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Natural products for infectious microbes and diseases:an overview of sources,compounds,and chemical diversities

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Science China(Life Sciences) 2022年第6期65卷 1123-1145页

作者： lu luo Jun Yang Cheng Wang Jie Wu Yafang Li Xu Zhang Hui Li Hui Zhang Yumei Zhou aiping lu Shilin Chen Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100006China Institute of Hematology&Blood Diseases Hospital Chinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China weMED Health Houston 77054USA Institute of Botany Chinese Academy of SciencesBeijing 100093China Akupunktur Akademiet Aabyhoej 8230Denmark The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine Guangzhou 518033China School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China

As coronavirus disease 2019(COVID-19) threatens human health globally,infectious disorders have become one of the most challenging problem for the medical *** products(NP) have been a prolific source of antimicrobial agents with widely divergent structures and a range of vast biological activities.A dataset comprising 618 articles,including 646 NP-based compounds from 672 species of natural sources with biological activities against 21 infectious pathogens from five categories,was assembled through manual selection of published *** data were used to identify 268 NP-based compounds classified into ten groups,which were used for network pharmacology analysis to capture the most promising lead-compounds such as agelasine D,dicumarol,dihydroartemisinin and *** distribution of maximum Tanimoto scores indicated that compounds which inhibited parasites exhibited low diversity,whereas the chemistries inhibiting bacteria,fungi,and viruses showed more structural diversity.A total of 331 species of medicinal plants with compounds exhibiting antimicrobial activities were selected to classify the family *** family Asteraceae possesses various compounds against ***,the family Anacardiaceae has compounds against Salmonella typhi,the family Cucurbitacea against the human immunodeficiency virus(HIV),and the family Ancistrocladaceae against *** review summarizes currently available data on NPbased antimicrobials against refractory infections to provide information for further discovery of drugs and synthetic strategies for anti-infectious agents.

关键词： natural product infectious pathogen drug discovery drug development in silico analysis

One-pot synthesis of silver colloid with body-heat for surface-enhanced Raman spectroscopy detections

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Chinese Chemical Letters 2019年第5期30卷 1027-1030页

作者： Wanchao Chen Yan Kang Han Zhang Tianxiong Huang Xin Tao aiping lu Yiping Du Shanghai Key Laboratory of Functional Materials Chemistry School of Chemistry&Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Quality Assurance Jiangsu Yangnong Chemical Group Co.Ltd.Yangzhou 225009China

In this study,a convenient method of preparing the substrate is proposed with one-pot synthesis of silver colloid under body heat,and the SERS detection uses the fresh substrate to avoid the drawback of substrates’short life of *** synthesis of silver colloid is carried out in a 10 mL vial by using ascorbic acid as a reductant and trisodium citrate as a *** vial is grasped with the palm of the experimenter for several minutes without *** proposed method is simple,rapid,green energy and *** adjusting the concentration of trisodium citrate,not only the particle size can be controlled from about 110 nm to 50 nm but also the homogeneity of nanoparticles can be *** a SERS substrate,the silver colloid has high batch reproducibility and showed good SERS *** relative standard deviation between different manufacturers is 5.51%when the substrate of silver colloid is used for the detection of rhodamine 6 *** the substrate,the lowest detection concentrations of rhodamine 6 G,crystal violet,enrofloxacin,melamine and leucomalachite green are 1.0×10-8,6.1×10-8,1.4×10-6,7.1×10-5 and 5.1×10-8 mol/L,*** demonstrate that the developed method has the advantage of convenience and high efficiency in the field preparation of reliable SERS substrate.

关键词： One-pot synthesis Silver colloid Substrate Surface-enhanced Raman spectroscopy (SERS)

Synchronous rectal adenocarcinoma and anal canal adenocarcinoma

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Frontiers of Medicine 2007年第3期1卷 333-337页

作者： GU Jin LI Jiyou YAO Yunfeng lu aiping WANG Hongyi Department of Surgery Beijing Cancer HospitalBeijing Institute for Cancer ResearchPeking University School of OncologyBeijing 100036China Department of Pathology Beijing Cancer HospitalBeijing Institute for Cancer ResearchPeking University School of OncologyBeijing 100036China

