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Evidence Mechanism of Power Dispatching Instruction Based on Blockchain

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Computer Systems Science & Engineering 2022年第11期43卷 559-571页

作者： Jian Geng Shaoyuan Yu ailin chen Hao Wang Bo Yan Liang Li Lei Song Qirun Wang China Electric Power Research Institute Nanjing210003China Nanjing University of Aeronautics and Astronautics Nanjing210008China State Grid Jibei Electric Power Company Beijing100053China School of Engineering and Technology University of HertfordshireHertfordAL109EUUK

With the development and application of energy Internet technology,the collaborative interaction of“source network,load and storage”has becomethe development trend of power grid *** large-scale access of renewableenergy on the load side,the unified management of adjustable loads,and theparticipation of multiple parties in energy operations have put forward requirementsfor the safety,credibility,openness,and transparency of the load *** the environment of carbon emission reduction,the paperproposed an architecture of the scheduling data blockchain,based on the in-depthstudy of ***,smart contracts are used to realize the applicationscenario of load dispatching instruction evidence on the *** contentand storage mode of scheduling instruction evidence on blockchain are *** different storage modes are adopted according to the actual *** smart contract system realizes the evidence generation of power *** is the basis for the normal circulation of power dispatchinginstruction *** research significance of this paper is highlighted as *** data and information generated in the power dispatching process arestored as *** the one hand,it can provide a basis for settlement betweenpower production and dispatching companies and power *** the other hand,it can prepare for distributed transactions in the power grid under the environmentof carbon emission reduction.

关键词： Evidence mechanism power dispatching instruction blockchain

CRISPR/Cas9 screening identifies a kinetochore-microtubule dependent mechanism for Aurora-A inhibitor resistance in breast cancer

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Cancer Communications 2021年第2期41卷 121-139页

作者： ailin chen Shijun Wen Fang Liu Zijian Zhang Meiling Liu Yuanzhong Wu Bin He Min Yan Tiebang Kang Eric W-F Lam Zifeng Wang Quentin Liu Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060P.R.China Institute of Cancer Stem Cell Dalian Medical UniversityDalianLiaoning 116044P.R.China Department of Surgery and Cancer Imperial College LondonW120NNLondonUK

Background:Overexpression of Aurora-A(AURKA)is a feature of breast cancer and associates with adverse *** selective Aurora-A inhibitor alisertib(MLN8237)has recently demonstrated promising antitumor responses as a single agent in various cancer types but its phase III clinical trial was reported as a failure since MLN8237 did not show an apparent effect in prolonging the survival of ***,identification of potential targets that could enhance the activity of MLN8237 would provide a rationale for drug combination to achieve better therapeutic ***:Here,we conducted a systematic synthetic lethality CRISPR/Cas9 screening of 507 kinases using MLN8237 in breast cancer cells and identified a number of targetable kinases that displayed synthetic lethality interactions with ***,we performed competitive growth assays,colony formation assays,cell viability assays,apoptosis assays,and xenograft murine model to evaluate the synergistic therapeutic effects of Haspin(GSG2)depletion or inhibition with *** mechanistic studies,immunofluorescence was used to detect the state of microtubules and the localization of Aurora-B and mitotic centromere-associated kinesin(MCAK).Results:Among the hits,we observed that Haspin depletion or inhibition marginally inhibited breast cancer cell growth but could substantially enhance the killing effects of *** studies showed that co-treatment with Aurora-A and Haspin inhibitors abolished the recruitment of Aurora-B and mitotic centromere-associated kinesin(MCAK)to centromeres which were associated with excessive microtubule depolymerization,kinetochore-microtubule(KT-MT)attachment failure,and severe mitotic *** further showed that the combination of MLN8237 and the Haspin inhibitor CHR-6494 synergistically reduced breast cancer cell viability and significantly inhibited both in vitro and in vivo tumor ***:These findings establish Haspin as a synthetic lethal targe

关键词： alisertib Aurora-A breast cancer CHR-6494 CRISPR/Cas9 screening haspin kinetochoremicrotubule mitotic centromere-associated kinesin synthetic lethal xenograft

Microsurgical clipping and endovascular coiling for ruptured anterior circulation aneurysms

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Microsurgical clipping and endovascular coiling for ruptured...

