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Usage of topical insulin for the treatment of diabetic keratopathy,including corneal epithelial defects

World Journal of Diabetes 2023年第6期14卷 930-938页

作者： Ching Yee Leong ainal adlin naffi Wan Haslina Wan Abdul Halim Mae-Lynn Catherine Bastion Department of Ophthalmology Universiti Kebangsaan Malaysia Medical CentreKuala Lumpur 56000Wilayah PersekutuanMalaysia

BACKGROUND Diabetic keratopathy(DK)occurs in 46%-64%of patients with diabetes and requires serious *** patients with diabetes,the healing of corneal epithelial defects or ulcers takes longer than in patients without *** is an effective factor in wound *** ability of systemic insulin to rapidly heal burn wounds has been reported for nearly a century,but only a few studies have been performed on the effects of topical insulin(TI)on the *** with TI is effective in treating *** To review clinical and experimental animal studies providing evidence for the efficacy of TI to heal corneal *** National and international databases,including PubMed and Scopus,were searched using relevant keywords,and additional manual searches were conducted to assess the effectiveness of TI application on corneal wound *** articles published from January 1,2000 to December 1,2022 were *** relevancy of the identified citations was checked against predetermined eligibility standards,and relevant articles were extracted and *** A total of eight articles were found relevant to be discussed in this review,including four animal studies and four clinical *** to the studies conducted,TI is effective for corneal re-epithelialization in patients with diabetes based on corneal wound size and healing *** Available animal and clinical studies have shown that TI promotes corneal wound healing by several *** use of TI was not associated with adverse effects in any of the published *** studies are needed to enhance our knowledge and understanding of TI in the healing of DK.

关键词： Diabetes mellitus Diabetic keratopathy Topical insulin Healing

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