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Visual perception alterations in COVID-19:a preliminary study

International Journal of Ophthalmology(English edition) 2023年第1期16卷 1-9页

作者： María Begoña Coco-martín Luis Leal-Vega Irene Alcoceba-Herrero ainhoa molina-martín Dolores de-Fez María JoséLuque Carlos Dueñas-Gutiérrez Juan Francisco Arenillas-Lara David PPiñero Group of Applied Clinical neurosciences and Advanced Data Analysis Department of MedicineDermatology and ToxicologyUniversity of ValladolidValladolid 47005Spain Group of Optics and Visual Perception Department of OpticsPharmacology and AnatomyUniversity of AlicanteAlicante 03690Spain Department of Optics and Optometry and Vision SciencesUniversity of ValenciaValencia 46100Spain COVID-19 Unit Department of Internal MedicineUniversity Clinical Hospital of ValladolidValladolid 47003Spain Stroke Unit Department of NeurologyUniversity Clinical Hospital of ValladolidValladolid 47003Spain Clinical Optometry Unit Department of OphthalmologyVithas Medimar International HospitalAlicante 03016Spain

AIM:To compare the visual perception(color and chromatic-achromatic contrast vision)of a small cohort of COVID-19 patients at the time of infection and after 6mo with that of a healthy population matched for sex and ***:A total of 25 patients(9 females,16 males,mean age:54±10y)with COVID-19 hospitalized in the COVID-19 Unit of the University Clinical Hospital of Valladolid were recruited for this preliminary *** perception,as determined by monocular measurement of contrast sensitivity function(CSF)and color vision was assessed in each patient using the Optopad *** results obtained were then compared with those of a sample of 16 age-and sex-matched healthy controls(5 females,11 males,mean age:50±6y)in which the same measurement procedure was *** significant differences between groups were assessed using the Mann-Whitney U *** were repeated after a minimum follow-up period of 6mo and statistically significant differences between the two time points in each group were assessed using the Wilcoxon signed rank ***:Discrimination thresholds(color and chromatic-achromatic contrast vision)and their corresponding sensitivity,calculated as the inverse of the discrimination threshold,were *** of the data revealed higher contrast threshold results(i.e.,worse contrast sensitivity)in the COVID-19 group than in the control group for all spatial frequencies studied in the Optopad-CSF achromatic test and most of the spatial frequencies studied in the Optopad-CSF chromatic test for the red-green and blue-yellow *** addition,color threshold results in the COVID-19 group were also significantly higher(i.e.,worse color sensitivity)for almost all color mechanisms studied in the Optopad-Color *** 6mo,most of the differences found between the groups were maintained despite COVID-19 ***:The present results provide preliminary evidence that visual perception may be impaired in COVID-19

关键词： SARS-CoV-2 COVID-19 visual perception contrast sensitivity function color vision

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普通用户电子设备使用距离的特征分析

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国际眼科杂志 2021年第9期21卷 1508-1514页

作者： Fernando Soler Alicia Sánchez-García ainhoa molina-martín Dolores de Fez Valentín Díaz David P Piñero Innova Ocular Clinica Dr Soler 西班牙埃尔切03202 Dr Soler Foundation of the Valencian Community 西班牙埃尔03202 阿里坎特大学药理学、解剖学与光学系西班牙阿里坎特03690

目的:分析普通用户使用电子设备/电脑的工作距离(WD)及移动电话使用距离(MPUD)的特征。方法:横向描述性研究。经过筛选后,纳入每天使用电子设备/电脑超过2h的专业人员100例,年龄20-62(平均41.2)岁,测量每位受试者工作环境中使用电子设备... 详细信息

目的:分析普通用户使用电子设备/电脑的工作距离(WD)及移动电话使用距离(MPUD)的特征。方法:横向描述性研究。经过筛选后,纳入每天使用电子设备/电脑超过2h的专业人员100例,年龄20-62(平均41.2)岁,测量每位受试者工作环境中使用电子设备/电脑的工作距离(WD)、手臂长度和MPUD。结果:纳入受检者WD明显长于MPUD(61.22±12.35 vs 32.22±6.35 cm;P<0.001),MPUD明显短于臂长(74.44±4.65 cm;P<0.001)。4%和91%的受检者WD和MPUD分别小于或等于40 cm。WD与MPUD、手臂长度均呈弱相关性(r=0.387,P<0.001;r=0.260,P<0.001)。不同职业受试者WD有显著差异(P=0.021),军队人员相比大学研究人员和讲师的WD更长(P=0.025)。结论:普通用户使用电子设备/电脑的工作距离与移动电话使用距离差别较大,移动电话使用距离较近,这对于矫正老视具有一定的参考意义。

关键词：老视工作距离移动电话使用距离电子设备

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Plant cell wall-mediated disease resistance:Current understanding and future perspectives