Spontaneous subarachnoid hemorrhage caused by ruptured aneurysm of basilar trunk perforator:a case report and literature review

第十四届中国医师协会神经外科医师年会

作者： Qing Zhu ailin chen Chungang Dai Chao Sun Yanming chen Qing Lan Department of Neurosurgery Second Affiliated Hospital Soochow University

Purpose: Either microsurgical clipping or endovascular coiling can be selected for the treatment of ruptured intracranial aneurysms of anterior circulation in most cases. However, which one is better is still controversial. There are few prospective randomized controlled trials comparing the above two modalities currently, especially comparing with microsurgery via keyhole approaches, of which no report has been identified. We compared the therapeutic efficacy of microsurgical clipping via keyhole approaches with that via conventional approaches and endovascular coiling for ruptured intracranial aneurysms of anterior circulation. Methods: 150 patients harbored 170 aneurysms of anterior circulation amenable to both microsurgical clipping and endovascular coiling were randomized. 50 cases experienced microsurgical clipping via keyhole approaches（Keyhole Group） as well as 50 via conventional approaches（Conventional Group）. Other 50 cases were treated by endovascular coiling（Endovascular Group）. Results: All 170 aneurysms were managed in one stage. Neck clipping was achieved in 48 patients（58 aneurysms） via keyhole approaches as well as in 49 patients（55 aneurysms） via conventional approaches. Complete obliteration by endovascular coiling was achieved in 50 aneurysms. Based on Glasgow Outcome Scale, there were no statistical difference（P＞0.05） at discharge. There was no statistical difference in postoperative hospitalization between Endovascular Group and Keyhole Group（P＞0.05）, but both were shorter than that in Conventional Group（P＜0.01）. In terms of total hospitalization costs, Keyhole Group was less than Conventional Group（P＜0.01）, while Endovascular Group was significantly highest（P＜0.01）. Conclusions: Keyhole approaches are suitable for the treatment of ruptured intracranial aneurysms of anterior circulation that do not necessitate decomprassive craniectomy and are superior to conventional approaches. Compared with endovascular coiling, the therapeutic effect is eq

关键词： neurosurgery intracranial aneurysm endovascular treatment surgical approach keyhole

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Chinese Neurosurgical Journal 2022年第3期8卷 209-214页

作者： Yao Wu Zhaoliang Li Dehong Yang Tao Wu ailin chen Chungang Dai Qing Zhu Second Affiliated Hospital of Soochow University Sanxiang Road 1055Suzhou 215004China

Background:Aneurysm of basilar perforator was rarely reported in the *** is difficult to treat due to its small size and deep-seated *** treatment may cause complications that resulted from ischemic events of parent ***,it is important to make clinical strategy for such patients to improve the *** presentation:One case,who presented as spontaneous subarachnoid hemorrhage,despite the negative result in computed tomography angiography firstly,was diagnosed angiographically as a ruptured aneurysm of the basilar perforator.A good clinical outcome of the case was achieved during the follow-up after conservative observation for 2 months,as well as the disappearance of previous lesion from ***:Aneurysm located at perforator of basilar trunk was rare and difficult to *** observation for certain cases with periodic angiography follow-up was considered in order to prevent the patients from potential iatrogenic effects.

关键词： Basilar trunk Intracranial aneurysm Perforator

Microsurgical clipping and endovascular coiling for ruptured anterior circulation aneurysms

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Microsurgical clipping and endovascular coiling for ruptured...

第十五届中国医师协会神经外科医师年会

作者： Qing Zhu ailin chen Chungang Dai Chao Sun Qing Lan Department of Neurosurgery Second Affiliated Hospital Soochow University