It is difficult to distinguish a rectal carcinoma with anal metastases from coexistent synchronous anorectal *** therapeutic strategy for rectal and anal carcinoma is so different that it should be clearly ***,we report on the case of a 63-year-old man who presented with an upper-third rectal *** months after resection,he developed an adenocarcinoma in the anal *** histological slides of both tumors were reviewed and immunohistochemical studies for cytokeratins(CKs)7 and 20 were *** index tumor demonstrated CK 7–/CK 20+and the second showed CK7+/CK20+.For this reason,we believe the present case had synchronous adenocarcinomas arising from anal canal and the rectum *** is very important to differentiate the anorectal lesions pathologically because of the impact on the therapeutic options available,especially for the lesion arising in the anal canal.

关键词： rectal neoplasms neoplasms,multiple primary anal canal

Pattern Classification in Chinese Medicine

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Pattern Classification in Chinese Medicine

Value of pre-treatment biomarkers in prediction of response to neoadjuvant endocrine therapy for hormone receptor-positive postmenopausal breast cancer

第十八届中国科协年会——分16 针灸大科学研究学术高峰论坛

作者： aiping lu School of Chinese Medicine Hong Kong Baptist University

Pattern classification, the core theory in Chinese medicine clinical practice, will be a complementary method to classify individual?s status and contribute to personalized medicine. The author provided a logical argument focuses on the innovation that may result from integrated pattern classification and biomedical diagnosis, and introduced some novel research design and methods of pattern classification researches using systemic biological approaches and evidence-based medicine design, as well as developed novel approaches on the methodology of clinical effectiveness evaluation on Chinese medicine and new drug research and development.

关键词： Pattern classification Chinese medicine system biology evidence-based medicine personalized medicine

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Chinese Journal of Cancer Research 2013年第4期25卷 397-404页

作者： Min Ying Yingjian He Meng Qi Bin Dong aiping lu Jinfeng Li Yuntao Xie Tianfeng Wang Benyao Lin Tao Ouyang Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Breast Cancer Center Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education)Department of Pathological Peking University Cancer Hospital&Institute

Objective： To determine the predictive ability of biomarkers for responses to neoadjuvant endocrine therapy （NET） in postmenopausal breast cancer. Methods： Consecutive 160 postmenopausal women with T 1-3 N 0-1 M 0 hormone receptor （HR）-positive invasive breast cancer were treated with anastrozole for 16 weeks before surgery. New slides of tumor specimens taken before and after treatment were conducted centrally for biomarker analysis and classified using the Applied Imaging Ariol MB-8 system. The pathological response was evaluated using the Miller ＆ Payne classification. The cell cycle response was classified according to the change in the Ki67 index after treatment. Multivariable logistic regression analysis was used to calculate the combined index of the biomarkers. Receiver operating characteristic （ROC） curves were used to determine whether parameters may predict response. Results： The correlation between the pathological and cell cycle responses was low （Spearman correlation coefficient =0.241, P〈0.001; Kappa value =0.119, P=0.032）. The cell cycle response was significantly associated with pre-treatment estrogen receptor （ER） status （P=0.001）, progesterone receptor （PgR） status （P〈0.001）, human epidermal growth factor receptor 2 （Her-2） status （P=0.050） and the Ki67 index （P〈0.001）, but the pathological response was not correlated with these factors. Pre-treatment ER levels [area under the curve （AUC） =0.634, 95% confidence interval （95% CI）, 0.534-0.735, P=0.008] and combined index of pre-treatment ER and PgR levels （AUC =0.684, 95% CI, 0.591-0.776, P〈0.001） could not predict the cell cycle response, but combined index including per-treatment ER/PR/Her-2/Ki67 expression levels could （AUC =0.830, 95% CI, 0.759-0.902, P〈0.001）. Conclusions： The combined use of pre-treatment ER/PgR/Her-2/Ki67 expression levels, instead of HR expression levels, may predict the cell cycle response to NET.

关键词： Breast cancer neoadjuvant endocrine therapy (NET) responsiveness predictive value

A Method of Data Preprocessing for Network Security Situational Awareness Based on Conditional Random Fields

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A Method of Data Preprocessing for Network Security Situatio...