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Molecular Plant 2024年第5期17卷 699-724页

作者： Antonio molina Lucıa Jorda Miguel Angel Torres Marina martın-Dacal Diego Jose Berlanga Patricia Fernandez-Calvo Elena Gomez-Rubio Sonsoles martın-Santamarıa Centro de Biotecnología y Genómica de Plantas Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPMPozuelo de Alarcon(Madrid)Spain Departamento de Biotecnologıa-Biología Vegetal Escuela Técnica Superior de Ingenierıa AgronomicaAlimentarıa y de BiosistemasUPMMadridSpain Centro de Investigaciones Biologicas Margarita Salas Consejo Superior de Investigaciones Científicas(CSIC)Ramiro de Maeztu 928040 MadridSpain Misión Biológica de Galicia Consejo Superior de Investigaciones Científicas(CSIC)Campus de Montegancedo UPMPozuelo de Alarcón(Madrid)Spain

Beyond their function as structural barriers,plant cell walls are essential elements for the adaptation of plants to environmental *** walls are dynamic structures whose composition and integrity can be altered in response to environmental challenges and developmental *** wall changes are perceived by plant sensors/receptors to trigger adaptative responses during development and upon stress *** cell wall damage caused by pathogen infection,wounding,or other stresses leads to the release of wall molecules,such as carbohydrates(glycans),that function as damage-associated molecular patterns(DAMPs).DAMPs are perceived by the extracellular ectodomains(ECDs)of pattern recognition receptors(PRRs)to activate pattern-triggered immunity(PTI)and disease ***,glycans released from the walls and extracellular layers of microorganisms interacting with plants are recognized as microbe-associated molecular patterns(MAMPs)by specific ECD-PRRs triggering PTI *** number of oligosaccharides DAMPs/MAMPs identified that are perceived by plants has increased in recent ***,the structural mechanisms underlying glycan recognition by plant PRRs remain ***,this knowledge is mainly focused on receptors of the LysM-PRR family,which are involved in the perception of various molecules,such as chitooligosaccharides from fungi and lipo-chitooligosaccharides(i.e.,nod/MYC factors from bacteria and mycorrhiza,respectively)that trigger differential physiological ***,additional families of plant PRRs have recently been implicated in oligosaccharide/polysaccharide *** include receptor kinases(RKs)with leucine-rich repeat and Malectin domains in their ECDs(LRR-MAL RKs),Catharanthus roseus RECEPTOR-LIKE KInASE 1-LIKE group(CrRLK1L)with Malectin-like domains in their ECDs,as well as wall-associated kinases,lectin-RKs,and *** characterization of structural basis of glycans recogniti

关键词： Arabidopsis thaliana cell wall damage-associated molecular patterns DAMPs disease resistance glycans oligosaccharides pattern-triggered immunity PTl pattern recognition receptor PRRs

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Supplying System for Drinking Water to Small Rural Communities with Zero Greenhouse Gasses: Sixteen Years of Experiences in Mexico

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Journal of Water Resource and Protection 2016年第12期8卷 1044-1052页

作者： martín Mundo-molina Investigation Centre Faculty of Engineer Autonomous University of Chiapas Tuxtla Gutiérrez Mexico Investigation Centre CIDESTA Tuxtla Gutiérrez México

In Chiapas highlands to southeast of Mexico, the scarcity of water is worrying, according to technical reports of the IPCC the runoff will less between 150 to 250 mm per year in the southeast of Mexico, this situation will increase the problems of water availability in Chiapas highlands in the future. For actually more of 18,160 small rural indigenous communities (SRIC) in Chiapas there is not drinking water. In order to contribute a given solution to scarcity of drinking water in the SRIC, The Autonomous University of Chiapas (UnACH in its Spanish acronym) and Mexican Institute of Water Technology (IMTA in its Spanish acronym) designed and constructed in 1999 the Rain Water Harvesting (RWH) in Yalentay municipality of Zinacantan in Chiapas, Mexico. The scientific and technical contributions of RWH are: The design guarantee the water quality for a prolonged time of storage avoiding the photosynthesis inside the system;not emitted greenhouse gasses because it doesn’t need any kind of fossil fuels;not produces anything kind of damage to the environment;It has to be inexpensive, using in its construction manpower and materials from de region;Store the maximum quantity of water in the minimum space. The RWH has increased the standard of living of the habitants from Yalentay and improving their health conditions.

