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Chinese Neurosurgical Journal 2022年第3期8卷 209-214页

作者： Yao Wu Zhaoliang Li Dehong Yang Tao Wu ailin chen Chungang Dai Qing Zhu Second Affiliated Hospital of Soochow University Sanxiang Road 1055Suzhou 215004China

Background:Aneurysm of basilar perforator was rarely reported in the literature.It is difficult to treat due to its small size and deep-seated location.Excessive treatment may cause complications that resulted from ischemic events of parent perforators.Therefore,it is important to make clinical strategy for such patients to improve the prognosis.Case presentation:One case,who presented as spontaneous subarachnoid hemorrhage,despite the negative result in computed tomography angiography firstly,was diagnosed angiographically as a ruptured aneurysm of the basilar perforator.A good clinical outcome of the case was achieved during the follow-up after conservative observation for 2 months,as well as the disappearance of previous lesion from angiography.Conclusions:Aneurysm located at perforator of basilar trunk was rare and difficult to treat.Conservative observation for certain cases with periodic angiography follow-up was considered in order to prevent the patients from potential iatrogenic effects.

关键词： Basilar trunk Intracranial aneurysm Perforator

Evidence Mechanism of Power Dispatching Instruction Based on Blockchain

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Computer Systems Science & Engineering 2022年第11期43卷 559-571页

作者： Jian Geng Shaoyuan Yu ailin chen Hao Wang Bo Yan Liang Li Lei Song Qirun Wang China Electric Power Research Institute Nanjing210003China Nanjing University of Aeronautics and Astronautics Nanjing210008China State Grid Jibei Electric Power Company Beijing100053China School of Engineering and Technology University of HertfordshireHertfordAL109EUUK

With the development and application of energy Internet technology,the collaborative interaction of“source network,load and storage”has becomethe development trend of power grid dispatching.The large-scale access of renewableenergy on the load side,the unified management of adjustable loads,and theparticipation of multiple parties in energy operations have put forward requirementsfor the safety,credibility,openness,and transparency of the load dispatchingenvironment.Under the environment of carbon emission reduction,the paperproposed an architecture of the scheduling data blockchain,based on the in-depthstudy of blockchain.Moreover,smart contracts are used to realize the applicationscenario of load dispatching instruction evidence on the blockchain.The contentand storage mode of scheduling instruction evidence on blockchain are studied.And different storage modes are adopted according to the actual needs.Andthe smart contract system realizes the evidence generation of power dispatchinginstruction.This is the basis for the normal circulation of power dispatchinginstruction evidence.The research significance of this paper is highlighted as follows.The data and information generated in the power dispatching process arestored as evidence.On the one hand,it can provide a basis for settlement betweenpower production and dispatching companies and power users.On the other hand,it can prepare for distributed transactions in the power grid under the environmentof carbon emission reduction.

关键词： Evidence mechanism power dispatching instruction blockchain

Gill rays of primitive vertebrate Yunnanozoon from Early Cambrian: a first record

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生物学前沿:英文版 2008年第2期3卷 241-244页

作者： ailin chen Diying HUANG Key Laboratory for Palaeontology Yunnan UniversityKunming 650091China chengjiang Fauna National Geopark of China Chengjiang 652500China Nanjing Institute of Geology and Palaeontology Chinese Academy of SciencesNanjing 210008China

Yunnanozoans(including Yunnanozoon and Haikouella)are important representatives of the primitive vertebrates in the Early Cambrian chengjiang fauna.For Yunnanozoans,we know less about Yunnanozoon than about Haikouella due to the poor preservation of Yunnanozoon.Up to now,there have been some reports that Haikouella had developed gill rays,while there have been no reports on Yunnanozoon.In this paper,we described our new findings of the distinct gill rays of Yunnanozoon lividum based on new well-preserved material collected from the Lower Cambrian Maotianshan Shale in Xiaolantian of Yunnan Province,China.This study provides new data on the evolutionary relationship of the primitive vertebrates and their early evolution.