Correlation between cold and hot pattern in traditional Chinese medicine and gene expression profiles in rheumatoid arthritis

2010 3rd International Conference on Computer and Electrical Engineering(ICCEE 2010)

作者： aiping lu Jianping Li School of Computer and Information Technology Northeast Petroleum University

Network Security Situational Awareness(NSSA) has been a hot research in the network security domain. Because of the large amount of Intrusion Detection System (IDS), We propose a new method of data preprocessing for NSSA based on conditional random fields(CRFs). It takes advantages of the CRFs models which can stitch to sequence data marking and add random attributes to deal with the amount of data from IDS, and provide the data for NSSA. It uses KDD Cup 1999 data sets as experimental data and comes to a conclusion that our proposed method is practicable, reliable and efficient.

关键词： network security situational awareness conditional Random Fields

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Frontiers of Medicine 2011年第2期5卷 219-228页

作者： Miao Jiang Cheng Xiao Gao Chen Cheng lu Qinglin Zha Xiaoping Yan Weiping Kong Shijie Xu Dahong Ju Pu Xu Youwen Zou aiping lu Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical ScienceBeijing 100700China Sino-Japan Friendship Hospital Beijing 100029China School of Life Sciences Hubei UniversityWuhan 430062China National Pharmaceutical Engineering Research Center Jiangxi University of Traditional Chinese MedicineNanchang 330004China Institute of Basic Theory China Academy of Chinese Medical ScienceBeijing 100700China University of British Columbia Vancouver V6T 1Z2Canada E-Institute of Shanghai Municipal Education Commission Shanghai TCM UniversityShanghai 200032China

Clinical manifestations of rheumatoid arthritis(RA)are diversified,and based on the manifestations,the patients with RA could be classified into different patterns under traditional Chinese *** patterns decide the selection of herbal prescription,and thus they can help find a subset of rheumatoid arthritis patients for a type of *** the present study,we combine genome-wide expression analysis with methods of systems biology to identify the functional gene networks for the sets of clinical symptoms that comprise the major information for pattern *** manifestations in rheumatoid arthritis were clustered with factor analysis,and two factors(similar to cold and hot patterns in traditional Chinese medicine)were *** technology was used to reveal gene expression profiles in CD4^(+)T cells from 21 rheumatoid arthritis ***-protein interaction information for these genes from databases and literature data was *** highly-connected regions were detected to infer significant complexes or pathways in this protein-protein interaction *** significant pathways and function were extracted from these subnetworks using the Biological Network Gene Ontology *** genes significantly related to hot and cold patterns were identified by correlations *** signalling pathway,Wnt signaling pathway,and insulin signaling pathway were found to be related to hot *** metabolism was related to both hot and cold ***,aspartate,and tyrosine metabolism were related to cold pattern,and histindine metabolism and lysine degradation were related to hot *** results suggest that cold and hot patterns in traditional Chinese medicine were related to different pathways,and the network analysis might be used for identifying the pattern classification in other diseases.

关键词： gene expression profile pathway rheumatoid arthritis traditional Chinese medicine systems biology

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自适应分组量子衍生蛙跳算法

系统工程理论与实践 2016年第5期36卷 1306-1317页

作者：李盼池卢爱平东北石油大学计算机与信息技术学院大庆163318

为提高传统蛙跳算法的优化能力,基于组内平均目标函数值实施动态分组,采用多量子比特概率幅实施个体编码,基于组内最优蛙和组间最优蛙确定旋转角度,采用基于张量积构造的多比特量子旋转门实施组内最差蛙的更新.标准函数极值优化的实验... 详细信息

为提高传统蛙跳算法的优化能力,基于组内平均目标函数值实施动态分组,采用多量子比特概率幅实施个体编码,基于组内最优蛙和组间最优蛙确定旋转角度,采用基于张量积构造的多比特量子旋转门实施组内最差蛙的更新.标准函数极值优化的实验结果表明,该算法的单步迭代时间较长但优化能力较传统蛙跳算法约有两个数量级的提高,从而表明提出的分组策略和编码方法切实能够提高传统蛙跳算法的优化能力.

关键词：量子计算群智能优化蛙跳算法自适应分组

Network Pharmacology Research of Ligustrazine Combined with Leflunomide On Rheumatoid Arthritis

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Network Pharmacology Research of Ligustrazine Combined with ...