关键词： Climatic Change Rain Water Harsvesting Technology Appropiatte Greenhouse Gasses

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Climate Change Effects on Evapotranspiration in Mexico

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American Journal of Climate Change 2015年第2期4卷 163-172页

作者： martín Mundo-molina Investigation Centre Faculty of Engineer Autonomous University of Chiapas Tuxtla Gutiérrez Mexico

In Mexico’s case, the scarcity of water in the north of the country is worrying, even more from the agricultural point of view because according to the results of general circulation models, a major impact due to global warming is expected in this region, and it will have important repercussions on the rural sector in the north of Mexico. According to [1] the results of the sensitivity analysis made in this study indicate that the most vulnerable zone is the north of Mexico, wherein the increase of evapotraspiration (ET) is greater in comparison to the rest of the country;up to 8% annual average for a +3°;C growth in mean annual temperature. Due to some limitations in this preliminary investigation (e.g., global temperature data was used without regionalizing it), it was decided to make more detailed studies to estimate the climate change effects on ET on a regional scale, using the downscaling method to adjust temperature data. In this study a new methodology to estimate the ET before climate change scenarios is introduced, which includes the selection of the Hargreaves-Samani method (HS), calibrated and compared against the Penman-Monteith ASCE method in various irrigation districts in the northern part of the country, obtaining ET estimations with a 93% precision. This procedure was applied to nine states in north Mexico: Baja California, Baja California Sur, Chihuahua, Sinaloa, Sonora, Tamaulipas, nuevo León, Coahuila y Durango. The principal results are enunciated as follows: the ET variations between the contemporary scenario and the 2030 scenario are quite significant, according to the data of 160 meteorological stations;for temperature variations between 0.1°;C to 0.45°;C the corresponding ET fluctuation goes from 2% in the current scenario to 7% in the 2030 scenario. These obtained percentages are greater than the ones expected to happen for the precision of the method. It is important to note that a 7% rise of ET (related to a regional temperature increase

关键词： Climatic Change Reference Evapotranspiration Irrigation Agriculture

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Kp Pan Evaporation and ETo Monthly Maps Using Information of 60 Weather Observatories Included in the Climate normals (1941-1970) from Mexico

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Journal of Water Resource and Protection 2014年第15期6卷 1475-1500页

作者： martín Mundo-molina Investigation Centre Faculty of Engineer Autonomous University of Chiapas Tuxtla Gutiérrez Mexico

The most precise equation in order to estimate the evapotranspiration (ET) of crops is the Penman-Monteith (PM). However, the PM equation needs specific data that, in the majority of Mexico’s irrigation districts, it is not available because there are few automated weather stations. For this reason, it is convenient to develop simple methods that allow to precise estimation of ET. A reliable way to estimate ET is by using the pan evaporation that, according to the revised literature, continues to be used nowadays. Investigators like to include its use in irrigation water management projects in various parts of the world. However, this method uses Kp from the FAO that is not calibrated in Mexico. The use of FAO Kp affects the precision of the results, since some variables like radiation, wind, temperature and relative humidity vary from place to place;therefore ET is under estimated or overestimated. This paper presents an original contribution across method to estimate “Kp pan evaporation and ETo monthly maps”, using information from 60 weather observatories included in The Climate normals (1941-1970) from Mexico, based on the PM method and the class A pan evaporation. Once the Kp values were obtained from each weather observatory, the Kringing method was used. This way, by interpolating data of the triad “latitude, longitude and Kp” and “latitude, longitude and ET”, monthly normalized maps of Kp and ET were established for Mexico, except the upland areas (Sierra Madre Occidental and Sierra Madre Oriental), as well as other highland zones above 2700 meters over sea level, for the highest observatory is located in Toluca, State of Mexico (key 14-0039), at 2680 m over sea level.

关键词： Reference Evapotranspiration Pan Evaporation Kp Pan Evaporation

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Potential of video games for the promotion of neuroadaptation to multifocal intraocular lenses: a narrative review

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International Journal of Ophthalmology(English edition) 2019年第11期12卷 1782-1787页

作者： Maria Begona Coco-martin Pedro LValenzuela Miguel JMaldonado-López Alejandro Santos-Lozano ainhoa molina-martin David P Pinero Research Unit Hospital Clínico Universitario de Valladolid.ICSCYLValladolid 47003Spain Grupo de Cirugía Refractivay Rehabilitación Visual.Instituto Universitario de Oftalmobiología Aplicada(IOBA) Universidad de ValladolidValladolid 47011Spain Physiology Unit Systems Biology DepartmentUniversity of AlcaláMadrid 28801Spain Grupo de Investigación i+Health Departamento de Ciencias de la SaludUniversidad Europea Miguel de CervantesValladolid 47012Spain Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicante 03690Spain Department of Ophthalmology(IMQO-Oftalmar) Vithas Medimar International HospitalAlicante 03016Spain

Multifocal intraocular lenses(IOLs) are currently usually implanted for the treatment of cataracts because they have been proved to be superior to monofocal IOLs with respect to spectacle independence. In turn, they are associated with a higher prevalence of dysphotopsia symptoms that is one of the most common causes of patient dissatisfaction. neuroadaptation seems to play a major role in the optimal adaptation to multifocal IOLs. In this context, the development of strategies that facilitate the neuroadaptation process to multifocality might be an effective strategy to reduce patients' dissatisfaction. Video games have been proved to be effective for the improvement of visual acuity and for the promotion of neuroplasticity in elderly subjects and other populations with cortical-related visual impairment. This narrative review highlights the physiological potential of video games as a perceptual strategy to improve visual acuity and promote neuroplasticity in patients using multifocalIOLs, although research is still needed to confirm these benefits in this specific population, with only one comparative study to this date providing evidence of them.

