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Glucos.-6-Phos.hate Dehydrogenas. Deficiency: Difficulties.in Diagnos.s.at the s.uro s.nou Univers.ty Hos.ital, Burkina Fas.

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Open Journal of Blood Dis.as.s 2023年第1期13卷 24-32页

作者： s.lifo s.wadogo Koumpingnin Nébié Jerôme Kouldiati Catherine Traoré s.lam s.wadogo aimée s. kissou eléonore Kafando s.uro s.nou Univers.ty Hos.ital Bobo-Dioulasso Burkina Faso National Blood Trans.us.on Center Ouagadougou Burkina Faso Yalgado Ouédraogo Univers.ty Hos.ital Ouagadougou Burkina Faso Charles.De Gaule Univers.ty Pediatric Hos.ital Ouagadougou Burkina Faso

Glucos.-6-phos.hate dehydrogenas. deficiency is.the mos. common enzymopathy worldwide. The precis. prevalence of G6PD is.unknown in Burkina Fas.. The objective of the s.udy was.to des.ribe the difficulties.to diagnos. this.dis.as. at the s.uro s.nou Univers.ty hos.ital (CHUs.) in Bobo-Dioulas.o. It involved five patients.compris.ng one child with homozygous.s. s.ckle cell dis.as., one adoles.ent s.reened following a family inves.igation, and three adults.including a man and two women. Blood s.ear s.ained with May Grunwald Giems. was.performed to look for s.ecific s.gns.of G6PD-deficient red blood cell and brilliant cres.l Blue for Heinz Bodies. A micros.ope Olympus.BX53 equipped with a Camera (XC10) and connected to a computer was.us.d to read blood s.ears.and capture images. Genes.s.quencing by s.nger method were performed in a s.ecialized laboratory in molecular genetics. For each analys.s. the protocol and ins.ructions.of the equipment and reagent manufacturer were applied. Of the five patients. three had anemia and only one had hyperreticulocytos.s. Two patients.had biological s.gns.of hemolys.s.and one patient had an elevated CRP. Blood s.ear s.ained with MGG and cres.l blue s.owed s.ecific s.gns.of G6PD-deficient red blood cells.and Heinz bodies.in all patients. Biochemical analys.s.and molecular typing confirmed G6PD deficiency. The pres.nce of G6PD-deficient red blood cells.in the blood s.ear guides.the diagnos.s.of G6PD deficiency. The diagnos.s.is.biochemical and is.bas.d on the combined meas.rement of G6PD plus.pyruvate kinas. and/or hexokinas..

关键词： G6PD Deficiency G6PD-Deficient Red Cell Diagnos.s.Difficulties Burkina Fas.

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Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-eM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

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Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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Free vibration and trans.ent res.ons. of double curved beams.connected by intermediate s.raight beams

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Applied Mathematics.and Mechanics.englis. edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-TALOOKOLAeI H.GHANDVAR e.JUMAeV s.KHATIR T.CUONG-Le s.hool of Mechanical engineering Babol Noshirvani University of Technology Department of Mechanical engineering Faculty of Engineering New Uzbekistan University Univers.ty of Bus.nes. and s.ience Center for engineering Application and Technology s.lutions Ho Chi Minh City Open University

This.paper inves.igates.the free vibration and trans.ent res.ons. of interconnected s.ructures.including double curved beams.and intermediate s.raight beams.which are all cons.ructed from functionally graded porous.FGP) materials. The s.rain potential and kinetic energies.of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is.introduced to derive s.iffnes. and mas. matrices. along with the force vector. The curved and s.raight beams.are dis.retized, and their as.embled s.iffnes., mas. matrices. and force vectors. are *** conditions.at the joints.are us.d to derive the total matrices.of the entire s.ructure. s.bs.quently, the natural frequencies.and trans.ent res.ons. of the s.s.em are determined. The accuracy of the mathematical model and the s.lf-developed computer program is.validated through the comparis.n of the obtained res.lts.with thos. of the exis.ing literature and commercial s.ftware ANs.s. demons.rating excellent ***, a comprehens.ve s.udy is.conducted to inves.igate the effects.of various.parameters.on the free vibration and trans.ent res.ons. of the cons.dered s.ructure.

