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nOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou Ying Xiaoli Si naijia Xue Yi Liu Ran Zheng Ying chen Jiali Pu Baorong Zhang Department of neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether nADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased nADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,nADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that nADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,nADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that nADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that nADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis nADPH oxidase 4(nOX4) neuroinflammation Parkinson's disease

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Einstein Probe discovery of EP240408a: A peculiar X-ray transient with an intermediate timescale

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 222-240页

作者： Wenda Zhang Weimin Yuan Zhixing Ling Yong chen nanda Rea Arne Rau Zhiming Cai Huaqing cheng Francesco Coti Zelati Lixin Dai Jingwei Hu Shumei Jia Chichuan Jin Dongyue Li Paul O’Brien Rongfeng Shen Xinwen Shu Shengli Sun Xiaojin Sun Xiaofeng Wang Lei Yang Bing Zhang chen Zhang Shuang-nan Zhang Yonghe Zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier Liming Dou Rob Eyles-Ferris Zhou Fan Hua Feng Shaoyu Fu Johan P.U.Fynbo Lluis Galbany Saurabh W.Jha Shuaiqing Jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong Li Bifang Liu Mingjun Liu Xing Liu Yuan Liu Zhu Liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal nandra Jeremy Sanders Roberto Soria Lian Tao Junfeng Wang Song Wang Tinggui Wang Zhongxiang Wang Qingwen Wu Xuefeng Wu Dong Xu Yanjun Xu Suijian Xue Yongquan Xue Zijian Zhang Zipei Zhu Hu Zou Congying Bao Fansheng chen Houlei chen Tianxiang chen Wei chen Yehai chen Yifan chen chenzhou Cui Weiwei Cui Yanfeng Dai Dongwei Fan Ju Guan Dawei Han Dongjie Hou Haibo Hu Maohai Huang Jia Huo Zhenqing Jia Bowen Jiang Ge Jin chengkui Li Junfei Li Longhui Li Maoshun Li Wei Li Zhengda Li Tianying Lian Congzhan Liu Heyang Liu Huaqiu Liu Fangjun Lu Laidan Luo Jia Ma Xuan Mao Haiwu Pan Xin Pan Liming Song Hui Sun Yunyin Tan Qingjun Tang Yihan Tao Hao Wang Juan Wang Lei Wang Wenxin Wang Yilong Wang Yusa Wang Qinyu Wu Haitao Xu Jingjing Xu Xinpeng Xu Yunfei Xu Zhao Xu Changbin Xue Yulong Xue Ailiang Yan Haonan Yang Xiongtao Yang Yanji Yang Juan Zhang Mo Zhang Wenjie Zhang Zhen Zhang Zhen Zhang Ziliang Zhang Donghua Zhao Haisheng Zhao Xiaofan Zhao Zijian Zhao Hongyan Zhou Yilin Zhou Yuxuan Zhu Zhencai Zhu national Astronomical Observatories Chinese Academy of Sciences School of Astronomy and Space Sciences University of Chinese Academy of Sciences Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Institute of Space Sciences (ICE) CSIC Institut d’Estudis Espacials de Catalunya (IEEC) Max Planck Institute for Extraterrestrial Physics Innovation Academy for Microsatellites Chinese Academy of Sciences Department of Physics University of Hong Kong School of Physics and Astronomy University of Leicester School of Physics and Astronomy Sun Yat-sen University Department of Physics Anhui normal University Shanghai Institute of Technical Physics Chinese Academy of Sciences Physics Department Tsinghua University nevada Center for Astrophysics University of nevada Las Vegas Department of Physics and Astronomy University of nevada Las Vegas South African Astronomical Observatory Department of Astronomy University of Cape Town Department of Physics University of the Free State Université Paris Cité CnRS Astroparticule et Cosmologie Université Paris Cité CEA Paris-Saclay IRFU/DAp-aim Department of Astronomy Guangzhou University Cosmic Dawn Center (DAWn) niels Bohr Institute University of Copenhagen Department of Physics and Astronomy Rutgers the State University of new Jersey Institute for Cosmic Ray Research The University of Tokyo ESA/ESTEC Department of Astronomy School of Physics Huazhong University of Science and Technology InAF-Osservatorio Astrofisico di Torino Sydney Institute for Astronomy School of Physics The University of Sydney Department of Astronomy Xiamen University Institute for Frontiers in Astronomy and Astrophysics Beijing normal University Department of Astronomy University of Science and Technology School of Astronomy and Space Sciences University of Science and Technology of China Institute of Deep Space Sciences Deep Space Exploration Laboratory Department of Astronomy School of Physics and Astronomy Yunnan University Shanghai Astronomical Observatory Chi