关键词： multifocal intraocular lens dysphotopsia photic phenomena halos video games neuroadaptation neuroplasticity

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Origin of Erosion and Hydraulic Problems of the San Roque Underground Arched Culvert Channel and Its Relationship with the Maximum Flow Rate and the Maximum Permissible Velocity

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Journal of Water Resource and Protection 2020年第12期12卷 1123-1139页

作者： martín Mundo-molina Daniel Hernández-Cruz Academic Group Science and Engineering Engineering Faculty Chiapas State University Chiapas Mexico

This work presents the hydrologic estimations of the hydraulic underground arched culvert channel (UACC) in Sabinal Basin, Chiapas, México and the hydrological problems associated with it, such as the erosion phenomenon and abrasion cavity formation in it. On the other hand, the maximum flows that the UACC could transport were analyzed, concluding that it no longer has the hydraulic capacity to transport the flow rate associated to return periods equal to or greater than five years and that maximum permissible velocity UACC’s bottom is 3 m/s.

关键词： Collapse Underground Arched Culvert Channel Maximum Flow Rate Maximum Permissible Water Velocity Open Channel Bottom Erosion

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Prognostic factors and time-related changes influence results of colorectal liver metastases surgical treatment:A single-center analysis

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World Journal of Gastroenterology 2009年第21期15卷 2587-2594页

作者： Josep martí María marta Modolo Josep Fuster Jaume Comas Rebeca Cosa Joana Ferrer Victor molina Juan Romero Constantino Fondevila Ramón Charco Juan Carlos García-Valdecasas Liver Surgery and Transplantation Unit IMDiMIDIBAPSHospital ClinicCIBERehdUniversity of Barcelona

AIM:To analyze the prognostic factors involved in survival and cancer recurrence in patients undergoing surgical treatment for colorectal liver metastases(CLM) and to describe the effects of time-related changes on survival and recurrence in these ***:From January 1994 to January 2006,236 patients with CLM underwent surgery with the aim of performing curative resection of neoplastic disease at our institution and 189(80%) of these patients underwent resection of CLM with curative ***,intraoperative and postoperative data,including primary tumor and CLM pathology results,were retrospectively *** were divided into two time periods:a first period from January 1994 to January 2000(n = 93),and a second period from February 2000 to January 2006(n = 143).RESULTS:Global survival at 1,3 and 5 years in patients undergoing hepatic resection was 91%,54% and 47%,*** with preoperative extrahepatic disease,carcinoembryonic antigen(CEA) levels over 20 ng/dL,more than four nodules or extrahepatic invasion at pathological analysis had worse *** recurrence rate at 1 year was 48.3%,being more frequent in patients with preoperative and pathological extrahepatic disease and CEA levels over 20 ng/*** patients in the second time period had more adverse prognostic factors,no differences in overall survival and recurrence were observed between the two ***:Despite advances in surgical technique and better adjuvant treatments and preoperative imaging,careful patient staging and selection is crucial to continue offering a chance of cure to patients with CLM.

关键词： Liver metastases Colorectal cancer Hepatic resection Survival Prognostic factors

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Physical-Mathematical Foundations of the Penman Equation from the Perspective of the First Law of Thermodynamics and Energy Balance Theory

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Journal of Water Resource and Protection 2017年第12期9卷 1377-1390页

作者： martín Mundo-molina Enrique De Coss-Gomez Investigation Centre Faculty of Engineer Autonomous University of Chiapas Tuxtla Gutierrez Mexico Investigation Centre CIDESTA Tuxtla Gutierrez Mexico

The evapotranspiration is indispensable for the planning and management of water resources in watersheds and for the design of important engineering projects. The accuracy of its estimation depends, among other things, on the proper determination of the date and frequency of irrigation. One of the most accurate equations for estimating the reference crop evapotranspiration (ETo) is the Penman-Monteith equation, which was derived from the Penman equation published in 1948, which in turn is based on the energy balance equation. In this paper we present the theoretical foundations of Penman’s equation from the perspective of the first law of thermodynamics and the theory of energy balance as a contribution for the students and engineers who use Penman’s or Penman-Monteith equations in a utilitarian way within the historical and theoretical framework of the origin of this equation.

关键词： Evapotranspiration Penman Penman-Monteith Irrigation Requirement

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