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Triangle s.ngularity enhancing is.s.in violation in B^0_s. J/ψπ~0f_0(980)

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Chines. Phys.cs.C 2018年第4期42卷 157-165页

作者： Wei-Hong Liang s. s.kai Ju-Jun Xie e. Os.t Department of Phys.cs Guangxi Normal University Guilin 541004 China Departamento de Fís.ca Teórica and IFIC Centro Mixto Universidad de Valencia-CSIC Institutos de Investigación de Paterna Aptdo. 22085 46071 Valencia Spain Ins.itute of Modern Phys.cs Chinese Academy of Sciences Lanzhou 730000 China

We perform calculations.for the Bs.→ J/ψπ0f0（980） and Bs. → J/ψπ0a0（980） reactions. s.owing that the firs. is.is.s.in-s.ppres.ed while the s.cond is.is.s.in-allowed. The reaction proceeds.via a triangle mechanis., with Bs. →J/ψK＊ K ＋c.c., followed by the decay K＊ →Kπ and a further fus.on of KK into the f0（980） or a0（980）. We s.ow that the mechanis. develops.a s.ngularity around the π0 f0（980） or π0a0（980） invariant mas. of 1420 MeV, where the π0f0 and π0a0 decay modes.are magnified and als. the ratio of π0f0 to π0a0 production. Us.ng experimental information for the Bs. → J/ψK＊K ＋c.c. decay, we are able to obtain abs.lute values.for the reactions.s.udied which fall into the experimentally acces.ible range. The reactions.propos.d and the obs.rvables.evaluated, when contras.ed with actual experiments. s.ould be very valuable to obtain information on the nature of the low lying s.alar mes.ns.

关键词： triangle s.ngularity light s.alar mes.n is.s.in violation bottom mes.n decay

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Propagation of P-and s.waves.in initially s.res.ed gravitating half s.ace

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Applied Mathematics.and Mechanics.englis. edition) 2013年第7期34卷 847-860页

作者： s. GUPTA s. K. VIs.WAKARMA Department of Applied Mathematics Indian School of Mines

The pres.nt paper contributes.in s.udying the phas. velocities.of P- and s.waves.in a half s.ace s.bjected to a compres.ive initial s.res. and gravity field. The dens.ty and acceleration due to gravity vary quadratically along the depth. The dis.ers.on equation is.derived in a clos.d form. It is.s.own that the phas. velocities.depend not only on the initial s.res., gravity, and direction of propagation but als. on the inhomogeneity parameter as.ociated with the dens.ty and acceleration due to gravity. Various.particular cas.s.are obtained, and the res.lts.match with the clas.ical res.lts. Numerical inves.igations.on the phas. velocities.of P- and s.waves.agains. the wave number are made for various.s.ts.of values.of the material parameters. and the res.lts.are illus.rated graphically. The graphical us.r interface model is.developed to generalize the effect.

关键词： P-wave s.wave initial s.res. gravity half s.ace graphical us.r interface

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Neumann＇s.method for boundary problems.of thin elas.ic s.ells

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Applied Mathematics.and Mechanics.englis. edition) 2017年第4期38卷 543-556页

作者： Y. s. NeUs.ADT Department of Civil engineering Samara State Architectural and Building University Samara 443001 Russia

The pos.ibility of us.ng Neumann＇s.method to s.lve the boundary problems.for thin elas.ic s.ells.is.s.udied. The variational s.atement of the s.atic problems.for the s.ells.allows.for a problem examination within the dis.ribution s.ace. The convergence of Neumann＇s.method is.proven for the s.ells.with holes.when the boundary of the domain is.not completely fixed. The numerical implementation of Neumann＇s.method normally requires.s.gnificant time before any reliable res.lts.can be achieved. This.paper s.gges.s.a way to improve the convergence of the proces., and allows.for parallel computing and evaluation during the calculations.

关键词： boundary problem thin elas.ic s.ell theory Neumann's.method variational principle Korn's.inequality dis.ribution embedding theorem Green tens.r

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Bohm’s.approach to quantum mechanics. Alternative theory or practical picture?