Purpose:Either microsurgical clipping or endovascular coiling can be selected for the treatment of ruptured intracranial aneurysms of anterior circulation in most ***,which one is better is still *** are few prospective randomized controlled trials comparing the above two modalities currently,especially comparing with microsurgery via keyhole approaches,of which no report has been *** compared the therapeutic efficacy of microsurgical clipping via keyhole approaches with that via conventional approaches and endovascular coiling for ruptured intracranial aneurysms of anterior ***:150 patients harbored 170 aneurysms of anterior circulation amenable to both microsurgical clipping and endovascular coiling were randomized.50 cases experienced microsurgical clipping via keyhole approaches（Keyhole Group） as well as 50 via conventional approaches（Conventional Group）.Other 50 cases were treated by endovascular coiling（Endovascular Group）.Results:All 170 aneurysms were managed in one *** clipping was achieved in 48 patients（58 aneurysms） via keyhole approaches as well as in 49 patients（55 aneurysms） via conventional *** obliteration by endovascular coiling was achieved in 50 *** on Glasgow Outcome Scale,there were no statistical difference（P＞0.05） at *** was no statistical difference in postoperative hospitalization between Endovascular Group and Keyhole Group（P＞0.05）,but both were shorter than that in Conventional Group（P＜0.01）.In terms of total hospitalization costs,Keyhole Group was less than Conventional Group（P＜0.01）,while Endovascular Group was significantly highest（P＜0.01）.Conclusions:Keyhole approaches are suitable for the treatment of ruptured intracranial aneurysms of anterior circulation that do not necessitate decomprassive craniectomy and are superior to conventional *** with endovascular coiling,the therapeutic effect is equivalent and the medical c

关键词： neurosurgery intracranial aneurysm endovascular treatment surgical approach keyhole

来源： cnki会议评论

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一种考虑系统复杂性的设备布局仿真评价方法

系统仿真学报 2017年第2期29卷 346-354页

作者：俞爱林陈庆新毛宁广东工业大学广东省计算机集成制造系统重点实验室广东广州510090

为研究不同设备布局方式下定制型装备制造系统的性能,提出了一种考虑制造系统复杂性的仿真评价方法。根据企业实际,归纳与抽象了三种典型的装备制造系统设备布局方案;考虑系统复杂性,构建了制造系统设备布局方案的评价指标体系,着重阐... 详细信息

为研究不同设备布局方式下定制型装备制造系统的性能,提出了一种考虑制造系统复杂性的仿真评价方法。根据企业实际,归纳与抽象了三种典型的装备制造系统设备布局方案;考虑系统复杂性,构建了制造系统设备布局方案的评价指标体系,着重阐述了系统结构熵模型及系统运行熵模型的构建方法;在抽象产品、工艺模型的基础上,构建了相应的系统仿真模型;通过仿真实验,获得了评价指标体系的各类参数,进而对布局方案进行评价。

关键词：设备布局仿真评价系统复杂性装备制造

Cancer cell employs a microenvironmental neural signal transactivating nucleus-mitochondria coordination to acquire stemness

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3818-3836页

作者： Bin He Rui Gao Shasha Lv ailin chen Junxiu Huang Luoxuan Wang Yunxiu Feng Jiesi Feng Bing Liu Jie Lei Bing Deng Bin He Bai Cui Fei Peng Min Yan Zifeng Wang Eric W-F Lam Bilian Jin Zhiming Shao Yulong Li Jianwei Jiao Xi Wang Quentin Liu State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer CenterGuangzhou 510060PR China Department of Medical Oncology The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 510275PR China Institute of Cancer Stem Cell Cancer CenterDalian Medical UniversityDalian 116023PR China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510080PR China State Key Laboratory of Membrane Biology Peking University School of Life SciencesBeijing 100871PR China Department of Surgery and Cancer Imperial College LondonLondon W120NNUK Department of Breast Surgery Precision Cancer Medicine CenterFudan University Shanghai Cancer CenterShanghai 200032PR China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101PR China

Cancer cell receives extracellular signal inputs to obtain a stem-like status,yet how tumor microenvironmental(TME)neural signals steer cancer stemness to establish the hierarchical tumor architectures remains ***,a pan-cancer transcriptomic screening for 10852 samples of 33 TCGA cancer types reveals that cAMP-responsive element(CRE)transcription factors are convergent activators for cancer *** of transcriptomic profiles,specification of neural markers and illustration of norepinephrine dynamics uncover a bond between TME neural signals and cancer-cell CRE ***,neural signal norepinephrine potentiates the stemness of proximal cancer cells by activating cAMP-CRE axis,where ATF1 serves as a conserved *** activation by norepinephrine,ATF1 potentiates cancer stemness by coordinated trans-activation of both nuclear pluripotency factors MYC/NANOG and mitochondrial biogenesis regulators NRF1/TFAM,thereby orchestrating nuclear reprograming and mitochondrial ***,single-cell transcriptomes confirm the coordinated activation of nuclear pluripotency with mitochondrial biogenesis in cancer stem-like *** findings elucidate that cancer cell acquires stemness via a norepinephrine-ATF1 driven nucleus-mitochondria collaborated program,suggesting a spatialized stemness acquisition by hijacking microenvironmental neural signals.

