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Chinese Chemical Letters 2024年第8期35卷 187-200页

作者： Si Ha Jiacheng Zhu Hua xiang Guoshun Luo State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry China Pharmaceutical UniversityNanjing 211198China

Small molecule inhibitors have dominated the pharmaceutical landscape for a long time as the primary therapeutic paradigm targeting pathogenic ***,their efficacy heavily relies on the amino acid composition and spatial constitution of proteins,rendering them susceptible to drug resistance and failing to target undruggable *** recent years,the advent of targeted protein degradation(TPD)technology has captured substantial attention from both industry and *** an event-driven mode,TPD offers a novel approach to eliminate pathogenic proteins by promoting their degrada-tion,thus circumventing the limitations associated with traditional small molecule ***-bic tag tethering degrader(HyTTD)technology represents one such TPD approach that is currently in the burgeoning *** employ endogenous protein degradation systems to induce the degrada-tion of target proteins through the proteasome pathway,which displays significant potential for medical *** this review,we provide a comprehensive overview of the development history and the reported mechanism of action of ***,we delve into the physiological roles,structure-activity re-lationships,and medical implications of HyTTDs targeting various disease-associated ***,we propose insights into the challenges that necessitate resolution for the successful development of HyTTDs,with the ultimate goal of initiating a new age of clinical treatment leveraging the immense po-tential of HyTTDs.

关键词： Targeted protein degradation(TPD) Hydrophobic tag Degrader Hydrophobic tag tethering degrader(HyTTD) Targeted therapy

d-Orbital steered FeN_(4)moiety through N,S dual-site adjustation for zinc-air flow battery

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Journal of Energy Chemistry 2024年第5期92卷 8-15页

作者： Chunzhu Bao Mingwei Tong Xueli Li Zhonghua xiang State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China

The implementation of pristine covalent organic polymer(CO_(2)P)with well-defined structure as air electrode may spark fresh vitality to rechargeable zinc-air flow batteries(ZAFBs),but it still remains challenges in synergistically regulating their electronic states and structural porosity for the great device ***,we conquer these issues by exploiting N and S co-doped graphene with COP rich in metal-ligand nitrogen to synergistically construct an effective catalyst for oxygen reduction reaction(ORR).Among them,the N and S co-doped sites with high electronegativity properties alter the number of electron occupations in the d orbital of the iron centre and form electron-transfer bridges,thereby boosting the selectivity of the ORR-catalysed four-electron ***,the introduction of COP materials aids the formation of pore interstices in the graphene lamellae,which both adequately expose the active sites and facilitate the transport of reactive *** from the synergistic effect,as-prepared catalyst exhibits excellent half-wave potentials(E_(1/2)=912 mV)and stability(merely 8.8%drop after a long-term durability test of 50000 s).Further,ZAFBs assembled with the N/SG@CO_(2)P catalyst demonstrate exceptional power density(163.8 mW cm^(-2))and continuous charge and discharge for approximately 140 h at 10 mA cm^(-2),outperforming the noble-metal benchmarks.

关键词： Nitrogen/sulfurdual sites Metal-coordinated nitrogen sites Covalent organic polymer Oxygen reduction reaction Zn-airflow battery

Engineering the Interface Between Au Nanoparticles and CoO-Ov to Enhance the Catalytic Performance of 5-Hydroxymethylfurfural(HMF)to 2,5-Dimethylfuran(DMF)

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Chemical Research in Chinese Universities 2024年第1期40卷 47-54页

作者： xiang Shuang GUO Yong LIU Xiaohui WANG Yanqin Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterResearch Institute of Industrial CatalysisSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237P.R.China