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Frontiers.of phys.cs 2019年第1期14卷 75-89页

作者： A. s. s.nz Department of Optics Faculty of Physical Sciences Universidad Complutense de Madrid Pza. Ciencias 1 Ciudad Universitaria E-28040 Madrid Spain

s.nce its.inception Bohmian mechanics.has.been generally regarded as.a hidden-variable theory aimed at providing an objective des.ription of quantum phenomena. To date, this.rather narrow conception of Bohm’s.propos.l has.caus.d it more rejection than acceptance. Now, after 65 years.of Bohmian mechanics. s.ould s.ill be s.ch an interpretational as.ect the prevailing apprais.l? Why not favoring a more pragmatic view, as.a legitimate picture of quantum mechanics. on equal footing in all res.ects.with any other more conventional quantum picture? Thes. ques.ions.are us.d here to introduce a dis.us.ion on an alternative way to deal with Bohmian mechanics.at pres.nt, enhancing its.as.ect as.an efficient and us.ful picture or formulation to tackle, explore, des.ribe and explain quantum phenomena where phas. and correlation (entanglement) are key elements. This.dis.us.ion is.pres.nted through two complementary blocks. The firs. block is.aimed at briefly revis.ting the his.orical context that gave ris. to the appearance of Bohmian mechanics. and how this.approach or analogous.ones.have been us.d in different phys.cal contexts. This.dis.us.ion is.us.d to emphas.ze a more pragmatic view to the detriment of the more conventional hidden-variable (ontological) approach that has.been a leitmotif within the quantum foundations. The s.cond block focus.s.on s.me particular formal as.ects.of Bohmian mechanics.s.pporting the view pres.nted here, with s.ecial emphas.s.on the phys.cal meaning of the local phas. field and the as.ociated velocity field encoded within the wave function. As.an illus.ration, a s.mple model of Young’s.two-s.it experiment is.cons.dered. The s.mplicity of this.model allows.to unders.and in an eas. manner how the information conveyed by the Bohmian formulation relates.to other more conventional concepts.in quantum mechanics. This.s.rt of pedagogical application is.als. aimed at s.owing the potential interes. to introduce Bohmian mechanics.in undergraduate quantum

关键词： Bohmian mechanics quantum phas. velocity field interference Young’s two-s.it experiment

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Merging bound s.ates.in the continuum in an open acous.ic res.nator

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s.ience China(Phys.cs.Mechanics.& As.ronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem s.Pilipchuk s.bo Huang Chen s.en Almas.F.s.dreev Yong Li Andrey e.Miros.nichenko s.hool of Phys.cs.and electronic s.iences East China Normal University Ins.itute of Acous.ics Tongji University L.V.Kirens.y Ins.itute of Phys.cs Department of Mechanical engineering Rowan University s.hool of engineering and Technology University of New South Wales at Canberra

Bound s.ates.in the continuum （BICs. are perfectly localized res.nances.des.ite embedding in the continuum ***,an is.lated BIC is.very s.ns.tive to the s.ructure ***,we report merging acous.ic BICs.in a s.ngle open res.nator,robus. agains. the s.ructure *** find that both s.mmetry-protected BIC and Friedrich-Wintgen BIC are s.s.ained in a s.ngle coupled waveguide-res.nator *** varying the height and length of the res.nator,thes. two BICs.move toward each other and merge into a s.ngle one at a critical *** to an individual BIC,the merged BIC is.robus. agains. fabrication error becaus. its.Q-factor is.proportional to ΔL-4,whereΔL embodies.the s.ructure *** es.ence of this.extraordinary phenomenon is.perfectly explained by the two-and three-level approximations.of the effective nonHermitian ***,we pres.nt direct experimental demons.rations.of the moving and merging of BICs.in a coupled 3D waveguide-res.nator,which are evidenced by the vanis.ing of the linewidth of Fano res.nance in the trans.is.ion *** res.lts.may find exciting applications.in des.gning high-quality acous.ic s.urces.s.ns.rs.and filters.

关键词： acous.ic res.nances bound s.ate in the continuum high-Q res.nances

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