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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi xia George Smith Rui Li Nai-Kui Liu xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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Entransy dissipation minimization for generalized heat exchange processes

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Science China(Technological Sciences) 2016年第10期59卷 1507-1516页

作者： xia ShaoJun Institute of Thermal Science and Power Engineering Naval University of EngineeringWuhan 430033China Military Key Laboratory for Naval Ship Power Engineering Naval University of EngineeringWuhan 430033China College of Power Engineering Naval University of EngineeringWuhan 430033China

This paper investigates the MED （Minimum Entransy Dissipation） optimization of heat transfer processes with the generalized heat transfer law q ∝ （A（T^n））m. For the fixed amount of heat transfer, the optimal temperature paths for the MED are obtained The results show that the strategy of the MED with generalized convective law q ∝ （△T）^m is that the temperature difference keeps constant, which is in accordance with the famous temperature-difference-field uniformity principle, while the strategy of the MED with linear phenomenological law q ∝ A（T^-1） is that the temperature ratio keeps constant. For special cases with Dulong-Petit law q ∝ （△T）^1.25 and an imaginary complex law q ∝ （△（T^4））^1.25, numerical examples are provided and further compared with the strategies of the MEG （Minimum Entropy Generation）, CHF （Constant Heat Flux） and CRT （Constant Reservoir Temperature） operations. Besides, influences of the change of the heat transfer amount on the optimization results with various heat resistance models are discussed in detail.

关键词： entransy theory finite time thermodynamics heat exchange process optimal temperature path generalized heattransfer law generalized thermodynamic optimization

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Analytical Solutions for an Isotropic Elastic Half-Plane with Complete Surface Effects Subjected to a Concentrated/Uniform Surface Load

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Acta Mechanica Solida Sinica 2024年第3期37卷 371-384页

作者： xia-Hui Pan School of Civil Engineering Henan Polytechnic UniversityJiaozuo454003China

Within the context of Gurtin-Murdoch surface elasticity theory,closed-form analytical solutions are derived for an isotropic elastic half-plane subjected to a concentrated/uniform surface *** the effects of residual surface stress and surface elasticity are *** stress function method and Fourier integral transform technique are *** solutions are provided in a compact manner that can easily reduce to special situations that take into account either one surface effect or none at *** results indicate that surface effects generally lower the stress levels and smooth the deformation profiles in the *** elasticity plays a dominant role in the in-plane elastic fields for a tangentially loaded half-plane,while the effect of residual surface stress is fundamentally crucial for the out-of-plane stress and displacement when the half-plane is normally *** the remaining situations,combined effects of surface elasticity and residual surface stress should be *** results for a concentrated surface force serve essentially as fundamental solutions of the Flamant and the half-plane Cerruti problems with surface *** solutions presented in this work may be helpful for understanding the contact behaviors between solids at the nanoscale.

关键词： Surface effects Residual surface stress Surface elasticity Half-plane Analytical solutions

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Intermolecular reductive coupling of aliphatic ketones with alkynes and alkenes by BCN photocatalysts

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Science China Chemistry 2025年第01期 181-185页

作者： Yanping xia Luyang Sun Jiajia Cheng Sibo Wang Meifang Zheng Xinchen Wang State Key Laboratory of Photocatalysis on Energy and Environment College of Chemistry Fuzhou University

A photocatalytic process was developed for intermolecular reductive coupling of aliphatic ketones with alkynes/alkenes to furnish tertiary alcohols. Mechanistic studies support that boron carbonitrides(BCN) promote the single electron reduction of unactivated aliphatic ketones to generate ketyl radicals with visible light irradiation, which then react with alkynes and alkenes to afford the allylic and aliphatic alcohols, respectively. The heterogeneous photocatalytic system is compatible with diverse substrates including pharmaceutical-related molecules(43 examples) with reusability and scale-up experiments, verifying the complementary synthetic utility of this method to the homogeneous catalysts.

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Finite dimensional modules over quantum toroidal algebras

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Frontiers of Mathematics in China 2020年第3期15卷 593-600页

作者： Limeng xia Institute of Applied System Analysis Jiangsu UniversityZhenjiang 212013China

For all generic q∈C^∗,when g is not of type A1;we prove that the quantum toroidal algebra Uq(gtor)has no nontrivial finite dimensional simple module.