关键词： gill rays Yunnanozoon Haikouella Early Cambrian Yunnan

高校初任教师教学能力提升类MOOC学习意愿研究

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扬州大学学报（高教研究版） 2024年第3期28卷 49-60页

作者：陈芳陈嫒琳南京邮电大学江苏南京210042

教学能力提升类MOOC有助于高校初任教师实现终身学习并更好地适应信息化教学,教师愿意学习是MOOC发挥作用的前提,而我国高校初任教师的学习意愿并不清晰。基于43所高校157名初任教师的问卷调查,采用UTAUT模型分析教学能力提升类MOOC的... 详细信息

教学能力提升类MOOC有助于高校初任教师实现终身学习并更好地适应信息化教学,教师愿意学习是MOOC发挥作用的前提,而我国高校初任教师的学习意愿并不清晰。基于43所高校157名初任教师的问卷调查,采用UTAUT模型分析教学能力提升类MOOC的学习意愿及其影响因素,结果表明:目前有44.59%的高校初任教师已经学习过教学能力提升类MOOC,超3/4的高校初任教师有学习教学能力提升类MOOC的意愿,学习意愿受到绩效期望、付出期望、社会影响的正向影响且影响程度依次递减,学习意愿转化为学习行为还面临科研、教学任务重等障碍。因此,高校应优化教学能力提升类MOOC及MOOC平台设计,并在新教师培训中纳入教学能力提升类MOOC,而“工学矛盾”的解决有待顶层设计的完善和高校理念的转变。

关键词：初任教师教学能力教学能力提升MOOC 学习意愿

Cancer cell employs a microenvironmental neural signal transactivating nucleus-mitochondria coordination to acquire stemness

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3818-3836页

作者： Bin He Rui Gao Shasha Lv ailin chen Junxiu Huang Luoxuan Wang Yunxiu Feng Jiesi Feng Bing Liu Jie Lei Bing Deng Bin He Bai Cui Fei Peng Min Yan Zifeng Wang Eric W-F Lam Bilian Jin Zhiming Shao Yulong Li Jianwei Jiao Xi Wang Quentin Liu State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer CenterGuangzhou 510060PR China Department of Medical Oncology The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 510275PR China Institute of Cancer Stem Cell Cancer CenterDalian Medical UniversityDalian 116023PR China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510080PR China State Key Laboratory of Membrane Biology Peking University School of Life SciencesBeijing 100871PR China Department of Surgery and Cancer Imperial College LondonLondon W120NNUK Department of Breast Surgery Precision Cancer Medicine CenterFudan University Shanghai Cancer CenterShanghai 200032PR China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101PR China

Cancer cell receives extracellular signal inputs to obtain a stem-like status,yet how tumor microenvironmental(TME)neural signals steer cancer stemness to establish the hierarchical tumor architectures remains elusive.Here,a pan-cancer transcriptomic screening for 10852 samples of 33 TCGA cancer types reveals that cAMP-responsive element(CRE)transcription factors are convergent activators for cancer stemness.Deconvolution of transcriptomic profiles,specification of neural markers and illustration of norepinephrine dynamics uncover a bond between TME neural signals and cancer-cell CRE activity.Specifically,neural signal norepinephrine potentiates the stemness of proximal cancer cells by activating cAMP-CRE axis,where ATF1 serves as a conserved hub.Upon activation by norepinephrine,ATF1 potentiates cancer stemness by coordinated trans-activation of both nuclear pluripotency factors MYC/NANOG and mitochondrial biogenesis regulators NRF1/TFAM,thereby orchestrating nuclear reprograming and mitochondrial rejuvenating.Accordingly,single-cell transcriptomes confirm the coordinated activation of nuclear pluripotency with mitochondrial biogenesis in cancer stem-like cells.These findings elucidate that cancer cell acquires stemness via a norepinephrine-ATF1 driven nucleus-mitochondria collaborated program,suggesting a spatialized stemness acquisition by hijacking microenvironmental neural signals.

