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The Shishugou Fauna of the middle-Late Jurassic Transition Period in the Junggar Basin of Western China

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Acta Geologica Sinica(English Edition) 2022年第4期96卷 1115-1135页

作者： XU Xing James m.clark David A.EBERTH Philip J.CURRIE Centre for Vertebrate Evolutionary Biology Yunnan UniversityKunming 650500China Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China Department of Biological Sciences George Washington UniversityWashington DC20052USA Royal Tyrrell museum of Palaeontology Box 7500DrumhellerAlberta T0J 0Y0Canada Department of Biological Sciences University of Alberta 116 Street and 85 AvenueEdmontonAB T6G 2R3Canada

The middle-Late Jurassic transition period is a critical period for the evolution of terrestrial vertebrates,but the global fossil record from this time is relatively *** Shishugou Fauna of this period has recently produced significant fossil remains of dinosaurs and other vertebrate groups,some representing the earliest known members of several dinosaurian groups and other vertebrate groups and some representing the best-known specimens of their *** discoveries are significant for our understanding of the origin and evolution of several vertebrate *** dating indicates that the fauna is aged approximately 159-164 *** with other similarly-aged terrestrial faunas such as Shaximiao and Yanliao show both taxonomic similarities and differences between these faunas and indicate that the Junggar deposits might have preserved the most complete vertebrate fossil record for a middle-Late Jurassic Laurasian terrestrial fauna.

关键词： middle-Late Jurassic Shishugou Fauna Shishugou Formation terrestrial ecosystem Shaximiao Yanliao Junggar Basin

Nonalcoholic fatty liver disease and type 2 diabetes: a burgeoning problem with unclear solutions

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 514-517页

作者： mariana Lazo Jeanne m.clark Division of General Internal medicine School of MedicineJohns Hopkins UniversityBaltimoreMDUSA Division of Gastroenterology&Hepatology Johns Hopkins University School of MedicineBaltimoreMDUSA

The association between chronic liver disease and diabetes has been known for long time,with reports in the literature as early as in 1952(1).Currently,a bidirectional association between type 2 diabetes and nonalcoholic fatty liver disease(NAFLD)has become more widely accepted,probably as a result of the common risk factors(e.g.,obesity)and pathophysiology(e.g.,insulin resistance)(2).

关键词： diabetes liver NAFLD

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猫慢性蜗外电刺激耳蜗组织病理学改变

中国医学科学院学报 1993年第4期15卷 261-265页

作者：倪道凤 Robert K.Shepherd Graeme m.clark 中国医学科学院中国协和医科大学协和医院澳大利亚墨尔本大学

本实验研究了5只猫蜗外电极慢性植入和电刺激引起的耳蜗组织病理学改变。刺激电极球分别固定在圆窗和鼓岬上,用双相平衡的0.4～1.8mA、脉宽100μS电脉冲作1276～1526h的慢性电刺激。光学显微镜检查耳蜗组织病理学改变发现:圆窗和鼓岬电... 详细信息

本实验研究了5只猫蜗外电极慢性植入和电刺激引起的耳蜗组织病理学改变。刺激电极球分别固定在圆窗和鼓岬上,用双相平衡的0.4～1.8mA、脉宽100μS电脉冲作1276～1526h的慢性电刺激。光学显微镜检查耳蜗组织病理学改变发现:圆窗和鼓岬电极固定良好;除1耳电极推压圆窗膜与Hook区骨螺旋板粘连外,电极固定部位的圆窗膜均增厚;刺激侧与对照侧耳蜗下基底转内可见不同程度外毛细胞损失、轻度内毛细胞损失和小范围Corti's结构消失;2个刺激侧耳蜗近圆窗2%基底膜长度范围内少量螺旋神经节细胞损失。提示蜗外电极行电刺激虽比蜗内电极安全,但在耳蜗下基底转仍有轻度组织病理学改变.

