & Continua 2024年第1期78卷 85-104页

作者： Dan Xu Jiale Ru Jinlong shi School of Computer Science Jiangsu University of Science and TechnologyZhenjiang212100China

Video salient object detection(VSOD)aims at locating the most attractive objects in a video by exploring the spatial and temporal features.VSOD poses a challenging task in computer vision,as it involves processing complex spatial data that is also influenced by temporal dynamics.Despite the progress made in existing VSOD models,they still struggle in scenes of great background diversity within and between frames.Additionally,they encounter difficulties related to accumulated noise and high time consumption during the extraction of temporal features over a long-term duration.We propose a multi-stream temporal enhanced network(MSTENet)to address these problems.It investigates saliency cues collaboration in the spatial domain with a multi-stream structure to deal with the great background diversity challenge.A straightforward,yet efficient approach for temporal feature extraction is developed to avoid the accumulative noises and reduce time consumption.The distinction between MSTENet and other VSOD methods stems from its incorporation of both foreground supervision and background supervision,facilitating enhanced extraction of collaborative saliency cues.Another notable differentiation is the innovative integration of spatial and temporal features,wherein the temporal module is integrated into the multi-stream structure,enabling comprehensive spatial-temporal interactions within an end-to-end framework.Extensive experimental results demonstrate that the proposed method achieves state-of-the-art performance on five benchmark datasets while maintaining a real-time speed of 27 fps(Titan XP).Our code and models are available at https://***/RuJiaLe/MSTENet.

关键词： Video salient object detection deep learning temporally enhanced foreground-background collaboration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

On the Application of Mixed Models of Probability and Convex Set for Time-Variant Reliability Analysis

引用

Computer Modeling in Engineering & Sciences 2024年第5期139卷 1981-1999页

作者： Fangyi Li Dachang Zhu Huimin shi Center for Research on Leading Technology of Special Equipment School of Mechanical and Electric EngineeringGuangzhou UniversityGuangzhou510006China

In time-variant reliability problems,there are a lot of uncertain variables from different sources.Therefore,it is important to consider these uncertainties in engineering.In addition,time-variant reliability problems typically involve a complexmultilevel nested optimization problem,which can result in an enormous amount of computation.To this end,this paper studies the time-variant reliability evaluation of structures with stochastic and bounded uncertainties using a mixed probability and convex set model.In this method,the stochastic process of a limit-state function with mixed uncertain parameters is first discretized and then converted into a timeindependent reliability problem.Further,to solve the double nested optimization problem in hybrid reliability calculation,an efficient iterative scheme is designed in standard uncertainty space to determine the most probable point(MPP).The limit state function is linearized at these points,and an innovative random variable is defined to solve the equivalent static reliability analysis model.The effectiveness of the proposed method is verified by two benchmark numerical examples and a practical engineering problem.

关键词： Mixed uncertainty probability model convex model time-variant reliability analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CAW-YOLO:Cross-Layer Fusion and Weighted Receptive Field-Based YOLO for Small Object Detection in Remote Sensing

引用

Computer Modeling in Engineering & Sciences 2024年第6期139卷 3209-3231页

作者： Weiya shi Shaowen Zhang shiqiang Zhang College of Artificial Intelligence and Big Data Henan University of TechnologyZhengzhou450001China College of Information Science and Engineering Henan University of TechnologyZhengzhou450001China

In recent years,there has been extensive research on object detection methods applied to optical remote sensing images utilizing convolutional neural networks.Despite these efforts,the detection of small objects in remote sensing remains a formidable challenge.The deep network structure will bring about the loss of object features,resulting in the loss of object features and the near elimination of some subtle features associated with small objects in deep layers.Additionally,the features of small objects are susceptible to interference from background features contained within the image,leading to a decline in detection accuracy.Moreover,the sensitivity of small objects to the bounding box perturbation further increases the detection difficulty.In this paper,we introduce a novel approach,Cross-Layer Fusion and Weighted Receptive Field-based YOLO(CAW-YOLO),specifically designed for small object detection in remote sensing.To address feature loss in deep layers,we have devised a cross-layer attention fusion module.Background noise is effectively filtered through the incorporation of Bi-Level Routing Attention(BRA).To enhance the model’s capacity to perceive multi-scale objects,particularly small-scale objects,we introduce a weightedmulti-receptive field atrous spatial pyramid poolingmodule.Furthermore,wemitigate the sensitivity arising from bounding box perturbation by incorporating the joint Normalized Wasserstein Distance(NWD)and Efficient Intersection over Union(EIoU)losses.The efficacy of the proposedmodel in detecting small objects in remote sensing has been validated through experiments conducted on three publicly available datasets.The experimental results unequivocally demonstrate the model’s pronounced advantages in small object detection for remote sensing,surpassing the performance of current mainstream models.