The interface between Au and support has attracted extensive interest because of its unique catalytic ability for hydrogen activation in catalytic hydrogenation/hydrogenolysis ***,we create the Au-CoO-OV interface in the 1.0%Au/Co3O4-Rod-250 catalyst,which could dissociate H2 via the heterolytic way to yield rich hydride species and achieve excellent catalytic performance in the hydrogenolysis of biomass-derived 5-hydroxymethylfurfural(HMF)to 2,5-dimethylfuran(DMF).The XRD and HRTEM analyses show that Au nanoparticles are uniformly dispersed on CoO-OV surface and in situ DRIFTS spectra show the enhancement of heterolytic dissociation of hydrogen(signals of Au-D and O-D vibration)compared with bare CoO(Co3O4-Rod-250).This work provides insights for fabricating highly active Au-support catalysts for catalytic hydrogenation/hydrogenolysis reactions.

关键词： Au-CoO-OV interface Hydride species Heterolytic dissociation 5-Hydroxymethylfurfural(HMF) 2 5-Dimethylfuran(DMF)

Versatile strategies for adult neurogenesis:avenues to repair the injured brain

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Neural Regeneration Research 2024年第4期19卷 774-780页

作者： Junyi Zhao Siyu Liu Xianyuan xiang Xinzhou Zhu The Brain Cognition and Brain Disease Institute(BCBDI) Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Faculty of Life and Health Sciences Shenzhen Institutes of Advanced TechnologyChinese Academy of Sciences Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions

Brain injuries due to trauma or stroke are major causes of adult death and ***,few interventions are effective for post-injury repair of brain *** a long debate on whether endogenous neurogenesis actually happens in the adult human brain,there is now substantial evidence to support its *** neurogenesis is usually significantly stimulated by injury,the reparative potential of endogenous differentiation from neural stem/progenitor cells is usually ***,exogenous stem cell transplantation has shown promising results in animal models,but limitations such as poor long-term survival and inefficient neuronal differentiation make it still challenging for clinical ***,a high focus was placed on glia-to-neuron conversion under single-factor *** some inspiring results,the validity of this strategy is still *** this review,we summarize historical findings and recent advances on neurogenesis strategies for neurorepair after brain *** also discuss their advantages and drawbacks,as to provide a comprehensive account of their potentials for further studies.

关键词： adult neurogenesis glia-to-neuron conversion ischemic stroke neurogenic niche neuroinflammation stem cell transplantation traumatic brain injury

Persistent mixing bursts in the equatorial Pacific thermocline induced by persistent equatorial waves

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Journal of Oceanology and Limnology 2024年第2期42卷 492-510页

作者： Jingjing ZHANG Chuanyu LIU xiang GONG Fan WANG School of Mathematics and Physics Qingdao University of Science and TechnologyQingdao 266100China Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laoshan Laboratory Qingdao 266237China

A recent study by Liu et al.(2020)suggested that due to the saturation of equatorially trapped planetary waves with different dynamical types,temporal periods,meridional and baroclinic modes,complex layer structures of vertical velocity shear and hence turbulent mixing could frequently occur in the thermocline of the eastern equatorial *** investigated the occurrence of the interior turbulent mixing as indicated by shear instabilities,above the Equatorial Undercurrent(EUC)core at three equatorial sites along 140°W,170°W,and 165°E,respectively,based mainly on data from the Tropical Atmosphere and Ocean(TAO)mooring *** found that turbulent mixing bursts persisted in the thermocline of all three ***,the interior turbulent mixing layers(ITMLs)could occur in probability of approximately 68%,53%,and 48%at the three sites,*** overall occurrence probability shows obvious and similar biannual variations at 140°W and 170°W,which is higher in boreal from late summer to winter and lower in ***,the ITMLs are primarily located above the EUC core and prevail in deeper(shallower)layers from late summer to winter(spring).Most ITMLs(70%)lasted for hours to 3 days,and a few of them(15%)for more than 7 *** thicknesses of ITMLs were concentrated between 15 and 55 *** 165°E,the vertical distribution of ITML occurrence probability was different from that at 140°W and 170°W,as it did not show a preference for depths;the durations of ITMLs are short(also from hours to several days)and their thicknesses were between 5 and 25 *** properties,particularly the high occurrence probability,and short durations demonstrated the persistence of thermocline mixing in the western to eastern equatorial Pacific thermocline and confirmed the generation mechanism by persistent equatorial waves as well.