关键词： Cancer neural architectures

CRISPR/Cas9 screening identifies a kinetochore-microtubule dependent mechanism for Aurora-A inhibitor resistance in breast cancer

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Cancer Communications 2021年第2期41卷 121-139页

作者： ailin chen Shijun Wen Fang Liu Zijian Zhang Meiling Liu Yuanzhong Wu Bin He Min Yan Tiebang Kang Eric W-F Lam Zifeng Wang Quentin Liu Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060P.R.China Institute of Cancer Stem Cell Dalian Medical UniversityDalianLiaoning 116044P.R.China Department of Surgery and Cancer Imperial College LondonW120NNLondonUK

Background:Overexpression of Aurora-A(AURKA)is a feature of breast cancer and associates with adverse prognosis.The selective Aurora-A inhibitor alisertib(MLN8237)has recently demonstrated promising antitumor responses as a single agent in various cancer types but its phase III clinical trial was reported as a failure since MLN8237 did not show an apparent effect in prolonging the survival of patients.Thus,identification of potential targets that could enhance the activity of MLN8237 would provide a rationale for drug combination to achieve better therapeutic outcome.Methods:Here,we conducted a systematic synthetic lethality CRISPR/Cas9 screening of 507 kinases using MLN8237 in breast cancer cells and identified a number of targetable kinases that displayed synthetic lethality interactions with MLN8237.Then,we performed competitive growth assays,colony formation assays,cell viability assays,apoptosis assays,and xenograft murine model to evaluate the synergistic therapeutic effects of Haspin(GSG2)depletion or inhibition with MLN8237.For mechanistic studies,immunofluorescence was used to detect the state of microtubules and the localization of Aurora-B and mitotic centromere-associated kinesin(MCAK).Results:Among the hits,we observed that Haspin depletion or inhibition marginally inhibited breast cancer cell growth but could substantially enhance the killing effects of MLN8237.Mechanistic studies showed that co-treatment with Aurora-A and Haspin inhibitors abolished the recruitment of Aurora-B and mitotic centromere-associated kinesin(MCAK)to centromeres which were associated with excessive microtubule depolymerization,kinetochore-microtubule(KT-MT)attachment failure,and severe mitotic catastrophe.We further showed that the combination of MLN8237 and the Haspin inhibitor CHR-6494 synergistically reduced breast cancer cell viability and significantly inhibited both in vitro and in vivo tumor growth.Conclusions:These findings establish Haspin as a synthetic lethal target and demonstrate CHR-6494 as a potential combin

关键词： alisertib Aurora-A breast cancer CHR-6494 CRISPR/Cas9 screening haspin kinetochoremicrotubule mitotic centromere-associated kinesin synthetic lethal xenograft

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徐玲治疗风湿寒性关节痛用药规律分析

陕西中医 2024年第5期45卷 679-682页

作者：刘茜陈爱林王颖白琳樊亚红西安市第五医院陕西西安710082

目的:通过数据挖掘方法,总结、提炼名医徐玲治疗风湿寒性关节痛的用药规律。方法:通过用数据挖掘方法分析徐玲治疗风湿寒性关节痛处方,探索名医徐玲治疗风湿寒性关节痛的用药规律及相关学术经验。结果:最终结果统计出名医徐玲一定时间... 详细信息

目的:通过数据挖掘方法,总结、提炼名医徐玲治疗风湿寒性关节痛的用药规律。方法:通过用数据挖掘方法分析徐玲治疗风湿寒性关节痛处方,探索名医徐玲治疗风湿寒性关节痛的用药规律及相关学术经验。结果:最终结果统计出名医徐玲一定时间段所涉及到的证型以风湿痹阻证、脾肾亏虚证、风寒阻络证为多,涉及中药有95味,其中频次超过20次的中药为桂枝、白芍、黄芪、甘草、当归、独活、防风等;四气五味统计出温性药物居多;药味统计以辛、甘味最多;药物归脾、肝两经居多;药物功效以补虚类药物使用频次最多,其次为祛风湿药、解表药等;通过关联规则可以看出强连接数的药对有16对;运用聚类分析结果可以得出治疗风湿寒性关节痛的核心处方3个。结论:徐玲治疗风湿寒性关节痛用药分析后得出,以补脾益肾,柔肝止痛,祛邪除痹为治疗原则,体现“祛邪守中”的治疗理念。