关键词： Quantum toroidal algebra finite dimensional module

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The Aubry Set and Mather Set in the Embedded Contact Hamiltonian System

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Acta Mathematica Sinica,English Series 2022年第7期38卷 1294-1302页

作者： xia LI School of Mathematics Science Suzhou University of Science and TechnologySuzhou 215009P.R.China

We embed the Aubry set and Mather set in the Tonelli Hamiltonian system to the contact Hamiltonian *** find the embedded Aubry set is the set of non-wandering points of the contact Hamiltonian system and the Mather set is the support of set of the invariant Borel probability measures for the contact Euler–Lagrange *** this viewpoint,we can conclude that Aubry set and Mather set are symplectic invariants.

关键词： Contact Hamiltonian system Aubry-Mather theory

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LSTM-DPPO based deep reinforcement learning controller for path following optimization of unmanned surface vehicle

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Journal of Systems Engineering and Electronics 2023年第5期34卷 1343-1358页

作者： xia Jiawei ZHU Xufang LIU Zhong xia Qingtao School of Weaponry Engineering Naval University of EngineeringWuhan 430033China Qingdao Campus Naval Aviation UniversityQingdao 266041China School of Electronic Engineering Naval University of EngineeringWuhan 430033China

To solve the path following control problem for unmanned surface vehicles(USVs),a control method based on deep reinforcement learning(DRL)with long short-term memory(LSTM)networks is proposed.A distributed proximal policy opti-mization(DPPO)algorithm,which is a modified actor-critic-based type of reinforcement learning algorithm,is adapted to improve the controller performance in repeated *** LSTM network structure is introduced to solve the strong temporal cor-relation USV control *** addition,a specially designed path dataset,including straight and curved paths,is established to simulate various sailing scenarios so that the reinforcement learning controller can obtain as much handling experience as *** numerical simulation results demonstrate that the proposed method has better control performance under missions involving complex maneuvers than trained with limited scenarios and can potentially be applied in practice.

关键词： unmanned surface vehicle(USV) deep reinforce-ment learning(DRL) path following path dataset proximal po-licy optimization long short-term memory(LSTM)

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Learning sparse and smooth functions by deep Sigmoid nets

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Applied Mathematics(A Journal of Chinese Universities) 2023年第2期38卷 293-309页

作者： LIU xia School of Sciences Xi’an University of TechnologyXi’an 710048China

To pursue the outperformance of deep nets in learning,we construct a deep net with three hidden layers and prove that,implementing the empirical risk minimization(ERM)on this deep net,the estimator can theoretically realize the optimal learning rates without the classical saturation *** other words,deepening the networks with only three hidden layers can overcome the saturation and not degrade the optimal learning *** obtained results underlie the success of deep nets and provide a theoretical guidance for deep learning.

关键词： generalization deep learning deep neural networks learning rate sparse

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Cloud-based control systems: towards the control architecture in cloud computing era

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Science China(Information Sciences) 2024年第10期67卷 386-388页

作者： Yuanqing xia School of Automation Beijing Institute of Technology Zhongyuan University of Technology

Era of cloud computing. After Google introduced the concept of “cloud computing”, this paradigm experienced rapid growth and found widespread applications across various industries, establishing itself as one of the... 详细信息

关键词： Cloud computing architecture

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ON HERMITIAN POSITIVE DEFINITE SOLUTION OF NONLINEAR MATRIX EQUATION X＋A^＊X^-2A=Q

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Journal of Computational Mathematics 2005年第5期23卷 513-526页

作者： xiao xia Guo ICMSEC Academy of Mathematics and System Sciences Chinese Academy of Sciences Beijing 100080 China

Based on the fixed-point theory, we study the existence and the uniqueness of the maximal Hermitian positive definite solution of the nonlinear matrix equation X＋A^＊X^-2A=Q, where Q is a square Hermitian positive definite matrix and A＊ is the conjugate transpose of the matrix A. We also demonstrate some essential properties and analyze the sensitivity of this solution. In addition, we derive computable error bounds about the approximations to the maximal Hermitian positive definite solution of the nonlinear matrix equation X＋A^＊X^-2A=Q. At last, we further generalize these results to the nonlinear matrix equation X＋A^＊X^-nA=Q, where n≥2 is a given positive integer.

关键词： Nonlinear matrix equation Hermitian positive definite solution Sensitivity analysis Error bound

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