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe （EP） and follow-up studies made with EP,Swift,nICER,GROnD,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope （WXT） on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for *** flare reached a peak flux of 3.9×10-9erg cm-2s-1in 0.5-4 ke V,～300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and nICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 ke V,with a power-law photon index varying *** X-ray light curve shows a plateau lasting for ～4 d,followed by a steep decay till becoming undetectable ～10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of～10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

关键词： X-ray transients ${\bm~{Einstein~~Probe}}$

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基于车路协同的农机信息采集与通信技术应用研究

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农机化研究 2025年第4期47卷 57-64页

作者：陈宁胡迪均浙江机电职业技术学院杭州310053 正大桑田(宁波)农业发展有限公司浙江慈溪310053

车路协同技术可以实现农机的智能调度、路径规划、远程监控等,提高农机作业效率和安全性。为了实现农业机械在复杂的农田环境中能够高效、快速地进行信息采集与交互,提出了一种改进的基于地理位置的路由协议算法,以车路协同的农机信息... 详细信息

车路协同技术可以实现农机的智能调度、路径规划、远程监控等,提高农机作业效率和安全性。为了实现农业机械在复杂的农田环境中能够高效、快速地进行信息采集与交互,提出了一种改进的基于地理位置的路由协议算法,以车路协同的农机信息采集与路由技术理论为基础,对车路协同信息采集与通信技术的硬件机软件系统进行设计与选型,可以实现农业机械载体信息采集时间、速度、航向和经纬度等地理位置数据的获取。同时,提出并实现了一种改进的基于地理位置的路由算法,并通过田间试验验证系统运行的稳定性和可靠性,结果表明:提出的IGPSR算法具有更高的数据传输速率和耕地端时延迟,可为推动农机作业智能、高效发展提供技术参考。

关键词：农机信息采集通信技术车路协同 CAn总线 GPSR 数据隐私

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Recent developments in three-dimensional Zn metal anodes for battery applications

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InfoMat 2024年第1期6卷 1-30页

作者： Jianyu chen Yizhou Wang Zhengnan Tian Jin Zhao Yanwen Ma Husam n.Alshareef State Key Laboratory of Organic Electronics and Information Displays(KLOEID)and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts&Telecommunications(NUPT)Nanjingthe People's Republic of China Materials Science and Engineering King Abdullah University of Science and Technology(KAUST)ThuwalSaudi Arabia Suzhou Vocational Institute of Industrial Technology Suzhouthe People's Republic of China

Aqueous zinc(Zn)ion batteries(AZIBs)are regarded as one of the promising candidates for next-generation electrochemical energy storage systems due to their low cost,high safety,and environmental ***,the commercialization of AZIBs has been severely restricted by the growth of dendrite at the Zn metal *** the planar-structured Zn anodes into threedimensional(3D)structures has proven to be an effective way to modulate the plating/stripping behavior of Zn anodes,resulting in the suppression of dendrite *** review provides an up-to-date review of 3D structured Zn metal anodes,including working principles,design,current status,and future *** aim to give the readers a comprehensive understanding of 3D-structured Zn anodes and their effective usage to enhance AZIB performance.

关键词： 3D metal anodes aqueous Zn ion batteries dendrite suppression Zn dendrite Zn metal anodes

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青藏高原高寒植物对生长季偶发性霜冻事件表现出深度过冷却现象

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Journal of Plant Ecology 2024年第3期17卷 84-94页

作者： Ji Suonan Wangwang Lü aimée TClassen Wenying Wang Ben La Xuwei Lu Cuo Songzha chenghao chen Qi Miao Fanghui Sun Lhamo Tsering Shiping Wang College of Life Sciences Qinghai Normal UniversityXining 810016China Key Laboratory of Biodiversity Formation Mechanism and Comprehensive Utilization of the Qinghai-Tibet Plateau in Qinghai Province Xining 810016China State Key Laboratory of Tibetan Plateau Earth System Resources and EnvironmentInstitute of Tibetan Plateau ResearchBeijing 100101China Department of Ecology and Evolutionary Biology University of MichiganMI 48109USA

气候变暖促进了植物的春季物候,打破了气候与植物生长之间原有的平衡。随着极端气候事件出现更加频繁,气候与植物生长之间的不匹配性会影响植物的生存、生长和繁殖。为了防止生长季节在细胞内结冰,植物会采用过冷却策略。然而,气候事件... 详细信息