关键词： interior turbulent mixing layer(ITML) weakly sheared layer(WSL) Equatorial Undercurrent(EUC)core occurrence probability seasonality

Classification of spin Hall effect in two-dimensional systems

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Frontiers of physics 2024年第3期19卷 103-114页

作者： Longjun xiang Fuming Xu Luyang Wang Jian Wang College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Quantum Science Center of Guangdong-Hongkong-Macao Greater Bay Area(Guangdong) Shenzhen 518045China Department of Physics The University of Hong KongPokfulam RoadHong KongChina

Physical properties such as the conductivity are usually classified according to the symmetry of the underlying system using Neumann’s principle, which gives an upper bound for the number of independent components of the corresponding property tensor. However, for a given Hamiltonian, this global approach usually can not give a definite answer on whether a physical effect such as spin Hall effect (SHE) exists or not. It is found that the parity and types of spin-orbit interactions (SOIs) are good indicators that can further reduce the number of independent components of the spin Hall conductivity for a specific system. In terms of the parity as well as various Rashba-like and Dresselhaus-like SOIs, we propose a local approach to classify SHE in two-dimensional (2D) two-band models, where sufficient conditions for identifying the existence or absence of SHE in all 2D magnetic point groups are presented.

关键词： spin Hall effect symmetry two-dimensional system

Light-assisted rechargeable zinc-air battery:Mechanism,progress,and prospects

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Journal of Energy Chemistry 2024年第4期91卷 178-193页

作者： Jiangchang Chen Jinlong Luo Youlin xiang Yingjian Yu College of Physics Science and Technology Kunming UniversityKunming 650214YunnanChina

Exploring effective energy storage systems is critical to alleviate energy *** zinc-air batteries are promising energy storage ***,conventional rechargeable zinc-air battery systems face many challenges associated with electrolytes and electrodes,causing inferior electrochemistry *** light-assisted strategy represents a novel and innovative approach to conventional zinc-air battery technology that uses only electrical *** strategy effectively combines both light and electrical energy conversion/storage *** addition,light-assisted rechargeable zinc-air batteries can achieve photocharging with or without applied electrical bias by partially using solar energy and the acceleration of oxygen reduction/evolution reaction *** this paper,the working mechanism and structural design of the light-assisted rechargeable zinc-air batteries are introduced based on the theory of photoelectrochemistry and its ***,the latest advances in electrolyte and photocathode design strategies are discussed in *** performance enhancement of aqueous light-assisted rechargeable zinc-air batteries using photoelectric materials is ***,a summary and outlook on the further modification of properties of light-assisted rechargeable zinc-air batteries,especially the photovoltaic electrode catalyst design strategies,are *** review provides insights and guidance for the design of high-performance light-assisted rechargeable Zn-air batteries for next-generation energy storage devices.

关键词： Zn-air battery Light-assisted Electrolyte Catalyst Semiconductor

Secondary bile acids are associated with body lipid accumulation in obese pigs

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ANIMAL NUTRITION 2024年第3期18卷 246-256页

作者： Hu, Yaolian Wu, aimin Yan, Hui Pu, Junning Luo, Junqiu Zheng, Ping Luo, Yuheng Yu, Jie He, Jun Yu, Bing Chen, Daiwen Sichuan Agr Univ Anim Nutr Inst Key Lab Anim Dis Resistant Nutr Minist Educ Yaan 625014 Peoples R China