关键词：人工耳蜗蜗外电刺激耳聋病理学

新疆准噶尔盆地侏罗纪石树沟组上部一大型兽脚类跖骨

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古脊椎动物学报 2013年第1期51卷 29-42页

作者：贺一鸣 James m.clark 徐星中国科学院古脊椎动物与古人类研究所中国科学院脊椎动物演化与人类起源重点实验室北京100044 美国乔治·华盛顿大学生物学系华盛顿特区20052 中国科学院大学北京100049

准噶尔盆地中侏罗世晚期到晚侏罗世早期沉积的石树沟组产出过包括多种兽脚类恐龙在内的大量脊椎动物化石。描述了一件新的采自准噶尔盆地东北缘五彩湾地区石树沟组上部的兽脚类恐龙左第四跖骨标本(IVPPV18060)。通过与其他兽脚类恐龙第... 详细信息

准噶尔盆地中侏罗世晚期到晚侏罗世早期沉积的石树沟组产出过包括多种兽脚类恐龙在内的大量脊椎动物化石。描述了一件新的采自准噶尔盆地东北缘五彩湾地区石树沟组上部的兽脚类恐龙左第四跖骨标本(IVPPV18060)。通过与其他兽脚类恐龙第四跖骨对比,该标本可归入异特龙超科(Allosauroidea)。它与其他异特龙超科第四跖骨的相似性包括:近端关节面三角形并有一向后方延伸的舌状突出,向外侧轻微弯曲的骨干,位于骨干后方靠近外侧边的半月形肌肉凹陷,三角形骨干横截面。在异特龙超科当中,V18060与准噶尔盆地将军庙地区石树沟组中发现的董氏中华盗龙(Sinraptordongi)最为相似(除了以上相似性,V18060和董氏中华盗龙的相似性还包括远端关节轮廓呈近梯形,骨干后部肌肉凹陷与周围边界呈半开放状态)。但是,V18060和董氏中华盗龙也存在着一些明显的区别:V18060明显比董氏中华盗龙的第四跖骨粗壮,远端内外两髁大小差异相反。这些形态差异可能是由于个体发育或者性双形造成的,也可能代表分类学差异。对比研究和基于第四跖骨形态信息进行的分支系统学分析结果更偏向后一种解释:V18060代表一个不同于董氏中华盗龙但与后者亲缘关系很近的新的兽脚类恐龙。新材料的发现增加了中晚侏罗世石树沟动物群兽脚类恐龙的分异度。在五彩湾和将军庙地区发现不同的中华盗龙类恐龙指示了晚侏罗世早期准噶尔盆地中相邻地区可能存在着一定的生态分异性或者地理隔离。

关键词：准噶尔盆地中晚侏罗世石树沟组兽脚类恐龙跖骨

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老年人糖尿病的特殊考量（英文）

老年人糖尿病的特殊考量（英文）

The Yin and Yang of Wnt/Ryk axon guidance in development and regeneration

第三届江浙沪三地老年医学高峰论坛暨2012年浙江省老年医学学术年会

作者： Charles m.clark 美国印第安纳大学

Special thanks to Carolyn Jennings,mPH,RD,CDE SouthEast michigan Diabetes Outreach Network whose slides have been adapted for this presentation

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Science China(Life Sciences) 2014年第4期57卷 366-371页

作者： clark Charlotte EJ LIU Yaobo COOPER Helen m Queensland Brain Institute The University of QueenslandBrisbane Institute of Neuroscience Soochow University

In the developing embryo,nascent axons navigate towards their specific targets to establish the intricate network of axonal connections linking neurons within the mature nervous *** navigational systems comprising repulsive and attractive guidance cues form chemotactic gradients along the pathway of the exploring growth ***-bound receptors detect these gradients and determine the trajectory of the migrating growth *** contrast to their benevolent role in the developing nervous system,repulsive guidance receptors are detrimental to the axon’s ability to regenerate after injury in the *** this review we explore the essential and beneficial role played by the chemorepulsive Wnt receptor,Ryk/Derailed in axon navigation in the embryonic nervous system(the Yin function).Specifically,we focus on the role of Wnt5a/Rykmediated guidance in the establishment of two major axon tracts in the mammalian central nervous system,the corticospinal tract and the corpus *** studies have also identified Ryk as a major suppressor of axonal regeneration after spinal cord ***,we also discuss this opposing aspect of Ryk function in axonal regeneration where its activity is a major impediment to axon regrowth(the Yang function).