气候变暖促进了植物的春季物候,打破了气候与植物生长之间原有的平衡。随着极端气候事件出现更加频繁,气候与植物生长之间的不匹配性会影响植物的生存、生长和繁殖。为了防止生长季节在细胞内结冰,植物会采用过冷却策略。然而,气候事件的严重程度和物候期可能会影响植物在霜冻事件后的恢复。本研究通过实验探究了4种不同严重程度的极端霜冻事件如何影响青藏高原上两种优势物种钉柱委陵菜(Potentilla saundersiana,仲夏开花)和小龙胆(Gentiana parvula,夏末开花)的过冷却点和枯黄期。探讨了物候期如何影响钉柱委陵菜对霜冻事件的反应。结果发现,两个物种在遭受霜冻损害时都表现出过冷现象。钉柱委陵菜的平均过冷却点为−6.9℃,并受最低温度、持续时间和物候期的影响,而小龙胆的平均过冷却点为−4.8℃,最低温度和持续时间对其过冷却点影响不显著。此外,两个物种在最低温度(−10℃)处理持续4小时后均快速枯黄。本研究首次探索并定量了青藏高原高寒植物的过冷却点。鉴于高寒植物遭遇霜冻事件的概率不断增加,上述结果对了解高寒植物的生长和生存如何应对极端气候的不利影响具有重要意义。

关键词：气候变化极端霜冻事件过冷却现象物候期枯黄

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千里光通过抑制肥大细胞P2X7受体缓解炎性疼痛

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中国药理学通报 2025年第1期41卷 131-137页

作者：叶凡廖利辉唐婧玥陈佳慧成江陈功锡唐宗湘吉首大学药学院湖南吉首416000 武陵山区药用资源化学与药理湖南省高校重点实验室湖南吉首416000 南京中医药大学医学院·整合医学学院江苏南京210000

目的探讨千里光对肥大细胞P2X7受体介导的炎症性疼痛的影响。方法采用高浓度ATP诱导脚掌炎症性疼痛模型,利用免疫荧光染色技术,甲苯胺蓝染色技术,探究千里光对肥大细胞上P2X7受体是否有抑制作用。利用钙离子成像实验技术,探究千里光是... 详细信息

目的探讨千里光对肥大细胞P2X7受体介导的炎症性疼痛的影响。方法采用高浓度ATP诱导脚掌炎症性疼痛模型,利用免疫荧光染色技术,甲苯胺蓝染色技术,探究千里光对肥大细胞上P2X7受体是否有抑制作用。利用钙离子成像实验技术,探究千里光是否可以抑制小鼠腹膜肥大细胞上P2X7受体激活引起的细胞内钙离子富集。利用全细胞膜片钳技术,探究千里光是否可以抑制小鼠腹膜肥大细胞上P2X7受体激活后引起的内向电流。结果体内实验结果显示,千里光(3.9 g·kg^(-1))明显缓解ATP诱导的炎性疼痛(P<0.05);千里光(3.9 g·kg^(-1))明显抑制P2X7受体阳性肥大细胞的浸润(P<0.01);敲除肥大细胞可以消减千里光(3.9 g·kg^(-1))的镇痛效果(P=0.645)。体外实验结果显示,千里光明显抑制肥大细胞P2X7受体介导的钙离子内流(300 mg·L^(-1),P<0.05;1 g·L^(-1),P<0.01;3 g·L^(-1):P<0.01);千里光(1 g·L^(-1))明显抑制肥大细胞P2X7受体介导的内向电流(P<0.01)。结论千里光通过抑制肥大细胞P2X7受体功能缓解ATP诱导的炎性疼痛。

关键词：千里光疼痛肥大细胞 P2X7受体炎症 ATP

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Effects of climate fluctuations on runoff in the headwater region of the Kaidu River in northwestern China

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Frontiers of Earth Science 2014年第2期8卷 309-318页

作者： Zhongsheng chen Yaning chen State key Laboratory of Geographic Information Science Ministry of Education East China Normal University Shanghai 200062 China State Key Laboratory of Desert and Oasis Ecology Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences Urumqi 830011 China

The aim of this study was to analyze the effects of climate fluctuations on runoff in the headwater region of the Kaidu River in northwestern China. For this purpose, precipitation and potential evaporation （PET） data from 5 meteorological stations and the runoff depth data from the Dashankou hydrological station in the headwater region of the Kaidu River from 1960 to 2009 were collected, then the trends and abrupt changes of precipitation, PET and runoff depth were analyzed by means of Mann-Kendall test （M-K test） and Mann-Kendall-Sneyers test （M-K-S test）, respectively. The runoff model driven by precipitation and PET was developed in this work and the sensitivity of runoff to climate fluctuation was simulated under different scenarios. Results showed that the annual precipitation and runoff depth both exhibited an increasing trend over the periods 1960-2009; however, this is not the case for the annual PET. The abrupt changes for annual precipitation, PETand runoff depth all occurred in the early 1990s. The established driving model could well reflect the compli- cated nonlinear relationship among runoff depth, precipitation and PET. The sensitivity analysis indicated that the precipitation had a positive effect on the runoff depth, opposite to what were observed between PET and runoff, and the runoff depth was more sensitive to precipitation than to PET in the headwater region of the Kaidu River.