The aim of this study was to investigate the reasons for the differences in lipid accumulation between lean and obese pigs. The bile acids with varying levels within two types of pigs were found and then in vitro experiments were conducted to identify whether these bile acids can directly affect lipid accumulation. Fourteen pigs, including seven lean and seven obese pigs with body weights of approximately 80 kg, were fed the same diet at an amount approximately equivalent to 3% of their respective body weights daily for 42 d. In vitro, 3T3-L1 preadipocytes were cultured in medium with high glucose levels and were differentiated into mature adipocytes using differentiation medium. Then, bile acids were added to mature adipocytes for 4 d. The results showed that there was a difference in body lipids levels and gut microbiota composition between obese and lean pigs (P < 0.05). According to the results of gut microbial function prediction, the bile acid biosynthesis in colonic digesta of obese pigs were different from that in lean pig. Sixty-five bile acids were further screened by metabolomics, of which 4 were upregulated (P < 0.05) and 2 were downregulated (P < 0.05) in obese pigs compared to lean pigs. The results of the correlation analysis demonstrated that chenodeoxycholic acid-3-b-D-glucuronide b- D-glucuronide (CDCA-3Gln) and a- muricholic acid (a a- MCA) had a negative correlation with abdominal fat weight and abdominal fat rate, while isoallolithocholic acid (IALCA) was positively associated with crude fat in the liver and abdominal fat rate. There was a positive correlation between loin muscle area and CDCA-3Gln and a- MCA (P P < 0.05), however, IALCA and 3-oxodeoxycholic acid (3-oxo-DCA) were negatively associated with loin eye muscle area (P < 0.05). Isoallolithocholic acid increased the gene expression of peroxisome proliferator-activated receptor gamma ( PPARG ) and the number of lipid droplets (P < 0.05), promoting the lipid storage when IALCA was added

关键词： Lean or obese pig Lipid accumulation Bile acid profile Gut microbiota DIET-INDUCED OBESITY GUT MICROBIOTA ADIPOSE-TISSUE PPAR-GAMMA METABOLISM QUALITY PERFORMANCE EXPRESSION RECEPTOR CARCASS

Weighted Composition Operators That Preserve Frames On Weighted Hardy Spaces

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1645-1654页

作者： Ya Li Dong Rui Liu Guo xiang Lu School of Mathematical Sciences and LPMC Nankai UniversityTianjin300071P.R.China School of Statistics and Mathematics Zhongnan University of Economics and LawWuhan430073P.R.China

In this paper, we characterize weighted composition operators that preserve frames on the weighted Hardy spaces in the unit disk. In particular, we obtain the symbol properties of the bounded invertible weighted composition operators. Moreover, we establish the equivalence between bounded invertible operators and frame-preserving operators. Furthermore, we show that weighted composition operator preserves frames if and only if it preserves the Riesz bases property. Additionally,we investigate the weighted composition operators that preserve tight or normalized tight frames on the Dirichlet space.

关键词： Weighted composition operators Weighted Hardy spaces frames invertible

A projected Newton algorithm based on chemically allowed interval for chemical equilibrium computations

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Frontiers of Chemical Science and Engineering 2024年第3期18卷 25-37页

作者： Hongbin Lu Shaohui Tao Xiaoyan Sun Li Xia Shuguang xiang Institute of Process Systems Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao266042China

The chemical equilibrium equations utilized in reactive transport modeling are complex and nonlinear,and are typically solved using the Newton-Raphson *** this algorithm is known for its quadratic convergence near the solution,it is less effective far from the solution,especially for ill-conditioned *** such cases,the algorithm may fail to converge or require excessive *** address these limitations,a projected Newton method is introduced to incorporate the concept of *** method constrains the Newton step by utilizing a chemically allowed interval that generates feasible descending ***,we utilize the positive continuous fraction method as a preconditioning technique,providing reliable initial values for solving the *** numerical results are compared with those derived using the regular Newton-Raphson method,the Newton-Raphson method based on chemically allowed interval updating rules,and the bounded variable least squares method in six different test *** numerical results highlight the robustness and efficacy of the proposed algorithm.

关键词： chemical equilibrium reactive transport modeling numerical methods projected Newton method