关键词： Ryk Derailed Wnt Wnt signalling axon guidance axonal regeneration spinal cord injury

Surfactant protein A (SP-A) binds to phosphatidylserine and competes with annexin V binding on late apoptotic cells

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Protein & Cell 2010年第2期1卷 188-197页

作者： Anne Jäkel Kenneth B.m.Reid Howard clark Department of Pharmacology University of OxfordMansfield RoadOxford OX13QTUK mRC Immunochemistry Unit Department of BiochemistryUniversity of OxfordSouth Parks RoadOxford OX13QUUK University of Southampton MP 803 Level FSouth BlockSouthampton General HospitalSouthampton SO166YDUK

The role of surfactant protein A(SP-A)in the recognition and clearance of apoptotic cells is well established,but to date,it is still not clear which surface molecules of apoptotic cells are involved in the *** we present evidence that phosphatidylserine(PS)is a relevant binding molecule for human *** binding is Ca^(2+)-dependent and is not inhibited by mannose,suggesting that the sugar-binding site of the carbohydrate recognition domain(CRD)of SP-A is not *** cytometry studies on apoptotic Jurkat cells revealed apparent inhibition of annexin V binding by increasing concentrations of SP-A in late apoptotic but not early apoptotic cells,and this was consistent for Jurkat cells and *** these data,confocal microscopy results show a co-localisation of annexin V and SP-A in late apoptotic but not early apoptotic ***,we cannot conclude that this inhibition is exclusively due to the binding of SP-A to PS on the cell surface,as annexin V is not wholly specific for PS and SP-A also interacts with other phospholipids that might become exposed on the apoptotic cell surface.

关键词： surfactant proteins phosphatidylserine apoptotic cells

Contribution of iron status at birth to infant iron status at 9 months

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Contribution of iron status at birth to infant iron status a...

2017浙江省营养学会年会暨西湖营养学术论坛

作者：朱冰泉 Blair Richards Niko Kaciroti Katy m.clark Zhengyan Zhao Jie Shao Betsy Lozoff Children's Hospital Zhejiang University School of medicine Center for Human Growth and Development University of Michigan Department of Pediatrics and Communicable Diseases University of Michigan

BACKGROUND/OBJECTIVE:A physiologic framework indicates that infant iron status will be determined by the iron the infant is born with and postnatal iron needs,availability,and *** previous studies did not assess iron status at *** used the framework to consider multiple measures of iron status at birth in assessing predictors of iron status at 9 ***/mETHODS:Hemoglobin(Hb),serum ferritin(SF),serum transferrin receptor(sTfR),and zinc protoporphyrin/heme(ZPP/H) were measured in cord blood and venous blood at 9 months for545 healthy term Chinese infants,along with mean cell volume(mCV) and red cell distribution width(RDW) at 9 *** deficiency(ID) at 9 months was defined as ≥2 abnormal iron measures,iron deficiency anemia(IDA) as ID+anemia(Hbmonth iron composite and calculated body iron based on SF and *** applied structural equation modeling to assess predictors of 9-month iron status and used logistic regression to calculate odds ratios(OR) for ID,IDA,and ***:At 9 months,34.7%of infants had ID overall(19.6%IDA).Higher cord ZPP/H and sTfR,lower Hb,lower birth weight,male sex,older age at testing,higher weight,and breastfeeding predicted poorer 9-month iron composite;cord ZPP/H,birth weight,sex,age,and feeding predicted body *** was the strongest single *** to formula-fed infants,the odds of IDA were19.1 and 3.6 times higher in breastfed and mixed-fed infants,***:The study showed that indicators of iron status at birth,postnatal iron needs,and external iron sources independently predicted iron status at 9 *** was an additional predictor.

关键词： iron deficiency cord blood iron status sex differences infant feeding infants China

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卒中的再灌注损伤

国际脑血管病杂志 2005年第5期 391-399页

作者： Wayne m.clark,曲东锋,李宏建 From the Oregon Stroke Center Department of Neurology Oregon Health Sciences University Portland 国外医学脑血管疾病分册编辑部国外医学脑血管疾病分册编辑部 211135南京市江宁区9号信箱 211135南京市江宁区9号信箱