关键词： climate fluctuation driving model runoffdepth sensitivity analysis

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DAMAGE DETECTIOn BASED On OPTIMIZED InCOMPLETE MODE SHAPE AnD FREQUEnCY

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Acta Mechanica Solida Sinica 2015年第1期28卷 74-82页

作者： Wei chen Wenguang Zhao Huizhen Yang Xuquan chen Hubei Key Laboratory of Control Structure Huazhong University of Science and Technology

For the purpose of structural health monitoring, a damage detection method combined with optimum sensor placement is proposed in this paper. The back sequential sensor placement （BSSP） algorithm is introduced to optimize the sensor locations with the aim of maximizing the 2-norm of information matrix, since the EI method is not suitable for optimum sensor placement based on eigenvector sensitivity analysis. Structural damage detection is carried out based on the respective advantages of mode shape and frequency. The optimized incomplete mode shapes yielded from the optimal sensor locations are used to localize structural damage. After the potential damage elements have been preliminarily identified, an iteration scheme is adopted to estimate the damage extent of the potential damage elements based on the changes in the frequency. The effectiveness of this method is demonstrated using a numerical example of a 31-bar truss structure.

关键词： structural damage detection optimum sensor placement sensitivity analysis information matrix

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Intensity modulated radiation therapy with simultaneous integrated boost based dose escalation on neoadjuvant chemoradiation therapy for locally advanced distal esophageal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2016年第5期8卷 474-480页

作者： Ming Zeng Fernando n Aguila Taral Patel Mark Knapp XueQiang Zhu XiLin chen Phillip D Price Department of Radiation Oncology Mount Carmel Health System Cancer Center Sichuan Academy of Medical SciencesSichuan Provincial Hospital Central Ohio Surgical Associates Inc. Department of Hematology and Oncology Zangmeister Cancer CenterMount Carmel Health System Department of Oncology 307 Hospital

aim:To evaluate impact of radiation therapy dose escalation through intensity modulated radiation therapy with simultaneous integrated boost(IMRT-SIB).METHODS:We retrospectively reviewed the patients who underwent four-dimensional-based IMRT-SIBbased neoadjuvant chemoradiation *** the concurrent chemoradiation therapy,radiation therapy was through IMRT-SIB delivered in 28 consecutive daily fractions with total radiation doses of 56 Gy to tumor and 5040 Gy dose-painted to clinical tumor volume,with a regimen at the discretion of the treating medical *** was followed by surgical tumor *** analyzed pathological completion response(p CR) rates its relationship with overall survival and ***:Seventeen patients underwent dose escalation with the IMRT-SIB protocol between 2007 and 2014 and their records were available for *** the IMRT-SIB-treated patients,the toxicity appeared mild,the most common side effects were grade 1-3 esophagitis(46%) and pneumonitis(11.7%).There were no cardiac *** Ro resection rate was 94%(n = 16),the p CR rate was 47%(n = 8),and the postoperative morbidity was *** was one mediastinal failure found,one patient had local failure at the anastomosis site,and the majority of failures were distant in the lung or *** 3-year diseasefree survival and overall survival rates were 41%(n = 7) and 53%(n = 9),***:The dose escalation through IMRT-SIB in the chemoradiation regimen seems responsible for down-staging the distal esophageal with well-tolerated complications.

关键词： Intensity modulated radiation therapy Esophageal adenocarcinoma Simultaneous integrated boost neoadjuvant chemoradiation Dose escalation Resection rate

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Investigation of MAS structure and intelligent^(+) information processing mechanism of hypersonic target detection and recognition system

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Journal of Systems Engineering and Electronics 2020年第6期31卷 1105-1115页

作者： WU Xia LI Yan SUn Yongjian chen Alei chen Jianwen MA Jianchao chen Hao Radar Sergeant School Air Force Early-Warning AcademyWuhan 430019China

The hypersonic target detection and recognition system is studied,on the basis of overall planning and design,a multi-agent system(MAS)structure and intelligent+information processing mechanism based on target detection and recognition are proposed,and the multi-agent operation process is analyzed and designed in *** the specific agents construction,the information fusion technology is introduced to defining the embedded agents and their interrelations in the system structure,and the intelligent processing ability of complex and uncertain problems is emphatically analyzed from the aspects of autonomy and *** aim is to optimize the information processing strategy of the hypersonic target detection and recognition system and improve the robustness and rapidity of the system.

关键词： hypersonic target detection recognition intelligent information fusion multi-agent system(MAS)

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