关键词：风湿寒性关节痛长安徐氏风湿流派徐玲临床经验数据挖掘祛邪守中

保加利亚产大马士革玫瑰精油的化学成分及其抗氧化活性研究

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云南化工 2024年第7期51卷 39-44页

作者：陈婕陈畅宇王有娣严斌古瑞圆陈爱琳陈香凝徐娟娟广州新华学院药学院广东广州510520

为研究大马士革玫瑰精油的化学成分及其抗氧化活性,采取气相色谱与质谱联用的方法对保加利亚产大马士革玫瑰精油的化学成分进行了分析,并以总抗氧化活性和羟自由基清除能力为指标,考察其体外抗氧化活性。结果表明,从保加利亚产大马士革... 详细信息

为研究大马士革玫瑰精油的化学成分及其抗氧化活性,采取气相色谱与质谱联用的方法对保加利亚产大马士革玫瑰精油的化学成分进行了分析,并以总抗氧化活性和羟自由基清除能力为指标,考察其体外抗氧化活性。结果表明,从保加利亚产大马士革玫瑰精油中检测到主要化学组分为香茅醇(45.97%)、香叶醇(22.8%)、正十九烷(14.89%)、正二十一烷(3.74%)等。抗氧化活性测试表明,在实验质量浓度范围内,无论是总抗氧化能力,还是革除羟自由基的能力,保加利亚产大马士革玫瑰精油均表现出良好的抗氧化活性,且一定程度上优于阳性对照药(食品级二丁基羟基甲苯)。

关键词：大马士革玫瑰精油化学成分抗氧化活性保加利亚

非优势供血侧眶上锁孔入路显微手术治疗破裂前交通动脉瘤的临床疗效

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中华脑血管病杂志（电子版） 2024年第2期18卷 115-120页

作者：杨德红万宇晖杨凯陈爱林戴纯刚陈延明陈炳霖朱卿苏州大学附属第二医院神经外科江苏苏州215004

目的探讨非优势供血侧眶上锁孔入路显微手术治疗破裂前交通动脉瘤的临床疗效。方法回顾性分析苏州大学附属第二医院2016年1月至2020年10月69例接受眶上锁孔入路显微手术治疗的破裂前交通动脉瘤患者的临床资料,其中经非优势供血侧入路32... 详细信息

目的探讨非优势供血侧眶上锁孔入路显微手术治疗破裂前交通动脉瘤的临床疗效。方法回顾性分析苏州大学附属第二医院2016年1月至2020年10月69例接受眶上锁孔入路显微手术治疗的破裂前交通动脉瘤患者的临床资料,其中经非优势供血侧入路32例,经优势供血侧入路37例。采用单因素分析比较2组病例的手术时间、术中动脉瘤破裂率、术中动脉瘤夹使用个数、是否切除额叶直回、动脉瘤夹闭不全率、前交通动脉瘤复合体变异扭转率及预后情况的差异。结果非优势供血侧入路组与优势供血侧入路组的手术时间分别为(190±61)min和(204±55)min,术中发生动脉瘤破裂分别有9例(24.3%)和4例(12.5%),术中动脉瘤夹使用个数分别为(1.38±0.61)个和(1.35±0.63)个,额叶直回切除率分别为37.5%(12/32)和48.6%(18/37),动脉瘤夹闭不全率分别为3.1%(1/32)和2.7%(1/37),前交通动脉瘤复合体变异扭转率分别为50.0%(16/32)和37.8%(14/37),出院时预后良好率分别为78.1%(25/32)和75.7%(28/37),出院后1个月、3个月、6个月、12个月的预后良好率均分别为78.1%(25/32)和73.0%(27/37),差异均无统计学意义(P均>0.05)。结论经非优势供血侧眶上锁孔入路显微手术治疗破裂前交通动脉瘤安全、有效。

关键词：前交通动脉动脉瘤锁孔手术入路显微夹闭术非优势供血

Microsurgical clipping and endovascular coiling for ruptured anterior circulation aneurysms

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Microsurgical clipping and endovascular coiling for ruptured...