关键词： Cancer neural architectures

澄江生物群具重要演化意义的原始单轴针海绵新属种——Ovulispongia multa *** ***.

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地质学报 2022年第11期96卷 3750-3759页

作者：杨继媛马海丹陈爱林侯先光玉溪师范学院古生物研究中心云南玉溪653100 现代古生物学和地层学国家重点实验室中国科学院南京地质古生物研究所江苏南京210008 云南大学云南省古生物研究重点实验室云南昆明650091

本文描述了云南寒武纪早期澄江生物群中原始单轴针海绵化石一新属种——群体小卵海绵Ovulispongia multa gen. et sp. nov.。群体小卵海绵为小型薄壁海绵,整体呈卵形,骨骼双层,由四个方向的单轴骨针穿插成网状,左倾方向和右倾方向骨针... 详细信息

本文描述了云南寒武纪早期澄江生物群中原始单轴针海绵化石一新属种——群体小卵海绵Ovulispongia multa gen. et sp. nov.。群体小卵海绵为小型薄壁海绵,整体呈卵形,骨骼双层,由四个方向的单轴骨针穿插成网状,左倾方向和右倾方向骨针与水平骨针和纵向骨针斜交呈45度角;骨针之间无叠接;海绵体无口须和根须。群体小卵海绵在外部形态和骨架类型上与其他的原始单轴针海绵存在明显差异,其半紧密型骨架处于无规则排列的鬃毛海绵骨架和规则排列的细丝海绵骨架之间。另外新材料显示在海底固着取食的生态环境中,新属种用高密度的个体分布来获得竞争优势。群体小卵海绵独特的过渡形态的骨架结构和高密度生态分布为研究古生代原始单轴针海绵的骨架演化与生态空间扩张之间的关系提供了线索,也为研究寒武纪早期海绵动物的起源和多样化提供新的化石材料。

关键词：寒武纪早期澄江生物群多孔动物普通海绵 Ovulispongia multa gen.et sp.nov

云南寒武纪早期澄江生物群中原始海绵科似斜纹海绵属新种

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地质学报 2019年第11期93卷 2715-2728页

作者：马海丹杨继媛陈爱林侯先光唐烽玉溪师范学院古生物研究中心云南玉溪653100 教育部云南重大生物演化事件及古环境国际合作联合实验室昆明650091 现代古生物学和地层学国家重点实验室中国科学院南京地质古生物研究所南京210008 云南大学云南省古生物研究重点实验室昆明650091 中国地质科学院地质研究所北京100037

本文报道澄江生物群似斜纹海绵属Paradiagoniella的两个新种:橄榄形似斜纹海绵*** sp. nov.和锥形似斜纹海绵*** sp. nov.。两个新种具有似斜纹海绵属的基本特征:体壁薄;由排列不规则、分级的十字骨针为基底构成骨骼;除十字骨针外,还穿... 详细信息

本文报道澄江生物群似斜纹海绵属Paradiagoniella的两个新种:橄榄形似斜纹海绵*** sp. nov.和锥形似斜纹海绵*** sp. nov.。两个新种具有似斜纹海绵属的基本特征:体壁薄;由排列不规则、分级的十字骨针为基底构成骨骼;除十字骨针外,还穿插排列有五射针、六射针、弯弓形和针形双尖单轴针等。然而与模式种不同,两个新种十字骨针分级不明显;同时,两个新种在外形、骨针组成、最大十字骨针射长比等方面,与本属的其他种都存在明显差异。新材料的发现增加了寒武纪早期原始海绵物种多样性,为研究海绵动物早期起源演化提供了新信息。

关键词：寒武纪澄江生物群多孔动物六射海绵网针海绵原始海绵