关键词： Small object detection attention mechanism cross-layer fusion discrete cosine transform

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Concise extraction and characterization of the pore-throat network in unconventional hydrocarbon reservoirs: A new perspective

引用

Petroleum Science 2024年第3期21卷 1474-1487页

作者： Shu-Heng Du Yong-Min shi State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences School of Earth and Space Sciences Peking University

In this study, a new image-based method for the extraction and characterization of pore-throat network for unconventional hydrocarbon storage and exploitation is proposed. “Pore-throat solidity”, which is analogous to particle solidity, and a new method for automatic identification of pores and throats in tight sandstone oil reservoirs are introduced. Additionally, the “pore-throat combination” and “pure pore” are defined and distinguished by drawing the cumulative probability curve of the pore-throat solidity and by selecting an appropriate cutoff point. When the discrete grid set is recognized as a pore-throat combination, Legendre ellipse fitting and minimum Feret diameter are used. When the pore and throat grid sets are identified as pure pores, the pore diameter can be directly calculated. Using the new method, the analytical results for the physical parameters and pore radius agree well with most prior studies. The results comparing the maximum ball and the new model could also prove the accuracy of the latter's in micro and nano scales. The new model provides a more practical theoretical basis and a new calculation method for the rapid and accurate evaluation of the complex processes of oil migration.

关键词： Hydrocarbon exploitation Pore Throat Porous media Identification

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Message from the New Editor-in-Chief

引用

Biomedical and Environmental Sciences 2024年第6期37卷 559-562页

作者： Xiaoming shi Deputy Director Chinese Center for Disease Control and Prevention

In this era,filled with challenges and opportunities,we pay tribute to the illustrious history of our esteemed journal,Biomedical and Environmental Sciences(BES),since its inception.In 1988,amid rapid socioeconomic development,China was taking nascent steps towards reform and opening-up with a heightened emphasis on environmental health hazards and increasing frequency of international academic exchanges.

关键词： steps filled illust

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The risk factors and threshold level of subchronic inhalation exposure of reclaimed water

引用

Journal of Environmental Sciences 2024年第3期137卷 639-650页

作者： Jiayang Kong Yun Lu Yunru Ren Menghao Chen Gang Liu Liangliang shi State Key Joint Laboratory of Environment Simulation and Pollution Control State Environment Protection Key Laboratory of Microorganism Application and Risk ControlSchool of EnvironmentTsinghua UniversityBeijing 100084China

Inhalation of reclaimed water is known to cause lung infammation,and free endotoxins have been shown to be a major risk factor for acute exposure.Subchronic exposure has also been shown to induce infammatory responses with visible tissue damage.However,subchronic risk factors have yet to be identified,and a threshold for the protection of occupational populations during urban reuse is necessary.In this study,potential risk factors in reclaimed water were examined by subchronic exposure with fractionated reclaimed water,and the health risk threshold was tested with a series of diluted reclaimed water.Accordingly,following a 12-week exposure,macromolecules and microorganisms were found to be two major risk factors in reclaimed water that could cause pulmonary infammation,including increased proportion of polymorphonuclear leukocytes in bronchoalveolar fuid,formation of inducible bronchus-associated lymphoid tissue,and elevation of Immunoglobulin A levels.Moreover,infammation persisted after a 4-week recovery period.The calculated threshold of reclaimed water exposure for mice was 31.8 Endotoxin Unit(EU)/(kg·day)under when exposed to 50%additional relative humidity from reclaimed water at 25℃ for 2 hr/day.Meanwhile,the subchronic threshold estimate for humans under the same exposure conditions was found to be 12.2 EU/(kg·day),corresponding to endotoxin levels of 61.7 EU/mL in reclaimed water.The threshold level of endotoxin was lower than that in most non-potable reclaimed water.The findings of this study suggest that occupational exposure of reclaimed water can serve as a potential risk to workers.

关键词： Reclaimed water Inhalation exposure Risk factor Threshold Infammation Endotoxin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：